Moritz Gerstung

Moritz Gerstung

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Moritz Gerstung

Publications by authors named "Moritz Gerstung"

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Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nature 2019 02;566(7742):E1

Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.

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http://www.nature.com/articles/s41586-019-0883-2
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http://dx.doi.org/10.1038/s41586-019-0883-2DOI Listing
February 2019

Immuno-oncology from the perspective of somatic evolution.

Semin Cancer Biol 2018 10 6;52(Pt 2):75-85. Epub 2017 Dec 6.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2017.12.001DOI Listing
October 2018

Classification and Personalized Prognosis in Myeloproliferative Neoplasms.

N Engl J Med 2018 10;379(15):1416-1430

From the Wellcome-MRC Cambridge Stem Cell Institute and Cambridge Institute for Medical Research (J.G., C.E.M., F.L.N., A.R.G., P.J.C.), the Department of Haematology, University of Cambridge (J.G., E.J.B., C.M., J.C., C.E.M., F.L.N., A.R.G.), and the Department of Haematology, Cambridge University Hospitals NHS Foundation Trust (J.G., E.J.B., A.L.G., C.M., J.C., A.R.G.), Cambridge, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus (J.N., D.C.W., N.A., E.P., G.G., L.O., S.O., J.W.T., A.P.B., N.W., P.J.C.), and the European Molecular Biology Laboratory, European Bioinformatics Institute (R.C., M.G.), Hinxton, Big Data Institute, University of Oxford, Oxford (D.C.W.), the Department of Haematology, Queen's University Belfast, Belfast (M.F.M.), and the Department of Haematology, Guy's and St. Thomas' NHS Foundation Trust, London (C.N.H.) - all in the United Kingdom; the Center for Molecular Oncology and the Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York (E.P., G.G.); the Department of Hematology, Zealand University Hospital, Roskilde, and the University of Copenhagen, Copenhagen (C.L.A., H.C.H.); and the Department of Experimental and Clinical Medicine, Center of Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy (P.G., A.M.V.).

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http://www.nejm.org/doi/10.1056/NEJMoa1716614
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http://dx.doi.org/10.1056/NEJMoa1716614DOI Listing
October 2018

Prediction of acute myeloid leukaemia risk in healthy individuals.

Nature 2018 07 9;559(7714):400-404. Epub 2018 Jul 9.

Princess Margaret Cancer Centre, University Health Network (UHN), Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41586-018-0317-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485381PMC
July 2018

Mutational signatures of DNA mismatch repair deficiency in and human cancers.

Genome Res 2018 05 10;28(5):666-675. Epub 2018 Apr 10.

Centre for Gene Regulation and Expression, University of Dundee, Dundee DD1 5EH, United Kingdom.

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http://genome.cshlp.org/lookup/doi/10.1101/gr.226845.117
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http://dx.doi.org/10.1101/gr.226845.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932607PMC
May 2018

Universal Patterns of Selection in Cancer and Somatic Tissues.

Cell 2017 Nov 19;171(5):1029-1041.e21. Epub 2017 Oct 19.

Wellcome Trust Sanger Institute, Hinxton CB10 1SA, Cambridgeshire, UK; Department of Haematology, University of Cambridge, Cambridge CB2 2XY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.09.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720395PMC
November 2017

A High-Density Map for Navigating the Human Polycomb Complexome.

Cell Rep 2016 10;17(2):583-595

Department of Biosystems Science and Engineering, ETH Zürich, 4058 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.08.096DOI Listing
October 2016

Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nature 2016 06 2;534(7605):47-54. Epub 2016 May 2.

Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1038/nature17676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910866PMC
June 2016

Genomic Classification and Prognosis in Acute Myeloid Leukemia.

N Engl J Med 2016 Jun;374(23):2209-2221

Cancer Genome Project, Wellcome Trust Sanger Institute (E.P., M.G., N.D.R., N.B., G.G., P.V.L., I.M., L.M., S.M., S.O., K.R., D.R.J., J.W.T., A.P.B., P.J.C.), and the European Bioinformatics Institute, European Molecular Biology Laboratory (EMBL-EBI) (M.G.), Hinxton, the Centre for Evolution and Cancer, Institute of Cancer Research, London (N.E.P., M.F.G.), and the Department of Haematology, University of Cambridge, Cambridge (N.B.) - all in the United Kingdom; the Departments of Epidemiology and Biostatistics and Cancer Biology, the Center for Molecular Oncology and the Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York (E.P.); the Department of Internal Medicine III, Ulm University, Ulm (L.B., V.I.G., P.P., K.D., R.F.S., H.D.), and the Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover (M.H., F.T., A.G.) - both in Germany; the Division of Hematology, Fondazione IRCCS, Istituto Nazionale dei Tumori, and Department of Oncology and Onco-Hematology, University of Milan, Milan (N.B.); the Department of Human Genetics, University of Leuven, Leuven, Belgium (P.V.L.); and the Department of Pathology, University of Otago, Christchurch, New Zealand (P.G., P.J.C.).

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http://dx.doi.org/10.1056/NEJMoa1516192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979995PMC
June 2016

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.

Nat Genet 2015 Mar 2;47(3):257-62. Epub 2015 Feb 2.

1] Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada. [2] The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. [3] Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada. [4] Department of Pediatrics, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/ng.3202DOI Listing
March 2015

Cancer evolution: mathematical models and computational inference.

Syst Biol 2015 Jan 7;64(1):e1-25. Epub 2014 Oct 7.

Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland; SIB Swiss Institute of Bioinformatics, 4058 Basel, Switzerland; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, United Kingdom; Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB10 1SA, United Kingdom; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, CB20RE, United Kingdom.

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http://dx.doi.org/10.1093/sysbio/syu081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265145PMC
January 2015

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.

Science 2014 Aug;345(6196):1251343

Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.

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http://dx.doi.org/10.1126/science.1251343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380235PMC
August 2014

Subclonal variant calling with multiple samples and prior knowledge.

Bioinformatics 2014 May 16;30(9):1198-204. Epub 2014 Jan 16.

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK, Department of Haematology, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK and Department of Haematology, University of Cambridge, Cambridge CB22XY, UK.

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http://dx.doi.org/10.1093/bioinformatics/btt750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998123PMC
May 2014

Kinetic, energetic, and mechanical differences between dark-state rhodopsin and opsin.

Structure 2013 Mar 21;21(3):426-37. Epub 2013 Feb 21.

Department of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland.

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http://dx.doi.org/10.1016/j.str.2013.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806332PMC
March 2013

Reliable detection of subclonal single-nucleotide variants in tumour cell populations.

Nat Commun 2012 May 1;3:811. Epub 2012 May 1.

Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland.

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http://dx.doi.org/10.1038/ncomms1814DOI Listing
May 2012

The temporal order of genetic and pathway alterations in tumorigenesis.

PLoS One 2011 1;6(11):e27136. Epub 2011 Nov 1.

Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0027136PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206070PMC
March 2012

Genome-wide expression and copy number analysis identifies driver genes in gingivobuccal cancers.

Genes Chromosomes Cancer 2012 Feb 10;51(2):161-73. Epub 2011 Nov 10.

Cancer Research Institute (CRI), Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Navi Mumbai, India.

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http://dx.doi.org/10.1002/gcc.20940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233671PMC
February 2012

Clinicopathological and prognostic implications of genetic alterations in oral cancers.

Oncol Lett 2011 May;2(3):445-451

Cancer Research Institute, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Kharghar Node, Navi Mumbai-410210, India.

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https://www.spandidos-publications.com/10.3892/ol.2011.271
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http://dx.doi.org/10.3892/ol.2011.271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085881PMC
May 2011

Polycomb preferentially targets stalled promoters of coding and noncoding transcripts.

Genome Res 2011 Feb 22;21(2):216-26. Epub 2010 Dec 22.

Department of Biosystems Science and Engineering, ETH Zurich, CH-4058 Basel, Switzerland.

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http://dx.doi.org/10.1101/gr.114348.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032925PMC
February 2011

Genomic profiling of advanced-stage oral cancers reveals chromosome 11q alterations as markers of poor clinical outcome.

PLoS One 2011 Feb 28;6(2):e17250. Epub 2011 Feb 28.

Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer, Cancer Research Institute, Navi Mumbai, India.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017250PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046132PMC
February 2011

Quantifying cancer progression with conjunctive Bayesian networks.

Bioinformatics 2009 Nov 19;25(21):2809-15. Epub 2009 Aug 19.

Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland.

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http://dx.doi.org/10.1093/bioinformatics/btp505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781752PMC
November 2009

A quantitative and dynamic model for plant stem cell regulation.

PLoS One 2008 29;3(10):e3553. Epub 2008 Oct 29.

Department of Mathematics and Physics, University of Freiburg, Freiburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0003553PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570333PMC
February 2009

Noisy signaling through promoter logic gates.

Phys Rev E Stat Nonlin Soft Matter Phys 2009 Jan 29;79(1 Pt 1):011923. Epub 2009 Jan 29.

Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, Switzerland.

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http://dx.doi.org/10.1103/PhysRevE.79.011923DOI Listing
January 2009

Control of plant organ size by KLUH/CYP78A5-dependent intercellular signaling.

Dev Cell 2007 Dec;13(6):843-56

Institut für Biologie III, Universität Freiburg, Schänzlestrasse 1, D-79104 Freiburg, Germany.

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http://dx.doi.org/10.1016/j.devcel.2007.10.001DOI Listing
December 2007