University of Mississippi
Oxford, MS | United States
Main Specialties: Pharmacology
Additional Specialties: Pharmacognosy
Primary Affiliation: University of Mississippi - Oxford, MS , United States
PubMed Central Citations
11PubMed Central Citations
Letters in Drug Design & Discovery
Introduction: According to WHO, cancer is one of the most leading causes of death. Development of anticancer drugs draw considerable attention. Pyridazinones analogues were reported to possess anticancer properties. Chemical modification of pyridazinone may lead to potential anticancer agent. Objective: The objective of this article is to develop new pyridazinone deriatives and evaluate their anticancer activities. Results: The target compounds were synthesized using Palladium cross coupling reactions, Buchwald and Suzuki, the synthesized compound were evaluated against BT-549, KB and SK-MEL cell lines. Some compounds showed moderate to significant inhibitory activity. Conclusion: Novel pyridazinone derivatives were synthesized in a good yield. Some of the synthesized analogues showed good anticancer properties against BT-549, KB and SK-MEL cell lines.
Phytochemistry 2014 Sep 14;105:79-84. Epub 2014 Jul 14.
National Center for Natural Products Research, The University of Mississippi, University, MS 38677, USA; Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS 38677, USA. Electronic address:
Medicinal Chemistry Research
A new 7-methoxy-2-benzoxazolinone dimer named zeaoxazolinone (2), together with four known compounds; 9-Z-hexadecenoic acid (1), 6-methoxy-benzoxazolinone (3), gallic acid (4), andb-sitosterol-3-O-b-D-glucopyranoside (5) were isolated fromZea maysL. roots. The structural elucidation of isolated metabolites was established on the basis of UV, IR, 1D, 2D NMR, and MS spectral analyses. Compound 2 exhibited a potent antifungal activity againstAspergillus flavus,Fusarium oxysporum,andCandida albicans.