Publications by authors named "Mohsen Moadeli"

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Effect of Remote Ischemic Preconditioning on Troponin I in CABG.

Anesth Pain Med 2017 Aug 21;7(4):e12549. Epub 2017 Aug 21.

Assistant Professor of Anesthesia, Department of Anesthesia, Ahvaz Anesthesiology and Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Elective open heart surgery is associated with troponin release in some cases due to myocyte necrosis.

Objectives: The aim of this study was to measure cardiac troponin I (cTnI) preoperatively in elective CABG after remote ischemic preconditioning.

Methods: Twenty-eight patients were selected for elective CABG. They were randomized to receive remote ischemic preconditioning (induced by three 5-min cycles of inflation with a pneumatic tourniquet and 5-min deflation between inflation episodes as reperfusion).

Outcomes: Primary outcomes were cardiac troponin I levels at 6 and 24 hours after the procedure, and the secondary outcomes included creatine phosphokinase, lactate dehydrogenase, and serum creatinine levels. Hemodynamic changes were evaluated between the treatment and control groups.

Results: Cardiac troponin I at 6 hours after preconditioning was significantly lower compared to the control group (P = 0.036), and after 24 hours, there was still a significant difference between the two groups (P < 0.05).

Conclusions: Remote ischemic preconditioning reduces ischemic biomarkers during coronary artery bypass graft and attenuates procedure-related cardiac troponin I release and eventually reduces cardiovascular events such as myocardial infarction, chest pain, and hemodynamic changes after cardiac surgery.
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Source
http://dx.doi.org/10.5812/aapm.12549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797663PMC
August 2017