Monsef Benkirane

Monsef Benkirane

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Monsef Benkirane

Publications by authors named "Monsef Benkirane"

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KAP1 targets actively transcribed genomic loci to exert pleomorphic effects on RNA polymerase II activity.

Philos Trans R Soc Lond B Biol Sci 2020 Mar 10;375(1795):20190334. Epub 2020 Feb 10.

School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1098/rstb.2019.0334DOI Listing
March 2020

Descours et al. reply.

Nature 2018 09;561(7723):E29

Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, UMR9002, CNRS, Université de Montpellier, Montpellier, France.

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http://www.nature.com/articles/s41586-018-0496-1
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http://dx.doi.org/10.1038/s41586-018-0496-1DOI Listing
September 2018

SAMHD1 acts at stalled replication forks to prevent interferon induction.

Nature 2018 05 18;557(7703):57-61. Epub 2018 Apr 18.

Institut de Génétique Humaine, CNRS, Université de Montpellier, Laboratoire Maintien de l'Intégrité du Génome au cours de la Réplication, Ligue Contre le Cancer, Montpellier, France.

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http://www.nature.com/articles/s41586-018-0050-1
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http://dx.doi.org/10.1038/s41586-018-0050-1DOI Listing
May 2018

HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response.

Mol Cell 2017 Aug 14;67(3):387-399.e5. Epub 2017 Jul 14.

Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, Université de Montpellier, CNRS UMR9002, 34000 Montpellier, France. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.06.020DOI Listing
August 2017

CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses.

Nature 2017 03 15;543(7646):564-567. Epub 2017 Mar 15.

Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, UMR9002, CNRS, Université de Montpellier, Montpellier, France.

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http://dx.doi.org/10.1038/nature21710DOI Listing
March 2017

Upregulated LINE-1 Activity in the Fanconi Anemia Cancer Susceptibility Syndrome Leads to Spontaneous Pro-inflammatory Cytokine Production.

EBioMedicine 2016 Jun 6;8:184-194. Epub 2016 May 6.

Institute of Human Genetics, CNRS UPR1142, Molecular Basis of Cancer-Related Inflammation Laboratory, University of Montpellier, Montpellier, France. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2016.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919473PMC
June 2016

Dasatinib inhibits HIV-1 replication through the interference of SAMHD1 phosphorylation in CD4+ T cells.

Biochem Pharmacol 2016 Apr 4;106:30-45. Epub 2016 Feb 4.

AIDS Immunopathology Unit, National Center of Microbiology, Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2016.02.002DOI Listing
April 2016

Phosphorylation of murine SAMHD1 regulates its antiretroviral activity.

Retrovirology 2015 Dec 15;12:103. Epub 2015 Dec 15.

Institute of Clinical and Molecular Virology, Friedrich-Alexander University Erlangen-Nürnberg, Schlossgarten 4, 91054, Erlangen, Germany.

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http://dx.doi.org/10.1186/s12977-015-0229-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678485PMC
December 2015

Shaping of the host cell by viral accessory proteins.

Front Microbiol 2015 23;6:142. Epub 2015 Feb 23.

Molecular Virology Laboratory, Centre National de la Recherche Scientifique, Institute of Human Genetics CNRS UPR1142 Montpellier, France.

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http://dx.doi.org/10.3389/fmicb.2015.00142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337327PMC
March 2015

Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes.

Nat Commun 2014 Nov 20;5:5531. Epub 2014 Nov 20.

1] Institute of Human Genetics, CNRS UPR1142, Laboratory of Molecular Virology; MGX-Montpellier GenomiX, 141 rue de la Cardonille, Montpellier 34396, France [2] LBME-CNRS, Cell Cycle Chromatin Dynamics Laboratory. University Paul Sabatier, Toulouse 31061, France [3] INRA, TOXALIM (Research Centre in Food Toxicology), Toulouse 31300, France [4] IGF, MGX-Montpellier GenomiX, France.

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http://dx.doi.org/10.1038/ncomms6531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263189PMC
November 2014

The Tudor domain protein Spindlin1 is involved in intrinsic antiviral defense against incoming hepatitis B Virus and herpes simplex virus type 1.

PLoS Pathog 2014 Sep 11;10(9):e1004343. Epub 2014 Sep 11.

Unité des Hépacivirus et Immunité Innée, Institut Pasteur, Paris, France; UMR CNRS 3569, Paris, France.

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http://dx.doi.org/10.1371/journal.ppat.1004343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161474PMC
September 2014

DNA damage repair machinery and HIV escape from innate immune sensing.

Front Microbiol 2014 22;5:176. Epub 2014 Apr 22.

Laboratoire de Virologie Moléculaire, Institut de Génétique Humaine CNRS UPR1142, Montpellier, France.

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http://dx.doi.org/10.3389/fmicb.2014.00176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001025PMC
June 2014

Identification of histone 3 variant 2 interacting factors.

Nucleic Acids Res 2014 Apr 6;42(6):3542-50. Epub 2014 Jan 6.

Laboratoire de Régulation des Gènes, Institut de Génétique Humaine, CNRS UPR1142, Montpellier 34396, France and Laboratoire de Virologie Moléculaire, Institut de Génétique Humaine, CNRS UPR1142, Montpellier 34396, France.

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http://dx.doi.org/10.1093/nar/gkt1355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973350PMC
April 2014

Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing.

Cell 2014 Jan 9;156(1-2):134-45. Epub 2014 Jan 9.

Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, CNRS UPR1142, Montpellier 34000, France. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2013.12.011DOI Listing
January 2014

Premature termination of transcription by RNAP II: the beginning of the end.

Transcription 2013 Mar-Apr;4(2):72-6

Institut de Génétique Humaine; CNRS UPR1142, Laboratoire de Régulation des Gènes, Montpellier, France.

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http://dx.doi.org/10.4161/trns.24148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646057PMC
December 2013

Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1.

Cell Rep 2013 Apr 17;3(4):1036-43. Epub 2013 Apr 17.

Institut de Génétique Humaine, CNRS UPR1142, Laboratoires de Virologie Moléculaire, Montpellier 34000, France.

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http://dx.doi.org/10.1016/j.celrep.2013.03.017DOI Listing
April 2013

Obituary: Kuan-Teh Jeang.

Retrovirology 2013 Mar 21;10:28. Epub 2013 Mar 21.

Department of Medical Microbiology, Laboratory of Experimental Virology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam, 1105 AZ, The Netherlands.

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http://dx.doi.org/10.1186/1742-4690-10-28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605318PMC
March 2013

Hyperthermia stimulates HIV-1 replication.

PLoS Pathog 2012 12;8(7):e1002792. Epub 2012 Jul 12.

Institut Pasteur, Unité Virus et Immunité, Département de Virologie, Paris, France.

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http://dx.doi.org/10.1371/journal.ppat.1002792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395604PMC
January 2013

Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac.

Retrovirology 2012 Jun 12;9:49. Epub 2012 Jun 12.

Department of Microbiology and Immunology, Albert Einstein College of Medicine Bronx, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1186/1742-4690-9-49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410799PMC
June 2012

Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein.

Cell Host Microbe 2012 Feb 1;11(2):205-17. Epub 2012 Feb 1.

Institut de Génétique Humaine, Centre National de la Recherche Scientifique, Unité Propre de Recherche 1142, Laboratoires de Virologie Moléculaire, 34000 Montpellier, France.

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http://dx.doi.org/10.1016/j.chom.2012.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595996PMC
February 2012

How SAMHD1 changes our view of viral restriction.

Trends Immunol 2012 Jan 15;33(1):26-33. Epub 2011 Dec 15.

Laboratoire de Virologie Moléculaire, Institut de Génétique Humaine, CNRS-UPR 1142, 141 rue de la Cardonille, 34296 Montpellier cedex 5, France.

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http://dx.doi.org/10.1016/j.it.2011.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595995PMC
January 2012

Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin.

Proc Natl Acad Sci U S A 2011 Sep 22;108(36):E636-45. Epub 2011 Aug 22.

Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.

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http://dx.doi.org/10.1073/pnas.1107107108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169135PMC
September 2011

Competition for XPO5 binding between Dicer mRNA, pre-miRNA and viral RNA regulates human Dicer levels.

Nat Struct Mol Biol 2011 Mar 6;18(3):323-7. Epub 2011 Feb 6.

Centre National de la Recherche Scientifique, Institut de Génétique Humaine UPR1142, Montpellier, France.

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http://dx.doi.org/10.1038/nsmb.1987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595992PMC
March 2011

Lessons from interconnected ubiquitylation and acetylation of p53: think metastable networks.

Biochem Soc Trans 2010 Feb;38(Pt 1):98-103

IGH, CNRS, UPR 1142, 141 rue de la Cardonille, 34396 Montpellier cedex 5, France.

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http://dx.doi.org/10.1042/BST0380098DOI Listing
February 2010

Suppression of HIV-1 replication by microRNA effectors.

Retrovirology 2009 Mar 9;6:26. Epub 2009 Mar 9.

Institut de Génétique Humaine CNRS UPR1142, Laboratoire de Virologie Moléculaire, Montpellier, France.

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http://dx.doi.org/10.1186/1742-4690-6-26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657893PMC
March 2009

Small non-coding RNAs, mammalian cells, and viruses: regulatory interactions?

Retrovirology 2007 Oct 15;4:74. Epub 2007 Oct 15.

Molecular Virology Section, Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, Maryland 20892-0460, USA.

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http://dx.doi.org/10.1186/1742-4690-4-74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2164956PMC
October 2007

[Interplay between HIV-1 replication and the microRNA-silencing pathway].

Med Sci (Paris) 2007 Jun-Jul;23(6-7):590-2

Laboratoire de Virologie Moléculaire, Institut de Génétique Humaine, CNRS UPR 1142, 141, rue de la Cardonille, 34396 Montpellier Cedex 5, France.

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http://dx.doi.org/10.1051/medsci/20072367590DOI Listing
September 2007

Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2.

Nat Cell Biol 2007 Mar 11;9(3):331-8. Epub 2007 Feb 11.

Centre de Recherches de Biochimie Macromoléculaire, CNRS-UMII UMR5237, Montpellier, France.

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http://dx.doi.org/10.1038/ncb1545DOI Listing
March 2007

Suppression of microRNA-silencing pathway by HIV-1 during virus replication.

Science 2007 Mar 22;315(5818):1579-82. Epub 2007 Feb 22.

Laboratoire de Virologie Moléculaire, Institut de Génétique Humaine, Montpellier, France.

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http://dx.doi.org/10.1126/science.1136319DOI Listing
March 2007

The proteasome regulates HIV-1 transcription by both proteolytic and nonproteolytic mechanisms.

Mol Cell 2007 Feb;25(3):369-83

Laboratoire de Virologie Moléculaire, Institut de Génétique Humaine, Centre National de la Recherche Scientifique UPR1142, Montpellier, France.

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https://linkinghub.elsevier.com/retrieve/pii/S10972765060088
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http://dx.doi.org/10.1016/j.molcel.2006.12.020DOI Listing
February 2007

ERK5 activates NF-kappaB in leukemic T cells and is essential for their growth in vivo.

J Immunol 2006 Dec;177(11):7607-17

Institut de Génétique Moléculaire de Montpellier, Centre National de la Recherche Scientifique-Unité Mixte de Recherche 5535, IFR 122, 1919 Route de Mende, 34293 Montpellier, France.

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http://dx.doi.org/10.4049/jimmunol.177.11.7607DOI Listing
December 2006

RNA interference and HIV-1: hits and misses.

Curr Opin HIV AIDS 2006 May;1(3):208-11

aNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA bInstitut de Genetique Humaine, CNRS UPR1142, Montpellier, France.

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http://dx.doi.org/10.1097/01.COH.0000221593.49412.56DOI Listing
May 2006

p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain.

J Biol Chem 2005 Dec 11;280(50):41537-45. Epub 2005 Oct 11.

Institut Cochin, Department of Maladies Infectieuses, INSERM U567, CNRS UMR8104, University Rene Descartes Paris V, Bat G. Roussy, 27 Rue du Faubourg Saint Jacques, 75014 Paris, France.

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http://dx.doi.org/10.1074/jbc.M505294200DOI Listing
December 2005

Changes in microRNA expression profiles in HIV-1-transfected human cells.

Retrovirology 2005 Dec 28;2:81. Epub 2005 Dec 28.

Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, Maryland 20892-0460, USA.

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http://dx.doi.org/10.1186/1742-4690-2-81DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1352379PMC
December 2005

Interferon-induced exonuclease ISG20 exhibits an antiviral activity against human immunodeficiency virus type 1.

J Gen Virol 2005 Aug;86(Pt 8):2221-9

CNRS, UMR-5160, EFS, 240 avenue Emile Jeanbrau, 34094 Montpellier Cedex 5, France.

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http://dx.doi.org/10.1099/vir.0.81074-0DOI Listing
August 2005

HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses.

EMBO J 2005 Jul 7;24(14):2634-45. Epub 2005 Jul 7.

Laboratoire de Biologie Moléculaire et Cellulaire de la Différenciation, INSERM U309, Equipe chromatine et expression des gènes, Institut Albert Bonniot, Faculté de Médecine, Domaine de la Merci, La Tronche, France.

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http://dx.doi.org/10.1038/sj.emboj.7600734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1176461PMC
July 2005

Evidence that HIV-1 encodes an siRNA and a suppressor of RNA silencing.

Immunity 2005 May;22(5):607-19

Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.immuni.2005.03.010DOI Listing
May 2005

Ubiquitination of human T-cell leukemia virus type 1 tax modulates its activity.

J Virol 2004 Nov;78(21):11686-95

Molecular Virology Section, Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1128/JVI.78.21.11686-11695.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC523283PMC
November 2004

Tat and trans-activation-responsive (TAR) RNA-independent induction of HIV-1 long terminal repeat by human and murine cyclin T1 requires Sp1.

J Biol Chem 2003 Feb 27;278(8):6404-10. Epub 2002 Nov 27.

Molecular Virology Section, Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0460, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M209162200
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http://dx.doi.org/10.1074/jbc.M209162200DOI Listing
February 2003

Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65.

J Biol Chem 2003 Jan 4;278(4):2758-66. Epub 2002 Nov 4.

Laboratoire de Virologie Moléculaire, Institut de Génétique Humaine, Montpellier 34296, France.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M209572200
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http://dx.doi.org/10.1074/jbc.M209572200DOI Listing
January 2003

Differential acetylation of Tat coordinates its interaction with the co-activators cyclin T1 and PCAF.

EMBO J 2002 Dec;21(24):6811-9

Laboratoire de Virologie Moléculaire et Transfert de Gène, Institut de Génétique Humaine, CNRS UPR1142, Montpellier, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC139090PMC
http://dx.doi.org/10.1093/emboj/cdf669DOI Listing
December 2002

Tat acetyl-acceptor lysines are important for human immunodeficiency virus type-1 replication.

J Biol Chem 2002 Jun 15;277(25):22215-21. Epub 2002 Apr 15.

Institut de Génétique Humaine, CNRS UPR 1142, 141 rue de la Cardonille, 34396 Montpellier cedex 5, France.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M201895200
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http://dx.doi.org/10.1074/jbc.M201895200DOI Listing
June 2002