Publications by authors named "Mohammad Mahdi Samadian"

2 Publications

  • Page 1 of 1

Role of long non-coding RNAs (LncRNAs) in multiple sclerosis: a brief review.

Neurol Sci 2020 Sep 30;41(9):2443-2451. Epub 2020 Apr 30.

Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Multiple sclerosis (MS) as chronic autoimmune inflammatory neurological disease of the central nervous system (CNS) occurs due to several environmental and genetic factors, whose pathogenesis is associated with genes with regulatory role in the immune system. Long non-coding RNAs (LncRNAs) are able to reportedly regulate responses of immune systems and expression of genes, and show the tissue specificity and complexity of biofunctions. Various studies have suggested that the aberrant LncRNA expression is an underlying factor involved in the incidence of MS and that the analysis of the expression profile of these molecules can be a specific biomarker of MS for preventing the course of the disease or responding to treatment. The purpose of this research was to review the recent studies for exploring the functions of LncRNAs in the processes leading to MS disease.
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http://dx.doi.org/10.1007/s10072-020-04425-2DOI Listing
September 2020

and rs35929607 polymorphisms and risk of Hypertension in Iranian Population.

Med J Islam Repub Iran 2018 20;32:14. Epub 2018 Feb 20.

Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.

ATP2B1 and STK39 have been introduced as essential hypertension candidate genes. The association of these genes' variations have not been studied in Iranian population yet. Here we aimed to investigate the association of ATP2B1 rs2681472 and STK39 rs35929607 polymorphisms with the risk of hypertension in an Iranian population. We included 400 individuals in our case-control study: 200 cases with essential hypertension and 200 healthy sex and age matched controls. All subjects were genotyped for rs2681472 and rs35929607 using a PCR-RFLP method. Genotype and allele frequencies were compared between the two groups using chi-squared test. The association was further assessed under log-additive, dominant and recessive genetic models. There was no association between rs2681472 and rs35929607 polymorphisms and risk of essential hypertension in our population (p>0.05). There was also no association between the studied polymorphisms and hypertension under different genetic models. Our study indicated that rs2681472 of ATP2B1 and rs35929607 of STK39 may not have a significant effect on the risk of essential hypertension in Iranian population. More studies are still needed to validate our results.
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http://dx.doi.org/10.14196/mjiri.32.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108259PMC
February 2018