Monica Gostissa

Monica Gostissa

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Monica Gostissa

Monica Gostissa

Publications by authors named "Monica Gostissa"

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Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching.

Nature 2015 Sep 26;525(7567):134-139. Epub 2015 Aug 26.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/nature14970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592165PMC
September 2015

A Rapid Embryonic Stem Cell-Based Mouse Model for B-cell Lymphomas Driven by Epstein-Barr Virus Protein LMP1.

Cancer Immunol Res 2015 Jun 1;3(6):641-9. Epub 2015 May 1.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Children's Hospital Boston, Department of Genetics, Harvard Medical School, Boston, Massachusetts.

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http://cancerimmunolres.aacrjournals.org/cgi/doi/10.1158/232
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http://dx.doi.org/10.1158/2326-6066.CIR-15-0058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456688PMC
June 2015

Aberrant TCRδ rearrangement underlies the T-cell lymphocytopenia and t(12;14) translocation associated with ATM deficiency.

Blood 2015 Apr 26;125(17):2665-8. Epub 2015 Feb 26.

Department of Pathology and Cell Biology, Institute for Cancer Genetics, and Herbert Irving Comprehensive Cancer Research Center, Columbia University Medical Center, New York, NY; Division of Hematology, Oncology, and Stem Cell Transplantation, Department of Pediatrics, College for Physicians and Surgeons, Columbia University Medical Center, New York, NY.

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http://dx.doi.org/10.1182/blood-2015-01-622621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408291PMC
April 2015

Mechanisms that can promote peripheral B-cell lymphoma in ATM-deficient mice.

Cancer Immunol Res 2014 Sep 9;2(9):857-66. Epub 2014 Jun 9.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital; and Department of Genetics, Harvard Medical School, Boston, Massachusetts

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http://dx.doi.org/10.1158/2326-6066.CIR-14-0090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156541PMC
September 2014

Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes.

Proc Natl Acad Sci U S A 2014 Jul 30;111(28):10269-74. Epub 2014 Jun 30.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1410112111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104897PMC
July 2014

IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances.

Proc Natl Acad Sci U S A 2014 Feb 3;111(7):2644-9. Epub 2014 Feb 3.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115.

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http://dx.doi.org/10.1073/pnas.1324176111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932927PMC
February 2014

Conditional inactivation of p53 in mature B cells promotes generation of nongerminal center-derived B-cell lymphomas.

Proc Natl Acad Sci U S A 2013 Feb 4;110(8):2934-9. Epub 2013 Feb 4.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1222570110
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http://dx.doi.org/10.1073/pnas.1222570110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581964PMC
February 2013

Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1).

Proc Natl Acad Sci U S A 2012 Feb 30;109(7):2473-8. Epub 2012 Jan 30.

Program in Cellular and Molecular Medicine, Howard Hughes Medical Institute, Children's Hospital Boston and Department of Genetics, Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1121470109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289296PMC
February 2012

Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells.

Cell 2011 Sep;147(1):107-19

Howard Hughes Medical Institute, Immune Disease Institute, Program in Cellular and Molecular Medicine, Children's Hospital Boston and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2011.07.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186939PMC
September 2011

Mechanisms that promote and suppress chromosomal translocations in lymphocytes.

Annu Rev Immunol 2011 ;29:319-50

Howard Hughes Medical Institute, Immune Disease Institute, Program in Cellular and Molecular Medicine, Children's Hospital Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1146/annurev-immunol-031210-101329DOI Listing
June 2011

Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region.

Nature 2009 Dec;462(7274):803-7

Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature08633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802177PMC
December 2009

Chromosomal location targets different MYC family gene members for oncogenic translocations.

Proc Natl Acad Sci U S A 2009 Feb 27;106(7):2265-70. Epub 2009 Jan 27.

The Howard Hughes Medical Institute, Children's Hospital Boston, and Department of Genetics, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0812763106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650145PMC
February 2009

H2AX prevents DNA breaks from progressing to chromosome breaks and translocations.

Mol Cell 2006 Jan;21(2):201-14

Howard Hughes Medical Institute, The Children's Hospital, Department of Genetics, Harvard Medical School and the CBR Institute for Biomedical Research, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.molcel.2006.01.005DOI Listing
January 2006

DNA repair, genome stability, and aging.

Cell 2005 Feb;120(4):497-512

Howard Hughes Medical Institute, The Children's Hospital, Department of Genetics, Harvard Medical School and, The CBR Institute for Biomedical Research, Boston, Massachusetts 02115, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S009286740500102
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http://dx.doi.org/10.1016/j.cell.2005.01.028DOI Listing
February 2005

The transcriptional repressor hDaxx potentiates p53-dependent apoptosis.

J Biol Chem 2004 Nov 31;279(46):48013-23. Epub 2004 Aug 31.

Laboratorio Nazionale Consorzio Interuniversitario Biotecnologie (LNCIB), Area Science Park, Padriciano 99, 34012, Trieste, Italy.

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http://dx.doi.org/10.1074/jbc.M310801200DOI Listing
November 2004

KeePin' the p53 family in good shape.

Cell Cycle 2004 Jul 2;3(7):905-11. Epub 2004 Jul 2.

Laboratorio Nazionale C.I.B., Area Science Park, Trieste, Italy.

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July 2004

Modification of the erythroid transcription factor GATA-1 by SUMO-1.

Proc Natl Acad Sci U S A 2004 Jun 1;101(24):8870-5. Epub 2004 Jun 1.

Laboratorio Nazionale Consorzio Interuniversitario Biotecnologie, AREA Science Park, Padriciano 99, 34012 Trieste, Italy.

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http://dx.doi.org/10.1073/pnas.0308605101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC428439PMC
June 2004

Pin1 links the activities of c-Abl and p300 in regulating p73 function.

Mol Cell 2004 Jun;14(5):625-36

Laboratorio Nazionale C.I.B., Area Science Park, Padriciano 99, I-34012 Trieste, Italy.

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http://dx.doi.org/10.1016/j.molcel.2004.05.007DOI Listing
June 2004

Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2.

Mol Cell Biol 2003 Dec;23(24):9104-16

Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole. Centre of Excellence in Biocristallography, University of Trieste, via L. Giorgieri 1, 34127 Trieste, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC309667PMC
http://dx.doi.org/10.1128/mcb.23.24.9104-9116.2003DOI Listing
December 2003

Adenosine deaminase, a key enzyme in DNA precursors control, is a new p73 target.

Oncogene 2003 Nov;22(54):8738-48

Istituto di Tecnologie Biomediche, Sezione di Bari di Bioinformatica e Genomica CNR, Via Amendola, 165/A Bari 70126, Italy.

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http://www.nature.com/articles/1206967
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http://dx.doi.org/10.1038/sj.onc.1206967DOI Listing
November 2003

Regulation of p53 functions: let's meet at the nuclear bodies.

Curr Opin Cell Biol 2003 Jun;15(3):351-7

Laboratorio Nazionale Consorzio Interuniversitario per le Biotecnologie, Area Science Park, Padriciano 99, 34012, Trieste, Italy.

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http://dx.doi.org/10.1016/s0955-0674(03)00038-3DOI Listing
June 2003

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults.

Nature 2002 Oct 2;419(6909):853-7. Epub 2002 Oct 2.

Laboratorio Nazionale CIB, AREA Science Park, Padriciano 99, 34012 Trieste, Italy.

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http://dx.doi.org/10.1038/nature01120DOI Listing
October 2002