Mohanish Deshmukh

Mohanish Deshmukh

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Mohanish Deshmukh

Mohanish Deshmukh

Publications by authors named "Mohanish Deshmukh"

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42Publications

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Apoptotic cell death regulation in neurons.

FEBS J 2019 Sep 12;286(17):3276-3298. Epub 2019 Jul 12.

Neuroscience Center, UNC Chapel Hill, NC, USA.

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http://dx.doi.org/10.1111/febs.14970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718311PMC
September 2019

Apoptosis versus axon pruning: Molecular intersection of two distinct pathways for axon degeneration.

Neurosci Res 2019 Feb 16;139:3-8. Epub 2018 Nov 16.

Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, 27599, USA; Neuroscience Center, University of North Carolina, Chapel Hill, NC, 27599, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01680102183065
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http://dx.doi.org/10.1016/j.neures.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503856PMC
February 2019

Physiological functions of non-apoptotic caspase activity in the nervous system.

Semin Cell Dev Biol 2018 10 7;82:127-136. Epub 2017 Dec 7.

Neuroscience Center, UNC Chapel Hill, Chapel Hill, NC, USA; Department of Cell Biology and Physiology, UNC Chapel Hill, Chapel Hill, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2017.11.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988915PMC
October 2018

Large SOD1 aggregates, unlike trimeric SOD1, do not impact cell viability in a model of amyotrophic lateral sclerosis.

Proc Natl Acad Sci U S A 2018 05 16;115(18):4661-4665. Epub 2018 Apr 16.

Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1800187115
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http://dx.doi.org/10.1073/pnas.1800187115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939103PMC
May 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

Axon degeneration: context defines distinct pathways.

Curr Opin Neurobiol 2016 08 16;39:108-15. Epub 2016 May 16.

Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA; Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.conb.2016.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987202PMC
August 2016

Bcl-xL Is Essential for the Survival and Function of Differentiated Neurons in the Cortex That Control Complex Behaviors.

J Neurosci 2016 05;36(20):5448-61

Neuroscience Center, Neurobiology Curriculum, Carolina Institute for Developmental Disabilities, Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina 27599

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http://dx.doi.org/10.1523/JNEUROSCI.4247-15.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871982PMC
May 2016

The paradox of dicer in cancer.

Mol Cell Oncol 2016 May 26;3(3):e1155006. Epub 2016 Feb 26.

Neuroscience Center, University of North Carolina at Chapel Hill , North Carolina.

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http://dx.doi.org/10.1080/23723556.2016.1155006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909435PMC
May 2016

Nonnative SOD1 trimer is toxic to motor neurons in a model of amyotrophic lateral sclerosis.

Proc Natl Acad Sci U S A 2016 Jan 30;113(3):614-9. Epub 2015 Dec 30.

Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; Program in Molecular and Cellular Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;

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http://www.pnas.org/content/113/3/614.full.pdf
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http://www.pnas.org/lookup/doi/10.1073/pnas.1516725113
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http://dx.doi.org/10.1073/pnas.1516725113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725519PMC
January 2016

Essential Function of Dicer in Resolving DNA Damage in the Rapidly Dividing Cells of the Developing and Malignant Cerebellum.

Cell Rep 2016 Jan 31;14(2):216-24. Epub 2015 Dec 31.

Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA; Neurobiology Curriculum, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.12.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716786PMC
January 2016

Neuronal Stress Pathway Mediating a Histone Methyl/Phospho Switch Is Required for Herpes Simplex Virus Reactivation.

Cell Host Microbe 2015 Dec;18(6):649-58

Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2015.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681005PMC
December 2015

Life after MOMP.

Mol Cell 2015 Apr;58(2):199-201

Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.03.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879686PMC
April 2015

Adaptations of energy metabolism during cerebellar neurogenesis are co-opted in medulloblastoma.

Cancer Lett 2015 Jan 22;356(2 Pt A):268-72. Epub 2014 Feb 22.

Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA; Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2014.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141892PMC
January 2015

The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells.

Sci Signal 2014 Jul 15;7(334):ra67. Epub 2014 Jul 15.

Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA. Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA. Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1126/scisignal.2005309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182917PMC
July 2014

Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning.

Nat Commun 2013 ;4:1876

Neurobiology Curriculum, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1038/ncomms2910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183061PMC
December 2013

Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma.

J Neurosci 2013 Nov;33(46):18098-108

Departments of Neurology, Radiation Oncology, and Radiology, Neuroscience Center, Lineberger Comprehensive Cancer Center, and Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599.

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http://dx.doi.org/10.1523/JNEUROSCI.2602-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828463PMC
November 2013

Cerebellar granule neuron progenitors are the source of Hk2 in the postnatal cerebellum.

Cancer Metab 2013 Jun 11;1(1):15. Epub 2013 Jun 11.

Department of Neurology, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1186/2049-3002-1-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178205PMC
June 2013

Adenosine: essential for life but licensed to kill.

Mol Cell 2013 May;50(3):307-8

Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.molcel.2013.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682465PMC
May 2013

Human embryonic stem cells: living on the edge.

Cell Cycle 2012 Nov 3;11(21):3905-6. Epub 2012 Oct 3.

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http://dx.doi.org/10.4161/cc.22233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507477PMC
November 2012

Activation of apoptosis by cytoplasmic microinjection of cytochrome c.

J Vis Exp 2011 Jun 29(52). Epub 2011 Jun 29.

Department of Cell and Developmental Biology, Neuroscience Center, University of North Carolina.

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http://dx.doi.org/10.3791/2773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197050PMC
June 2011

miR-29b is activated during neuronal maturation and targets BH3-only genes to restrict apoptosis.

Genes Dev 2011 Jan;25(2):125-30

Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1101/gad.1975411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022258PMC
January 2011

Skeletal muscle differentiation evokes endogenous XIAP to restrict the apoptotic pathway.

PLoS One 2009 31;4(3):e5097. Epub 2009 Mar 31.

Department of Cell and Developmental Biology and Neuroscience Center, University of North Carolina, Chapel Hill, NC, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005097PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658743PMC
May 2009

Lack of X-linked inhibitor of apoptosis protein leads to increased apoptosis and tissue loss following neonatal brain injury.

ASN Neuro 2009 Apr 14;1(1). Epub 2009 Apr 14.

Department of Pediatrics, Washington University, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1042/AN20090005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695579PMC
April 2009

Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c.

Nat Cell Biol 2008 Dec 23;10(12):1477-83. Epub 2008 Nov 23.

Department of Cell & Developmental Biology, Box 7250, 115 Mason Farm Road, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1038/ncb1807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626347PMC
December 2008

Chromatin modification of Apaf-1 restricts the apoptotic pathway in mature neurons.

J Cell Biol 2007 Dec;179(5):825-32

Neuroscience Center and 2Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://www.jcb.org/lookup/doi/10.1083/jcb.200708086
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http://dx.doi.org/10.1083/jcb.200708086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2099178PMC
December 2007

Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC.

Cell Host Microbe 2007 Sep;2(3):147-59

Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.chom.2007.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2083260PMC
September 2007

Restricting apoptosis for postmitotic cell survival and its relevance to cancer.

Cell Cycle 2006 Aug 1;5(15):1616-20. Epub 2006 Aug 1.

Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.4161/cc.5.15.3129DOI Listing
August 2006

Enhanced sensitivity to cytochrome c-induced apoptosis mediated by PHAPI in breast cancer cells.

Cancer Res 2006 Feb;66(4):2210-8

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-3923DOI Listing
February 2006

Reduced Apaf-1 levels in cardiomyocytes engage strict regulation of apoptosis by endogenous XIAP.

J Cell Biol 2005 Dec 12;171(6):925-30. Epub 2005 Dec 12.

Neuroscience Center, Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1083/jcb.200504082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171313PMC
December 2005

Bcr-Abl-mediated protection from apoptosis downstream of mitochondrial cytochrome c release.

Mol Cell Biol 2004 Dec;24(23):10289-99

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 3813, Durham, NC 27710, USA.

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http://dx.doi.org/10.1128/MCB.24.23.10289-10299.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC529043PMC
December 2004

Decreased apoptosome activity with neuronal differentiation sets the threshold for strict IAP regulation of apoptosis.

J Cell Biol 2004 Oct;167(2):303-13

Curriculum in Neurobiology, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1083/jcb.200406073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172554PMC
October 2004

Stability and apoptotic activity of recombinant human cytochrome c.

Biochem Biophys Res Commun 2003 Dec;312(3):733-40

Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.bbrc.2003.10.182DOI Listing
December 2003

Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis.

J Cell Biol 2003 Nov 17;163(4):789-99. Epub 2003 Nov 17.

Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1083/jcb.200307130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173693PMC
November 2003

Exogenous smac induces competence and permits caspase activation in sympathetic neurons.

J Neurosci 2002 Sep;22(18):8018-27

Department of Cell and Developmental Biology and the Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 275997090, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758081PMC
September 2002

Multiple channel interactions explain the protection of sympathetic neurons from apoptosis induced by nerve growth factor deprivation.

J Neurosci 2002 Jan;22(1):114-22

Department of Neurology and Center for the Study of Nervous System Injury, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757625PMC
January 2002