Mohammad Kamran Ikram

Mohammad Kamran Ikram

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Mohammad Kamran Ikram

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Homocysteine and Cerebral Atrophy: The Epidemiology of Dementia in Singapore Study.

J Alzheimers Dis 2018 ;62(2):877-885

Memory Ageing and Cognition Center (MACC), National University Health System, Singapore.

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http://dx.doi.org/10.3233/JAD-170796DOI Listing
February 2019

Clinical interpretation of negative mediated interaction.

Int J Epidemiol 2018 Dec 1. Epub 2018 Dec 1.

Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1093/ije/dyy252DOI Listing
December 2018

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.

Authors:
Jason Flannick Christian Fuchsberger Anubha Mahajan Tanya M Teslovich Vineeta Agarwala Kyle J Gaulton Lizz Caulkins Ryan Koesterer Clement Ma Loukas Moutsianas Davis J McCarthy Manuel A Rivas John R B Perry Xueling Sim Thomas W Blackwell Neil R Robertson N William Rayner Pablo Cingolani Adam E Locke Juan Fernandez Tajes Heather M Highland Josee Dupuis Peter S Chines Cecilia M Lindgren Christopher Hartl Anne U Jackson Han Chen Jeroen R Huyghe Martijn van de Bunt Richard D Pearson Ashish Kumar Martina Müller-Nurasyid Niels Grarup Heather M Stringham Eric R Gamazon Jaehoon Lee Yuhui Chen Robert A Scott Jennifer E Below Peng Chen Jinyan Huang Min Jin Go Michael L Stitzel Dorota Pasko Stephen C J Parker Tibor V Varga Todd Green Nicola L Beer Aaron G Day-Williams Teresa Ferreira Tasha Fingerlin Momoko Horikoshi Cheng Hu Iksoo Huh Mohammad Kamran Ikram Bong-Jo Kim Yongkang Kim Young Jin Kim Min-Seok Kwon Juyoung Lee Selyeong Lee Keng-Han Lin Taylor J Maxwell Yoshihiko Nagai Xu Wang Ryan P Welch Joon Yoon Weihua Zhang Nir Barzilai Benjamin F Voight Bok-Ghee Han Christopher P Jenkinson Teemu Kuulasmaa Johanna Kuusisto Alisa Manning Maggie C Y Ng Nicholette D Palmer Beverley Balkau Alena Stančáková Hanna E Abboud Heiner Boeing Vilmantas Giedraitis Dorairaj Prabhakaran Omri Gottesman James Scott Jason Carey Phoenix Kwan George Grant Joshua D Smith Benjamin M Neale Shaun Purcell Adam S Butterworth Joanna M M Howson Heung Man Lee Yingchang Lu Soo-Heon Kwak Wei Zhao John Danesh Vincent K L Lam Kyong Soo Park Danish Saleheen Wing Yee So Claudia H T Tam Uzma Afzal David Aguilar Rector Arya Tin Aung Edmund Chan Carmen Navarro Ching-Yu Cheng Domenico Palli Adolfo Correa Joanne E Curran Dennis Rybin Vidya S Farook Sharon P Fowler Barry I Freedman Michael Griswold Daniel Esten Hale Pamela J Hicks Chiea-Chuen Khor Satish Kumar Benjamin Lehne Dorothée Thuillier Wei Yen Lim Jianjun Liu Marie Loh Solomon K Musani Sobha Puppala William R Scott Loïc Yengo Sian-Tsung Tan Herman A Taylor Farook Thameem Gregory Wilson Tien Yin Wong Pål Rasmus Njølstad Jonathan C Levy Massimo Mangino Lori L Bonnycastle Thomas Schwarzmayr João Fadista Gabriela L Surdulescu Christian Herder Christopher J Groves Thomas Wieland Jette Bork-Jensen Ivan Brandslund Cramer Christensen Heikki A Koistinen Alex S F Doney Leena Kinnunen Tõnu Esko Andrew J Farmer Liisa Hakaste Dylan Hodgkiss Jasmina Kravic Valeri Lyssenko Mette Hollensted Marit E Jørgensen Torben Jørgensen Claes Ladenvall Johanne Marie Justesen Annemari Käräjämäki Jennifer Kriebel Wolfgang Rathmann Lars Lannfelt Torsten Lauritzen Narisu Narisu Allan Linneberg Olle Melander Lili Milani Matt Neville Marju Orho-Melander Lu Qi Qibin Qi Michael Roden Olov Rolandsson Amy Swift Anders H Rosengren Kathleen Stirrups Andrew R Wood Evelin Mihailov Christine Blancher Mauricio O Carneiro Jared Maguire Ryan Poplin Khalid Shakir Timothy Fennell Mark DePristo Martin Hrabé de Angelis Panos Deloukas Anette P Gjesing Goo Jun Peter Nilsson Jacquelyn Murphy Robert Onofrio Barbara Thorand Torben Hansen Christa Meisinger Frank B Hu Bo Isomaa Fredrik Karpe Liming Liang Annette Peters Cornelia Huth Stephen P O'Rahilly Colin N A Palmer Oluf Pedersen Rainer Rauramaa Jaakko Tuomilehto Veikko Salomaa Richard M Watanabe Ann-Christine Syvänen Richard N Bergman Dwaipayan Bharadwaj Erwin P Bottinger Yoon Shin Cho Giriraj R Chandak Juliana C N Chan Kee Seng Chia Mark J Daly Shah B Ebrahim Claudia Langenberg Paul Elliott Kathleen A Jablonski Donna M Lehman Weiping Jia Ronald C W Ma Toni I Pollin Manjinder Sandhu Nikhil Tandon Philippe Froguel Inês Barroso Yik Ying Teo Eleftheria Zeggini Ruth J F Loos Kerrin S Small Janina S Ried Ralph A DeFronzo Harald Grallert Benjamin Glaser Andres Metspalu Nicholas J Wareham Mark Walker Eric Banks Christian Gieger Erik Ingelsson Hae Kyung Im Thomas Illig Paul W Franks Gemma Buck Joseph Trakalo David Buck Inga Prokopenko Reedik Mägi Lars Lind Yossi Farjoun Katharine R Owen Anna L Gloyn Konstantin Strauch Tiinamaija Tuomi Jaspal Singh Kooner Jong-Young Lee Taesung Park Peter Donnelly Andrew D Morris Andrew T Hattersley Donald W Bowden Francis S Collins Gil Atzmon John C Chambers Timothy D Spector Markku Laakso Tim M Strom Graeme I Bell John Blangero Ravindranath Duggirala E Shyong Tai Gilean McVean Craig L Hanis James G Wilson Mark Seielstad Timothy M Frayling James B Meigs Nancy J Cox Rob Sladek Eric S Lander Stacey Gabriel Karen L Mohlke Thomas Meitinger Leif Groop Goncalo Abecasis Laura J Scott Andrew P Morris Hyun Min Kang David Altshuler Noël P Burtt Jose C Florez Michael Boehnke Mark I McCarthy

Sci Data 2018 01 23;5:180002. Epub 2018 Jan 23.

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http://dx.doi.org/10.1038/sdata.2018.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779067PMC
January 2018

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.

Authors:
Jason Flannick Christian Fuchsberger Anubha Mahajan Tanya M Teslovich Vineeta Agarwala Kyle J Gaulton Lizz Caulkins Ryan Koesterer Clement Ma Loukas Moutsianas Davis J McCarthy Manuel A Rivas John R B Perry Xueling Sim Thomas W Blackwell Neil R Robertson N William Rayner Pablo Cingolani Adam E Locke Juan Fernandez Tajes Heather M Highland Josee Dupuis Peter S Chines Cecilia M Lindgren Christopher Hartl Anne U Jackson Han Chen Jeroen R Huyghe Martijn van de Bunt Richard D Pearson Ashish Kumar Martina Müller-Nurasyid Niels Grarup Heather M Stringham Eric R Gamazon Jaehoon Lee Yuhui Chen Robert A Scott Jennifer E Below Peng Chen Jinyan Huang Min Jin Go Michael L Stitzel Dorota Pasko Stephen C J Parker Tibor V Varga Todd Green Nicola L Beer Aaron G Day-Williams Teresa Ferreira Tasha Fingerlin Momoko Horikoshi Cheng Hu Iksoo Huh Mohammad Kamran Ikram Bong-Jo Kim Yongkang Kim Young Jin Kim Min-Seok Kwon Juyoung Lee Selyeong Lee Keng-Han Lin Taylor J Maxwell Yoshihiko Nagai Xu Wang Ryan P Welch Joon Yoon Weihua Zhang Nir Barzilai Benjamin F Voight Bok-Ghee Han Christopher P Jenkinson Teemu Kuulasmaa Johanna Kuusisto Alisa Manning Maggie C Y Ng Nicholette D Palmer Beverley Balkau Alena Stančáková Hanna E Abboud Heiner Boeing Vilmantas Giedraitis Dorairaj Prabhakaran Omri Gottesman James Scott Jason Carey Phoenix Kwan George Grant Joshua D Smith Benjamin M Neale Shaun Purcell Adam S Butterworth Joanna M M Howson Heung Man Lee Yingchang Lu Soo-Heon Kwak Wei Zhao John Danesh Vincent K L Lam Kyong Soo Park Danish Saleheen Wing Yee So Claudia H T Tam Uzma Afzal David Aguilar Rector Arya Tin Aung Edmund Chan Carmen Navarro Ching-Yu Cheng Domenico Palli Adolfo Correa Joanne E Curran Dennis Rybin Vidya S Farook Sharon P Fowler Barry I Freedman Michael Griswold Daniel Esten Hale Pamela J Hicks Chiea-Chuen Khor Satish Kumar Benjamin Lehne Dorothée Thuillier Wei Yen Lim Jianjun Liu Marie Loh Solomon K Musani Sobha Puppala William R Scott Loïc Yengo Sian-Tsung Tan Herman A Taylor Farook Thameem Gregory Wilson Tien Yin Wong Pål Rasmus Njølstad Jonathan C Levy Massimo Mangino Lori L Bonnycastle Thomas Schwarzmayr João Fadista Gabriela L Surdulescu Christian Herder Christopher J Groves Thomas Wieland Jette Bork-Jensen Ivan Brandslund Cramer Christensen Heikki A Koistinen Alex S F Doney Leena Kinnunen Tõnu Esko Andrew J Farmer Liisa Hakaste Dylan Hodgkiss Jasmina Kravic Valeri Lyssenko Mette Hollensted Marit E Jørgensen Torben Jørgensen Claes Ladenvall Johanne Marie Justesen Annemari Käräjämäki Jennifer Kriebel Wolfgang Rathmann Lars Lannfelt Torsten Lauritzen Narisu Narisu Allan Linneberg Olle Melander Lili Milani Matt Neville Marju Orho-Melander Lu Qi Qibin Qi Michael Roden Olov Rolandsson Amy Swift Anders H Rosengren Kathleen Stirrups Andrew R Wood Evelin Mihailov Christine Blancher Mauricio O Carneiro Jared Maguire Ryan Poplin Khalid Shakir Timothy Fennell Mark DePristo Martin Hrabé de Angelis Panos Deloukas Anette P Gjesing Goo Jun Peter Nilsson Jacquelyn Murphy Robert Onofrio Barbara Thorand Torben Hansen Christa Meisinger Frank B Hu Bo Isomaa Fredrik Karpe Liming Liang Annette Peters Cornelia Huth Stephen P O'Rahilly Colin N A Palmer Oluf Pedersen Rainer Rauramaa Jaakko Tuomilehto Veikko Salomaa Richard M Watanabe Ann-Christine Syvänen Richard N Bergman Dwaipayan Bharadwaj Erwin P Bottinger Yoon Shin Cho Giriraj R Chandak Juliana Cn Chan Kee Seng Chia Mark J Daly Shah B Ebrahim Claudia Langenberg Paul Elliott Kathleen A Jablonski Donna M Lehman Weiping Jia Ronald C W Ma Toni I Pollin Manjinder Sandhu Nikhil Tandon Philippe Froguel Inês Barroso Yik Ying Teo Eleftheria Zeggini Ruth J F Loos Kerrin S Small Janina S Ried Ralph A DeFronzo Harald Grallert Benjamin Glaser Andres Metspalu Nicholas J Wareham Mark Walker Eric Banks Christian Gieger Erik Ingelsson Hae Kyung Im Thomas Illig Paul W Franks Gemma Buck Joseph Trakalo David Buck Inga Prokopenko Reedik Mägi Lars Lind Yossi Farjoun Katharine R Owen Anna L Gloyn Konstantin Strauch Tiinamaija Tuomi Jaspal Singh Kooner Jong-Young Lee Taesung Park Peter Donnelly Andrew D Morris Andrew T Hattersley Donald W Bowden Francis S Collins Gil Atzmon John C Chambers Timothy D Spector Markku Laakso Tim M Strom Graeme I Bell John Blangero Ravindranath Duggirala E Shyong Tai Gilean McVean Craig L Hanis James G Wilson Mark Seielstad Timothy M Frayling James B Meigs Nancy J Cox Rob Sladek Eric S Lander Stacey Gabriel Karen L Mohlke Thomas Meitinger Leif Groop Goncalo Abecasis Laura J Scott Andrew P Morris Hyun Min Kang David Altshuler Noël P Burtt Jose C Florez Michael Boehnke Mark I McCarthy

Sci Data 2017 12 19;4:170179. Epub 2017 Dec 19.

Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/sdata.2017.179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735917PMC
December 2017

Influence of cerebrovascular disease on brain networks in prodromal and clinical Alzheimer's disease.

Brain 2017 Nov;140(11):3012-3022

Centre for Cognitive Neuroscience, Neuroscience and Behavioural Disorders Programme, Duke-National University of Singapore Medical School, Singapore.

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http://dx.doi.org/10.1093/brain/awx224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841199PMC
November 2017

Prevalence, risk factors and consequences of cerebral small vessel diseases: data from three Asian countries.

J Neurol Neurosurg Psychiatry 2017 08 9;88(8):669-674. Epub 2017 Jun 9.

Memory Aging and Cognition Center, National University Health System, Singapore.

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http://dx.doi.org/10.1136/jnnp-2016-315324DOI Listing
August 2017

Ankle brachial index, MRI markers and cognition: The Epidemiology of Dementia in Singapore study.

Atherosclerosis 2017 08 5;263:272-277. Epub 2017 Jul 5.

Memory Aging & Cognition Centre, National University Health System, Singapore; Department of Pharmacology, National University of Singapore, Singapore.

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http://dx.doi.org/10.1016/j.atherosclerosis.2017.07.002DOI Listing
August 2017

Cerebral microbleeds and neuropsychiatric symptoms in an elderly Asian cohort.

J Neurol Neurosurg Psychiatry 2017 Jan 3;88(1):7-11. Epub 2016 Jun 3.

Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore.

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http://dx.doi.org/10.1136/jnnp-2016-313271DOI Listing
January 2017

Comparison of Common Retinal Vessel Caliber Measurement Software and a Conversion Algorithm.

Transl Vis Sci Technol 2016 Oct 12;5(5):11. Epub 2016 Oct 12.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore ; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong.

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http://tvst.arvojournals.org/article.aspx?doi=10.1167/tvst.5
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http://dx.doi.org/10.1167/tvst.5.5.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063055PMC
October 2016

Cortical cerebral microinfarcts on 3T MRI: A novel marker of cerebrovascular disease.

Neurology 2016 Oct 2;87(15):1583-1590. Epub 2016 Sep 2.

From the Memory Ageing and Cognition Centre (S.H., M.A.S., Q.L.C., C.C., M.K.I.), National University Health System, Singapore; Department of Pharmacology (S.H., M.A.S., Q.L.C., C.C.), National University of Singapore; Department of Neurology (E.S., S.J.v.V., G.J.B., M.K.I.), Brain Center Rudolf Magnus, University Medical Center Utrecht; Departments of Radiology and Medical Informatics (H.V.) and Neurology and Epidemiology (M.K.I.), Erasmus University Medical Center, Rotterdam, the Netherlands; Singapore Eye Research Institute (C.-Y. Cheng, C.S., C.Y. Cheung, T.Y.W.), Singapore National Eye Center; Academic Medicine Research Institute (T.Y.W., M.K.I.), Duke-NUS Graduate Medical School; and Raffles Neuroscience Centre (N.V.), Raffles Hospital, Singapore.

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http://dx.doi.org/10.1212/WNL.0000000000003110DOI Listing
October 2016

Changing Patterns of Patient Characteristics in a Memory Clinic in Singapore.

J Am Med Dir Assoc 2016 09 20;17(9):863.e9-863.e14. Epub 2016 Jul 20.

Department of Pharmacology, National University of Singapore, Singapore, Singapore; Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore.

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http://dx.doi.org/10.1016/j.jamda.2016.06.002DOI Listing
September 2016

Inter-hemispheric functional dysconnectivity mediates the association of corpus callosum degeneration with memory impairment in AD and amnestic MCI.

Sci Rep 2016 09 1;6:32573. Epub 2016 Sep 1.

Center for Cognitive Neuroscience, Neuroscience and Behavioral Disorders Program, Duke-National University of Singapore Graduate Medical School, Singapore.

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http://www.nature.com/articles/srep32573
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http://dx.doi.org/10.1038/srep32573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007647PMC
September 2016

The genetic architecture of type 2 diabetes.

Authors:
Christian Fuchsberger Jason Flannick Tanya M Teslovich Anubha Mahajan Vineeta Agarwala Kyle J Gaulton Clement Ma Pierre Fontanillas Loukas Moutsianas Davis J McCarthy Manuel A Rivas John R B Perry Xueling Sim Thomas W Blackwell Neil R Robertson N William Rayner Pablo Cingolani Adam E Locke Juan Fernandez Tajes Heather M Highland Josee Dupuis Peter S Chines Cecilia M Lindgren Christopher Hartl Anne U Jackson Han Chen Jeroen R Huyghe Martijn van de Bunt Richard D Pearson Ashish Kumar Martina Müller-Nurasyid Niels Grarup Heather M Stringham Eric R Gamazon Jaehoon Lee Yuhui Chen Robert A Scott Jennifer E Below Peng Chen Jinyan Huang Min Jin Go Michael L Stitzel Dorota Pasko Stephen C J Parker Tibor V Varga Todd Green Nicola L Beer Aaron G Day-Williams Teresa Ferreira Tasha Fingerlin Momoko Horikoshi Cheng Hu Iksoo Huh Mohammad Kamran Ikram Bong-Jo Kim Yongkang Kim Young Jin Kim Min-Seok Kwon Juyoung Lee Selyeong Lee Keng-Han Lin Taylor J Maxwell Yoshihiko Nagai Xu Wang Ryan P Welch Joon Yoon Weihua Zhang Nir Barzilai Benjamin F Voight Bok-Ghee Han Christopher P Jenkinson Teemu Kuulasmaa Johanna Kuusisto Alisa Manning Maggie C Y Ng Nicholette D Palmer Beverley Balkau Alena Stančáková Hanna E Abboud Heiner Boeing Vilmantas Giedraitis Dorairaj Prabhakaran Omri Gottesman James Scott Jason Carey Phoenix Kwan George Grant Joshua D Smith Benjamin M Neale Shaun Purcell Adam S Butterworth Joanna M M Howson Heung Man Lee Yingchang Lu Soo-Heon Kwak Wei Zhao John Danesh Vincent K L Lam Kyong Soo Park Danish Saleheen Wing Yee So Claudia H T Tam Uzma Afzal David Aguilar Rector Arya Tin Aung Edmund Chan Carmen Navarro Ching-Yu Cheng Domenico Palli Adolfo Correa Joanne E Curran Denis Rybin Vidya S Farook Sharon P Fowler Barry I Freedman Michael Griswold Daniel Esten Hale Pamela J Hicks Chiea-Chuen Khor Satish Kumar Benjamin Lehne Dorothée Thuillier Wei Yen Lim Jianjun Liu Yvonne T van der Schouw Marie Loh Solomon K Musani Sobha Puppala William R Scott Loïc Yengo Sian-Tsung Tan Herman A Taylor Farook Thameem Gregory Wilson Tien Yin Wong Pål Rasmus Njølstad Jonathan C Levy Massimo Mangino Lori L Bonnycastle Thomas Schwarzmayr João Fadista Gabriela L Surdulescu Christian Herder Christopher J Groves Thomas Wieland Jette Bork-Jensen Ivan Brandslund Cramer Christensen Heikki A Koistinen Alex S F Doney Leena Kinnunen Tõnu Esko Andrew J Farmer Liisa Hakaste Dylan Hodgkiss Jasmina Kravic Valeriya Lyssenko Mette Hollensted Marit E Jørgensen Torben Jørgensen Claes Ladenvall Johanne Marie Justesen Annemari Käräjämäki Jennifer Kriebel Wolfgang Rathmann Lars Lannfelt Torsten Lauritzen Narisu Narisu Allan Linneberg Olle Melander Lili Milani Matt Neville Marju Orho-Melander Lu Qi Qibin Qi Michael Roden Olov Rolandsson Amy Swift Anders H Rosengren Kathleen Stirrups Andrew R Wood Evelin Mihailov Christine Blancher Mauricio O Carneiro Jared Maguire Ryan Poplin Khalid Shakir Timothy Fennell Mark DePristo Martin Hrabé de Angelis Panos Deloukas Anette P Gjesing Goo Jun Peter Nilsson Jacquelyn Murphy Robert Onofrio Barbara Thorand Torben Hansen Christa Meisinger Frank B Hu Bo Isomaa Fredrik Karpe Liming Liang Annette Peters Cornelia Huth Stephen P O'Rahilly Colin N A Palmer Oluf Pedersen Rainer Rauramaa Jaakko Tuomilehto Veikko Salomaa Richard M Watanabe Ann-Christine Syvänen Richard N Bergman Dwaipayan Bharadwaj Erwin P Bottinger Yoon Shin Cho Giriraj R Chandak Juliana C N Chan Kee Seng Chia Mark J Daly Shah B Ebrahim Claudia Langenberg Paul Elliott Kathleen A Jablonski Donna M Lehman Weiping Jia Ronald C W Ma Toni I Pollin Manjinder Sandhu Nikhil Tandon Philippe Froguel Inês Barroso Yik Ying Teo Eleftheria Zeggini Ruth J F Loos Kerrin S Small Janina S Ried Ralph A DeFronzo Harald Grallert Benjamin Glaser Andres Metspalu Nicholas J Wareham Mark Walker Eric Banks Christian Gieger Erik Ingelsson Hae Kyung Im Thomas Illig Paul W Franks Gemma Buck Joseph Trakalo David Buck Inga Prokopenko Reedik Mägi Lars Lind Yossi Farjoun Katharine R Owen Anna L Gloyn Konstantin Strauch Tiinamaija Tuomi Jaspal Singh Kooner Jong-Young Lee Taesung Park Peter Donnelly Andrew D Morris Andrew T Hattersley Donald W Bowden Francis S Collins Gil Atzmon John C Chambers Timothy D Spector Markku Laakso Tim M Strom Graeme I Bell John Blangero Ravindranath Duggirala E Shyong Tai Gilean McVean Craig L Hanis James G Wilson Mark Seielstad Timothy M Frayling James B Meigs Nancy J Cox Rob Sladek Eric S Lander Stacey Gabriel Noël P Burtt Karen L Mohlke Thomas Meitinger Leif Groop Goncalo Abecasis Jose C Florez Laura J Scott Andrew P Morris Hyun Min Kang Michael Boehnke David Altshuler Mark I McCarthy

Nature 2016 08 11;536(7614):41-47. Epub 2016 Jul 11.

Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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http://hmg.oxfordjournals.org/content/early/2015/07/21/hmg.d
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http://www.nature.com/doifinder/10.1038/nature18642
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http://dx.doi.org/10.1038/nature18642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034897PMC
August 2016

Growth differentiation factor-15 and white matter hyperintensities in cognitive impairment and dementia.

Medicine (Baltimore) 2016 Aug;95(33):e4566

aDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore bMemory Aging and Cognition Centre, National University Health System cCardiovascular Research Institute, National University Heart Centre, Singapore dDepartments of Neurology and Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands eRaffles Neuroscience Centre, Raffles Hospital, Singapore.

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http://dx.doi.org/10.1097/MD.0000000000004566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370808PMC
August 2016

Subcortical Atrophy in Cognitive Impairment and Dementia.

J Alzheimers Dis 2015 ;48(3):813-23

Memory Ageing and Cognition Centre (MACC), National University Health System, Singapore.

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http://dx.doi.org/10.3233/JAD-150473DOI Listing
July 2016

Is there a link between passive smoke exposure and early-onset myopia in preschool Asian children?

Ophthalmic Physiol Opt 2016 07 7;36(4):370-80. Epub 2016 Apr 7.

Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1111/opo.12285DOI Listing
July 2016

Retinal vascular imaging in early life: insights into processes and risk of cardiovascular disease.

J Physiol 2016 Apr 23;594(8):2175-203. Epub 2015 Nov 23.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

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http://doi.wiley.com/10.1113/JP270947
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http://dx.doi.org/10.1113/JP270947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933111PMC
April 2016

Plasma Metabonomic Profiling of Diabetic Retinopathy.

Diabetes 2016 04 28;65(4):1099-108. Epub 2016 Jan 28.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Ophthalmology & Visual Sciences Academic Clinical Program, Duke-National University of Singapore Graduate Medical School, Singapore Saw Swee Hock School of Public Health, National University of Singapore, Singapore

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http://dx.doi.org/10.2337/db15-0661DOI Listing
April 2016

Serum Cystatin C, Markers of Chronic Kidney Disease, and Retinopathy in Persons with Diabetes.

J Diabetes Res 2015 20;2015:404280. Epub 2015 Oct 20.

Singapore Eye Research Institute, Singapore National Eye Centre, The Academia, 20 College Road, Discovery Tower Level 6, Singapore 169856 ; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Graduate Medical School, 8 College Road, Singapore 119074 ; Department of Ophthalmology, Singapore National University Hospital, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074.

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http://dx.doi.org/10.1155/2015/404280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630396PMC
February 2016

Cortical microinfarcts on 3T MRI: Clinical correlates in memory-clinic patients.

Alzheimers Dement 2015 Dec 5;11(12):1500-1509. Epub 2015 May 5.

Memory Aging & Cognition Centre, National University Health System, Singapore, Singapore; Department of Pharmacology, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1016/j.jalz.2014.12.010DOI Listing
December 2015

Beyond Screening: Can the Mini-Mental State Examination be Used as an Exclusion Tool in a Memory Clinic?

Diagnostics (Basel) 2015 Nov 4;5(4):475-86. Epub 2015 Nov 4.

Memory, Aging and Cognition Center, Department of Pharmacology, National University Health System, Singapore 117600, Singapore.

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http://dx.doi.org/10.3390/diagnostics5040475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728469PMC
November 2015

Impact of maternal smoking during pregnancy on microvasculature in childhood. The Generation R Study.

Early Hum Dev 2015 Oct 27;91(10):607-11. Epub 2015 Aug 27.

Department of Pediatrics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.earlhumdev.2015.07.009DOI Listing
October 2015

Association of Magnetic Resonance Imaging Markers of Cerebrovascular Disease Burden and Cognition.

Stroke 2015 Oct 1;46(10):2808-14. Epub 2015 Sep 1.

From the Departments of Pharmacology (X.X., S.H., E.J.Y.C., C.L.-H.C.) and Psychology (S.L.C.) and Academic Medicine Research Institute, Duke-NUS Graduate Medical School (M.K.I.), National University of Singapore, Singapore, Singapore; Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore (X.X., S.H., E.J.Y.C., M.K.I., N.V., C.L.-H.C.); and Raffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore (N.V.).

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.115.010700
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http://dx.doi.org/10.1161/STROKEAHA.115.010700DOI Listing
October 2015

Repeatability of Perimacular Ganglion Cell Complex Analysis with Spectral-Domain Optical Coherence Tomography.

J Ophthalmol 2015 1;2015:605940. Epub 2015 Jul 1.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856 ; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597 ; Ophthalmology and Visual Sciences Academic Clinical Programme, Duke-NUS Graduate Medical School, National University of Singapore, Singapore 169857.

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http://dx.doi.org/10.1155/2015/605940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502302PMC
August 2015

Risk Factors and Consequences of Cortical Thickness in an Asian Population.

Medicine (Baltimore) 2015 Jun;94(23):e852

From the Memory Ageing and Cognition Centre (MACC), National University Health System (SH, XX, SLA, CC, MKI); Department of Pharmacology, National University of Singapore (SH, XX, SLA, CC, MKI); Saw Swee Hock School of Public Health, National University of Singapore (CST); Raffles Neuroscience Centre, Raffles Hospital, Singapore (NV); Departments of Radiology and Medical Informatics, Erasmus University Medical Center, Rotterdam (WJN, HV); Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands (WJN); Singapore Eye Research Institute, Singapore National Eye Center, Singapore (TYW, MKI); Academic Medicine Research Institute, Duke-NUS Graduate Medical School, Singapore (TYW, MKI); Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands (MKI).

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http://dx.doi.org/10.1097/MD.0000000000000852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616471PMC
June 2015

Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2.

Authors:
Nick Orr Frank Dudbridge Nicola Dryden Sarah Maguire Daniela Novo Eleni Perrakis Nichola Johnson Maya Ghoussaini John L Hopper Melissa C Southey Carmel Apicella Jennifer Stone Marjanka K Schmidt Annegien Broeks Laura J Van't Veer Frans B Hogervorst Peter A Fasching Lothar Haeberle Arif B Ekici Matthias W Beckmann Lorna Gibson Zoe Aitken Helen Warren Elinor Sawyer Ian Tomlinson Michael J Kerin Nicola Miller Barbara Burwinkel Frederik Marme Andreas Schneeweiss Chistof Sohn Pascal Guénel Thérèse Truong Emilie Cordina-Duverger Marie Sanchez Stig E Bojesen Børge G Nordestgaard Sune F Nielsen Henrik Flyger Javier Benitez Maria Pilar Zamora Jose Ignacio Arias Perez Primitiva Menéndez Hoda Anton-Culver Susan L Neuhausen Hermann Brenner Aida Karina Dieffenbach Volker Arndt Christa Stegmaier Ute Hamann Hiltrud Brauch Christina Justenhoven Thomas Brüning Yon-Dschun Ko Heli Nevanlinna Kristiina Aittomäki Carl Blomqvist Sofia Khan Natalia Bogdanova Thilo Dörk Annika Lindblom Sara Margolin Arto Mannermaa Vesa Kataja Veli-Matti Kosma Jaana M Hartikainen Georgia Chenevix-Trench Jonathan Beesley Diether Lambrechts Matthieu Moisse Guiseppe Floris Benoit Beuselinck Jenny Chang-Claude Anja Rudolph Petra Seibold Dieter Flesch-Janys Paolo Radice Paolo Peterlongo Bernard Peissel Valeria Pensotti Fergus J Couch Janet E Olson Seth Slettedahl Celine Vachon Graham G Giles Roger L Milne Catriona McLean Christopher A Haiman Brian E Henderson Fredrick Schumacher Loic Le Marchand Jacques Simard Mark S Goldberg France Labrèche Martine Dumont Vessela Kristensen Grethe Grenaker Alnæs Silje Nord Anne-Lise Borresen-Dale Wei Zheng Sandra Deming-Halverson Martha Shrubsole Jirong Long Robert Winqvist Katri Pylkäs Arja Jukkola-Vuorinen Mervi Grip Irene L Andrulis Julia A Knight Gord Glendon Sandrine Tchatchou Peter Devilee Robertus A E M Tollenaar Caroline M Seynaeve Christi J Van Asperen Montserrat Garcia-Closas Jonine Figueroa Stephen J Chanock Jolanta Lissowska Kamila Czene Hatef Darabi Mikael Eriksson Daniel Klevebring Maartje J Hooning Antoinette Hollestelle Carolien H M van Deurzen Mieke Kriege Per Hall Jingmei Li Jianjun Liu Keith Humphreys Angela Cox Simon S Cross Malcolm W R Reed Paul D P Pharoah Alison M Dunning Mitul Shah Barbara J Perkins Anna Jakubowska Jan Lubinski Katarzyna Jaworska-Bieniek Katarzyna Durda Alan Ashworth Anthony Swerdlow Michael Jones Minouk J Schoemaker Alfons Meindl Rita K Schmutzler Curtis Olswold Susan Slager Amanda E Toland Drakoulis Yannoukakos Kenneth Muir Artitaya Lophatananon Sarah Stewart-Brown Pornthep Siriwanarangsan Keitaro Matsuo Hidema Ito Hiroji Iwata Junko Ishiguro Anna H Wu Chiu-Chen Tseng David Van Den Berg Daniel O Stram Soo Hwang Teo Cheng Har Yip Peter Kang Mohammad Kamran Ikram Xiao-Ou Shu Wei Lu Yu-Tang Gao Hui Cai Daehee Kang Ji-Yeob Choi Sue K Park Dong-Young Noh Mikael Hartman Hui Miao Wei Yen Lim Soo Chin Lee Suleeporn Sangrajrang Valerie Gaborieau Paul Brennan James Mckay Pei-Ei Wu Ming-Feng Hou Jyh-Cherng Yu Chen-Yang Shen William Blot Qiuyin Cai Lisa B Signorello Craig Luccarini Caroline Bayes Shahana Ahmed Mel Maranian Catherine S Healey Anna González-Neira Guillermo Pita M Rosario Alonso Nuria Álvarez Daniel Herrero Daniel C Tessier Daniel Vincent Francois Bacot David J Hunter Sara Lindstrom Joe Dennis Kyriaki Michailidou Manjeet K Bolla Douglas F Easton Isabel dos Santos Silva Olivia Fletcher Julian Peto

Hum Mol Genet 2015 May 4;24(10):2966-84. Epub 2015 Feb 4.

Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406292PMC
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Influence of maternal angiogenic factors during pregnancy on microvascular structure in school-age children.

Hypertension 2015 Apr 17;65(4):722-8. Epub 2015 Feb 17.

From the Generation R Study Group (O.G., V.W.V.J., J.F.F., R.G.), and Departments of Pediatrics (O.G., V.W.V.J., I.R., R.G.), Epidemiology (O.G., V.W.V.J., J.F.F., A.H., R.G.), Ophthalmology (M.K.I.), Obstetrics and Gynecology (E.A.P.S.), and Neonatology (I.R.), Erasmus MC, University Medical Center, Rotterdam, the Netherlands; Singapore Eye Research Institute and Duke-NUS Graduate Medical School, National University of Singapore, Singapore, Singapore (M.K.I.); and Memory Aging & Cognition Centre (MACC), National University of Health System, Singapore, Singapore (M.K.I.).

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Retinal microvasculature and cardiovascular health in childhood.

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The Generation R Study Group, Department of Pediatrics, Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, Netherlands;

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http://dx.doi.org/10.1542/peds.2014-3341DOI Listing
April 2015

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.

Hum Mol Genet 2015 Mar 26;24(6):1791-800. Epub 2014 Nov 26.

Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.

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Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium.

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National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive Suite 1200, Baltimore, MD, 21224, USA.

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Retinal neurodegeneration on optical coherence tomography and cerebral atrophy.

Neurosci Lett 2015 Jan 19;584:12-6. Epub 2014 Oct 19.

Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore; Memory, Aging and Cognition Center, National University Health System, Singapore, Singapore; Ophthalmology and Visual Science Academic Clinical Program, Duke-NUS Graduate Medical School, National University of Singapore, Singapore, Singapore; Academic Medicine Research Institute, Duke-NUS Graduate Medical School, Singapore, Singapore. Electronic address:

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Markers of cardiac dysfunction in cognitive impairment and dementia.

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Prevalence and risk factors for retinopathy in persons without diabetes: the Singapore Indian Eye Study.

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Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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Microvascular network alterations in retina of subjects with cerebral small vessel disease.

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Memory, Aging & Cognition Center, National University Health System, Singapore, Singapore; Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore; Office of Clinical Sciences, Duke-National University of Singapore Graduate Medical School, Singapore, Singapore. Electronic address:

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Retinal vascular caliber and age-related macular degeneration in an Indian population from Singapore.

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Singapore Eye Research Institute, Singapore National Eye Centre , Singapore .

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Retinal vascular fractals and cognitive impairment.

Dement Geriatr Cogn Dis Extra 2014 May 27;4(2):305-13. Epub 2014 Aug 27.

Department of Singapore Eye Research Institute, Singapore National Eye Center, Singapore ; Department of Memory, Aging and Cognition Center, National University Health System, Singapore ; Department of Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore.

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Association of silent lacunar infarct with brain atrophy and cognitive impairment.

J Neurol Neurosurg Psychiatry 2013 Nov 9;84(11):1219-25. Epub 2013 Aug 9.

Department of Bioengineering, National University of Singapore, , Singapore, Singapore.

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http://dx.doi.org/10.1136/jnnp-2013-305310DOI Listing
November 2013

Microvascular structure and network in the retina of patients with ischemic stroke.

Stroke 2013 Aug 28;44(8):2121-7. Epub 2013 May 28.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.

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Racial differences in retinal vessel geometric characteristics: a multiethnic study in healthy Asians.

Invest Ophthalmol Vis Sci 2013 May 1;54(5):3650-6. Epub 2013 May 1.

Singapore Eye Research Institute, Singapore.

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May 2013

Retinal pathology as biomarker for cognitive impairment and Alzheimer's disease.

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Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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http://dx.doi.org/10.1136/jnnp-2011-301628DOI Listing
September 2012

Translational Epidemiology in Ophthalmology: From Etiologic Research to Personalized Health Impact.

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