Mohammad Hojjat-Farsangi

Mohammad Hojjat-Farsangi

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Mohammad Hojjat-Farsangi

Mohammad Hojjat-Farsangi

Publications by authors named "Mohammad Hojjat-Farsangi"

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63Publications

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Silencing of IL-6 and STAT3 by siRNA loaded hyaluronate-N,N,N-trimethyl chitosan nanoparticles potently reduces cancer cell progression.

Int J Biol Macromol 2020 Apr 28;149:487-500. Epub 2020 Jan 28.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

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http://dx.doi.org/10.1016/j.ijbiomac.2020.01.273DOI Listing
April 2020

PD-L1/PD-1 axis as a potent therapeutic target in breast cancer.

Life Sci 2020 Apr 16;247:117437. Epub 2020 Feb 16.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

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http://dx.doi.org/10.1016/j.lfs.2020.117437DOI Listing
April 2020

Cancer associated fibroblasts as novel promising therapeutic targets in breast cancer.

Pathol Res Pract 2020 Mar 2:152915. Epub 2020 Mar 2.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

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http://dx.doi.org/10.1016/j.prp.2020.152915DOI Listing
March 2020

Nanomedicine for improvement of dendritic cell-based cancer immunotherapy.

Int Immunopharmacol 2020 Mar 31;83:106446. Epub 2020 Mar 31.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

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http://dx.doi.org/10.1016/j.intimp.2020.106446DOI Listing
March 2020

CDK1 in Breast Cancer: Implications for Theranostic Potential.

Anticancer Agents Med Chem 2020 02 3. Epub 2020 Feb 3.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

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http://dx.doi.org/10.2174/1871520620666200203125712DOI Listing
February 2020

E2 ubiquitin-conjugating enzymes in cancer: Implications for immunotherapeutic interventions.

Clin Chim Acta 2019 Nov 21;498:126-134. Epub 2019 Aug 21.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2019.08.020DOI Listing
November 2019

Prostaglandin E2 as a potent therapeutic target for treatment of colon cancer.

Prostaglandins Other Lipid Mediat 2019 10 15;144:106338. Epub 2019 May 15.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

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http://dx.doi.org/10.1016/j.prostaglandins.2019.106338DOI Listing
October 2019

Dimethyl fumarate: Regulatory effects on the immune system in the treatment of multiple sclerosis.

J Cell Physiol 2019 Jul 7;234(7):9943-9955. Epub 2018 Dec 7.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

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http://dx.doi.org/10.1002/jcp.27930DOI Listing
July 2019

Downregulation of A2AR by siRNA loaded PEG-chitosan-lactate nanoparticles restores the T cell mediated anti-tumor responses through blockage of PKA/CREB signaling pathway.

Int J Biol Macromol 2019 Jul 30;133:436-445. Epub 2019 Mar 30.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01418130193165
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http://dx.doi.org/10.1016/j.ijbiomac.2019.03.223DOI Listing
July 2019

Smac mimetics as novel promising modulators of apoptosis in the treatment of breast cancer.

J Cell Biochem 2019 06 3;120(6):9300-9314. Epub 2018 Dec 3.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

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http://doi.wiley.com/10.1002/jcb.28205
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http://dx.doi.org/10.1002/jcb.28205DOI Listing
June 2019

Promising immunotherapy: Highlighting cytokine-induced killer cells.

J Cell Biochem 2019 06 16;120(6):8863-8883. Epub 2018 Dec 16.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28250
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http://dx.doi.org/10.1002/jcb.28250DOI Listing
June 2019

Metabolic syndrome mediates proinflammatory responses of inflammatory cells in preeclampsia.

Am J Reprod Immunol 2019 03 5;81(3):e13086. Epub 2019 Feb 5.

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

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http://dx.doi.org/10.1111/aji.13086DOI Listing
March 2019

CD73 as a potential opportunity for cancer immunotherapy.

Expert Opin Ther Targets 2019 02 26;23(2):127-142. Epub 2018 Dec 26.

i Drug Applied Research Center , Tabriz University of Medical Sciences , Tabriz , Iran.

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http://dx.doi.org/10.1080/14728222.2019.1559829DOI Listing
February 2019

Polymorphism of Foxp3 gene affects the frequency of regulatory T cells and disease activity in patients with rheumatoid arthritis in Iranian population.

Immunol Lett 2018 12 4;204:16-22. Epub 2018 Oct 4.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01652478183024
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http://dx.doi.org/10.1016/j.imlet.2018.10.001DOI Listing
December 2018

The significant role of interleukin-6 and its signaling pathway in the immunopathogenesis and treatment of breast cancer.

Biomed Pharmacother 2018 Dec 6;108:1415-1424. Epub 2018 Oct 6.

Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183511
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http://dx.doi.org/10.1016/j.biopha.2018.09.177DOI Listing
December 2018

Adenosine and adenosine receptors in the immunopathogenesis and treatment of cancer.

J Cell Physiol 2018 Mar 3;233(3):2032-2057. Epub 2017 May 3.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

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http://dx.doi.org/10.1002/jcp.25873DOI Listing
March 2018

Nanoparticles and targeted drug delivery in cancer therapy.

Immunol Lett 2017 10 29;190:64-83. Epub 2017 Jul 29.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

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http://dx.doi.org/10.1016/j.imlet.2017.07.015DOI Listing
October 2017

Targeting Receptor Tyrosine Kinases Using Monoclonal Antibodies: The Most Specific Tools for Targeted-Based Cancer Therapy.

Curr Drug Targets 2016 ;17(14):1687-1703

Department of Oncology- Pathology, Cancer Center Karolinska (CCK), Karolinska University Hospital, Solna, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.2174/1389450116666151001104133DOI Listing
August 2017

Recent advances in targeting mTOR signaling pathway using small molecule inhibitors.

J Drug Target 2017 03 3;25(3):189-201. Epub 2016 Oct 3.

b Department of Oncology-Pathology, Immune and Gene therapy Lab , Cancer Center Karolinska (CCK), Karolinska University Hospital Solna and Karolinska Institute , Stockholm , Sweden.

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https://www.tandfonline.com/doi/full/10.1080/1061186X.2016.1
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http://dx.doi.org/10.1080/1061186X.2016.1236112DOI Listing
March 2017

Ibrutinib-A double-edge sword in cancer and autoimmune disorders.

J Drug Target 2016 11;24(5):373-85. Epub 2015 Sep 11.

b Department of Oncology-Pathology, Immune and Gene therapy Lab , Cancer Center Karolinska (CCK), Karolinska University Hospital Solna and Karolinska Institute , Stockholm , Sweden .

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http://dx.doi.org/10.3109/1061186X.2015.1086357DOI Listing
December 2016

Targeting non-receptor tyrosine kinases using small molecule inhibitors: an overview of recent advances.

J Drug Target 2016 27;24(3):192-211. Epub 2015 Jul 27.

a Department of Oncology-Pathology, Immune and Gene Therapy Lab , Cancer Center Karolinska (CCK), Karolinska University Hospital Solna and Karolinska Institute , Stockholm , Sweden and.

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http://dx.doi.org/10.3109/1061186X.2015.1068319DOI Listing
October 2016

Application of nanomedicine for crossing the blood-brain barrier: Theranostic opportunities in multiple sclerosis.

J Immunotoxicol 2016 09 14;13(5):603-19. Epub 2016 Jul 14.

g Immunology Research Center, Tabriz University of Medical Sciences , Tabriz , Iran ;

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http://dx.doi.org/10.3109/1547691X.2016.1159264DOI Listing
September 2016

Whole Tumor Cell Vaccine Adjuvants: Comparing IL-12 to IL-2 and IL-15.

Iran J Immunol 2016 Sep;13(3):148-66

Department of Immunology, Dezful University of Medical Sciences, Dezful, Iran.

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http://dx.doi.org/IJIv13i3A1DOI Listing
September 2016

Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia.

Tumour Biol 2016 Sep 16;37(9):11947-11957. Epub 2016 Apr 16.

Department of Oncology-Pathology, Immune and Gene Therapy Lab, Cancer Center Karolinska (CCK), Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s13277-016-5039-5DOI Listing
September 2016

Mechanisms of tumor cell resistance to the current targeted-therapy agents.

Tumour Biol 2016 Aug 7;37(8):10021-39. Epub 2016 May 7.

Department of Oncology-Pathology, Immune and Gene therapy Lab, Cancer Center Karolinska (CCK), Karolinska University Hospital Solna and Karolinska Institutet, SE-171 76, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s13277-016-5059-1DOI Listing
August 2016

The skewed balance between Tregs and Th17 in chronic lymphocytic leukemia.

Future Oncol 2015 ;11(10):1567-82

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

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http://dx.doi.org/10.2217/fon.14.298DOI Listing
February 2016

Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy.

Tumour Biol 2015 Aug 5;36(8):5727-42. Epub 2015 Jul 5.

Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

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http://dx.doi.org/10.1007/s13277-015-3706-6DOI Listing
August 2015

The PI3K/AKT/mTOR pathway is involved in direct apoptosis of CLL cells induced by ROR1 monoclonal antibodies.

Br J Haematol 2015 May 19;169(3):455-8. Epub 2014 Nov 19.

Department of Oncology-Pathology, Immune and Gene Therapy Lab, CCK, Karolinska Institute and Karolinska University Hospital Solna, Stockholm, Sweden.

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http://dx.doi.org/10.1111/bjh.13228DOI Listing
May 2015

The tyrosine kinase receptor ROR1 is constitutively phosphorylated in chronic lymphocytic leukemia (CLL) cells.

PLoS One 2013 24;8(10):e78339. Epub 2013 Oct 24.

Department of Oncology-Pathology, Immune and Gene therapy Lab, Cancer Center Karolinska (CCK), Karolinska University Hospital Solna and Karolinska Institute, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078339PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813472PMC
February 2015

Novel and emerging targeted-based cancer therapy agents and methods.

Tumour Biol 2015 Feb 9;36(2):543-56. Epub 2015 Feb 9.

Department of Oncology-Pathology, Immune and Gene therapy Lab, Cancer Center Karolinska (CCK), Karolinska University Hospital Solna and Karolinska Institute, SE-171 76, Stockholm, Sweden,

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http://dx.doi.org/10.1007/s13277-015-3184-xDOI Listing
February 2015

The receptor tyrosine kinase ROR1--an oncofetal antigen for targeted cancer therapy.

Semin Cancer Biol 2014 Dec 25;29:21-31. Epub 2014 Jul 25.

Department of Oncology-Pathology, Immune and Gene Therapy Lab, Cancer Center Karolinska (CCK), Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2014.07.005DOI Listing
December 2014

Ligation of human Fc receptor like-2 by monoclonal antibodies down-regulates B-cell receptor-mediated signalling.

Immunology 2014 Nov;143(3):341-53

Monoclonal Antibody Research Centre, Avicenna Research Institute, ACECR, Tehran, Iran; Department of Immunology, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.

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http://doi.wiley.com/10.1111/imm.12311
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http://dx.doi.org/10.1111/imm.12311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212948PMC
November 2014

Small-molecule inhibitors of the receptor tyrosine kinases: promising tools for targeted cancer therapies.

Int J Mol Sci 2014 Aug 8;15(8):13768-801. Epub 2014 Aug 8.

Department of Oncology-Pathology, Immune and Gene Therapy Lab, Cancer Center Karolinska (CCK), Karolinska University Hospital Solna and Karolinska Institute, Stockholm 17176, Sweden.

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http://www.mdpi.com/1422-0067/15/8/13768
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http://dx.doi.org/10.3390/ijms150813768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159824PMC
August 2014

Inhibition of the receptor tyrosine kinase ROR1 by anti-ROR1 monoclonal antibodies and siRNA induced apoptosis of melanoma cells.

PLoS One 2013 8;8(4):e61167. Epub 2013 Apr 8.

Department of Oncology-Pathology, Immune and Gene therapy Lab, Cancer Center Karolinska, Karolinska University Hospital Solna and Karolinska Institute, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061167PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620154PMC
November 2013

Telomere length and expression of human telomerase reverse transcriptase splice variants in chronic lymphocytic leukemia.

Exp Hematol 2013 Jul 30;41(7):615-26. Epub 2013 Mar 30.

Immune and Gene Therapy Laboratory, Department of Oncology and Pathology, Cancer Centre Karolinska, Karolinska Institutet, Stockholm, Sweden.

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https://linkinghub.elsevier.com/retrieve/pii/S0301472X130012
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http://dx.doi.org/10.1016/j.exphem.2013.03.008DOI Listing
July 2013

Orphan receptor tyrosine kinases ROR1 and ROR2 in hematological malignancies.

Leuk Lymphoma 2013 Apr 9;54(4):843-50. Epub 2012 Oct 9.

Immune and Gene Therapy Laboratory, Cancer Center Karolinska, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.3109/10428194.2012.731599DOI Listing
April 2013

T cells from indolent CLL patients prevent apoptosis of leukemic B cells in vitro and have altered gene expression profile.

Cancer Immunol Immunother 2013 Jan 27;62(1):51-63. Epub 2012 Jun 27.

Institute of Cancer, Barts and The London School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, UK.

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http://dx.doi.org/10.1007/s00262-012-1300-yDOI Listing
January 2013

Induction of IgM, IgA and IgE antibodies in colorectal cancer patients vaccinated with a recombinant CEA protein.

J Clin Immunol 2012 Aug 2;32(4):855-65. Epub 2012 Mar 2.

Department of Oncology and CancerCentreKarolinska at the Karolinska Institute, Karolinska University Hospital Solna, SE-171 76, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s10875-012-9662-7DOI Listing
August 2012

Immunoglobulin heavy chain variable region gene usage and mutational status of the leukemic B cells in Iranian patients with chronic lymphocytic leukemia.

Cancer Sci 2009 Dec 2;100(12):2346-53. Epub 2009 Sep 2.

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1111/j.1349-7006.2009.01341.xDOI Listing
December 2009

Variation in WNT genes expression in different subtypes of chronic lymphocytic leukemia.

Leuk Lymphoma 2009 Dec;50(12):2061-70

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.3109/10428190903331082DOI Listing
December 2009

Human leukocyte antigen class II allele association to disease progression in Iranian patients with chronic lymphocytic leukemia.

Hum Immunol 2008 Oct 21;69(10):666-74. Epub 2008 Aug 21.

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1016/j.humimm.2008.07.015DOI Listing
October 2008