Morag Park

Morag Park

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Arf6 regulates RhoB subcellular localization to control cancer cell invasion.

J Cell Biol 2019 Oct 7. Epub 2019 Oct 7.

Department of Biochemistry, McGill University, Montreal, Quebec, Canada

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http://dx.doi.org/10.1083/jcb.201806111DOI Listing
October 2019

Reduction of Global H3K27me Enhances HER2/ErbB2 Targeted Therapy.

Cell Rep 2019 Oct;29(2):249-257.e8

Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montréal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montréal, QC H3A 1A3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.08.105DOI Listing
October 2019

CLIP-170 spatially modulates receptor tyrosine kinase recycling to coordinate cell migration.

Traffic 2019 03 15;20(3):187-201. Epub 2019 Jan 15.

Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/tra.12629
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http://dx.doi.org/10.1111/tra.12629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519375PMC
March 2019

Infiltration of CD8 T cells into tumor cell clusters in triple-negative breast cancer.

Proc Natl Acad Sci U S A 2019 02 7;116(9):3678-3687. Epub 2019 Feb 7.

Center for Theoretical Biological Physics, Rice University, Houston, TX 77030;

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http://dx.doi.org/10.1073/pnas.1817652116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397588PMC
February 2019

HGF-induced migration depends on the PI(3,4,5)P-binding microexon-spliced variant of the Arf6 exchange factor cytohesin-1.

J Cell Biol 2019 01 7;218(1):285-298. Epub 2018 Nov 7.

Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada

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http://dx.doi.org/10.1083/jcb.201804106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314551PMC
January 2019

The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression.

Cell Rep 2018 05;23(5):1476-1490

Montreal Clinical Research Institute (IRCM), Montréal, QC H2W 1R7, Canada; Molecular Biology Programs, Université de Montréal, Montréal, QC H3T 1J4, Canada; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada; Department of Anatomy and Cell Biology, McGill University, Montréal, QC H3A 0C7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.04.019DOI Listing
May 2018

CrosstalkNet: A Visualization Tool for Differential Co-expression Networks and Communities.

Cancer Res 2018 04 19;78(8):2140-2143. Epub 2018 Feb 19.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-1383DOI Listing
April 2018

KIBRA (WWC1) Is a Metastasis Suppressor Gene Affected by Chromosome 5q Loss in Triple-Negative Breast Cancer.

Cell Rep 2018 03;22(12):3191-3205

Goodman Cancer Research Centre, McGill University, Montreal, QC H3G 0B1, Canada; Department of Biochemistry, McGill University, Montreal, QC H2W 1S6, Canada; Department of Oncology, McGill University, Montreal, QC H2W 1S6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.02.095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873529PMC
March 2018

Laser Capture Microdissection as a Tool to Study Tumor Stroma.

Methods Mol Biol 2016 ;1458:13-25

Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montréal, QC, Canada.

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http://dx.doi.org/10.1007/978-1-4939-3801-8_2DOI Listing
January 2018

A Targetable EGFR-Dependent Tumor-Initiating Program in Breast Cancer.

Cell Rep 2017 Oct;21(5):1140-1149

Department of Human Genetics, McGill University, Montréal, QC H3A 0C7, Canada; McGill University and Genome Québec Innovation Centre, Montréal, QC H3A 1A4, Canada; Center of Innovation in Personalized Medicine, Cancer and Mutagen Unit, King Fahd Center for Medical Research, Department of Biochemistry, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.10.015DOI Listing
October 2017

Identification of Interacting Stromal Axes in Triple-Negative Breast Cancer.

Cancer Res 2017 09 26;77(17):4673-4683. Epub 2017 Jun 26.

Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-3427DOI Listing
September 2017

Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation.

Dev Cell 2017 05;41(4):392-407.e6

Solid Tumor Biology Program, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA; Department of Molecular Genetics, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210, USA; Department of Cancer Biology and Genetics, McGill University, Montreal, QC H3A 1A1, Canada; Hollings Cancer Center, Medical University of South Carolina, Hollings Cancer Center 124J, 86 Jonathan Lucas Street, Charleston, SC 29425, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.04.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508591PMC
May 2017

Lineage Specification from Prostate Progenitor Cells Requires Gata3-Dependent Mitotic Spindle Orientation.

Stem Cell Reports 2017 04 9;8(4):1018-1031. Epub 2017 Mar 9.

Rosalind and Morris Goodman Cancer Research Centre, McGill University, 1160 Pine Avenue West, Room 415, Montreal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montreal, QC H3G 1Y6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390093PMC
April 2017

5'-Inositol phosphatase SHIP2 recruits Mena to stabilize invadopodia for cancer cell invasion.

J Cell Biol 2016 09 5;214(6):719-34. Epub 2016 Sep 5.

Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montréal, Québec H3A 1A1, Canada Department of Biochemistry, McGill University, Montréal, Québec H3A 1A1, Canada Department of Medicine, McGill University, Montréal, Québec H3A 1A1, Canada Department of Oncology, McGill University, Montréal, Québec H3A 1A1, Canada

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http://dx.doi.org/10.1083/jcb.201501003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021089PMC
September 2016

Regulation of Cell Migration and β1 Integrin Trafficking by the Endosomal Adaptor GGA3.

Traffic 2016 06 5;17(6):670-88. Epub 2016 Apr 5.

Department of Biochemistry, McGill University, Montreal, Quebec, H3G 1Y6, Canada.

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http://dx.doi.org/10.1111/tra.12390DOI Listing
June 2016

Abl Kinases Regulate HGF/Met Signaling Required for Epithelial Cell Scattering, Tubulogenesis and Motility.

PLoS One 2015 6;10(5):e0124960. Epub 2015 May 6.

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124960PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422589PMC
January 2016

Loss of PTPN12 Stimulates Progression of ErbB2-Dependent Breast Cancer by Enhancing Cell Survival, Migration, and Epithelial-to-Mesenchymal Transition.

Mol Cell Biol 2015 Dec 21;35(23):4069-82. Epub 2015 Sep 21.

Laboratory of Molecular Oncology, Clinical Research Institute of Montréal, Montréal, Québec, Canada Department of Medicine, McGill University, Montréal, Québec, Canada Department of Medicine, University of Montréal, Montréal, Québec, Canada

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http://dx.doi.org/10.1128/MCB.00741-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628068PMC
December 2015

The Human Adenovirus Type 5 E4orf4 Protein Targets Two Phosphatase Regulators of the Hippo Signaling Pathway.

J Virol 2015 Sep 17;89(17):8855-70. Epub 2015 Jun 17.

Department of Biochemistry, McGill University, Montreal, Québec, Canada The Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Québec, Canada Department of Oncology, McGill University, Montreal, Québec, Canada

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http://dx.doi.org/10.1128/JVI.03710-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524087PMC
September 2015

Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo.

Genes Dev 2015 Aug;29(16):1707-20

Solid Tumor Biology Program, James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA; Department of Molecular Genetics, College of Arts and Sciences, The Ohio State University, Columbus, Ohio 43210, USA; Department of Molecular Virology, Immunology, and Medical Genetics, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA;

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http://dx.doi.org/10.1101/gad.262568.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561480PMC
August 2015

The chromatin regulator Brpf1 regulates embryo development and cell proliferation.

J Biol Chem 2015 May 15;290(18):11349-64. Epub 2015 Mar 15.

From the The Rosalind and Morris Goodman Cancer Research Center, Department of Medicine, and Department of Biochemistry, McGill University, Montreal, Quebec H3A 1A3, McGill University Health Center, Montreal, Quebec H3A 1A3, Canada

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http://dx.doi.org/10.1074/jbc.M115.643189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416840PMC
May 2015

Deficiency of the chromatin regulator BRPF1 causes abnormal brain development.

J Biol Chem 2015 Mar 7;290(11):7114-29. Epub 2015 Jan 7.

From the Rosalind & Morris Goodman Cancer Research Center, Department of Medicine, McGill University, Quebec H3A 1A3, the Department of Biochemistry, McGill University and McGill University Health Center, Montreal, Quebec H3A 1A3, Canada

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http://dx.doi.org/10.1074/jbc.M114.635250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358132PMC
March 2015

DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior.

J Cell Biol 2015 Mar 23;208(5):629-48. Epub 2015 Feb 23.

Department of Neurology and Neurosurgery, Montreal Neurological Institute; and Department of Biochemistry, Goodman Cancer Centre; McGill University, Montreal, Quebec H3A 0G4, Canada

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http://dx.doi.org/10.1083/jcb.201407068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347646PMC
March 2015

The lysine acetyltransferase activator Brpf1 governs dentate gyrus development through neural stem cells and progenitors.

PLoS Genet 2015 Mar 10;11(3):e1005034. Epub 2015 Mar 10.

The Rosalind & Morris Goodman Cancer Research Center, McGill University, Montreal, Quebec, Canada; Department of Medicine, McGill University, Montreal, Quebec, Canada; Department of Biochemistry, McGill University, Montreal, Quebec, Canada; McGill University Health Center, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1371/journal.pgen.1005034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355587PMC
March 2015

MS/MS-based strategies for proteomic profiling of invasive cell structures.

Proteomics 2015 Jan 15;15(2-3):272-86. Epub 2014 Dec 15.

Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada; Department of Medicine, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1002/pmic.201400220DOI Listing
January 2015

Breast cancer anti-estrogen resistance 3 inhibits transforming growth factor β/Smad signaling and associates with favorable breast cancer disease outcomes.

Breast Cancer Res 2014 Dec 13;16(6):476. Epub 2014 Dec 13.

Division of Medical Oncology, Department of Medicine, McGill University Health Center, H7 Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Quebec, H3A 1A1, Canada.

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http://breast-cancer-research.biomedcentral.com/articles/10.
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http://dx.doi.org/10.1186/s13058-014-0476-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311507PMC
December 2014

p66ShcA promotes breast cancer plasticity by inducing an epithelial-to-mesenchymal transition.

Mol Cell Biol 2014 Oct 28;34(19):3689-701. Epub 2014 Jul 28.

Lady Davis Institute for Medical Research, Montreal, Quebec, Canada Department of Oncology, McGill University, Montreal, Quebec, Canada

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http://dx.doi.org/10.1128/MCB.00341-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187732PMC
October 2014

The prognostic ease and difficulty of invasive breast carcinoma.

Cell Rep 2014 Oct 2;9(1):129-142. Epub 2014 Oct 2.

The Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC H3A1A3, Canada; Centre for Bioinformatics, McGill University, Montreal, QC H3G0B1, Canada; Department of Biochemistry, McGill University, Montreal, QC H3G1Y6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.08.073DOI Listing
October 2014

Autocrine Activation of the Wnt/β-Catenin Pathway by CUX1 and GLIS1 in Breast Cancers.

Biol Open 2014 Sep 12;3(10):937-46. Epub 2014 Sep 12.

Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada Department of Medicine, McGill University, Montreal, QC H3A 1A1, Canada Department of Oncology, McGill University, Montreal, QC H2W 1S6, Canada

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http://dx.doi.org/10.1242/bio.20148193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197442PMC
September 2014

The ShcA PTB domain functions as a biological sensor of phosphotyrosine signaling during breast cancer progression.

Cancer Res 2013 Jul 21;73(14):4521-32. Epub 2013 May 21.

Lady Davis Institute for Medical Research, McGill Centre for Bioinformatics, McGill University, Goodman Cancer Research Centre, Montreal, Quebec, Canada.

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http://cancerres.aacrjournals.org/content/73/14/4521.full.pd
Web Search
http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-12-4178DOI Listing
July 2013

It takes two to tango in the microenvironment!

Breast Cancer Res 2013 Mar 12;15(2):102. Epub 2013 Mar 12.

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http://dx.doi.org/10.1186/bcr3388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672805PMC
March 2013

Dynamics of receptor trafficking in tumorigenicity.

Trends Cell Biol 2012 May 5;22(5):231-40. Epub 2012 Mar 5.

Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.tcb.2012.02.002DOI Listing
May 2012

Crk adaptor proteins act as key signaling integrators for breast tumorigenesis.

Breast Cancer Res 2012 May 8;14(3):R74. Epub 2012 May 8.

Department of Biochemistry, McGill University, Rosalind and Morris Goodman Cancer Research Centre, 3655 Promenade Sir William Osler, Montréal, QC H3G 1Y6, Canada.

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http://dx.doi.org/10.1186/bcr3183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446336PMC
May 2012

Models of crk adaptor proteins in cancer.

Genes Cancer 2012 May;3(5-6):341-52

McGill University, Montréal, QC, Canada.

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http://dx.doi.org/10.1177/1947601912459951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513787PMC
May 2012

Met kinase-dependent loss of the E3 ligase Cbl in gastric cancer.

J Biol Chem 2012 Mar 18;287(11):8048-59. Epub 2012 Jan 18.

Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 1A3, Canada.

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http://dx.doi.org/10.1074/jbc.M112.339820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318713PMC
March 2012

Breast cancer - one term, many entities?

J Clin Invest 2011 Oct 3;121(10):3789-96. Epub 2011 Oct 3.

Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1172/JCI57100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195465PMC
October 2011

Stromal retinoic acid receptor beta promotes mammary gland tumorigenesis.

Proc Natl Acad Sci U S A 2011 Jan 27;108(2):774-9. Epub 2010 Dec 27.

Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada H3A 1A3.

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http://dx.doi.org/10.1073/pnas.1011845108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021047PMC
January 2011

Overexpression of the protein tyrosine phosphatase PRL-2 correlates with breast tumor formation and progression.

Cancer Res 2010 Nov 14;70(21):8959-67. Epub 2010 Sep 14.

Department of Biochemistry, The Goodman Cancer Center, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-2041DOI Listing
November 2010

In silico ascription of gene expression differences to tumor and stromal cells in a model to study impact on breast cancer outcome.

PLoS One 2010 Nov 19;5(11):e14002. Epub 2010 Nov 19.

Department of Genetics, Institute for Cancer Research, Division of Surgery and Cancer, Oslo University Hospital Radiumhospitalet, Oslo, Norway.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014002PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988804PMC
November 2010

miR-378(∗) mediates metabolic shift in breast cancer cells via the PGC-1β/ERRγ transcriptional pathway.

Cell Metab 2010 Oct;12(4):352-361

Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3, Canada; Department of Biochemistry, McGill University, Montréal, PQ H3G 1Y6, Canada; Department of Medicine and Oncology, McGill University, Montréal, PQ H3G 1Y6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2010.09.002DOI Listing
October 2010

Dorsal ruffle microdomains potentiate Met receptor tyrosine kinase signaling and down-regulation.

J Biol Chem 2010 Aug 7;285(32):24956-67. Epub 2010 Jun 7.

Department of Biochemistry, Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montréal, Québec H3A 1A1, Canada.

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http://dx.doi.org/10.1074/jbc.M110.127985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915731PMC
August 2010

PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2.

J Biol Chem 2010 Jul 26;285(31):23899-907. Epub 2010 May 26.

Rosalind and Morris Goodman Cancer Centre and Departments of Biochemistry and Oncology, McGill University, Montreal, Quebec H3A 1A3, Canada.

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http://dx.doi.org/10.1074/jbc.M110.115295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911340PMC
July 2010

Glycoprotein nonmetastatic B is an independent prognostic indicator of recurrence and a novel therapeutic target in breast cancer.

Clin Cancer Res 2010 Apr 9;16(7):2147-56. Epub 2010 Mar 9.

Department of Medicine, Goodman Cancer Research Centre, McGill University, 1160 Pine Avenue West Montréal, Québec, Canada, H3A 1A3.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-1611DOI Listing
April 2010

The Gab1 scaffold regulates RTK-dependent dorsal ruffle formation through the adaptor Nck.

J Cell Sci 2010 Apr 23;123(Pt 8):1306-19. Epub 2010 Mar 23.

Department of Biochemistry, McGill University, Montréal, Québec H3A 1A1, Canada.

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http://dx.doi.org/10.1242/jcs.062570DOI Listing
April 2010

The Met receptor tyrosine kinase and basal breast cancer.

Cell Cycle 2010 Mar 15;9(6):1043-50. Epub 2010 Mar 15.

Rosalind and Morris Goodman Cancer Centre, Department of Experimental Medicine,McGill University, Montreal, QC, CA.

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http://www.tandfonline.com/doi/abs/10.4161/cc.9.6.11033
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http://dx.doi.org/10.4161/cc.9.6.11033DOI Listing
March 2010

CrkII transgene induces atypical mammary gland development and tumorigenesis.

Am J Pathol 2010 Jan 11;176(1):446-60. Epub 2009 Dec 11.

Departments of Biochemistry, Rosalind and Morris Goodman Cancer Centre, McGill University, Montréal, QC H3A 1A3, Canada.

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http://dx.doi.org/10.2353/ajpath.2010.090383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797903PMC
January 2010

Cracking Cancer with CRK.

Mcgill J Med 2009 Nov 16;12(2):11. Epub 2009 Nov 16.

- Marymount Academy, Montreal, Quebec, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997237PMC
November 2009

Crosstalk in Met receptor oncogenesis.

Trends Cell Biol 2009 Oct 14;19(10):542-51. Epub 2009 Sep 14.

Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.tcb.2009.07.002DOI Listing
October 2009

Genome-wide identification of direct target genes implicates estrogen-related receptor alpha as a determinant of breast cancer heterogeneity.

Cancer Res 2009 Aug 21;69(15):6149-57. Epub 2009 Jul 21.

Rosalind and Morris Goodman Cancer Centre, Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-1251DOI Listing
August 2009

Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor.

Mol Cell Biol 2009 Jun 16;29(11):3018-32. Epub 2009 Mar 16.

McGill University Health Centre, Royal Victoria Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1128/MCB.01286-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682017PMC
June 2009

Breakdown of endocytosis in the oncogenic activation of receptor tyrosine kinases.

Am J Physiol Endocrinol Metab 2009 May 24;296(5):E973-84. Epub 2009 Feb 24.

Rosalind and Morris Goodman Cancer Centre, Montreal, H3A 1A3, QC, Canada.

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http://dx.doi.org/10.1152/ajpendo.90857.2008DOI Listing
May 2009

[The tumor microenvironment: a new tool to predict breast cancer outcome].

Med Sci (Paris) 2009 May;25(5):439-41

McGill Center for Bioinformatics, Université McGill, Montréal, Québec, Canada.

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http://www.medecinesciences.org/10.1051/medsci/2009255439
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http://dx.doi.org/10.1051/medsci/2009255439DOI Listing
May 2009

Distinct recruitment of Eps15 via Its coiled-coil domain is required for efficient down-regulation of the met receptor tyrosine kinase.

J Biol Chem 2009 Mar 24;284(13):8382-94. Epub 2008 Dec 24.

Departments of Biochemistry, Medicine, and Oncology, McGill University, Montreal, Quebec H3G 1Y6, Canada.

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http://dx.doi.org/10.1074/jbc.M807607200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659196PMC
March 2009

Regulation of endocytosis via the oxygen-sensing pathway.

Nat Med 2009 Mar 1;15(3):319-24. Epub 2009 Mar 1.

Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1038/nm.1922DOI Listing
March 2009

Stromal gene expression predicts clinical outcome in breast cancer.

Nat Med 2008 May 27;14(5):518-27. Epub 2008 Apr 27.

McGill Centre for Bioinformatics, 3775 University Street, McGill University, Québec H3A 2B4, Canada.

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http://dx.doi.org/10.1038/nm1764DOI Listing
May 2008

Gab2 requires membrane targeting and the Met binding motif to promote lamellipodia, cell scatter, and epithelial morphogenesis downstream from the Met receptor.

J Cell Physiol 2008 Mar;214(3):694-705

Department of Biochemistry, Molecular Oncology Group, McGill University Health Centre, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1002/jcp.21264DOI Listing
March 2008

Structural basis of ubiquitin recognition by the ubiquitin-associated (UBA) domain of the ubiquitin ligase EDD.

J Biol Chem 2007 Dec 25;282(49):35787-95. Epub 2007 Sep 25.

Department of Biochemistry, McGill University, Montréal, Québec H3G 1Y6, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M705655200
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December 2007

Structural basis for UBA-mediated dimerization of c-Cbl ubiquitin ligase.

J Biol Chem 2007 Sep 16;282(37):27547-55. Epub 2007 Jul 16.

Departments of Biochemistry, Medicine, and Oncology, McGill University, Molecular Oncology Group, McGill University Health Center, Montréal, Québec, Canada.

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http://dx.doi.org/10.1074/jbc.M703333200DOI Listing
September 2007

Gab1 is required for cell cycle transition, cell proliferation, and transformation induced by an oncogenic met receptor.

Mol Biol Cell 2006 Sep 14;17(9):3717-28. Epub 2006 Jun 14.

Laboratory of Protein Dynamics and Signaling, National Cancer Institute-Frederick, Frederick, MD 21702, USA.

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http://www.molbiolcell.org/doi/10.1091/mbc.e06-03-0244
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1556377PMC
September 2006

Oncogenic Met receptor induces cell-cycle progression in Xenopus oocytes independent of direct Grb2 and Shc binding or Mos synthesis, but requires phosphatidylinositol 3-kinase and Raf signaling.

J Cell Physiol 2006 Apr;207(1):271-85

Laboratory of Protein Dynamics and Signaling, National Cancer Institute-Frederick, Frederick, Maryland 21702, USA.

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April 2006