Publications by authors named "Molly Gasperini"

13 Publications

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Swab-Seq: A high-throughput platform for massively scaled up SARS-CoV-2 testing.

Authors:
Joshua S Bloom Eric M Jones Molly Gasperini Nathan B Lubock Laila Sathe Chetan Munugala A Sina Booeshaghi Oliver F Brandenberg Longhua Guo James Boocock Scott W Simpkins Isabella Lin Nathan LaPierre Duke Hong Yi Zhang Gabriel Oland Bianca Judy Choe Sukantha Chandrasekaran Evann E Hilt Manish J Butte Robert Damoiseaux Aaron R Cooper Yi Yin Lior Pachter Omai B Garner Jonathan Flint Eleazar Eskin Chongyuan Luo Sriram Kosuri Leonid Kruglyak Valerie A Arboleda

medRxiv 2020 Sep 3. Epub 2020 Sep 3.

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September 2020

Towards a comprehensive catalogue of validated and target-linked human enhancers.

Authors:
Molly Gasperini Jacob M Tome Jay Shendure

Nat Rev Genet 2020 05 27;21(5):292-310. Epub 2020 Jan 27.

Department of Genome Sciences, University of Washington, Seattle, WA, USA.

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May 2020

A Genome-wide Framework for Mapping Gene Regulation via Cellular Genetic Screens.

Authors:
Molly Gasperini Andrew J Hill José L McFaline-Figueroa Beth Martin Seungsoo Kim Melissa D Zhang Dana Jackson Anh Leith Jacob Schreiber William S Noble Cole Trapnell Nadav Ahituv Jay Shendure

Cell 2019 Mar;176(6):1516

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March 2019

A Genome-wide Framework for Mapping Gene Regulation via Cellular Genetic Screens.

Authors:
Molly Gasperini Andrew J Hill José L McFaline-Figueroa Beth Martin Seungsoo Kim Melissa D Zhang Dana Jackson Anh Leith Jacob Schreiber William S Noble Cole Trapnell Nadav Ahituv Jay Shendure

Cell 2019 01 3;176(1-2):377-390.e19. Epub 2019 Jan 3.

Department of Genome Sciences, University of Washington, Seattle, WA 98105, USA; Brotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA 98105, USA; Howard Hughes Medical Institute, Seattle, WA 98105, USA. Electronic address:

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January 2019

Accurate classification of BRCA1 variants with saturation genome editing.

Authors:
Gregory M Findlay Riza M Daza Beth Martin Melissa D Zhang Anh P Leith Molly Gasperini Joseph D Janizek Xingfan Huang Lea M Starita Jay Shendure

Nature 2018 10 12;562(7726):217-222. Epub 2018 Sep 12.

Department of Genome Sciences, University of Washington, Seattle, WA, USA.

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October 2018

On the design of CRISPR-based single-cell molecular screens.

Authors:
Andrew J Hill José L McFaline-Figueroa Lea M Starita Molly J Gasperini Kenneth A Matreyek Jonathan Packer Dana Jackson Jay Shendure Cole Trapnell

Nat Methods 2018 04 19;15(4):271-274. Epub 2018 Feb 19.

Department of Genome Sciences, University of Washington, Seattle, Washington, USA.

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April 2018

Identifying Novel Enhancer Elements with CRISPR-Based Screens.

Authors:
Jason C Klein Wei Chen Molly Gasperini Jay Shendure

ACS Chem Biol 2018 02 10;13(2):326-332. Epub 2018 Jan 10.

Department of Genome Sciences, University of Washington , Seattle, Washington 98195, United States.

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February 2018

CRISPR/Cas9-Mediated Scanning for Regulatory Elements Required for HPRT1 Expression via Thousands of Large, Programmed Genomic Deletions.

Authors:
Molly Gasperini Gregory M Findlay Aaron McKenna Jennifer H Milbank Choli Lee Melissa D Zhang Darren A Cusanovich Jay Shendure

Am J Hum Genet 2017 Aug 14;101(2):192-205. Epub 2017 Jul 14.

Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA; Howard Hughes Medical Institute, Seattle, WA 98195, USA. Electronic address:

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August 2017

The power of multiplexed functional analysis of genetic variants.

Authors:
Molly Gasperini Lea Starita Jay Shendure

Nat Protoc 2016 10 1;11(10):1782-7. Epub 2016 Sep 1.

Department of Genome Sciences, University of Washington, Seattle, Washington, USA.

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October 2016

Dystrophic muscle improvement in zebrafish via increased heme oxygenase signaling.

Authors:
Genri Kawahara Molly J Gasperini Jennifer A Myers Jeffrey J Widrick Alal Eran Peter R Serafini Matthew S Alexander Mathew T Pletcher Carl A Morris Louis M Kunkel

Hum Mol Genet 2015 Aug 1;24(15):4480-1. Epub 2015 Jun 1.

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August 2015

MicroRNA-486-dependent modulation of DOCK3/PTEN/AKT signaling pathways improves muscular dystrophy-associated symptoms.

Authors:
Matthew S Alexander Juan Carlos Casar Norio Motohashi Natássia M Vieira Iris Eisenberg Jamie L Marshall Molly J Gasperini Angela Lek Jennifer A Myers Elicia A Estrella Peter B Kang Frederic Shapiro Fedik Rahimov Genri Kawahara Jeffrey J Widrick Louis M Kunkel

J Clin Invest 2014 Jun 1;124(6):2651-67. Epub 2014 May 1.

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June 2014

Dystrophic muscle improvement in zebrafish via increased heme oxygenase signaling.

Authors:
Genri Kawahara Molly J Gasperini Jennifer A Myers Jeffrey J Widrick Alal Eran Peter R Serafini Matthew S Alexander Mathew T Pletcher Carl A Morris Louis M Kunkel

Hum Mol Genet 2014 Apr 13;23(7):1869-78. Epub 2013 Nov 13.

Division of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, USA.

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April 2014

Formation of chimeric genes by copy-number variation as a mutational mechanism in schizophrenia.

Authors:
Caitlin Rippey Tom Walsh Suleyman Gulsuner Matt Brodsky Alex S Nord Molly Gasperini Sarah Pierce Cailyn Spurrell Bradley P Coe Niklas Krumm Ming K Lee Jonathan Sebat Jon M McClellan Mary-Claire King

Am J Hum Genet 2013 Oct;93(4):697-710

Departments of Medicine and of Genome Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address:

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October 2013