Publications by authors named "Mohammad Tajik"

14 Publications

  • Page 1 of 1

Engineering strategies for enhancing the performance of electrochemical paper-based analytical devices.

Biosens Bioelectron 2020 Nov 8;167:112506. Epub 2020 Aug 8.

Graduate School of Biomedical Engineering, The University of New South Wales, Sydney NSW, 2052, Australia. Electronic address:

Applications of electrochemical detection methods in microfluidic paper-based analytical devices (μPADs) has revolutionized the area of point-of-care (POC) testing towards highly sensitive and selective quantification of various (bio)chemical analytes in a miniaturized, low-coat, rapid, and user-friendly manner. Shortly after the initiation, these relatively new modulations of μPADs, named as electrochemical paper-based analytical devices (ePADs), gained widespread popularity within the POC research community thanks to the inherent advantages of both electrochemical sensing and usage of paper as a suitable substrate for POC testing platforms. Even though general aspects of ePADs such as applications and fabrication techniques, have already been reviewed multiple times in the literature, herein, we intend to provide a critical engineering insight into the area of ePADs by focusing particularly on the practical strategies utilized to enhance their analytical performance (i.e. sensitivity), while maintaining the desired simplicity and efficiency intact. Basically, the discussed strategies are driven by considering the parameters potentially affecting the generated electrochemical signal in the ePADs. Some of these parameters include the type of filter paper, electrode fabrication methods, electrode materials, fluid flow patterns, etc. Besides, the limitations and challenges associated with the development of ePADs are discussed, and further insights and directions for future research in this field are proposed.
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http://dx.doi.org/10.1016/j.bios.2020.112506DOI Listing
November 2020

Quantitative determination of trace phenazopyridine in human urine samples by hyphenation of dispersive solid-phase extraction and liquid-phase microextraction followed by gas chromatography/mass spectrometry analysis.

J Sep Sci 2020 Jul 4;43(14):2897-2904. Epub 2020 Jun 4.

Department of Analytical Chemistry, Faculty of Chemistry, K. N. Toosi University of Technology, Tehran, Iran.

Magnetic dispersive solid-phase extraction followed by dispersive liquid-liquid microextraction coupled with gas chromatography/mass spectrometry was applied for the quantitative analysis of phenazopyridine in urinary samples. Magnetic dispersive solid-phase extraction was carried out using magnetic graphene oxide nanoparticles modified by poly(thiophene-pyrrole) copolymer. The eluting solvent of this step was used as the disperser solvent for the dispersive liquid-liquid microextraction procedure. To reach the maximum efficiency of the method, effective parameters including sorbent amount, adsorption time, type and volume of disperser and extraction solvents, pH of the sample solution, and ionic strength as well as desorption time, and approach were optimized, separately. Characterization of the synthesized sorbent was studied by utilizing infrared spectroscopy, scanning electron microscopy, and energy-dispersive X-ray analysis. Calibration curve was linear in the range of 0.5-250 ng/mL (R  = 0.9988) with limits of detection and quantification of 0.1 and 0.5 ng/mL, respectively. Intra- and interday precisions (RSD%, n = 3) of the method were in the range of 4.6-5.4% and 4.0-5.5%, respectively, at three different concentration levels. Under the optimal condition, this method was successfully applied for the determination of phenazopyridine in human urine samples. The relative recoveries were obtained in the range of 85.0-89.0%.
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http://dx.doi.org/10.1002/jssc.202000055DOI Listing
July 2020

Hollow fiber-based liquid phase microextraction followed by analytical instrumental techniques for quantitative analysis of heavy metal ions and pharmaceuticals.

J Pharm Anal 2020 Apr 12;10(2):109-122. Epub 2019 Dec 12.

Department of Chemistry, Tarbiat Modares University, P. O. Box 14115-175, Tehran, Iran.

Hollow-fiber liquid-phase microextraction (HF-LPME) and electromembrane extraction (EME) are miniaturized extraction techniques, and have been coupled with various analytical instruments for trace analysis of heavy metals, drugs and other organic compounds, in recent years. HF-LPME and EME provide high selectivity, efficient sample cleanup and enrichment, and reduce the consumption of organic solvents to a few micro-liters per sample. HF-LPME and EME are compatible with different analytical instruments for chromatography, electrophoresis, atomic spectroscopy, mass spectrometry, and electrochemical detection. HF-LPME and EME have gained significant popularity during the recent years. This review focuses on hollow fiber based techniques (especially HF-LPME and EME) of heavy metals and pharmaceuticals (published 2017 to May 2019), and their combinations with atomic spectroscopy, UV-VIS spectrophotometry, high performance liquid chromatography, gas chromatography, capillary electrophoresis, and voltammetry.
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http://dx.doi.org/10.1016/j.jpha.2019.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192972PMC
April 2020

Spin-column micro-solid phase extraction of chlorophenols using MFU-4l metal-organic framework.

Mikrochim Acta 2019 12 10;187(1):39. Epub 2019 Dec 10.

Department of Chemistry, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran.

A novel metal-organic framework called MFU-4 l was synthesized from ZnCl and 1H-1,2,3-triazolo[4,5-b][4',5'-i])dibenzo[1,4]dioxin. MFU-4 l was characterized and is shown to be a viable sorbent for spin-column micro-solid phase extraction of 4-chlorophenol, 2,3-dichlorophenol, 2,4-dichlorophenol, and 2,4,6-trichlorophenol. Following extraction and elution with methanol, the chlorophenols were quantified by a GC-MS instrument. Various parameters affecting adsorption and desorption were optimized by the one variable at-a-time method. The main feature of the utilized metal-organic framework is its outstanding performance in ultratrace extraction of the target analytes due to the different amino groups existed in the linker structure. Under optimal conditions, the calibration plots are linear in the 0.5-400 μg kg concentration range for water samples, and from 1.0-400 μg kg for soil samples. The respective limits of detection are 0.10 and 0.50 μg kg-1 for water and soil samples, respectively. On top of that, limits of detections are lower than 0.10 and 0.50 μg Kg for water and soil samples, respectively. Inter-day and intra-day relative standard deviations were in the range of 4.4-7.8% for the selected chlorophenols. Preconcentration factors are in the range of 26.3-29.6 for aqueous samples. The method was used to analyze soil and environmental water samples. Graphical abstractSchematic representation of spin-column micro-solid phase extraction of chlorophenols using the MFU-4 l metal-organic framework.
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http://dx.doi.org/10.1007/s00604-019-4023-3DOI Listing
December 2019

Synthesis and characterization of polyamide-graphene oxide-polypyrrole electrospun nanofibers for spin-column micro solid phase extraction of parabens in milk samples.

J Chromatogr A 2019 Aug 8;1599:25-34. Epub 2019 Apr 8.

Department of Chemistry, Tarbiat Modares University, Tehran, Iran.

In the present study, an electrospun composite of polyamide-graphene oxide-polypyrrole was synthesized. The characterization of the synthesized material was accomplished using field emission scanning electron microscopy (FESEM) and Fourier transform infrared spectroscopy (FT-IR). FESEM images showed uniform and beadles nanofibers. The composite was employed as a novel sorbent for spin-column micro solid phase extraction to determine parabens in milk samples. Addition of graphene oxide and polypyrrole into the polymeric network of polyamide significantly improves the extraction efficiency of the electrospun sorbent due to providing the possibility of various interactions with the target analytes such as hydrogen bonding, hydrophobic and π-π stacking. All effective parameters on the efficiency of both adsorption and desorption steps were optimized. These parameters were pH of sample solution (5.0), sorbent amount (20 mg), type and volume of desorption solvent (200 μL of methanol), number of cycles (7 and 14) and centrifugation speed (600 and 500 rpm) of both adsorption and desorption steps. Under the optimal conditions, the calibration plots were linear within the range of 10-1000, 15-1000, and 20-1000 ng mL for methyl paraben, ethyl paraben and propyl paraben, respectively. Limits of detection were obtained lower than 7.0 ng mL by HPLC-UV. Intra- and inter-assay relative standard deviations were less than 8.6% and 5.8%, respectively. Finally, the method was successfully applied for determination of parabens in some milk samples and good recoveries were obtained within the range of 81.7-97.8%. The results demonstrated good efficiency of the synthesized electrospun composite nanofibers as the packing material for spin-column micro solid phase extraction.
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http://dx.doi.org/10.1016/j.chroma.2019.04.014DOI Listing
August 2019

A promising design of microfluidic electromembrane extraction coupled with sensitive colorimetric detection for colorless compounds based on quantum dots fluorescence.

Talanta 2019 Mar 18;194:298-307. Epub 2018 Oct 18.

Department of Chemistry, Faculty of Sciences, Tarbiat Modares University, Tehran, Iran.

In the present study, a microfluidic platform was exploited for electromembrane extraction. For device integration as a lab-on-a-chip system, the detection step was carried out by a colorimetric method based on fluorescence quenching of quantum dots. The model analyte was transferred under a pulsed applied electrical field across a polypropylene membrane, impregnated with 1-Octanol, into a final aqueous acceptor phase. The obtained acceptor phase was added into a solution containing CdTe quantum dots. Quenching of the quantum dots was tracked by analyzing the main three color components of red, green, and blue in different concentration levels of the analyte. All effective parameters on the extraction efficiency, fluorescence detection, and synthesis of quantum dots were optimized. Under the optimal conditions, the detection was accomplished by three different detection methods including HPLC-UV, spectrofluorometric detection, as well as colorimetry detection via a smartphone. Calibration curves were linear in the range of 2.0-500 µg L for LC-UV, 30-2500 µg L for fluorescence detection, and 2.5-20 µg mL for image analysis. Inter- and intra-assay relative standard deviations were less than 10.1% in all detection modes.
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http://dx.doi.org/10.1016/j.talanta.2018.10.046DOI Listing
March 2019

Compare Complication of Classic versus Patent Hemostasis in Transradial Coronary Angiography.

Adv Biomed Res 2017 26;6:159. Epub 2017 Dec 26.

Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Coronary artery disease (CAD) is multifactorial disease, in which thrombotic occlusion and calcification occur usually. New strategies have been made for diagnosis and treatment of CAD, such as transradial catheterization. Hemostasis could be done in two approaches: traditional and patent. Our aim is to find the best approach with lowest complication.

Materials And Methods: In a comparative study, 120 patients were recruited and divided randomly into two subgroups, including traditional group (60 patients; 24 females, 36 males; mean age: 64.35 ± 10.56 years) and patent group (60 patients; 28 females, 32 males; mean age: 60.15 ± 8.92 years). All demographic data including age, gender, body mass index, and CAD-related risk factors (smoking, diabetes, hypertension) and technical data including the number of catheters, procedure duration, and hemostatic compression time and clinical outcomes (radial artery occlusion [RAO], hematoma, bleeding) were collected. Data were analyzed by SPSS version 16.

Results: Our findings revealed that the incidence of RAO was significantly lower in patent groups compared with traditional group ( = 0.041). Furthermore, the difference incidence of RAO was higher in early occlusion compare with late one ( = 0.041). Moreover, there were significant relationship between some factors in patients of traditional group with occlusion (gender [ = 0.038], age [ = 0.031], diabetes mellitus [ = 0.043], hemostatic compression time [ = 0.036]) as well as in patent group (age [ = 0.009], hypertension [ = 0.035]).

Conclusion: Our findings showed that RAO, especially type early is significantly lower in patent method compared classic method; and patent hemostasis is the safest method and good alternative for classical method.
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http://dx.doi.org/10.4103/abr.abr_164_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767800PMC
December 2017

Arylhydrazone derivatives of naproxen as new analgesic and anti-inflammatory agents: Design, synthesis and molecular docking studies.

J Mol Graph Model 2016 06 24;67:127-36. Epub 2016 May 24.

Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran. Electronic address:

A series of new arylidenehydrazone derivatives of naproxen were synthesized and evaluated for their analgesic and anti-inflammatory activities. Some of the synthesized analogues showed comparable activities when compared against naproxen for their analgesic and anti-inflammatory properties. 2-(6-methoxy-2-naphthyl)-N'-[(pyridine-4-yl)methylene]propanoic acid hydrazide 4j was found to be the most active analgesic agent. 2-(6-methoxy-2-naphthyl)-N'-[4-nitrobenzylidene]propanoic acid hydrazide 4g showed highest anti-inflammatory activity in comparison to the naproxen. Molecular modeling study of the synthesized compounds suggested that the designed molecules were well located and bound to the COX-1 and COX-2 active sites. Compound 4g showed the highest selectivity for COX-2 (RCOX-2/COX-1=1.94) and higher affinity rather than naproxen in COX-2 active site (RCOX-2/naproxen=1.28). Moreover, the structural analyses confirmed that the E-ap rotamer is the preferred structure for the arylidenehydrazone derivatives.
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http://dx.doi.org/10.1016/j.jmgm.2016.05.009DOI Listing
June 2016

Nano polypyrrole-coated magnetic solid phase extraction followed by dispersive liquid phase microextraction for trace determination of megestrol acetate and levonorgestrel.

Anal Chim Acta 2015 Jul 3;885:98-105. Epub 2015 Jun 3.

Department of Chemistry, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran.

The aim of the present work is combination of the advantages of magnetic solid phase extraction (MSPE) and dispersive liquid phase microextraction (DLLME) followed by filtration-based phase separation. A new pretreatment method was developed for trace determination of megestrol acetate and levonorgestrel by liquid chromatography/ultraviolet detection in biological and wastewater samples. After magnetic solid phase extraction, the eluent of MSPE was used as the disperser solvent for DLLME. Emulsion resulted from DLLME procedure was passed through the in-line filter for phase separation. Finally the retained analytes in the filter was washed with mobile phase of liquid chromatography and transferred to the column for separation. This approach offers the preconcentration factors of 3680 and 3750 for megestrol acetate and levonorgestrel, respectively. This guarantees determination of the organic compounds at trace levels. The important parameters influencing the extraction efficiency were studied and optimized. Under the optimal extraction conditions, a linear range of 0.05-50ngmL(-1) (R(2)>0.998) and limit of detection of 0.03ngmL(-1) were obtained for megestrol acetate and levonorgestrel. Under optimal conditions, the method was successfully applied for determination of target analytes in urine and wastewater samples and satisfactory results were obtained (RSDs<6.8%).
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http://dx.doi.org/10.1016/j.aca.2015.05.025DOI Listing
July 2015

Reactive hyperplastic lesions of the oral cavity.

Iran J Otorhinolaryngol 2015 Mar;27(79):137-44

Dental Research Center, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.

Introduction: Peripheral reactive lesions of soft tissue are common oral lesions that dentists face during routine examinations. Diagnosis and development of a treatment plan is difficult if dentists are not aware of the prevalence and clinical symptoms of these lesions. The frequency of these lesions differs across various populations. The aim of this study was to determine the frequency and distribution of oral reactive lesions over a period of 7 years (2006-2012).

Materials And Methods: In this retrospective study, available records from the archives of the Department of Pathology, Dental School and the two main hospitals in southeast of Iran (Zahedan) over a period of 7 years (2006-2012) were reviewed. Information relating to the type of reactive lesion, age, gender and location was extracted and recorded on data forms. Data were analyzed using SPSS statistical software (V.18) using the chi-square and Fisher's exact test.

Results: Of 451 oral lesions, 91 cases (20.2%) were reactive hyperplastic lesions. The most common lesions were pyogenic granuloma and irritation fibroma, respectively. These lesions were more frequent in women (60%) than men (40%). The most common locations of involvement were the gingiva and alveolar mucosa of the mandible, and lesions were more common in the 21-40-year age group. The relationship between age group and reactive lesions was statistically significant (P=0.01).

Conclusion: The major findings in this study are broadly similar to the results of previous studies, with differences observed in some cases. However, knowledge of the frequency and distribution of these lesions is beneficial when establishing a diagnosis and treatment plan in clinical practice.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409958PMC
March 2015

Automated hollow fiber microextraction based on two immiscible organic solvents for the extraction of two hormonal drugs.

J Pharm Biomed Anal 2015 Mar 23;107:24-31. Epub 2014 Dec 23.

Department of Chemistry, Faculty of Sciences, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran.

In this research, a rapid efficient and automated instrument based on hollow fiber liquid-phase microextraction (HF-LPME) followed by high performance liquid chromatography (HPLC) with UV-vis detection was applied for the preconcentration and determination of two hormonal drugs (megestrol acetate and levonorgestrel) in water and urinary samples. n-Dodecane was used as the supported liquid membrane (SLM) and methanol was used as the acceptor phase in the hollow fiber lumen. The effects of different parameters such as fiber length, extraction time, stirring rate, and ionic strength on the extraction efficiency were investigated using modified simplex and central composite design as the screening and optimization methods, respectively. The composition effect of SLM and type of acceptor phase were optimized separately. For adjustment of the SLM composition, trioctylphosphine oxide (TOPO) was chosen. Under optimized condition, the calibration curves were linear (r(2)>0.997) in the range of 0.5-200 μg L(-1). LOD for both of the drugs were 0.25 μg L(-1). The applicability of this technique was examined by analyzing drugs in water and urine samples. The relative recoveries of the drugs were in the range of 86.2-102.3% that show the capability of the method for the determination of the drugs in various matrices.
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http://dx.doi.org/10.1016/j.jpba.2014.12.028DOI Listing
March 2015

On-line extraction and determination of two herbicides: comparison between two modes of three-phase hollow fiber microextraction.

J Sep Sci 2015 Feb 13;38(4):649-55. Epub 2015 Jan 13.

Department of Chemistry, Faculty of Sciences, Tarbiat Modares University, Tehran, Iran.

Two different modes of three-phase hollow fiber liquid-phase microextraction were studied for the extraction of two herbicides, bensulfuron-methyl and linuron. In these two modes, the acceptor phases in the lumen of the hollow fiber were aqueous and organic solvents. The extraction and determination were performed using an automated hollow fiber microextraction instrument followed by high-performance liquid chromatography. For both three-phase hollow fiber liquid-phase microextraction modes, the effect of the main parameters on the extraction efficiency were investigated and optimized by central composite design. Under optimal conditions, both modes showed good linearity and repeatability, but the three-phase hollow fiber liquid-phase microextraction based on two immiscible organic solvents has a better extraction efficiency and figures of merit. The calibration curves for three-phase hollow fiber liquid-phase microextraction with an organic acceptor phase were linear in the range of 0.3-200 and 0.1-150 μg/L and the limits of detection were 0.1 and 0.06 μg/L for bensulfuron-methyl and linuron, respectively. For the conventional three-phase hollow fiber liquid-phase microextraction, the calibration curves were linear in the range of 3.0-250 and 15-400 μg/L and LODs were 1.0 and 5.0 μg/L for bensulfuron-methyl and linuron, respectively. The real sample analysis was carried out by three-phase hollow fiber liquid phase microextraction based on two immiscible organic solvents because of its more favorable characteristics.
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http://dx.doi.org/10.1002/jssc.201401075DOI Listing
February 2015

Synthesis, analgesic and anti-inflammatory activities of new methyl-imidazolyl-1,3,4-oxadiazoles and 1,2,4-triazoles.

Daru 2014 Jan 22;22(1):22. Epub 2014 Jan 22.

Department of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran.

Background: Long-term clinical employment of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with significant side effects including gastrointestinal (GI) lesions and kidney toxicity. In this paper we designed and synthesized new imidazolyl-1,3,4-oxadiazoles and 1,2,4-triazoles by molecular hybridization of previously described anti-inflammatory compounds in the hope of obtaining new safer analgesic and anti-inflammatory agents.

Methods: The target structures were synthesized by preparation of 5-methyl-1H-imidazole-4-carboxylic acid ethyl ester 5. The reaction of hydrazine hydrate with this ester afforded the 5-methyl-1H-imidazole-4-carboxylic acid hydrazide 6 which was converted to target compounds 7-15 according to the known procedures. In silico toxicity risk assessment and drug likeness predictions were done, in order to consider the privileges of the synthesized structures as drug candidates.

Results And Discussion: The analgesic and anti-inflammatory profile of the synthesized compounds were evaluated by writhing and carrageenan induced rat paw edema tests respectively. Compounds 8, 9 and 11-13 and 15 were active analgesic agents and compounds 8, 9 and 11-13 showed significant anti-inflammatory response in comparison with control. Compounds 11 and 13 were screened for their ulcerogenic activities and none of them showed significant ulcerogenic activity. The active Compounds 11 and 12 showed the highest drug likeness and drug score.

Conclusions: The analgesic and anti-inflammatory activities of title compounds were comparable to that of standard drug indomethacin with a safer profile of activity. The results revealed that both of oxadiazole and triazole scaffolds can be determined as pharmacophores. The in silico predictions and pharmacological evaluations showed that compounds 11 and 12 can be chosen as lead for further investigations.
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http://dx.doi.org/10.1186/2008-2231-22-22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914383PMC
January 2014

Synthesis and analgesic activity of N-Arylhydrazone derivatives of mefenamic acid.

J Pharm Pharm Sci 2005 Sep 1;8(3):419-25. Epub 2005 Sep 1.

Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: A series of N-Arylhydrazone derivatives of mefenamic acid (a known non-steroidal anti-inflammatory drug) were synthesized in order to obtain new compounds with potential analgesic and anti-inflammatory activity.

Methods: The structures of all synthesized compounds were confirmed by means of infrared, proton magnetic resonance and mass spectroscopy. All compounds were evaluated for their analgesic and anti-inflammatory activities by abdominal constriction test (writhing test) and carrageenan-induced rat paw edema test respectively.

Results: Most of the synthesized compounds induced significant reduction in the writhing response when compared to control. Among them, compounds 11, 12, 15, 16, 19, 20, and 21 were significantly more potent than mefenamic acid in the writhing test. The anti-inflammatory activity of these 7 compounds were evaluated and compounds 11, 12, 16, 19 and 20 showed significant anti-inflammatory activity in comparison to control but their effect was weaker than mefenamic acid.

Conclusions: The antinociceptive relative activity of some of these newly synthesized compounds is greater than mefenamic acid but they are not potent anti-inflammatory agents.
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September 2005