Dr.  Monte S Willis, MD, PhD, MBA - University of North Carolina - Professor

Dr. Monte S Willis

MD, PhD, MBA

University of North Carolina

Professor

Chapel Hill, NC | United States

Main Specialties: Cardiovascular Disease

Additional Specialties: Cardiology/Cardivascular Pathology


Top Author

Dr.  Monte S Willis, MD, PhD, MBA - University of North Carolina - Professor

Dr. Monte S Willis

MD, PhD, MBA

Introduction

Primary Affiliation: University of North Carolina - Chapel Hill, NC , United States

Specialties:

Additional Specialties:

Research Interests:


View Dr. Monte S Willis’s Resume / CV

Metrics

Number of Publications

125

Publications

Number of Profile Views

640

Profile Views

Number of Article Reads

997

Reads

Number of Citations

2355

Citations

Education

Sep 2014
Kenan-Flagler Business School, Chapel Hill, NC
Executive MBA
Sep 2005
University of NC at Chapel Hill, Chapel Hill, NC
Pathology Residency/CV Disease Post-Doc
Jul 2004
University of Texas Southwestern, Dallas, TX
Pathology Residency/CV Disease Post-Doc
May 2001
University of Nebraska Medical Ctr, Omaha, NE
MD/PhD
May 1992
University of Nebraska, Lincoln, NE
B.S. Biology

Experience

Sep 2005
Asst/Assoc/Full Professor
Tenure Track Faculty

Top co-authors

Cam Patterson
Cam Patterson

McAllister Heart Institute

34
Jonathan C Schisler
Jonathan C Schisler

McAllister Heart Institute

17
Pamela Lockyer
Pamela Lockyer

University of North Carolina

8
William E Stansfield
William E Stansfield

University of North Carolina

7
Traci L Parry
Traci L Parry

McAllister Heart Institute

7
Kristine M Wadosky
Kristine M Wadosky

Roswell Park Cancer Institute

6
Megan T Quintana
Megan T Quintana

University of North Carolina

6
Brian C Jensen
Brian C Jensen

McAllister Heart Institute

6

Publications

125Publications

997Reads

2355PubMed Central Citations

Ubiquitin Ligases and Posttranslational Regulation of Energy in the Heart: The Hand that Feeds.

Compr Physiol 2017 06 18;7(3):841-862. Epub 2017 Jun 18.

McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina, USA.

View Article
June 2017
4 Reads
1 Citation
1.680 Impact Factor

BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo.

Cardiovasc Pathol 2016 May-Jun;25(3):258-269. Epub 2016 Mar 4.

McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA; Department of Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address:

View Article
January 2017
22 Reads
4 Citations
2.340 Impact Factor

The Head and the Heart: The Alzheimer's Connection.

J Am Coll Cardiol 2016 12;68(22):2408-2411

McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina; Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina; Department of Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina. Electronic address:

View Article
December 2016
3 Reads
1 Citation
16.500 Impact Factor

Cardiac ubiquitin ligases: Their role in cardiac metabolism, autophagy, cardioprotection and therapeutic potential.

Biochim Biophys Acta 2016 12 13;1862(12):2259-2269. Epub 2016 Jul 13.

McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA; Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA. Electronic address:

View Article
December 2016
4 Reads
2 Citations

Fenofibrate unexpectedly induces cardiac hypertrophy in mice lacking MuRF1.

Cardiovasc Pathol 2016 Mar-Apr;25(2):127-140. Epub 2015 Oct 29.

McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA.

View Article
December 2016
5 Reads
2 Citations
2.340 Impact Factor

Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures.

Skelet Muscle 2016 4;6:14. Epub 2016 Apr 4.

The Hugo W. Moser Research Institute at Kennedy Krieger Institute and Departments of Neurology and Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205 USA.

View Article
October 2016
20 Reads
6 Citations

Cessation of biomechanical stretch model of C2C12 cells models myocyte atrophy and anaplerotic changes in metabolism using non-targeted metabolomics analysis.

Int J Biochem Cell Biol 2016 10 8;79:80-92. Epub 2016 Aug 8.

McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA; Department of Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA; Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA. Electronic address:

View Article
October 2016
10 Reads
1 Citation
4.050 Impact Factor

Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling.

Am J Pathol 2016 08 17;186(8):1989-2007. Epub 2016 Jun 17.

McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina; Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina. Electronic address:

View Article
August 2016
16 Reads
8 Citations
4.590 Impact Factor

Corticosteroids Are Essential for Maintaining Cardiovascular Function in Male Mice.

Endocrinology 2016 07 24;157(7):2759-71. Epub 2016 May 24.

Signal Transduction Laboratory (D.C.-T., J.A.C.), Comparative Medicine Branch (P.H.M.), and Cellular and Molecular Pathology Branch (J.F.F.), National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892; and McAllister Heart Institute (M.S.W.), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514.

View Article
July 2016
8 Reads
5 Citations
4.500 Impact Factor

IL-6/STAT3 signaling in mice with dysfunctional type-2 ryanodine receptor.

JAKSTAT 2015 7;4(4):e1158379. Epub 2016 Mar 7.

Department of Biochemistry & Biophysics; University of North Carolina ; Chapel Hill, NC USA.

View Article
May 2016
7 Reads

MuRF1 mono-ubiquitinates TRα to inhibit T3-induced cardiac hypertrophy in vivo.

J Mol Endocrinol 2016 04 9;56(3):273-90. Epub 2016 Feb 9.

Department of Pathology and Laboratory MedicineUniversity of North Carolina, Chapel Hill, NC, USA McAllister Heart InstituteUniversity of North Carolina, Chapel Hill, NC, USA

View Article
April 2016
7 Reads
9 Citations
3.080 Impact Factor

Endothelial inflammatory transcriptional responses to an altered plasma exposome following inhalation of diesel emissions.

Inhal Toxicol 2015 5;27(5):272-80. Epub 2015 May 5.

Department of Pathology and Laboratory Medicine, McAllister Heart Institute, University of North Carolina , Chapel Hill, NC , USA .

View Article
March 2016
6 Reads
6 Citations
2.260 Impact Factor

Functional Amyloid Signaling via the Inflammasome, Necrosome, and Signalosome: New Therapeutic Targets in Heart Failure.

Front Cardiovasc Med 2015 19;2:25. Epub 2015 May 19.

McAllister Heart Institute, University of North Carolina , Chapel Hill, NC , USA ; Department of Pathology and Laboratory Medicine, University of North Carolina , Chapel Hill, NC , USA.

View Article
December 2015
4 Reads
7 Citations

Genome- and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study.

J Hum Genet 2015 Dec 17;60(12):755-61. Epub 2015 Sep 17.

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

View Article
December 2015
16 Reads
7 Citations
2.460 Impact Factor

Non-targeted metabolomics of double-mutant cardiomyocytes reveals a novel role for SWI/SNF complexes in metabolic homeostasis.

Metabolomics 2015 Oct;11(5):1287-1301

Department of Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA. McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA.

View Article
October 2015
7 Reads
14 Citations
3.860 Impact Factor

The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination.

Mol Cell Endocrinol 2015 Sep 25;413:36-48. Epub 2015 Jun 25.

Department of Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA; McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA. Electronic address:

View Article
September 2015
25 Reads
15 Citations
4.410 Impact Factor

MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet.

Cardiovasc Diabetol 2015 Aug 5;14:97. Epub 2015 Aug 5.

Department of Pathology and Laboratory Medicine, University of North Carolina, 111 Mason Farm Road, MBRB 2340B, Chapel Hill, NC, USA.

View Article
August 2015
11 Reads
6 Citations
4.010 Impact Factor

Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet.

BMC Endocr Disord 2015 Jul 28;15:36. Epub 2015 Jul 28.

Department of Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA.

View Article
July 2015
10 Reads
4 Citations
1.670 Impact Factor

Cancer cachexia update in head and neck cancer: Pathophysiology and treatment.

Head Neck 2015 Jul 7;37(7):1057-72. Epub 2015 Apr 7.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, Vermont Cancer Center, University of Vermont, College of Medicine, Burlington, Vermont.

View Article
July 2015
9 Reads
2 Citations
2.640 Impact Factor

Genetics and heart failure: a concise guide for the clinician.

Curr Cardiol Rev 2015 ;11(1):10-7

UNC Division of Cardiology, 160 Dental Circle, CB 7075, Chapel Hill, NC 27599-7075, USA.

View Article
May 2015
2 Reads
6 Citations

Cancer cachexia update in head and neck cancer: Definitions and diagnostic features.

Head Neck 2015 Apr 25;37(4):594-604. Epub 2014 Mar 25.

Division of Otolaryngology - Head and Neck Surgery, Department of Surgery, Vermont Cancer Center, University of Vermont, College of Medicine, Burlington, Vermont.

View Article
April 2015
5 Reads
4 Citations
2.640 Impact Factor

Clinical Relevance of Trace Bands on Serum Electrophoresis in Patients Without a History of Gammopathy.

EJIFCC 2015 Mar 10;26(2):114-24. Epub 2015 Mar 10.

The Ottawa Hospital , General Campus Pathology & Laboratory Medicine, Ottawa, ON, Canada.

View Article
March 2015
8 Reads

Depletion of PHD3 protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis.

J Mol Cell Cardiol 2015 Mar 26;80:156-65. Epub 2015 Jan 26.

NewYork-Presbyterian Hospital/Weill-Cornell Medical Center, New York, NY 10065, USA.

View Article
March 2015
3 Reads
9 Citations
4.660 Impact Factor

Cardiac energy dependence on glucose increases metabolites related to glutathione and activates metabolic genes controlled by mechanistic target of rapamycin.

J Am Heart Assoc 2015 Feb 24;4(2). Epub 2015 Feb 24.

Department of Nutrition, University of North Carolina, Chapel Hill, NC (T.J.G., F.P., D.E.C., J.M.E., D.S.P., R.A.C.).

View Article
February 2015
29 Reads
10 Citations
2.880 Impact Factor

Platelet endothelial cell adhesion molecule-1 mediates endothelial-cardiomyocyte communication and regulates cardiac function.

J Am Heart Assoc 2015 Jan 19;4(1):e001210. Epub 2015 Jan 19.

Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC (M.E.M.C., C.C., Z.C., E.T.) McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC (M.R., E.T.).

View Article
January 2015
6 Reads
6 Citations
2.880 Impact Factor

SWI/SNF chromatin-remodeling complexes in cardiovascular development and disease.

Cardiovasc Pathol 2014 Mar-Apr;23(2):85-91. Epub 2013 Oct 4.

Department of Genetics, University of North Carolina, Chapel Hill, Chapel Hill, NC, USA. Electronic address:

View Article
October 2014
2 Reads
12 Citations
2.340 Impact Factor

Protein quality control, the ubiquitin proteasome system, and autophagy: when worlds collide. [Corrected].

J Mol Cell Cardiol 2014 Jun 27;71:1-2. Epub 2014 Mar 27.

McAllister Heart Institute, University of North Carolina at Chapel Hill, NC, USA; New York-Presbyterian Hospital/Weill-Cornell Medical Center, New York, NY, USA.

View Article
June 2014
12 Reads
1 Citation
4.660 Impact Factor

The role of ubiquitin ligases in cardiac disease.

J Mol Cell Cardiol 2014 Jun 19;71:43-53. Epub 2013 Nov 19.

Departments of Cell and Developmental Biology, Medicine (Cardiology), and Pharmacology, University of North Carolina, Chapel Hill, NC, USA.

View Article
June 2014
5 Reads
19 Citations
4.660 Impact Factor

Deficiency of cardiac Acyl-CoA synthetase-1 induces diastolic dysfunction, but pathologic hypertrophy is reversed by rapamycin.

Biochim Biophys Acta 2014 Jun 12;1841(6):880-7. Epub 2014 Mar 12.

Department of Nutrition, University of NC at Chapel Hill, 27599, USA; McAllister Heart Institute, University of NC at Chapel Hill, 27599, USA. Electronic address:

View Article
June 2014
3 Reads
8 Citations

MuRF1 activity is present in cardiac mitochondria and regulates reactive oxygen species production in vivo.

J Bioenerg Biomembr 2014 Jun 15;46(3):173-87. Epub 2014 Apr 15.

Department of Pharmacology, East Carolina University, Greenville, NC, USA.

View Article
June 2014
5 Reads
7 Citations
3.210 Impact Factor

Cardio-metabolic effectsof HIV protease inhibitors (lopinavir/ritonavir).

PLoS One 2013 30;8(9):e73347. Epub 2013 Sep 30.

Cardio-Metabolic Research Group, Department of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa.

View Article
May 2014
7 Reads
12 Citations
3.230 Impact Factor

Regulation of large conductance Ca2+-activated K+ (BK) channel β1 subunit expression by muscle RING finger protein 1 in diabetic vessels.

J Biol Chem 2014 Apr 25;289(15):10853-64. Epub 2014 Feb 25.

From the Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905.

View Article
April 2014
8 Reads
12 Citations
4.570 Impact Factor

Muscle RING finger-1 attenuates IGF-I-dependent cardiomyocyte hypertrophy by inhibiting JNK signaling.

Am J Physiol Endocrinol Metab 2014 Apr 14;306(7):E723-39. Epub 2014 Jan 14.

Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;

View Article
April 2014
27 Reads
11 Citations
3.790 Impact Factor

Precision-cut liver slices from diet-induced obese rats exposed to ethanol are susceptible to oxidative stress and increased fatty acid synthesis.

Am J Physiol Gastrointest Liver Physiol 2014 Feb 27;306(3):G208-17. Epub 2013 Nov 27.

Experimental Immunology Laboratory, Veterans Affairs Nebraska-Western Iowa Health Care System (VA NWIHCS), Omaha, Nebraska;

View Article
February 2014
5 Reads
6 Citations
3.800 Impact Factor

Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1-mediated gene expression in vivo.

Cell Biochem Funct 2014 Jan 20;32(1):39-50. Epub 2013 Mar 20.

McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA.

View Article
January 2014
3 Reads
19 Citations
2.000 Impact Factor

BMPER regulates cardiomyocyte size and vessel density in vivo.

Cardiovasc Pathol 2013 May-Jun;22(3):228-40. Epub 2012 Nov 28.

Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

View Article
December 2013
3 Reads
6 Citations
2.340 Impact Factor

Carboxyl terminus of Hsp70-interacting protein (CHIP) is required to modulate cardiac hypertrophy and attenuate autophagy during exercise.

Cell Biochem Funct 2013 Dec 2;31(8):724-35. Epub 2013 Apr 2.

McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA.

View Article
December 2013
5 Reads
14 Citations
2.000 Impact Factor

Essential role of stress hormone signaling in cardiomyocytes for the prevention of heart disease.

Proc Natl Acad Sci U S A 2013 Oct 30;110(42):17035-40. Epub 2013 Sep 30.

Laboratory of Signal Transduction, Comparative Medicine Branch, and Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709.

View Article
October 2013
4 Reads
28 Citations
9.810 Impact Factor

Ephrin-Eph signaling as a potential therapeutic target for the treatment of myocardial infarction.

Med Hypotheses 2013 Jun 4;80(6):738-44. Epub 2013 Apr 4.

Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.

View Article
June 2013
6 Reads
6 Citations
1.150 Impact Factor

Metabolic derangements in the gastrocnemius and the effect of Compound A therapy in a murine model of cancer cachexia.

J Cachexia Sarcopenia Muscle 2013 Jun 24;4(2):145-55. Epub 2013 Jan 24.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Vermont, Burlington, VT, USA.

View Article
June 2013
5 Reads
11 Citations
7.410 Impact Factor

Proteotoxicity and cardiac dysfunction.

N Engl J Med 2013 05;368(18):1755

View Article
May 2013
6 Reads
8 Citations
55.870 Impact Factor

Persistent lactic acidosis after chronic topical application of silver sulfadiazine in a pediatric burn patient: a review of the literature.

Int J Burns Trauma 2013 24;3(1):1-8. Epub 2013 Jan 24.

Department of Pathology & Laboratory Medicine, University of North Carolina Chapel Hill, NC 27599, USA.

View Article
April 2013
8 Reads

Evaluation of digital images for identification and characterization of monoclonal immunoglobulins by immunofixation.

Clin Biochem 2013 Feb 2;46(3):255-8. Epub 2012 Nov 2.

Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA.

View Article
February 2013
4 Reads
1 Citation
2.230 Impact Factor

Proteotoxicity and cardiac dysfunction--Alzheimer's disease of the heart?

N Engl J Med 2013 Jan;368(5):455-64

McAllister Heart Institute, and Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, USA.

View Article
January 2013
5 Reads
78 Citations
55.870 Impact Factor

Myosin light chain phosphorylation is critical for adaptation to cardiac stress.

Circulation 2012 Nov 24;126(22):2575-88. Epub 2012 Oct 24.

Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL 32610-0274, USA.

View Article
November 2012
8 Reads
34 Citations
14.430 Impact Factor

Bmper inhibits endothelial expression of inflammatory adhesion molecules and protects against atherosclerosis.

Arterioscler Thromb Vasc Biol 2012 Sep 5;32(9):2214-22. Epub 2012 Jul 5.

UNC McAllister Heart Institute, 8200 Medical Biomolecular Research Building, Chapel Hill, NC 27599-7126, USA.

View Article
September 2012
9 Reads
11 Citations
6.000 Impact Factor

Functional redundancy of SWI/SNF catalytic subunits in maintaining vascular endothelial cells in the adult heart.

Circ Res 2012 Aug 27;111(5):e111-22. Epub 2012 Jun 27.

120 Mason Farm Rd, Genetic Medicine Bldg, Room 5060, Chapel Hill, NC 27516-7264, USA.

View Article
August 2012
7 Reads
26 Citations
11.020 Impact Factor

The legacy of Charles R. Drew, MD, CM, MDSc.

Immunohematology 2011 ;27(3):94-100

Department of Molecular Medicine and Translational Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

View Article
August 2012
7 Reads

Back to your heart: ubiquitin proteasome system-regulated signal transduction.

J Mol Cell Cardiol 2012 Mar 6;52(3):526-37. Epub 2011 Nov 6.

McAllister Heart Institute, University of North Carolina, Chapel Hill, NC 27599-7525, USA.

View Article
March 2012
4 Reads
32 Citations
4.660 Impact Factor

The story so far: post-translational regulation of peroxisome proliferator-activated receptors by ubiquitination and SUMOylation.

Am J Physiol Heart Circ Physiol 2012 Feb 28;302(3):H515-26. Epub 2011 Oct 28.

Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina 27599-7525, USA.

View Article
February 2012
2 Reads
24 Citations
3.840 Impact Factor

Mitochondria as a source and target of lipid peroxidation products in healthy and diseased heart.

Clin Exp Pharmacol Physiol 2012 Feb;39(2):179-93

Department of Medicine, Pathology & Laboratory Medicine, 111 Mason Farm Road, 2340BMBRB,Chapel Hill, NC 27599–7525, USA.

View Article
February 2012
3 Reads
23 Citations

All the little pieces. -Regulation of mitochondrial fusion and fission by ubiquitin and small ubiquitin-like modifer and their potential relevance in the heart.-.

Circ J 2011 15;75(11):2513-21. Epub 2011 Oct 15.

Department of Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA.

View Article
February 2012
3 Reads
17 Citations
3.940 Impact Factor

Dietary salt exacerbates isoproterenol-induced cardiomyopathy in rats.

Toxicol Pathol 2011 Oct 30;39(6):925-37. Epub 2011 Aug 30.

Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, North Carolina, USA.

View Article
October 2011
6 Reads
4 Citations
2.140 Impact Factor

Rise above: muscle ring-finger-1 (MURF1) regulation of cardiomyocyte size and energy metabolism.

Trans Am Clin Climatol Assoc 2011 ;122:70-81

Division of Cardiology and McAllister Heart Institute, University of North Carolina at Chapel Hill, 8200 Medical Biomolecular Research Building, Chapel Hill, NC 27599-7126, USA.

View Article
September 2011
6 Reads
2 Citations

Tear me down: role of calpain in the development of cardiac ventricular hypertrophy.

Circ Res 2011 Aug;109(4):453-62

McAllister Heart Institute, University of North Carolina at Chapel Hill, 27599-7525, USA.

View Article
August 2011
4 Reads
17 Citations
11.020 Impact Factor

Merits of non-invasive rat models of left ventricular heart failure.

Cardiovasc Toxicol 2011 Jun;11(2):91-112

Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, 27599 USA.

View Article
June 2011
3 Reads
10 Citations
2.060 Impact Factor

Tearin' up my heart: proteolysis in the cardiac sarcomere.

J Biol Chem 2011 Mar 21;286(12):9929-34. Epub 2011 Jan 21.

McAllister Heart Institute, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599-7126, USA.

View Article
March 2011
7 Reads
24 Citations
4.570 Impact Factor

NF-κB inhibition protects against tumor-induced cardiac atrophy in vivo.

Am J Pathol 2011 Mar;178(3):1059-68

Duke University School of Medicine, Durham, North Carolina, USA.

View Article
March 2011
8 Reads
23 Citations
4.590 Impact Factor

Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs Fatty Acid oxidation and induces cardiac hypertrophy.

Mol Cell Biol 2011 Mar 18;31(6):1252-62. Epub 2011 Jan 18.

Department of Nutrition, CB 7461, University of North Carolina at Chapel Hill, 135 Dauer Drive, MHRC 2301, Chapel Hill, NC 27599, USA.

View Article
March 2011
19 Reads
60 Citations
4.780 Impact Factor

The ubiquitin ligase MuRF1 protects against cardiac ischemia/reperfusion injury by its proteasome-dependent degradation of phospho-c-Jun.

Am J Pathol 2011 Mar;178(3):1043-58

Department of Pathology, School of Basic Medical Sciences, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Capital Medical University, Ministry of Education, Beijing, China.

View Article
March 2011
5 Reads
28 Citations
4.590 Impact Factor

Regulation of AMPK by the ubiquitin proteasome system.

Am J Pathol 2011 Jan 23;178(1):4-11. Epub 2010 Dec 23.

Discipline of Human Physiology, University of KwaZulu Natal, Durban, South Africa.

View Article
January 2011
19 Reads
20 Citations
4.590 Impact Factor

Edge of the world: practical considerations and a clinical perspective of next-generation sequencing for hereditary cardiac disease.

Expert Opin Med Diagn 2011 Jan 8;5(1):5-8. Epub 2010 Dec 8.

University of North Carolina, Division of Cardiology, Department of Medicine, Chapel Hill, NC 27599-7075, USA.

View Article
January 2011
3 Reads

The therapeutic potential of heat shock proteins in cardiomyopathies due to mutations in cardiac structural proteins.

J Mol Cell Cardiol 2010 Dec 1;49(6):904-7. Epub 2010 Oct 1.

View Article
December 2010
3 Reads
4.660 Impact Factor

Autoimmune hepatitis induced by syngeneic liver cytosolic proteins biotransformed by alcohol metabolites.

Alcohol Clin Exp Res 2010 Dec 22;34(12):2126-36. Epub 2010 Sep 22.

Experimental Immunology Laboratory, Department of Internal Medicine, Section of Rheumatology, University of Nebraska Medical Center, 983025 Nebraska Medical Center, Omaha, Nebraska, USA.

View Article
December 2010
4 Reads
16 Citations
3.210 Impact Factor

Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy.

Proc Natl Acad Sci U S A 2010 Nov 18;107(44):19079-83. Epub 2010 Oct 18.

Departments of Pharmacology, University of Washington, Seattle, WA 98195, USA.

View Article
November 2010
6 Reads
61 Citations
9.810 Impact Factor

Hold me tight: Role of the heat shock protein family of chaperones in cardiac disease.

Circulation 2010 Oct;122(17):1740-51

McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7126, USA.

View Article
October 2010
5 Reads
33 Citations
14.430 Impact Factor

Minireview: Won't get fooled again: the nonmetabolic roles of peroxisome proliferator-activated receptors (PPARs) in the heart.

Mol Endocrinol 2010 Jun 16;24(6):1111-9. Epub 2009 Dec 16.

McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina 27599-7525, USA.

View Article
June 2010
4 Reads
9 Citations
4.020 Impact Factor

Evolving molecular diagnostics for familial cardiomyopathies: at the heart of it all.

Expert Rev Mol Diagn 2010 Apr;10(3):329-51

PGxHealth Division, Clinical Data, Inc., 5 Science Park, New Haven, CT 06511, USA.

View Article
April 2010
3 Reads
9 Citations
3.520 Impact Factor

Long-term improvement in mdx cardiomyopathy after therapy with peptide-conjugated morpholino oligomers.

Cardiovasc Res 2010 Feb 8;85(3):444-53. Epub 2009 Oct 8.

Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

View Article
February 2010
5 Reads
31 Citations
5.940 Impact Factor

Cardiac muscle ring finger-1--friend or foe?

Trends Cardiovasc Med 2010 Jan;20(1):12-6

McAllister Heart Institute, University of North Carolina, Chapel Hill, NC 27599-7126, USA.

View Article
January 2010
5 Reads
6 Citations
2.910 Impact Factor

Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms.

Cardiovasc Res 2010 Jan 22;85(2):357-66. Epub 2009 Oct 22.

Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany.

View Article
January 2010
5 Reads
34 Citations
5.940 Impact Factor

The ubiquitin-proteasome system and nonsense-mediated mRNA decay in hypertrophic cardiomyopathy.

Cardiovasc Res 2010 Jan 17;85(2):330-8. Epub 2009 Jul 17.

Institute of Experimental and Clinical Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany.

View Article
January 2010
3 Reads
28 Citations
5.940 Impact Factor

Seek and destroy: the ubiquitin----proteasome system in cardiac disease.

Curr Hypertens Rep 2009 Dec;11(6):396-405

View Article
December 2009
5 Reads
10 Citations
3.440 Impact Factor

MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice.

J Clin Invest 2009 Sep 10;119(9):2772-86. Epub 2009 Aug 10.

Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, North Carolina, USA.

View Article
September 2009
107 Reads
243 Citations
13.210 Impact Factor

Cardiac muscle ring finger-1 increases susceptibility to heart failure in vivo.

Circ Res 2009 Jul 4;105(1):80-8. Epub 2009 Jun 4.

Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, 27599-7525, USA.

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July 2009
4 Reads
44 Citations
11.020 Impact Factor

Familial hypertrophic cardiomyopathy: basic concepts and future molecular diagnostics.

Clin Biochem 2009 Jun 9;42(9):755-65. Epub 2009 Feb 9.

Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599-7525, USA.

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June 2009
2 Reads
9 Citations
2.230 Impact Factor

Muscle ring finger 1 mediates cardiac atrophy in vivo.

Am J Physiol Heart Circ Physiol 2009 Apr 23;296(4):H997-H1006. Epub 2009 Jan 23.

Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, North Carolina, USA.

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April 2009
9 Reads
45 Citations
3.840 Impact Factor

Build it up-Tear it down: protein quality control in the cardiac sarcomere.

Cardiovasc Res 2009 Feb 29;81(3):439-48. Epub 2008 Oct 29.

Carolina Cardiovascular Biology Center, University of North Carolina, 8200 Medical Biomolecular Research Bldg, 103 Mason Farm Road, Chapel Hill, NC 27599-7126, USA.

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February 2009
2 Reads
50 Citations
5.940 Impact Factor

The ubiquitin-proteasome system in cardiac dysfunction.

Biochim Biophys Acta 2008 Dec 25;1782(12):749-63. Epub 2008 Jun 25.

Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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December 2008
3 Reads
48 Citations

Increased immunogenicity to P815 cells modified with malondialdehyde and acetaldehyde.

Int Immunopharmacol 2008 Aug 28;8(8):1112-8. Epub 2008 Apr 28.

University of Nebraska Medical Center, Department of Internal Medicine, 983025 Nebraska Medical Center, Omaha, NE 68198-3025, United States.

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August 2008
4 Reads
4 Citations
2.470 Impact Factor

Cystic fibrosis: newborn screening in America.

MLO Med Lab Obs 2008 Jul;40(7):16-8, 22, 24-7

University of North Carolina Hospitals, USA.

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July 2008
2 Reads
3 Citations

Performance comparison of capillary and agarose gel electrophoresis for the identification and characterization of monoclonal immunoglobulins.

Am J Clin Pathol 2008 Mar;129(3):451-8

Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

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March 2008
3 Reads
3 Citations
2.510 Impact Factor

You spin me round: MaFBx/Atrogin-1 feeds forward on FOXO transcription factors (like a record).

Cell Cycle 2008 Feb 12;7(4):440-3. Epub 2007 Dec 12.

Carolina Cardiovascular Biology Center and Division of Cardiology, University of North Carolina, Chapel Hill, North Carolina 27599-7126, USA.

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February 2008
2 Reads
12 Citations

Proteasome inhibition promotes regression of left ventricular hypertrophy.

Am J Physiol Heart Circ Physiol 2008 Feb 21;294(2):H645-50. Epub 2007 Nov 21.

Division of Cardiothoracic Surgery, Department of Surgery, University of North Carolina at Chapel Hill 27599-7065, USA.

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February 2008
6 Reads
41 Citations
3.840 Impact Factor

Appetite for destruction: E3 ubiquitin-ligase protection in cardiac disease.

Future Cardiol 2008 Jan;4(1):65-75

Department of Pathology & Laboratory Medicine, Carolina Cardiovascular Biology Center, 2340B Medical Biomolecular Research Building, University of North Carolina, Chapel Hill, NC 27599-7525, USA.

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January 2008
2 Reads
15 Citations

Persistent low concentration of human chorionic gonadotropin in a nonpregnant woman.

Clin Chem 2008 Jan 16;54(1):209-13; discussion 213-4. Epub 2007 Nov 16.

University of North Carolina School of Medicine, Department of Pathology and Laboratory Medicine, Chapel Hill, NC, USA.

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January 2008
3 Reads
7.910 Impact Factor

Blood bank management of sickle cell patients at comprehensive sickle cell centers.

Transfusion 2007 Nov;47(11):2089-97

Department of Pathology & Laboratory Medicine and the Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, North Carolina 27514-7600, USA.

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November 2007
2 Reads
4 Citations
3.230 Impact Factor

The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle.

Cell Metab 2007 Nov;6(5):376-85

Novartis Institutes for Biomedical Research, 100 Technology Square, Cambridge, MA 02139, USA.

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November 2007
30 Reads
166 Citations
17.570 Impact Factor

Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins.

J Clin Invest 2007 Nov;117(11):3211-23

Carolina Cardiovascular Biology Center, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599-7126, USA.

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November 2007
3 Reads
96 Citations
13.210 Impact Factor

IKKbeta inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injury.

Am J Physiol Heart Circ Physiol 2007 Oct 3;293(4):H2248-53. Epub 2007 Aug 3.

Department of Surgery, University of North Carolina, Chapel Hill, North Carolina 27599-7065, USA.

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October 2007
6 Reads
33 Citations
3.840 Impact Factor

Proteasome inhibition attenuates infarct size and preserves cardiac function in a murine model of myocardial ischemia-reperfusion injury.

Ann Thorac Surg 2007 Jul;84(1):120-5

Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7065, USA.

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July 2007
4 Reads
25 Citations
3.850 Impact Factor

The bitter end: the ubiquitin-proteasome system and cardiac dysfunction.

Circulation 2007 Mar;115(11):1456-63

Division of Cardiology and Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, 8200 Medical Biomolecular Research Building, Chapel Hill, NC 27599-7126, USA.

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March 2007
3 Reads
37 Citations
14.430 Impact Factor

Muscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivo.

Circ Res 2007 Mar 1;100(4):456-9. Epub 2007 Feb 1.

Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC 27599-7126, USA.

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March 2007
20 Reads
82 Citations
11.020 Impact Factor

Bovine cardiac troponin T is not accurately quantified with a common human clinical immunoassay.

J Vet Diagn Invest 2007 Jan;19(1):106-8

University of North Carolina, School of Medicine, CB#7525, Chapel Hill, NC 27599-7525, USA.

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January 2007
7 Reads
1 Citation
1.350 Impact Factor

DNA bar code: screening methods of colorectal cancer.

MLO Med Lab Obs 2006 Nov;38(11):10, 12, 14-5 passim; quiz 22-3

University of North Carolina Hospitals, McLendon Clinical Laboratories, Chapel Hill, NC, USA.

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November 2006
3 Reads

Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition.

Circulation 2006 Oct 9;114(17):1838-46. Epub 2006 Oct 9.

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.

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October 2006
4 Reads
33 Citations
14.430 Impact Factor

Into the heart: the emerging role of the ubiquitin-proteasome system.

J Mol Cell Cardiol 2006 Oct 1;41(4):567-79. Epub 2006 Sep 1.

Carolina Cardiovascular Biology Center, Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599-7126, USA.

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October 2006
5 Reads
36 Citations
4.660 Impact Factor

Immunofixation reveals an apparent alpha heavy chain caused by precipitation of fibrinogen with IgA antiserum.

Clin Chim Acta 2006 Jun 7;368(1-2):192-4. Epub 2006 Feb 7.

University of North Carolina at Chapel Hill, School of Medicine, Department of Pathology and Laboratory Medicine, CB #7525, Chapel Hill, NC 27599, USA.

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June 2006
3 Reads
2.820 Impact Factor

Relapse of thrombotic thrombocytopenic purpura: is it a continuum of disease?

Semin Thromb Hemost 2005 Dec;31(6):700-8

University of North Carolina, Department of Pathology & Laboratory Medicine, Chapel Hill, North Carolina 27514, USA.

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December 2005
3 Reads
1 Citation
3.880 Impact Factor

Rat sinusoidal liver endothelial cells (SECs) produce pro-fibrotic factors in response to adducts formed from the metabolites of ethanol.

Biochem Pharmacol 2005 Nov 3;70(11):1593-600. Epub 2005 Oct 3.

University of Nebraska Medical Center, Department of Internal Medicine, 983025 Nebraska Medical Center, Omaha, NE 68198-3025, USA.

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November 2005
6 Reads
13 Citations
5.010 Impact Factor

Scavenger receptors on sinusoidal liver endothelial cells are involved in the uptake of aldehyde-modified proteins.

Mol Pharmacol 2005 Nov 16;68(5):1423-30. Epub 2005 Aug 16.

Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, Omaha, NE 68105, USA.

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November 2005
5 Reads
15 Citations
4.130 Impact Factor

Low blast count myeloid disorders with Auer rods: a clinicopathologic analysis of 9 cases.

Am J Clin Pathol 2005 Aug;124(2):191-8

Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA.

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August 2005
3 Reads
1 Citation
2.510 Impact Factor

Effect of anemia on plasma concentrations of NT-proBNP.

Clin Chim Acta 2005 Aug;358(1-2):175-81

Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599-7525, United States.

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August 2005
5 Reads
6 Citations
2.820 Impact Factor

Tumor necrosis factor-alpha-induced caspase activation mediates endotoxin-related cardiac dysfunction.

Crit Care Med 2005 May;33(5):1021-8

Department of Pediatrics, University of Texas Southwestern, Dallas, TX, USA.

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May 2005
4 Reads
23 Citations
6.310 Impact Factor

Bone marrow-derived cells contribute to contractile dysfunction in endotoxic shock.

Am J Physiol Heart Circ Physiol 2005 Feb 30;288(2):H577-83. Epub 2004 Sep 30.

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9063, USA.

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February 2005
5 Reads
12 Citations
3.840 Impact Factor

Macrophage migration inhibitory factor mediates late cardiac dysfunction after burn injury.

Am J Physiol Heart Circ Physiol 2005 Feb 23;288(2):H795-804. Epub 2004 Sep 23.

Department of Pediatrics, University of Texas Southwestern, Dallas, Texas 75390-9063, USA.

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February 2005
6 Reads
19 Citations

Zinc-induced copper deficiency: a report of three cases initially recognized on bone marrow examination.

Am J Clin Pathol 2005 Jan;123(1):125-31

Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75390-9072, USA.

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January 2005
9 Reads
19 Citations
2.510 Impact Factor

Lipopolysaccharide is a cofactor for malondialdehyde-acetaldehyde adduct-mediated cytokine/chemokine release by rat sinusoidal liver endothelial and Kupffer cells.

Alcohol Clin Exp Res 2004 Dec;28(12):1931-8

Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.

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December 2004
6 Reads
21 Citations
3.210 Impact Factor

Mechanisms of alcohol liver damage: aldehydes, scavenger receptors, and autoimmunity.

Front Biosci 2004 Sep 1;9:3145-55. Epub 2004 Sep 1.

University of Nebraska Medical Center, Department of Internal Medicine, 988090 Nebraska Medical Center, Omaha, NE 68198-8090, USA.

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September 2004
6 Reads
5 Citations

Malondialdehyde-acetaldehyde haptenated protein binds macrophage scavenger receptor(s) and induces lysosomal damage.

Int Immunopharmacol 2004 Jul;4(7):885-99

Department of Internal Medicine, University of Nebraska Medical Center, 983025 Nebraska Medical Center, Omaha, NE 68198-3025, USA.

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July 2004
12 Reads
7 Citations

Malondialdehyde-acetaldehyde (MAA) modified proteins induce pro-inflammatory and pro-fibrotic responses by liver endothelial cells.

Comp Hepatol 2004 Jan 14;3 Suppl 1:S25. Epub 2004 Jan 14.

University of Nebraska Medical Center, Department of Internal Medicine, 983025 Nebraska Medical Center, Omaha, NE 68198-3025, USA.

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January 2004
6 Reads
10 Citations

Macrophage migration inhibitory factor is a cardiac-derived myocardial depressant factor.

Am J Physiol Heart Circ Physiol 2003 Dec 28;285(6):H2500-9. Epub 2003 Aug 28.

Department of Pediatrics, University of Texas Southwestern, 5323 Harry Hines Blvd., Dallas, TX 75390-9063, USA.

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December 2003
7 Reads
22 Citations

T cell proliferative responses to malondialdehyde-acetaldehyde haptenated protein are scavenger receptor mediated.

Int Immunopharmacol 2003 Oct;3(10-11):1381-99

Veterans Affairs Alcohol Research Center, Omaha Veterans Affairs Medical Center, 4101 Woolworth Ave., Omaha, NE 68105.

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October 2003
7 Reads
9 Citations

Chronic ethanol consumption impairs receptor-mediated endocytosis of MAA-modified albumin by liver endothelial cells.

Biochem Pharmacol 2003 Sep;66(6):1045-54

Department of Internal Medicine, University of Nebraska Medical Center, 600 South 42nd Street, Omaha, NE 68198-3025, USA.

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September 2003
5 Reads
5 Citations

The role of nutrition in preventing prostate cancer: a review of the proposed mechanism of action of various dietary substances.

Clin Chim Acta 2003 Apr;330(1-2):57-83

Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, USA.

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April 2003
8 Reads
16 Citations

Current methods of colorectal cancer screening.

MLO Med Lab Obs 2002 May;34(5):12-6, 19; quiz 20-1

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May 2002
5 Reads

In vitro exposure to malondialdehyde-acetaldehyde adducted protein inhibits cell proliferation and viability.

Alcohol Clin Exp Res 2002 Feb;26(2):158-64

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

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February 2002
6 Reads
2 Citations

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Cam Patterson
Cam Patterson

McAllister Heart Institute

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Jonathan C Schisler
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McAllister Heart Institute

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Pamela Lockyer
Pamela Lockyer

University of North Carolina

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William E Stansfield
William E Stansfield

University of North Carolina

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Traci L Parry
Traci L Parry

McAllister Heart Institute

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Kristine M Wadosky
Kristine M Wadosky

Roswell Park Cancer Institute

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Megan T Quintana
Megan T Quintana

University of North Carolina

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Brian C Jensen
Brian C Jensen

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