Urinary tract infection is second widespread infection in human body and regarding its bad consequences prescribing
appropriate antibiotic and at suitable time is very important. What in recent years has made medical community highly
concerned is resistance against antibiotics. With increase of drug resistance among microorganism some antibiotics that
were effective at a certain moment, currently have very low effect on bacteria causing urinary tract infection. This event
takes place for the reason of nonstandard usage of antibiotics. The objective of present study is to examine antibiotic
resistance and determining prevalence of multidrug resistance in isolated microorganism from urinary tract infections
in Iran. Within one year from total of 3635 urinary sample from patients hospitalized in three hospitals of Iran number
of 420 cases reported positive culture. Among isolated pathogens Escherichia coli with 227 cases (54.04 %) reported as
most widespread isolated organism. Highest drug resistance of Escherichia coli is reported related to Ampicillin 80.7%
cotrimoxazole 37% and cefalotin27.7%. From one side most sensitivity was related to antibiotics such as
norfloxacin 89.6%, nitrofurantoin 89%, and ceftizoxime77.3%.
Key words: multidrug resistant, uropathogenic bacteria, UTI, MDR, Hospitalized patients, Iran.
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