Publications by authors named "Mohammad-Ali Karimi"

43 Publications

An uncommon presentation of hepatic hydatid cyst leading to biliary cirrhosis and portal hypertension.

Gastroenterol Hepatol Bed Bench 2020 ;13(Suppl1):S145-S148

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Hydatid disease is an ongoing issue in endemic areas. Hydatid cysts can be seen in any organ but, liver is one of the most common involved organs. Cystobiliary communication as an overwhelming complication of hepatic hydatid cysts can contribute to the obstructive jaundice, cholangitis, sepsis and even biliary cirrhosis if left untreated. The patient we are trying to present is a 61-year-old farmer who presented with obstructive jaundice, multiple common bile duct stones and biliary cirrhosis attributed to a long-lasting untreated hepatic hydatid cyst. Portal hypertension is introduced to be an uncommon presentation of hydatid cyst. Extrinsic compression of the porta hepatis and obstruction of inferior vena cava are amongst major causes of hydatidosis leading up to portal hypertension as reported in the literature. Portal hypertension in the presented case is proposed to emerge from long-lasting cystobiliary communication ending in biliary cirrhosis.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881412PMC
January 2020

An algorithmic approach to gastrointestinal bleeding in patients receiving antithrombotic agents.

Gastroenterol Hepatol Bed Bench 2020 ;13(Suppl1):S8-S17

Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Gastrointestinal bleeding is an overwhelming complication of patients taking antithrombotic agents. These drugs pose a challenge to physicians in the management of bleeding to establish hemostasis without putting these patients at a higher risk for thromboembolism. This study aims to propose an algorithmic approach to four major groups of patients receiving antithrombotic agents (single antiplatelet agents, dual antiplatelet agents, anticoagulants and direct oral anticoagulants) to decide when and how these drugs should be held or restarted to offset between the risk of re-bleeding and thromboembolism. Four case-based algorithms are proposed in this article based on some relevant articles. Having designed four case-based algorithms, we are hoping to guide physicians who face a dilemma on the management of patients receiving antithrombotics when gastrointestinal bleeding occurs. Patients using antithrombotics referred for gastrointestinal bleeding were stratified into four groups based on the medication which is used as an antithrombotic agent and four algorithms were designed which are presented here. We have made an attempt to have a stepwise approach to four cases relevant to the study and have an evaluation on the management of their antithrombotic agents during an episode of gastrointestinal bleeding. It is widely accepted that antithrombotic agents should be restarted as soon as possible after the establishment of hemostasis in a patient taking antithrombotics referring for gastrointestinal bleeding. The time for resuming these drugs is different based on the severity of bleeding, the probability of thromboembolic events, and the nature of the antithrombotic medication which is used by the patient.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881411PMC
January 2020

Fast and efficient removal of Pb(II) ion and malachite green dye from wastewater by using magnetic activated carbon-cobalt nanoparticles.

Water Sci Technol 2020 Sep;82(5):829-842

School of Public Health, Bam University of Medical Sciences, Bam, Iran.

A high-surface-area and inexpensive activated carbon has been produced from lemon peel using chemical activation with HPO at 500 °C in a N atmosphere. Afterwards, the synthesized cobalt nanoparticles using coprecipitation method were adsorbed on the activated carbon surface, and as a result magnetic activated carbon was obtained. Sample characterization has been assessed via X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, X-ray photoelectron spectroscopy, nitrogen adsorption-desorption and magnetic properties. It was found that magnetic activated carbon-cobalt nanoparticles (MAC/Co) synthesized had a high saturation magnetization. The MAC/Co revealed super-paramagnetic behaviors at room temperature, and have been readily isolated from solution by using an exterior magnet. Next, adsorption behavior of malachite green and Pb(II) onto the generated MAC/Co has been examined. Sorption kinetics and equilibrium have been studied using batch procedure. The kinetic and isothermal adsorption results were matched completely with the Elovich and Langmuir models, respectively. Based on the Langmuir model, the highest adsorption capacities of malachite green dye and Pb(II) ion respectively were 263.2 and 312.5 mg g at room temperature. Based on the results, the MAC/Co is a probable economic and effective adsorbent that can be employed as a new adsorbent to remove malachite green dye and Pb(II) from wastewater.
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http://dx.doi.org/10.2166/wst.2020.375DOI Listing
September 2020

Dye/metal ion-based chemosensing ensemble towards l-histidine and l-lysine determination in water via different optical responses.

Anal Biochem 2020 09 3;604:113811. Epub 2020 Jul 3.

Department of Chemistry, Payame Noor University, 19395-4697, Tehran, Islamic Republic of Iran. Electronic address:

In this study, a novel simple type of label-free, ultra-sensitive, and highly selective UV-Vis absorption and naked-eye detection of histidine (His) and lysine (Lys) using a dye/metal ion ensemble is developed. The outcoming high sensitivity and selectivity for histidine and lysine were attained by changing the metal ions. The indicator is released due to its displacement from the murexide (Mure)/Cu complex by histidine and the change in absorbance may be due to the further complexation of lysine with the additional coordination sites present in the zinc atom of Mure/Zn complex. The label-free chemosensor provided sensitive and selective detection of l-histidine and l-lysine with detection limits of 9.1 and 9.4 nmol L, respectively. The protocol especially offers high selectivity for the determination of His and Lys among amino acids found in human urine samples. Furthermore, INHIBIT and NAND molecular logic gates were obtained using chemical inputs and UV-Vis absorbance signal output.
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http://dx.doi.org/10.1016/j.ab.2020.113811DOI Listing
September 2020

COVID-19 Protection Guidelines in Outpatient Medical Imaging Centers.

Acad Radiol 2020 06 17;27(6):904. Epub 2020 Apr 17.

Department of Radiology, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1016/j.acra.2020.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164879PMC
June 2020

Proposed Imaging Guidelines for Pregnant Women Suspected of Having COVID-19.

Acad Radiol 2020 06 17;27(6):902-903. Epub 2020 Apr 17.

Resident of Radiology, Advanced Diagnostic and Interventional Radiology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1016/j.acra.2020.04.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164866PMC
June 2020

COVID-19 Evaluation by Low-Dose High Resolution CT Scans Protocol.

Acad Radiol 2020 06 17;27(6):901. Epub 2020 Apr 17.

Radiology department, Shohada Tajrish hospital, Shahid Beheshti University of Medical Science, Tehran, Iran.

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http://dx.doi.org/10.1016/j.acra.2020.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164844PMC
June 2020

Role of Social Media and Telemedicine in Diagnosis & Management of COVID-19; An Experience of the Iranian Society of Radiology.

Arch Iran Med 2020 04 1;23(4):285-286. Epub 2020 Apr 1.

Iranian Society of Radiology, Tehran, Iran.

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http://dx.doi.org/10.34172/aim.2020.15DOI Listing
April 2020

Gemfibrozil attenuates doxorubicin induced toxicity in renal tissues of male rats by reducing the oxidative insult and inflammation.

Biotech Histochem 2020 Oct 3;95(7):532-539. Epub 2020 Apr 3.

Student Research Committee, Ahvaz Jundishapur University of Medical Sciences , Ahvaz, Iran.

Nephrotoxicity is a significant side effect of doxorubicin (DXN) treatment. We investigated the protective effect of gemfibrozil (GEM) co-administration with DXN on DXN induced nephrotoxicity. We divided 28 male Wistar rats into four groups of seven. Group 1 received normal saline for 2 weeks. Group 2 received 15 mg/kg DXN for 2 weeks. Group 3 received DXN + GEM for 2 weeks. Group 4 received GEM for 2 weeks. On day 15 of the experiment, blood samples were collected, animals were sacrificed and kidneys were excised for biochemical and histological evaluation. We measured serum creatinine, blood urine nitrogen, renal malondialdehyde, nitric oxide, glutathione, superoxide dismutase, glutathione peroxidase, catalase, tumor necrosis factor-α and interleukin-1β. GEM administration mitigated DXN induced nephrotoxicity. GEM co-administered with DXN attenuated the inflammatory and oxidative responses associated with DXN induced nephrotoxicity.
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http://dx.doi.org/10.1080/10520295.2020.1730967DOI Listing
October 2020

Calcitriol modulates Cholesteryl ester transfer protein (CETP) levels and lipid profile in hypercholesterolemic male rabbits: A pilot study.

Int J Vitam Nutr Res 2019 Dec 17:1-5. Epub 2019 Dec 17.

Department of Clinical Biochemistry, Tehran University of Medical Sciences, Tehran, Iran.

Vitamin D3 efficacy against cardiovascular disease prevention has been reported in many experimental studies. We aimed to investigate the effect of the calcitriol or active form of Vitamin D3 (1, 25(OH) 2D3) on serum Cholesteryl ester transfer protein (CETP) levels in a rabbit model of atherosclerosis. New Zealand white male rabbits were fed with 1% cholesterol diet and randomly assigned into two groups (n = 6). The case group was administrated with 50000 calcitriol (IU/kg/per wk) and the control group which administrated with calcitriol solvent (sesame oil) for 2 months. Then, after two months the lipid profile, CETP and 25OHD3 levels were measured. The serum concentration of CETP was increased after treatment with calcitriol in case group as compared to the control group (41.75 ± 3.19 vs. 34.5 ± 2.3, ng/ml, P < 0.05). We also observed higher levels of the 25OHD3 in the calcitriol group at the 1 month (16.3 ± 1.64 vs. 12.8 ± 1.33 ng/ml) and the 2 month (19.5 ± 2.14 vs. 12.5 ± 1.25 ng/ml) as compared with the control group. the significant increase in the level of HDL-C was observed in the case group than the control group (P < 0.01). In addition, serum levels of LDL- Cholesterol (LDL-C), Triglyceride (TG) were reduced after assessment at 1 and 2 month after administration of calcitriol. Our research indicated the significant anti-atherogenic effects of calcitriol in the rabbit model of atherosclerosis. However, increased in CETP levels by calcitriol may know as an additional way, which interfere with the anti-atherogenic effects of calcitriol.
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http://dx.doi.org/10.1024/0300-9831/a000613DOI Listing
December 2019

A signal-on fluorescence based biosensing platform for highly sensitive detection of DNA methyltransferase enzyme activity and inhibition.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Mar 2;228:117731. Epub 2019 Nov 2.

Department of Biotechnology, University of Tehran, Tehran, Iran.

DNA methylation mediated by DNA methyltransferase (MTase) enzyme is internal cell mechanism which regulate the expression or suppression of crucial genes involve in cancer early diagnosis. Herein, highly sensitive fluorescence biosensing platform was developed for monitoring of DNA Dam MTase enzyme activity and inhibition based on fluorescence signal on mechanism. The specific Au NP functionalized oligonucleotide probe with overhang end as a template for the synthesis of fluorescent silver nanoclusters (Ag NCs) was designed to provide the FRET occurrence. Following, methylation and cleavage processes by Dam MTAse and DpnI enzymes respectively at specific probe recognition site could resulted to release of AgNCs synthesizer DNA fragment and returned the platform to fluorescence signal-on state through interrupting in FRET. Subsequently, amplified fluorescence emission signals of Ag NCs showed increasing linear relationship with amount of Dam MTase enzyme at the range of 0.1-20 U/mL and the detection limit was estimated at 0.05 U/mL. Superior selectivity of experiment was illustrated among other tested MTase and restriction enzymes due to the specific recognition of MTase toward its substrate. Furthermore, the inhibition effect of applied Dam MTase drug inhibitors screened and evaluated with satisfactory results which would be helpful for discovery of antimicrobial drugs. The real sample assay also showed the applicability of proposed method in human serum condition. This novel strategy presented an efficient and cost effective platform for sensitive monitoring of DNA MTase activity and inhibition which illustrated its great potential for further application in medical diagnosis and drug discovery.
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http://dx.doi.org/10.1016/j.saa.2019.117731DOI Listing
March 2020

User-centred web design, usability and user satisfaction: The case of online banking websites in Iran.

Appl Ergon 2019 Nov 3;81:102892. Epub 2019 Jul 3.

Department of Computer Engineering, Bushehr Branch, Islamic Azad University, Bushehr, Iran. Electronic address:

The relationship of Web design attributes (personalisation, structure, navigation, layout, search and performance) and users' personal characteristics to website usability and user satisfaction was investigated among 798 online banking users in Iran. The design and usability of the evaluated websites were not satisfactory from the users' perspectives. Multivariate regression models indicated that Web layout and performance were the main predictors of website usability, while personal characteristics including gender, age and Web usage experience of users had no effect. User satisfaction was also influenced only by the Web design attributes (particularly Web structure) and not by the personal characteristics of the users. There was also a significant relationship between website usability and user satisfaction. The findings suggest that the website designers should focus more on the Web design attributes (particularly Web layout and structure), regardless of the personal characteristics of their users, to improve the usability and user satisfaction of websites.
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http://dx.doi.org/10.1016/j.apergo.2019.102892DOI Listing
November 2019

A novel dye-based colorimetric chemosensors for sequential detection of Cu and cysteine in aqueous solution.

Anal Biochem 2019 10 24;583:113376. Epub 2019 Jul 24.

An IDAs based chemosensing ensembles for sensitive and selective sequential detection of Cu and cysteine (Cys) in 100% aqueous solution was designed on the basis of the complex formation between 4-(2-Pyridylazo)resorcinol (PAR). In the first step, PAR was used for colorimetric detection of Cu in aqueous solution by the obvious color change. The detection limit (31.0 nmol L) for Cu much lower than the guideline (31.5 μmol L) of WHO in drinking water. In the second step the produced ensemble (PAR-Cu), sensitively and selectively detected a low concentration of Cys via indicator displacement assay system. The detection limit for Cys was determined to be 72 nmol L. The colorimetric detection operation is low-cost using PAR and copper ion and has a simple operation without any further modifications. Any enzymatic reactions, separation processes, chemical modifications, and sophisticated instrumentations are also not required in this experiment. It could find applications for the detection of analytes in environmental, biological samples based on these results, dual logic gates (IMPLICATION and INHIBIT) were obtained by controlling the chemical inputs.
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http://dx.doi.org/10.1016/j.ab.2019.113376DOI Listing
October 2019

Development of air-assisted dispersive micro-solid-phase extraction-based supramolecular solvent-mediated Fe O @Cu-Fe-LDH for the determination of tramadol in biological samples.

Biomed Chromatogr 2019 Sep 29;33(9):e4572. Epub 2019 May 29.

Department of Chemistry, University of Environment, Karaj, Iran.

A simple method, air-assisted dispersive micro-solid-phase extraction-based supramolecular solvent was developed for the preconcentration of tramadol in biological samples prior to gas chromatography-flame ionization detection. A new type of carrier liquid, supramolecular solvent based on a mixture of 1-dodecanol and tetrahydrofuran was combined with layered double hydroxide coated on a magnetic nanoparticle (Fe O @SiO @Cu-Fe-LDH). The supramolecular solvent was injected into the solution containing Fe O @SiO @Cu-Fe-LDH in order to provide high stability and dispersion of the sorbent without any stabilizer agent. Air assisted was applied to enhance the dispersion of the sorbent and solvent. A number of analytical techniques such as Fourier transform-infrared spectrometry, field emission scanning electron microscope, energy-dispersive X-ray spectroscopy and X-ray diffraction measurements were applied to assess the surface chemical characteristics of Fe O @SiO @Cu-Fe-LDH nanoparticles. The effects of important parameters on the extraction recovery were also investigated. Under optimized conditions, the limits of detection and quantification were obtained in the range of 0.9-2.4 and 2.7-7.5 μg L with preconcentration factors in the range of 450-472 in biological samples. This method was used for the determination of tramadol in biological samples (plasma, urine and saliva samples) with good recoveries.
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http://dx.doi.org/10.1002/bmc.4572DOI Listing
September 2019

Bovine lactoferrin ameliorates antioxidant esterase activity and 8-isoprostane levels in high-cholesterol-diet fed rats.

Int J Vitam Nutr Res 2017 05 21;87(3-4):201-206. Epub 2019 Feb 21.

1 Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

The main aim of the present study was to show the effect of bovineLactoferrin (bLF), an 80 kD iron-binding glycoprotein, its application on antioxidant esterase activities and 8-isoprostane changes in high-cholesterol-diet fed (HCD-Fed) rats. The 44 adult Sprague-Dawley male rats were randomly assigned into four experimental groups. They were randomly assigned into four equivalent groups (n = 11). The groups included the control group which was fed with normal diet, bLF group, the third group which were made hypercholesterolemia by being fed with high cholesterol diet, and the last group which consisted of hypercholesterolemia rats treated with bLF (HCD + bLF) for 4 weeks (200 mg.kg per day wt. dissolved in 0.9% normal saline).After 4 weeks, the serum Paraoxonase1 (PON1), Arylesterase (ARE) activity and 8-isoprostane with lipid profile were measured. Upon treatment with the bLF, the decrease in LDL-Cholesterol (LDL-C), Glucoses, Triglyceride (TG) and Total-Cholesterol (TC) levels and an increase in HDL-Cholesterol (HDL-C) level were observed. The co-administration of bLf for 4 weeks had decreased the 8-isoprostane levels significantly (P < 0.001) (86.36 ± 7.1 vs 117.18 ± 8.62) when compared to hypercholesterolemia-induced rats. Also, the Atherogenic Index (AI) in HCD + bLF group showed a significant decrease as compared to the HCD group (P < 0.001) (0.37 ± 0.07 vs 0.57 ± 0.09). The results indicated that bLF was effective against oxidative stress by its ability to increase PON1 activity and reduce the lipid peroxidation in high-cholesterol-fed rats.
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http://dx.doi.org/10.1024/0300-9831/a000516DOI Listing
May 2017

Ultrasonically formation of supramolecular based ultrasound energy assisted solidification of floating organic drop microextraction for preconcentration of methadone in human plasma and saliva samples prior to gas chromatography-mass spectrometry.

Ultrason Sonochem 2019 Jan 24;50:182-187. Epub 2018 Sep 24.

Department of Chemistry, Payame Noor University, P.O. Box: 19395-3697, Tehran, Iran.

In this work, an ultrasonic-assisted supramolecular based on solidification of floating organic drop microextraction (UA-SM-SFO-ME) was developed as a green method for preconcentration of methadone prior to gas chromatography-mass spectrometry (GC-MS). The supramolecular solvent aggregates containing reverse micelles of 1-dodecanol in tetrahydrofuran (THF) were formed by ultrasonication that subsequently dispersed in the sample solution. Ultrasonic waves caused the fast formation of supramolecular solvent aggregates. In this work, ultrasonication was used in two phases: First phase, the formation of reverse micelles and the second phase, the dispersion of supramolecular solvent in the sample solution. Actually, ultrasonication was basic of this presented work. In order to provide the highest extraction efficiency, the influence of various parameters on the method performance (supramolecular solvent type and volume, disperser solvent condition, pH, extraction time and salt concentration) was investigated. Based on the obtained optimum conditions, the limits of detection (LODs) and the limits of quantitation (LOQs) were obtained 0.5-1.2 µg L and 1.2-2.5 µg L with preconcentration factors in the range of 182-191, in water and biological samples, respectively. Subsequently, the method was assessed for preconcentration of the methadone in human plasma and saliva samples.
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http://dx.doi.org/10.1016/j.ultsonch.2018.09.019DOI Listing
January 2019

Deep Eutectic Solvent Based Air Assisted Ligandless Emulsification Liquid-Liquid Microextraction for Preconcentration of Some Heavy Metals in Biological and Environmental Samples.

Bull Environ Contam Toxicol 2018 Dec 29;101(6):814-819. Epub 2018 Sep 29.

Department of Chemistry, Payame Noor University, P.O. BOX 19395-3697, Tehran, Iran.

In this study, a deep eutectic solvent (DES) based on air-assisted ligandless emulsification liquid-liquid microextraction method (DES-AA-LL-ELLME) was considered for preconcentration and extraction of some metals (Cd, Ni, Pb and Cu). A 1:1 mixture of the synthesized DES and triethylamine was added as an extractant to extract metal ions in the absence of chelating agent. Tetrahydrofuran as the aprotic solvent provided a turbid state. To disperse the aggregated DES droplets into the aqueous phase, air-assisted was performed. The influence of several effective parameters was monitored. Under optimum conditions, limits of detection were found in the range of 0.31-0.99 µg L with preconcentration factor from 67 to 69. The relative standard deviation (n = 10) was in the range of 2.1%-3.1% for all analytes. This procedure was applied to determine some metals in both biological and environmental samples with appropriate recoveries about 98.7%-106%.
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http://dx.doi.org/10.1007/s00128-018-2456-8DOI Listing
December 2018

Poly-Dianix Blue/Multi-Walled Carbon Nanotube Modified Electrode for Detection of Levodopa in the Presence of High Concentrations of Ascorbic and Uric Acids.

Acta Chim Slov 2017 Mac;64(1):193-201

A selective and sensitive electrochemical sensor was studied for determination of levodopa (LD) in the presence of uric acid (UA) and ascorbic acid (AA) using poly-dianix blue and multi-walled carbon nanotubes (PDB/MWCNTs) modified glassy carbon electrode. Cyclic voltammetry, differential pulse voltammetry, and chronoamperometry methods were applied to investigate the electrocatalytic oxidation of LD, UA and AA in aqueous solutions. By DPV technique, LD, UA and AA give oxidation peaks at 0.380, 0.520 and 0.180 V, respectively. Under the optimized experimental conditions LD, UA and AA give a linear response in the range of 0.09-75 μmol L-1, 0.3-110 μmol L-1 and 10-160 μmol L-1, respectively. Accordingly, the obtained detection limits were 0.003, 0.002 and 0.023 μmol L-1. The method provides a simple electrochemical sensor for successful determination of LD in human blood serum samples.
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http://dx.doi.org/10.17344/acsi.2016.3097DOI Listing
September 2017

Ultrasound-air-assisted demulsified liquid-liquid microextraction by solidification of a floating organic droplet for determination of three antifungal drugs in water and biological samples.

Anal Bioanal Chem 2017 Mar 27;409(8):2119-2126. Epub 2016 Dec 27.

Department of Chemistry, Payame Noor University, P.O. Box 19395-3697, Tehran, Iran.

A novel ultrasound-air-assisted demulsified liquid-liquid microextraction by solidification of a floating organic droplet (UAAD-LLM-SFO) followed by HPLC-UV detection was developed for the analysis of three antifungal drugs in water and biological samples. In this method, 1-dodecanol was used as the extraction solvent. The emulsion was rapidly formed by pulling in and pushing out the mixture of sample solution and extraction solvent for 5 times repeatedly using a 10-mL glass syringe while sonication was performed. Therefore, an organic dispersive solvent required in common microextraction methods was not used in the proposed method. After dispersing, an aliquot of acetonitrile was introduced as a demulsifier solvent into the sample solution to separate two phases. Therefore, some additional steps, such as the centrifugation, ultrasonication, or agitation of the sample solution, are not needed. Parameters influencing the extraction recovery were investigated. The proposed method showed a good linearity for the three antifungal drugs studied with the correlation coefficients (R  > 0.9995). The limits of detection (LODs) and the limits of the quantification (LOQs) were between 0.01-0.03 μg L and 0.03-0.08 μg L, respectively. The preconcentration factors (PFs) were in the range of 107-116, respectively. The precisions, as the relative standard deviations (RSDs) (n = 5), for inter-day and intra-day analysis were in the range of 2.1-4.5% and 6.5-8.5%, respectively. This method was successfully applied to determine the three antifungal drugs in tap water and biological samples. The recoveries of antifungal drugs in these samples were 92.4-98.5%. Graphical abstract Ultrasound-air-assisted demulsified liquid-liquid microextraction by solidification of a floating organic droplet for the analysis of three antifungal drugs prior HPLC-UV.
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http://dx.doi.org/10.1007/s00216-016-0158-9DOI Listing
March 2017

Musculoskeletal symptoms among handicraft workers engaged in hand sewing tasks.

J Occup Health 2016 Nov 30;58(6):644-652. Epub 2016 Sep 30.

Department of Occupational Health, Faculty of Health, Tabriz University of Medical Sciences.

Objectives: This study was conducted to determine the prevalence of musculoskeletal symptoms and associated risk factors among Iranian handicraft workers engaged in different hand sewing tasks.

Methods: Data were collected using questionnaires (including the Nordic Musculoskeletal Questionnaire) as well as direct observations of posture (using the Rapid Upper Limb Assessment [RULA] method) from 632 workers including carpet handicraft workers (n=222), textiles handicraft workers (n=209), and leather handicraft workers (n=201) in Tabriz, Iran.

Results: The response rate was 88.8%. The overall prevalence of musculoskeletal complaints, particularly in the neck (57.9%), lower back (51.6%), and shoulders (40.5%) was relatively high. The prevalence of neck and shoulder pain was higher among females and with increasing age. Working posture and fast working were associated with neck, shoulder, and lower back pain. Years worked as a sewing worker was associated with neck and lower back pain. Long duration of continuous sitting work (>2 h) without a break was associated with neck pain. Body mass index, marital status, sport/physical activity, smoking, daily working hours, job satisfaction, and perceived pressure due to work had no effect.

Conclusions: The findings indicate a high prevalence of musculoskeletal pain among the studied handicraft workers and emphasize the importance of individual, physical, and psychosocial aspects of hand sewing tasks in this regard.
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http://dx.doi.org/10.1539/joh.15-0196-OADOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373915PMC
November 2016

Are general practitioners well informed about fibromyalgia?

Int J Rheum Dis 2017 Dec 22;20(12):1917-1921. Epub 2015 Jul 22.

Department of Rheumathology, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Aim: Fibromyalgia syndrome (FMS) is a common rheumatologic disorder characterized by easy fatigability, widespread musculoskeletal pain and sleep disorder. In spite of its high prevalence, general practitioners, as primary care providers, seem to have inadequate knowledge about FMS. This study aimed to assess Iranian general practitioners' knowledge about FMS and its treatment.

Method: A detailed questionnaire (including items on signs and symptoms, diagnostic criteria and treatment) was completed by 190 general practitioners (54.7% male; mean age: 41 years). Data analysis was performed with SPSS for Windows 15.0 and awareness about all aspects of FMS was reported as percentages.

Results: About one-third (30%) of the participants had seen at least one case of FMS during their practice. Most subjects (62.7%) claimed to know 1-6 tender points. Only 3.2% knew 16-18 points. The common proposed symptoms of FMS were widespread pain (72.6%), excessive fatigue (72.6%), weakness (60.5%), sleep disorder (36.3%), anxiety (34.7%) and depression (34.2%). Wrong symptoms including elevated erythrocyte sedimentation rate and C-reactive protein, arthritis, joint swelling, weight loss and abnormal radiologic findings were selected by 27.9%, 18.9%, 14.7%, 12.6% and 2.1% of the physicians, respectively. Moreover, selective serotonin reuptake inhibitors, tricyclic antidepressant and pregabalin were identified as treatment options for FMS by, respectively, 45.8%, 22.1% and 15.3% of the participants. Finally, 52.1% and 23.7% of the subjects incorrectly considered nonsteroidal anti-inflammatory drugs and corticosteroids as treatment modalities for FMS.

Conclusion: Iranian general practitioners are not well informed about FMS. Therefore, FMS should be specifically integrated in continuing medical education programs and undergraduate medical training curriculum.
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http://dx.doi.org/10.1111/1756-185X.12716DOI Listing
December 2017

Association of individual and work-related risk factors with musculoskeletal symptoms among Iranian sewing machine operators.

Appl Ergon 2015 Nov 28;51:180-8. Epub 2015 May 28.

Human Systems Integration Group, Faculty of Engineering & Computing, Coventry University, UK. Electronic address:

This cross-sectional study evaluated working conditions and the occurrence of self-reported musculoskeletal symptoms among 251 Iranian sewing machine operators. A questionnaire and direct observations of working postures using the rapid upper limb assessment (RULA) method were used. A high prevalence of musculoskeletal symptoms, particularly in the neck/shoulders, back and hands/wrists were found. The mean RULA grand score of 5.7 highlighted a poor sewing workstation design and indicated that most operators (with posture assessed at action level 3) needed an investigation and changes in their working habits soon. Work-related factors (including number of years worked as an operator, prolonged working hours per shift, long duration of sitting work without a break, feeling pressure due to work and working postures) and individual factors (including age, gender, BMI and regular sport/physical activities) were associated with musculoskeletal symptoms in multiple logistic regression models. The findings add to the understanding of working conditions of those jobs involving sewing activities and emphasise the need for ergonomic interventions to reduce musculoskeletal symptoms in the future.
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http://dx.doi.org/10.1016/j.apergo.2015.04.017DOI Listing
November 2015

Central nervous system tuberculosis: an imaging-focused review of a reemerging disease.

Radiol Res Pract 2015 12;2015:202806. Epub 2015 Jan 12.

Department of Neurology, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Central nervous system (CNS) tuberculosis is a potentially life threatening condition which is curable if the correct diagnosis is made in the early stages. Its clinical and radiologic manifestations may mimic other infectious and noninfectious neurological conditions. Hence, familiarity with the imaging presentations of various forms of CNS tuberculosis is essential in timely diagnosis, and thereby reducing the morbidity and mortality of this disease. In this review, we describe the imaging characteristics of the different forms of CNS tuberculosis, including meningitis, tuberculoma, miliary tuberculosis, abscess, cerebritis, and encephalopathy.
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http://dx.doi.org/10.1155/2015/202806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306383PMC
February 2015

Gonadal vein tumor thrombosis due to renal cell carcinoma.

Indian J Urol 2015 Jan-Mar;31(1):79-80

Department of Radiology, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Renal cell carcinoma (RCC) had a tendency to extend into the renal vein and inferior vena cava, while extension into the gonadal vein has been rarely reported. Gonadal vein tumor thrombosis appears as an enhancing filling defect within the dilated gonadal vein anterior to the psoas muscle and shows an enhancement pattern identical to that of the original tumor. The possibility of gonadal vein thrombosis should be kept in mind when looking at an imaging study of patients with RCC.
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http://dx.doi.org/10.4103/0970-1591.139553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300581PMC
January 2015

Computed tomography features of pulmonary nocardiosis in immunocompromised and immunocompetent patients.

Pol J Radiol 2015 7;80:13-7. Epub 2015 Jan 7.

Department of Radiology, Zanjan University of Medical Sciences, Zanjan, Iran.

Background: Nocardiosis primarily occurs in the setting of immunocompromising conditions. However, it may also occur in immunocompetent patients. We described computed tomography features of pulmonary nocardiosis and compared immunocompetent and immunocompromised patients.

Material/methods: CT images of 25 patients (Mean age of 39.5 years; 76% male) with pulmonary nocardiosis proved by bronchoalveolar lavage or biopsy were reviewed by two experienced pulmonary radiologists and detailed findings were reported on. Fourteen patients (56%) were immunocompetent, while 44% had an underlying immunocompromising condition, including chronic granulomatous disease (CGD) (n=4), diabetes mellitus (DM) (n=2), malignancy (n=2), HIV (n=1), concomitant CGD and DM (n=1), and steroid therapy for nephrotic syndrome (n=1).

Results: Most patients had bilateral involvement with no zonal predominance. Multiple pulmonary nodules (96%) were the most common CT findings, followed by consolidation (76%) and cavity (52%). Other findings included bronchiectasis (48%), pleural thickening (40%), ground glass opacity (32%), mass-like consolidation (20%), intrathoracic lymphadenopathy (16%), pleural effusion (12%), reticular infiltration (4%), and pericardial effusion (4%). There was no statistically significant difference in the CT findings of immunocompromised and immunocompetent groups.

Conclusions: Pulmonary nocardiosis presents mainly as multiple pulmonary nodules, consolidations, and cavity in both immunocompromised and immunocompetent patients. However, these features are more suggestive of nocardiosis in the setting of an underling immunocompromised condition.
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http://dx.doi.org/10.12659/PJR.892042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288394PMC
January 2015

The spectrum of presentations of cryptogenic organizing pneumonia in high resolution computed tomography.

Pol J Radiol 2014 5;79:456-60. Epub 2014 Dec 5.

Chronic Respiratory Disaeses Research Center, National Research Institute of Tuberculosis and Lung Disease, Masih-e-Daneshvari Hospital, Shahid Beheshti Medical University, Tehran, Iran ; Department of Radiology, Masih-e-Daneshvari Hospital, Shahid Beheshti Medical University, Tehran, Iran.

Background: Various radiologic patterns of cryptogenic organizing pneumonia (COP) in X-rays have been reported for more than 20 years, and later, in computed tomography scans. The aim of the present study was to describe the spectrum of radiologic findings on high resolution computed tomography (HRCT) scans in patients with COP.

Material/methods: HRCT scans of 31 sequential patients (mean age: 54.3±11 years; 55% male) with biopsy-proven COP in a tertiary lung center between 2009 and 2012 were reviewed by two experienced pulmonary radiologists with almost perfect interobserver agreement (kappa=0.83). Chest HRCTs from the lung apex to the base were performed using a 16-slice multi-detector CT scanner.

Results: The most common HRCT presentation of COP was ground-glass opacity (GGO) in 83.9% of cases, followed by consolidation in 71%. Both findings were mostly asymmetric bilateral and multifocal. Other common findings were the reverse halo (48.4%), parenchymal bands (54.8%) and subpleural bands (32.3%). Pulmonary nodules were found in about one-third of patients and were frequently smaller than 5 mm in diameter. Both GGOs and consolidations were revealed more often in the lower lobes.

Conclusions: The main presentations of COP on HRCT include bilateral GGOs and consolidations in the lower lobes together with the reverse halo sign.
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http://dx.doi.org/10.12659/PJR.891011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259518PMC
December 2014

The value of coronary artery calcium score assessed by dual-source computed tomography coronary angiography for predicting presence and severity of coronary artery disease.

Pol J Radiol 2014 30;79:169-74. Epub 2014 Jun 30.

Department of Radiology, Day General Hospital, Tehran, Iran.

Background: Measuring coronary artery calcium score (CACS) using a dual-source CT scanner is recognized as a major indicator for assessing coronary artery disease. The present study aimed to validate the clinical significance of CACS in predicting coronary artery stenosis and its severity.

Material/methods: This prospective study was conducted on 202 consecutive patients who underwent both conventional coronary angiography and dual-source (256-slice) computed tomography coronary angiography (CTA) for any reason in our cardiac imaging center from March to September 2013. CACS was measured by Agatston algorithm on non-enhanced CT. The severity of coronary artery disease was assessed by Gensini score on conventional angiography.

Results: There was a significant relationship between the number of diseased coronary vessels and mean calcium score, i.e. the mean calcium score was 202.25±450.06 in normal coronary status, 427.50±607.24 in single-vessel disease, 590.03±511.34 in two-vessel disease, and 953.35±1023.45 in three-vessel disease (p<0.001). There was a positive association between calcium score and Gensini score (r=0.636, p<0.001). In a linear regression model, calcium score was a strong determinant of the severity of coronary artery disease. Calcium scoring had an acceptable value for discriminating coronary disease from normal condition with optimal cutoff point of 350, yielding a sensitivity and specificity of 83% and 70%, respectively.

Conclusions: Our study confirmed the strong relationship between the coronary artery calcium score and the presence and severity of stenosis in coronary arteries assessed by both the number of diseased coronary vessels and also by the Gnesini score.
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http://dx.doi.org/10.12659/PJR.890809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079648PMC
July 2014

Comparison of diagnostic accuracy of dual-source CT and conventional angiography in detecting congenital heart diseases.

Pol J Radiol 2014 25;79:164-8. Epub 2014 Jun 25.

Department of Radiology, Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Cardiac dual-source computed tomography (DSCT) is primarily used for coronary arteries. There are limited studies about the application of DSCT for congenital heart diseases. The aim of this study was to determine the diagnostic value of DSCT in the cardiac anomalies.

Material/methods: The images of DSCTs and conventional angiographies of 36 patients (21 male; mean age: 8.5 month) with congenital heart diseases were reviewed and the parameters of diagnostic value of these methods were compared. Cardiac surgery was the gold standard.

Results: A total of 105 cardiac anomalies were diagnosed at surgery. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of DSCT were 98.25%, 97.9%, 98.1%, 99.07%, and 98.2%, respectively. The corresponding values of angiography were 95.04%, 98.7%, 97.8%, 98.1%, and 98%, respectively. Only one atrial septal defect (ASD) and two patent ductus arteriosus (PDA) were missed by DSCT. Angiography missed two ASD and two PDA. DSCT also provided important additional findings (n=35) about the intrathoracic or intraabdominal organs.

Conclusions: DSCT is a highly accurate diagnostic modality for congenital heart diseases, obviating the need for invasive modalities. Beside its noninvasive nature, the advantage of DSCT over the angiography is its ability to provide detailed anatomical information about the heart, vessels, lungs and intraabdominal organs.
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http://dx.doi.org/10.12659/PJR.890732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076227PMC
July 2014

Ultrasound as a feasible method for the assessment of malrotation.

Pol J Radiol 2014 19;79:112-6. Epub 2014 May 19.

Department of Radiology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: In malrotation the position of third portion of duodenum (D3) is always intramesenteric. Demonstration of normal retromesenteric-retroperitoneal position of D3 on ultrasound (US) can rule out malrotation. The aim of this study was to evaluate the feasibility of US in demonstrating the retroperitoneal D3.

Material/methods: Abdominal US study was done for various indications in 60 newborns and infants (mean age: 33 days [range: 4-100 days]; 56.7% male) by an expert pediatric radiologist. The position of D3 and its adjacent structures was evaluated in axial and longitudinal planes by linear and curved transducers.

Results: A normal retromesenteric-retroperitoneal D3 located between the superior mesenteric artery and the aorta was seen on US in all patients, including those with extensive gas in the bowel. The mean time of D3 observation was 47.8 s (10-180 s). Ultrasound was also capable of demonstrating D3 structure, diameter, content, adjacent structures, relative position of the superior mesenteric artery and vein.

Conclusions: Ultrasound is a simple, fast and highly accurate tool to confirm the retroperitoneal position of D3. Ultrasound can be used as a screening method for malrotation eliminating the need for unnecessary barium studies.
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http://dx.doi.org/10.12659/PJR.890219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031226PMC
May 2014

Features of idiopathic pulmonary alveolar proteinosis in high resolution computed tomography.

Pol J Radiol 2014 1;79:65-9. Epub 2014 Apr 1.

National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran ; Department of Radiology, Masih-e-Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Although the crazy-paving pattern on computed tomography is characteristic for pulmonary alveolar proteinosis (PAP), it is not specific and has not been compared between idiopathic and secondary PAPs in the large studies. The aim of this study was to determine the high resolution computed tomography (HRCT) features of idiopathic PAP.

Material/methods: HRCT images of 35 patients (mean age: 38±14years; 54.3% male) with idiopathic PAP (proved by bronchoalveolar lavage or biopsy) were reviewed by two experienced pulmonary radiologist and detailed findings were reported.

Results: The predominant HRCT presentation of PAP was interlobular septal thickening (ILST;100%) and ground glass opacities (GGOs; 91.7%), resulting in crazy-paving pattern (83%). All patients had diffuse bilateral lung involvement that was symmetric in 97%. ILST and GGO without crazy-paving were seen in 17% and 14.7%, respectively. The overall extent of parenchymal involvement was 50 to 75% in 80% of patients. Thirty three cases (94%) had areas of geographic sparing within the affected lung. Peripheral sparing was seen in 85.7% of patients, including three patterns with some overlap: costophrenic angle (80%), apices (60%), and subpleural (57%) sparing. Other HRCT findings were: consolidation (63%), pulmonary nodules (31.4%), mediastinal and/or hilar lymphadenopathy (23%), mass-like consolidation (17%), pleural effusion (8.6%), and honey combing (5.7%). All female patients (n=16) had crazy-paving, while 13 out of 19 (68%) male patients had crazy-paving on their lung HRCT (p=0.02).

Conclusions: This study demonstrated that the predominant HRCT presentation of idiopathic PAP was interlobular septal thickening and ground glass opacities, resulting in crazy-paving pattern.
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http://dx.doi.org/10.12659/PJR.890218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974628PMC
April 2014