Publications by authors named "Monica Della Rosa"

2 Publications

  • Page 1 of 1

Silencers in the spotlight.

Nat Genet 2020 03;52(3):244-245

MRC London Institute of Medical Sciences, London, UK.

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http://dx.doi.org/10.1038/s41588-020-0583-8DOI Listing
March 2020

Tri-methylation of histone H3 lysine 4 facilitates gene expression in ageing cells.

Elife 2018 10 2;7. Epub 2018 Oct 2.

Epigenetics Programme, The Babraham Institute, Cambridge, United Kingdom.

Transcription of protein coding genes is accompanied by recruitment of COMPASS to promoter-proximal chromatin, which methylates histone H3 lysine 4 (H3K4) to form H3K4me1, H3K4me2 and H3K4me3. Here, we determine the importance of COMPASS in maintaining gene expression across lifespan in budding yeast. We find that COMPASS mutations reduce replicative lifespan and cause expression defects in almost 500 genes. Although H3K4 methylation is reported to act primarily in gene repression, particularly in yeast, repressive functions are progressively lost with age while hundreds of genes become dependent on H3K4me3 for full expression. Basal and inducible expression of these genes is also impaired in young cells lacking COMPASS components Swd1 or Spp1. Gene induction during ageing is associated with increasing promoter H3K4me3, but H3K4me3 also accumulates in non-promoter regions and the ribosomal DNA. Our results provide clear evidence that H3K4me3 is required to maintain normal expression of many genes across organismal lifespan.
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http://dx.doi.org/10.7554/eLife.34081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168286PMC
October 2018