Mona Bafadhel

Mona Bafadhel

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Mona Bafadhel

Mona Bafadhel

Publications by authors named "Mona Bafadhel"

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Benralizumab for the Prevention of COPD Exacerbations.

N Engl J Med 2019 09 20;381(11):1023-1034. Epub 2019 May 20.

From the Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia (G.J.C.); Pulmonary and Critical Care Division, Brigham and Women's Hospital, Harvard Medical School, Boston (B.R.C.); the Institute for Lung Health, Leicester National Institute for Health Research Biomedical Research Centre, Department of Respiratory Sciences, University of Leicester, Leicester (C.E.B.), the University of Manchester, Manchester University NHS Hospital Trust, Manchester (D.S.), and the Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford (M.B.) - all in the United Kingdom; Respiratory Institute, Hospital Clinic, University of Barcelona, Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red (CIBER) Enfermedades Respiratorias, Barcelona (A.A.); the Department of Medical Sciences, University of Ferrara, Ferrara, Italy (A.P.); the Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, BC, Canada (D.D.S.); the Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-Universität Marburg, German Center for Lung Research (DZL), Marburg, Germany (C.F.V.); University of Pittsburgh School of Medicine, Pittsburgh (F.C.S.); the Department of Respiratory Medicine, Bispebjerg University Hospital, Copenhagen (V.B.); Kishiwada City Hospital, Osaka, Japan (M.K.); the Departamento de Investigación en Tabaquismo y EPOC, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosio Villegas, Mexico City (A.R.-V.); the Division of Respiratory and Chest Medicine, E-Da Hospital and I-Shou University, Kaohsiung, Taiwan (Y.-F.W.); the Department of Respiratory Medicine and Allergology, Skane University Hospital, Lund University, Lund, Sweden (L.B.); and AstraZeneca, Gaithersburg, MD (V.H.S., M.J., S.O., N.M., P.N., M.G., U.J.M.).

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http://dx.doi.org/10.1056/NEJMoa1905248DOI Listing
September 2019

Building toolkits for COPD exacerbations: lessons from the past and present.

Thorax 2019 Sep 3;74(9):898-905. Epub 2019 Jul 3.

Respiratory Epidemiology, Occupational Medicine and Public Health, Imperial College London, London, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2018-213035DOI Listing
September 2019

Neutrophil elastase as a biomarker for bacterial infection in COPD.

Respir Res 2019 Jul 30;20(1):170. Epub 2019 Jul 30.

Respiratory Medicine Unit, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Level 7, Oxford, OX3 7DU, UK.

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http://dx.doi.org/10.1186/s12931-019-1145-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668103PMC
July 2019

What will Happen in the World of COPD 2030?

Turk Thorac J 2019 Jul 30:1-5. Epub 2019 Jul 30.

Respiratory Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.5152/TurkThoracJ.2019.190307DOI Listing
July 2019

Investigating blood eosinophil count thresholds in patients with COPD.

Lancet Respir Med 2018 Nov 5;6(11):823-824. Epub 2018 Oct 5.

Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(18)30415-6DOI Listing
November 2018

Symptomatic COPD: is it time for triple therapy?

Authors:
Mona Bafadhel

Lancet Respir Med 2018 10 16;6(10):728-729. Epub 2018 Sep 16.

Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(18)30370-9DOI Listing
October 2018

Shall We Focus on the Eosinophil to Guide Treatment with Systemic Corticosteroids during Acute Exacerbations of COPD?: PRO.

Med Sci (Basel) 2018 Sep 11;6(3). Epub 2018 Sep 11.

Respiratory Medicine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7FZ, UK.

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http://dx.doi.org/10.3390/medsci6030074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163385PMC
September 2018

Biological exacerbation clusters demonstrate asthma and chronic obstructive pulmonary disease overlap with distinct mediator and microbiome profiles.

J Allergy Clin Immunol 2018 06 28;141(6):2027-2036.e12. Epub 2018 Apr 28.

Institute for Lung Health, NIHR Leicester Biomedical Research Centre, Department of Infection, Immunity & Inflammation, University of Leicester and University Hospitals of Leicester NHS Trust, Leicester, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986707PMC
June 2018

Investigating the role of pentraxin 3 as a biomarker for bacterial infection in subjects with COPD.

Int J Chron Obstruct Pulmon Dis 2017 18;12:1199-1205. Epub 2017 Apr 18.

Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford.

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http://dx.doi.org/10.2147/COPD.S123528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402921PMC
March 2018

COPD exacerbations: transforming outcomes through research.

Lancet Respir Med 2018 03 9;6(3):172-174. Epub 2018 Feb 9.

University of Southampton, Southampton.

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http://dx.doi.org/10.1016/S2213-2600(18)30049-3DOI Listing
March 2018

Eosinophils in COPD: are we nearly there yet?

Authors:
Mona Bafadhel

Lancet Respir Med 2017 12 13;5(12):913-914. Epub 2017 Nov 13.

Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(17)30445-9DOI Listing
December 2017

Precision medicine in airway diseases: moving to clinical practice.

Eur Respir J 2017 10 19;50(4). Epub 2017 Oct 19.

Dept of Respiratory Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1183/13993003.01655-2017DOI Listing
October 2017

Eosinophils in COPD: just another biomarker?

Lancet Respir Med 2017 09 7;5(9):747-759. Epub 2017 Jun 7.

Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/S2213-2600(17)30217-5DOI Listing
September 2017

Alternatives to induced sputum for identifying inflammatory subtypes of asthma.

Respirology 2017 05 29;22(4):624-625. Epub 2017 Mar 29.

Respiratory Medicine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/resp.13036DOI Listing
May 2017

Blood Eosinophils and Outcomes in Severe Hospitalized Exacerbations of COPD.

Chest 2016 08 3;150(2):320-8. Epub 2016 Feb 3.

Centre for Exercise and Rehabilitation Science, University of Leicester NHS Hospitals Trust, Glenfield Hospital, Leicester, UK; NIHR Respiratory Biomedical Research Unit, University of Leicester, Leicester, UK; School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.

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http://dx.doi.org/10.1016/j.chest.2016.01.026DOI Listing
August 2016

Impaired P2X1 Receptor-Mediated Adhesion in Eosinophils from Asthmatic Patients.

J Immunol 2016 06 9;196(12):4877-84. Epub 2016 May 9.

Institute for Lung Health, National Institute for Health Research Respiratory Biomedical Research Unit, University Hospitals of Leicester National Health Service Trust, Leicester LE3 9QP, United Kingdom; Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 9HN, United Kingdom;

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http://dx.doi.org/10.4049/jimmunol.1501585DOI Listing
June 2016

Are COPD and cardiovascular disease fundamentally intertwined?

Eur Respir J 2016 05;47(5):1307-9

Respiratory Medicine Unit, Nuffield Dept of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1183/13993003.00399-2016DOI Listing
May 2016

Lung microbiome dynamics in COPD exacerbations.

Eur Respir J 2016 Apr 25;47(4):1082-92. Epub 2016 Feb 25.

Computational Biology, Target Sciences, GSK R&D, Collegeville, PA, USA Both authors contributed equally.

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http://dx.doi.org/10.1183/13993003.01406-2015DOI Listing
April 2016

Airway bacteria measured by quantitative polymerase chain reaction and culture in patients with stable COPD: relationship with neutrophilic airway inflammation, exacerbation frequency, and lung function.

Int J Chron Obstruct Pulmon Dis 2015 9;10:1075-83. Epub 2015 Jun 9.

Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK ; Institute for Lung Health, National Institute for Health Research Respiratory Biomedical Research Unit, Glenfield Hospital, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.2147/COPD.S80091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468933PMC
March 2016

Toll-like receptor 9 dependent interferon-α release is impaired in severe asthma but is not associated with exacerbation frequency.

Immunobiology 2015 Jul 22;220(7):859-64. Epub 2015 Jan 22.

Institute of Lung Health, Respiratory Biomedical Unit, University Hospitals of Leicester NHS Trust, Leicestershire, UK; Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S01712985150000
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http://dx.doi.org/10.1016/j.imbio.2015.01.005DOI Listing
July 2015

Systemic and pulmonary inflammation is independent of skeletal muscle changes in patients with chronic obstructive pulmonary disease.

Int J Chron Obstruct Pulmon Dis 2014 15;9:975-81. Epub 2014 Sep 15.

Respiratory Medicine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus, Oxford, United Kingdom.

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http://dx.doi.org/10.2147/COPD.S63568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168852PMC
February 2015

Association between pathogens detected using quantitative polymerase chain reaction with airway inflammation in COPD at stable state and exacerbations.

Chest 2015 Jan;147(1):46-55

Respiratory Medicine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus, Oxford, England. Electronic address:

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http://dx.doi.org/10.1378/chest.14-0764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285081PMC
January 2015

Biological clustering supports both "Dutch" and "British" hypotheses of asthma and chronic obstructive pulmonary disease.

J Allergy Clin Immunol 2015 Jan 13;135(1):63-72. Epub 2014 Aug 13.

Department of Infection, Immunity and Inflammation, Institute for Lung Health, University of Leicester, Leicester, United Kingdom; NIHR Respiratory Biomedical Research Unit, University Hospitals of Leicester, Leicester, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.06.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282726PMC
January 2015

Inhaled glucocorticoids and COPD exacerbations.

N Engl J Med 2015 01;372(1):93

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http://dx.doi.org/10.1056/NEJMc1413308DOI Listing
January 2015

Blood eosinophil guided prednisolone therapy for exacerbations of COPD: a further analysis.

Eur Respir J 2014 Sep 12;44(3):789-91. Epub 2014 Jun 12.

Dept of Respiratory Medicine, Nuffield Dept of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1183/09031936.00062614DOI Listing
September 2014

Effect of levofloxacin on neutrophilic airway inflammation in stable COPD: a randomized, double-blind, placebo-controlled trial.

Int J Chron Obstruct Pulmon Dis 2014 7;9:179-86. Epub 2014 Feb 7.

Department of Respiratory Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus, Oxford, UK.

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http://dx.doi.org/10.2147/COPD.S55419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923615PMC
August 2014

COPD exacerbation severity and frequency is associated with impaired macrophage efferocytosis of eosinophils.

BMC Pulm Med 2014 Jul 9;14:112. Epub 2014 Jul 9.

Institute for Lung Health, NIHR Respiratory Biomedical Research Unit, Department of Infection, Immunity & Inflammation, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1186/1471-2466-14-112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115214PMC
July 2014

Children must be protected from the tobacco industry's marketing tactics.

Authors:
Nicholas Hopkinson Colin Wallis Bernard Higgins Stephen Gaduzo Rebecca Sherrington Sarah Keilty Myra Stern John Britton Andrew Bush John Moxham Karl Sylvester Valerie Griffiths Tim Sutherland Iain Crossingham Raghu Raju Charlotte Spencer Shahideh Safavi Paul Deegan John Seymour Katherine Hickman John Hughes Jason Wieboldt Fizah Shaheen Clive Peedell Nesta Mackenzie David Nicholl Caroline Jolley Gillian Crooks Gillian Crooks Claire Dow Pete Deveson Oliver Bintcliffe Barry Gray Sanjay Kumar Sarah Haney Marianne Docherty Angela Thomas Felix Chua Akshay Dwarakanath Geoffrey Summers Keith Prowse Stephen Lytton Yee Ean Ong Jennifer Graves Tushar Banerjee Peter English Andrew Leonard Martin Brunet Nauman Chaudhry Robert Ian Ketchell Natalie Cummings Jenny Lebus Charles Sharp Chris Meadows Amelie Harle Tara Stewart Diane Parry Suzanne Templeton-Wright John Moore-Gillon James Stratford- Martin Sarvesh Saini Simon Matusiewicz Simon Merritt Lee Dowson Karnan Satkunam Luke Hodgson Eui-Sik Suh Hannah Durrington Emma Browne Nicola Walters Joerg Steier Simon Barry Mark Griffiths Nicholas Hart Marko Nikolic Matthew Berry Ajit Thomas Joy Miller Diarmuid McNicholl Paul Marsden Geoffrey Warwick Laura Barr David Adeboyeku Mohd Shahrin Mohd Noh Paul Griffiths Lisa Davies Jennifer Quint Rebecca Lyall Jonathan Shribman Andrea Collins Jon Goldman Susannah Bloch Alison Gill William Man Anne Christopher Razouqi Yasso Ashwin Rajhan Dinesh Shrikrishna Caroline Moore Gareth Absalom Richard Booton Robert William Fowler Carolyn Mackinlay Elizabeth Sapey Sara Lock Paul Walker Akhilesh Jha Imran Satia Bethia Bradley Naveed Mustfa Raana Haqqee Matt Thomas Anant Patel Anthony Redington Anilkumar Pillai Niall Keaney Stephen Fowler Lesley Lowe Amanda Brennan Douglas Morrison Clare Murray Jenny Hankinson P Dutta Matthew Maddocks Martino Pengo Katrina Curtis Gerrard Rafferty John Hutchinson Ruth Whitfield Steve Turner Ronan Breen Shams-un-nisa Naveed Chris Goode Georgina Esterbrook Liju Ahmed Woolf Walker David Ford Gary Connett Philip Davidson Will Elston Andrew Stanton David Morgan James Myerson David Maxwell Ann Harrris Sonia Parmar Catherine Houghton Robert Winter Zudin Puthucheary Fiona Thomson Sharon Sturney John Harvey Patricia L Haslam Irem Patel David Jennings Simon Range Brendan Mallia-Milanes Anne Collett Paul Tate Richard Russell Johanna Feary Ronan O'Driscoll James Eaden Jonathan Round Emma Sharkey Mary Montgomery Sophie Vaughan Kate Scheele Anna Lithgow Samuel Partridge Richard Chavasse Louise Restrick Sanjay Agrawal Said Abdallah Amruta Lacy-Colson Nick Adams Sally Mitchell Helmy Haja Mydin Ann Ward Sarah Denniston Mark Steel Dipansu Ghosh Stephen Connellan Lucy Rigge Ruth Williams Alison Grove Sadia Anwar Lee Dobson Harold Hosker David Stableforth Neil Greening Tim Howell Georgina Casswell Sarah Davies Georgia Tunnicliffe Philip Mitchelmore Elpida Phitidis Louise Robinson Keith Prowse Mona Bafadhel Grace Robinson Alison Boland Marc Lipman Stephen Bourke Sundeep Kaul Calvin Cowie Ian Forrest Elizabeth Starren Hannah Burke John Furness Angshu Bhowmik Caroline Everett Douglas Seaton Steve Holmes Simon Doe Samuel Parker Annika Graham Ian Paterson Usman Maqsood Chandra Ohri Peter Iles Samuel Kemp Ahsan Iftikhar Chris Carlin Tim Fletcher Peter Emerson Victoria Beasley Michelle Ramsay Robert Buttery Sarah Mungall Stephen Crooks John Ridyard David Ross Alison Guadagno Emma Holden Ian Coutts Kathy Cullen Sally O'Connor Jack Barker Katherine Sloper John Watson Peter Smith Paul Anderson Louise Brown Cyril Nyman Heather Milburn Amelia Clive Matthew Serlin Charlotte Bolton Jonathan Fuld Helen Powell Mark Dayer Ian Woolhouse Adamantia Georgiadi Helen Leonard James Dodd Ian Campbell Gary Ruiz Andrew Zurek James Y Paton Adam Malin Fraser Wood Gareth Hynes David Connell David Spencer Sarah Brown David Smith David Cooper Cecilia O'Kane Alex Hicks Ben Creagh-Brown James Lordan Annabel Nickol Robert Primhak Louise Fleming Duncan Powrie Joanna Brown Zaid Zoumot Sarah Elkin Joanna Szram Anthony Scaffardi Robert Marshall Ian Macdonald Darren Lightbody Ray Farmer Iain Wheatley Paul Radnan Ian Lane Andrew Booth Sean Tilbrook Toby Capstick Lee Hewitt Martin McHugh Christopher Nelson Patrick Wilson Vijay Padmanaban John White John Davison Una O'Callaghan Matthew Hodson John Edwards Colin Campbell Simon Ward Edwina Wooler Elizabeth Ringrose Diana Bridges Matthew Hodson John Edwards Colin Campbell Simon Ward Edwina Wooler Elizabeth Ringrose Diana Bridges Rosalind Backham Kim Randall Tracey Mathieson Alex Long Marilyn Parkes Sarah Clarke Bev Allen Carol Connelly Georgia Forster Jacky Hoadley Katharine Martin Kate Barnham Katie Khan Maureen Munday Catherine Edwards Doreen O'Hara Sally Turner Sue Pieri-Davies Kate Ford Tracey Daniels Joanne Wright Rebecca Towns Karen Fern Jane Butcher Karen Burgin Barbara Winter Debbie Freeman Sandra Olive Linda Gray Kathy Pye Debbie Roots Nicola Cox Carol-Anne Davies Jacquelyne Wicker Kay Hilton Jananee Lloyd Vicky MacBean Marion Wood Julia Kowal Janis Downs Helen Ryan Fran Guyatt Debby Nicoll Elizabeth Lyons Divya Narasimhan Anne Rodman Sandy Walmsley Alison Newey Maria Buxton Maria Dewar Angela Cooper Jacqui Reilly Julie Lloyd Alison Bennett Macmillan Debbie Roots Amy Olley Nia Voase Sarah Martin Iona McCarvill Anne Christensen Rowan Agate Karen Heslop Amber Timlett Karen Hailes Claire Davey Barbara Pawulska Amber Lane Shona Ioakim Alexandra Hough Jo Treharne Helen Jones Alice Winter-Burke Lauren Miller Bronwen Connolly Lyn Bingham Una Fraser Julia Bott Carol Johnston Alison Graham Denise Curry Helen Sumner Carol Ann Costello Charlotte Bartoszewicz Ros Badman Kathryn Williamson Amy Taylor Helen Purcell Emma Barnett Alanna Molloy Laura Crawfurd Nicola Collins Valerie Monaghan Misbah Mir Victoria Lord Janet Stocks Adrian Edwards Trish Greenhalgh Warren Lenney Martin McKee Danny McAuley Azeem Majeed John Cookson Emma Baker Sam Janes Wisia Wedzicha David Lomas Dean Brian Harrison Tony Davison Peter Calverley Robert Wilson Robert Stockley Jon Ayres John Gibson John Simpson Sherwood Burge John Warner Warren Lenney Neil Thomson Peter Davies Ashley Woodcock Mark Woodhead Stephen Spiro Lawrence Ormerod Graham Bothamley Martyn Partridge Michael Shields Hugh Montgomery Anita Simonds Peter Barnes Stephen Durham Sarah Malone Gilda Arabnia Sharon Olivier Karen Gardiner Sheila Edwards

BMJ 2013 Dec 9;347:f7358. Epub 2013 Dec 9.

British Thoracic Society Chronic Obstructive Pulmonary Disease Specialist Advisory Group, National Heart and Lung Institute, Imperial College, London SW3 6NP, UK.

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http://dx.doi.org/10.1136/bmj.f7358DOI Listing
December 2013

Exhaled nitric oxide and blood eosinophilia: independent markers of preventable risk.

J Allergy Clin Immunol 2013 Oct 31;132(4):828-9. Epub 2013 Aug 31.

Department of Respiratory Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2013.07.045DOI Listing
October 2013

The role of CT scanning in multidimensional phenotyping of COPD.

Chest 2011 Sep 31;140(3):634-642. Epub 2011 Mar 31.

Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, England. Electronic address:

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http://dx.doi.org/10.1378/chest.10-3007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168858PMC
September 2011

Body mass and fat mass in refractory asthma: an observational 1 year follow-up study.

J Allergy (Cairo) 2010 1;2010:251758. Epub 2010 Dec 1.

Institute for Lung Health, Clinical Sciences Wing, University Hospitals of Leicester, Groby Road, Leicester LE3 9QP, UK.

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http://dx.doi.org/10.1155/2010/251758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995902PMC
July 2011

Procalcitonin and C-reactive protein in hospitalized adult patients with community-acquired pneumonia or exacerbation of asthma or COPD.

Chest 2011 Jun 28;139(6):1410-1418. Epub 2010 Oct 28.

Institute for Lung Health, University of Leicester, Leicester, England; Department of Infection, Immunity, and Inflammation, University of Leicester, Leicester, England. Electronic address:

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http://dx.doi.org/10.1378/chest.10-1747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109646PMC
June 2011

Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD.

Chest 2010 Nov 10;138(5):1140-7. Epub 2010 Jun 10.

Institute for Lung Health, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Groby Rd, Leicester, LE3 9QP, England.

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http://dx.doi.org/10.1378/chest.09-3058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972626PMC
November 2010