University of Mississippi
Oxford, MS | United States
Additional Specialties: Pharmacognosy
Primary Affiliation: University of Mississippi - Oxford, MS , United States
12PubMed Central Citations
Letters in Drug Design & Discovery
Introduction: According to WHO, cancer is one of the most leading causes of death. Development of anticancer drugs draw considerable attention. Pyridazinones analogues were reported to possess anticancer properties. Chemical modification of pyridazinone may lead to potential anticancer agent. Objective: The objective of this article is to develop new pyridazinone deriatives and evaluate their anticancer activities. Results: The target compounds were synthesized using Palladium cross coupling reactions, Buchwald and Suzuki, the synthesized compound were evaluated against BT-549, KB and SK-MEL cell lines. Some compounds showed moderate to significant inhibitory activity. Conclusion: Novel pyridazinone derivatives were synthesized in a good yield. Some of the synthesized analogues showed good anticancer properties against BT-549, KB and SK-MEL cell lines.
Nat Prod Res 2014 28;28(12):868-73. Epub 2014 Feb 28.
a Department of Natural Drugs , Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno , Palackého 1-3, 612 42 Brno , Czech Republic.
Phytochemistry 2014 Sep 14;105:79-84. Epub 2014 Jul 14.
National Center for Natural Products Research, The University of Mississippi, University, MS 38677, USA; Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS 38677, USA. Electronic address:
Med Chem Res 2014 Jul 11;23(7):3510-3515. Epub 2014 Feb 11.
Department of Pharmacognosy and National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
Medicinal Chemistry Research
A new 7-methoxy-2-benzoxazolinone dimer named zeaoxazolinone (2), together with four known compounds; 9-Z-hexadecenoic acid (1), 6-methoxy-benzoxazolinone (3), gallic acid (4), andb-sitosterol-3-O-b-D-glucopyranoside (5) were isolated fromZea maysL. roots. The structural elucidation of isolated metabolites was established on the basis of UV, IR, 1D, 2D NMR, and MS spectral analyses. Compound 2 exhibited a potent antifungal activity againstAspergillus flavus,Fusarium oxysporum,andCandida albicans.
Nat Prod Commun 2013 Aug;8(8):1117-9
National Center for Natural Products Research School of Pharmacy, The University of Mississippi, University, MS 38677, USA.