Moritz Gaidt

Moritz Gaidt

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Moritz Gaidt

Moritz Gaidt

Publications by authors named "Moritz Gaidt"

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17Publications

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TLR8 Is a Sensor of RNase T2 Degradation Products.

Cell 2019 Nov;179(6):1264-1275.e13

Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany; Center for Integrated Protein Science (CiPSM), Ludwig-Maximilians-Universität München, Munich, Germany; Max Planck Institute of Biochemistry, Martinsried, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.11.001DOI Listing
November 2019

BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages.

Cell Rep 2018 11;25(9):2354-2368.e5

Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, 81377 Munich, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183169
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http://dx.doi.org/10.1016/j.celrep.2018.10.087DOI Listing
November 2018

Modeling Primary Human Monocytes with the Trans-Differentiation Cell Line BLaER1.

Methods Mol Biol 2018 ;1714:57-66

Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Feodor-Lynen-Str. 25, 81377, Munich, Germany.

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http://dx.doi.org/10.1007/978-1-4939-7519-8_4DOI Listing
July 2018

The NLRP3 Inflammasome Renders Cell Death Pro-inflammatory.

J Mol Biol 2018 01 2;430(2):133-141. Epub 2017 Dec 2.

Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich 81377, Germany; Center for Integrated Protein Science (CIPSM), Ludwig-Maximilians-Universität München, Munich 81377, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2017.11.013DOI Listing
January 2018

ICG-001 affects DRP1 activity and ER stress correlative with its anti-proliferative effect.

Oncotarget 2017 Dec 1;8(63):106764-106777. Epub 2017 Nov 1.

MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, United Kingdom.

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http://dx.doi.org/10.18632/oncotarget.22264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739772PMC
December 2017

The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.

Cell 2017 Nov 12;171(5):1110-1124.e18. Epub 2017 Oct 12.

Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, 81377 Munich, Germany; Center for Integrated Protein Science (CIPSM), Ludwig-Maximilians-Universität München, 81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.09.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901709PMC
November 2017

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders.

Nature 2017 09 13;549(7672):394-398. Epub 2017 Sep 13.

Department of Biochemistry, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.

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http://dx.doi.org/10.1038/nature23890DOI Listing
September 2017

Alternative inflammasome activation enables IL-1β release from living cells.

Curr Opin Immunol 2017 Feb 11;44:7-13. Epub 2016 Nov 11.

Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Feodor-Lynen-Str. 25, 81377 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.coi.2016.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894802PMC
February 2017

Pore formation by GSDMD is the effector mechanism of pyroptosis.

EMBO J 2016 10 29;35(20):2167-2169. Epub 2016 Aug 29.

Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.

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http://dx.doi.org/10.15252/embj.201695415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069554PMC
October 2016

Designer Nuclease-Mediated Generation of Knockout THP1 Cells.

Methods Mol Biol 2016 ;1338:261-72

Institute of Molecular Medicine, University Hospital, University of Bonn, Sigmund-Freud-Straße 25, Bonn, Germany.

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http://dx.doi.org/10.1007/978-1-4939-2932-0_19DOI Listing
July 2016

Human Monocytes Engage an Alternative Inflammasome Pathway.

Immunity 2016 Apr 29;44(4):833-46. Epub 2016 Mar 29.

Institute of Molecular Medicine, University Hospital Bonn, 53127 Bonn, Germany; Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, 81377 München, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.01.012DOI Listing
April 2016

Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells.

Eur J Immunol 2015 Oct 6;45(10):2911-7. Epub 2015 Aug 6.

Institute of Molecular Medicine, University Hospital, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1002/eji.201545523DOI Listing
October 2015

Cytosolic RNA:DNA hybrids activate the cGAS-STING axis.

EMBO J 2014 Dec 25;33(24):2937-46. Epub 2014 Nov 25.

Institute of Molecular Medicine, University Hospital University of Bonn, Bonn, Germany

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http://dx.doi.org/10.15252/embj.201488726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282641PMC
December 2014

OutKnocker: a web tool for rapid and simple genotyping of designer nuclease edited cell lines.

Genome Res 2014 Oct 3;24(10):1719-23. Epub 2014 Sep 3.

Institute of Molecular Medicine, University Hospital, University of Bonn, 53127 Bonn, Germany;

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http://dx.doi.org/10.1101/gr.176701.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199374PMC
October 2014