Publications by authors named "Mohammad Ghanbari Ghozikali"

13 Publications

  • Page 1 of 1

Associations between short term exposure to ambient particulate matter from dust storm and anthropogenic sources and inflammatory biomarkers in healthy young adults.

Sci Total Environ 2021 Mar 14;761:144503. Epub 2020 Dec 14.

Center for Air Pollution Research (CAPR), Institute for Environmental Research (IER), Tehran University of Medical Sciences, Tehran, Iran; Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

This study examined the association between particulate matter from anthropogenic and natural sources and inflammatory biomarkers, including hs-CRP, IL-6, sTNF-RII, and WBCs, in two groups of healthy young subjects. We followed up subjects of two panels (16 to 22 years old), including 22 subjects selected from the urban area (Tehran city) with high-level pollution background and 22 subjects selected from the rural area (Ahmadabad) with low-level pollution background. In each group, we collected 4 times blood samples in various air pollution conditions, In the subjects of the urban group, there was a substantial difference (p < 0.05) between inversion days and cold season control days, and between dust storm days and warm season control days for concentrations of hs-CRP, IL-6, and WBCs biomarkers. In the subjects of the rural group, a significant difference could be detected in the concentration of hs-CRP, IL-6, and WBCs biomarkers (p < 0.05) between inversion days and cold season control days, and between dust storm and warm control days. We found that the difference in concentrations of hs-CRP, IL-6, and WBCs biomarkers between dust storm days and warm control conditions in the rural group were higher than the difference in inversion and cold control conditions, which can be attributed to low background air pollution in the rural area. In the urban area, the health effect of anthropogenic sources of PM is higher than the dust storm condition, which can be attributed to the stronger effect of anthropogenic pollution effect.
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http://dx.doi.org/10.1016/j.scitotenv.2020.144503DOI Listing
March 2021

The acute effects of short term exposure to particulate matter from natural and anthropogenic sources on inflammation and coagulation markers in healthy young adults.

Sci Total Environ 2020 Sep 15;735:139417. Epub 2020 May 15.

Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Center for Solid Waste Research, Institute for Environmental Research, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Airborne particulate matter is associated with increasing the risk of cardiovascular diseases. The purpose of this study was to investigate the association between air pollution conditions and MDA, vWF, and fibrinogen markers in the blood of two panels of healthy young individuals in an urban area in Tehran city with a high air pollution background and another group was living in a rural area (Ahmad Abad Mostofi), with a low air pollution background. In each group, 4 blood samples were taken as follows: one in inversion days, the second in winter, but during the existence of normal condition in terms of air pollution, the third sample in the spring during the normal condition in terms of air pollution and the fourth sample during the dust storm conditions. In the urban and rural groups, there was a significant difference between the concentration of MDA, vWF, fibrinogen between inversion and cold season control conditions, and between dust storm conditions and warm season control conditions (p < 0.05). The results showed that the association of dust storm condition on the measured biomarkers was stronger than the inversion condition, which health consideration in the dust conditions be taken into account similar to the inversion conditions.
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http://dx.doi.org/10.1016/j.scitotenv.2020.139417DOI Listing
September 2020

Proinflammatory effects of dust storm and thermal inversion particulate matter (PM) on human peripheral blood mononuclear cells (PBMCs) in vitro: a comparative approach and analysis.

J Environ Health Sci Eng 2019 Jun 18;17(1):433-444. Epub 2019 Apr 18.

1Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Particulate matter (PM) as the carcinogenic air pollutants can lead to aggravated health outcomes. Epidemiological studies demonstrated that PM can be engaged in different diseases such as cardiovascular, respiratory and cancer. The in vitro secretion of proinflammatory cytokines by human peripheral blood mononuclear cells (PBMCs) has been used to assess the effects of PM with an aerodynamic diameter < 10 μm (PM). This study compared the proinflammatory cytokines tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), and interleukin 1-beta (IL1-β) secretions of PBMCs exposed to PM of dust storm and inversion. We collected PM samples during the spring and autumn seasons in two locations. Isolated PBMCs were exposed separately to 50, 150, and 300 μg/ml of different type of PM for 4 and 24 h. The mean concentrations of TNF-α for the PM of dust storm and inversion were 6305.61 ± 2421 and 6651.74 ± 2820, respectively. Also the mean concentrations of IL1-β for the PM of dust storm and inversion were 556.86 ± 162 and 656.35 ± 196, respectively. Furthermore, these values for the production of IL-6 were 12,655 ± 5661 and 16,685 ± 8069, respectively. Although no significant difference was observed between the PM of dust storm and that of inversion with regard to PBMCs, the results showed a significant increase in the proinflammatory cytokine secretion of both PMs compared with the controls. Moreover, TNF-α, IL1-β, and IL-6 secreted in cells exposed to PM of dust storm were about 10 times more than the controls, these values for cells exposed to PM of inversion were around 10, 12, and 14 times more than the controls, respectively. It can be concluded that the PM of both dust storm and inversion can play a significant role in proinflammatory cytokine secretion due to its harmful effect on human health. Graphical abstractThis picture shows the Proinflammatory cytokine producing potential of PM with two sources (dust storm and urban air pollution) in exposure with human PBMCs in vitro.
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http://dx.doi.org/10.1007/s40201-019-00362-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582270PMC
June 2019

Physiochemical characteristics and oxidative potential of ambient air particulate matter (PM) during dust and non-dust storm events: a case study in Tehran, Iran.

J Environ Health Sci Eng 2018 Dec 29;16(2):147-158. Epub 2018 Jun 29.

7Health and Environment Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

In the present study, we investigated the characteristics of metal(loid)s, polycyclic aromatic hydrocarbons (PAHs) and oxidative potential (OP) in PM during dust and non-dust days in a rural and an urban area in Tehran. Water-soluble ions, metal(loid)s, PAHs, and OP were measured using ion chromatography (IC), inductively coupled plasma optical emission spectrometer (ICP-OES) and gas chromatography/mass spectrometry (GC-MS), and dithiothreitol (DTT) assay respectively. The results showed that the average concentrations of ambient PM were 284 ± 90.4 and 123 ± 31.4 μg m on dusty and regular days in urban areas respectively, and were 258 ± 48.3 and 124 ± 41.4 μg m on dusty and regular days in rural areas, respectively; these values were 95% above the World Health Organization (WHO) guideline level. The crustal elements Na, Mg, Ca, Al, Si, Fe and Ti were the dominant for PM on dusty days, and NO and SO were dominant for PM on regular days. The average ± SD concentrations of total PAHs were 34.3 ± 22.5 and 55.1 ± 28.3 ng m on dusty and regular days, respectively, with the maximum value occurring on inversion days. The average OP was 8.90 ± 7.15 and 1.41 ± 0.35 and was 11.4 ± 3.97 and 19.9 ± 8.67 (nmol min μg PM ) for water and methanol extracts on dusty and regular days, respectively, with the lowest value occurring on dusty days. The OP was highly associated with Cu and Mn. Briefly; the results of this study demonstrate that OP is mass independent and consequence a promising proxy for PM mass.
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http://dx.doi.org/10.1007/s40201-018-0303-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277329PMC
December 2018

Correction to: Investigation and Comparison of In Vitro Genotoxic Potency of PM Collected in Rural and Urban Sites at Tehran in Different Metrological Conditions and Different Seasons.

Biol Trace Elem Res 2019 05;189(1):311

Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

The original version of this article unfortunately contained a mistake. Figure 6 caption should be "The light microscopic image (a) and transmission electron microscopic image (b) of A549 cell after 24 h of exposure to PM10 (150 μg/ml).
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http://dx.doi.org/10.1007/s12011-018-1487-7DOI Listing
May 2019

On the chemical nature of precipitation in a populated Middle Eastern Region (Ahvaz, Iran) with diverse sources.

Ecotoxicol Environ Saf 2018 Nov 1;163:558-566. Epub 2018 Aug 1.

Health and Environment Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

This study reports on the chemical composition of rainwater collected at three ground sites with varying degrees of pollution in Ahvaz, Iran, between January 2014 and February 2015. A total of 24 rainwater samples were analyzed for pH and concentrations of trace elements (Fe, Al, Pb, and Cd) and major ions (Na, NH, Ca, Mg, HCO, NO, Cl and SO). Principle Component Analysis (PCA) was used to identify sources of the measured species. The equivalent concentration of the components followed the order of Ca > SO > HCO > NH > Cl > Na > NO > Mg. The average pH of the rainwater samples was 6, and only three events exhibited acidic conditions below a pH of 5.6. The lowest and the highest average pH values were observed in the high traffic area (5.96) and industrial area (6.54), respectively. The highest and lowest Ca levels were observed in the industrial and high traffic areas, respectively. Na, Mg, and SO exhibited their highest and lowest concentrations in the industrial and high traffic areas, respectively. 70.36% of the total variance was due to anthropogenic species (Ca, SO, Mg, NO, Cl), soil particles (Cl, Na, and HCO), and biomass burning (NH, pH). The results of this study show that local anthropogenic sources and Middle Eastern Dust (MED) storms affect the rainwater chemistry strongly, which the latter stems from the Arabian Peninsula, Kuwait, Iraq, and some parts of Iran.
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http://dx.doi.org/10.1016/j.ecoenv.2018.07.103DOI Listing
November 2018

Investigation and Comparison of In Vitro Genotoxic Potency of PM Collected in Rural and Urban Sites at Tehran in Different Metrological Conditions and Different Seasons.

Biol Trace Elem Res 2019 May 3;189(1):301-310. Epub 2018 Aug 3.

Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

The particulate matter has become a serious health problem in some large cities in the world. These particles are a complex mixture of chemical compounds which change based on location and time and, consequently, can cause different health-related effects. The exact mechanism of the effect of these particles is not yet known for certain. However, it seems that numerous mechanisms through the production of ROS and, eventually, DNA destruction, which are related to a wide range of diseases, are among the causes of particles' health-related effects. The present study is aimed to evaluate and compare the genotoxicity potential of particles collected in Tehran, Iran, in urban and rural regions during spring and autumn as well as dusty and inversion conditions. These effects were examined using the comet assay on human pulmonary epithelial cells (A549). Results showed that all the particles had the potential for genotoxicity at the concentration used in this study (75,150 and 300 μg/ml). Moreover, DNA destruction changed with season, site, and even dusty and inversion atmospheric conditions. These changes mostly belonged to urban particles. In general, urban particles in autumn and, specifically, on days with inversion had higher genotoxicity (p < 0.01). Difference was observed between dusty and regular days so that regular days were more potent (p < 0.05). A strong correlation was observed between the effects of most PAH compounds and other metals such as Cr, Co, Cd, Mn, As, and also SO, which were mostly the result of combustion in vehicle engines in urban regions. No difference was observed for rural particles at different conditions and seasons.
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http://dx.doi.org/10.1007/s12011-018-1469-9DOI Listing
May 2019

Short-term effects of particle size fractions on lung function of late adolescents.

Environ Sci Pollut Res Int 2018 Aug 23;25(22):21822-21832. Epub 2018 May 23.

Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Although ambient air pollution has been linked to reduced lung function in healthy students, longitudinal studies that compare the response of asthmatic and healthy adolescents are lacking. To evaluate lung function responses to short-term ambient air particulate matter (PM, PM, and PM) levels, we conducted a study on high school students aged 15-18 years. The aim of this study was to assess effects of acute exposure to ambient air particulate matter (PM) on lung function in healthy and asthmatic late adolescents. We examined associations of lung function indices and ambient PM levels in 23 asthmatic and 23 healthy students. Paired-samples T test was used to evaluate the association of exposure to airborne PM concentrations with lung function test results (FVC, FEV, FEV/FVC, and FEF). We observed negative impact of exposure to an increased concentration of ambient air PM, PM, and PM on lung function parameters of asthmatic and healthy late adolescents. These findings are consistent with other similar short-term studies which have confirmed the adverse effect of PM air pollution. These associations were stronger in asthmatic subjects compared with those in healthy ones. There are significant adverse effects of ambient air PM on pulmonary function of adolescents, especially asthmatics.
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http://dx.doi.org/10.1007/s11356-018-2264-zDOI Listing
August 2018

Prevalence of asthma and associated factors among male late adolescents in Tabriz, Iran.

Environ Sci Pollut Res Int 2018 Jan 8;25(3):2184-2193. Epub 2017 Nov 8.

Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Asthma is an important chronic disease all over the world. The aim of this study was to determine the prevalence of asthma in a population of male late adolescents and its association with some contributing risk factors in northwest of Iran. This cross-sectional study was carried out in selected high schools of Tabriz, Iran, in 2016. The asthma prevalence and patient background information were examined using a questionnaire that prepared by the ISAAC. One hundred forty-two out of 1134 subjects (12.4%) identified to have asthma, 23.3% had history of current wheeze, and 16.3% had wheezing in the previous year. Family history of asthma was present in 17.1% of the participants; prevalence of active smoking in the study subjects was 3.1%; 25.1% of all subjects had exposure to secondhand tobacco smoke and keeping pets at home was present in 9.1%. Excess weight (overweight and obesity) was positively associated with prevalence of asthma (p < 0.001). No statistically significant associations were observed between asthma and father's education level (p = 0.570), mother's education level (p = 0.584), type of birth subjects (p = 0.571), and time spent outdoors during a full day (p = 0.863). Our results suggest that family history of asthma and atopy, exposure to secondhand tobacco smoke, active smoking, amount of automobile traffic around subjects' home, and keeping pets at homes are important risk factors for asthma, while time spent outdoors, educations of parents, and delivery type (normal vaginal delivery vs. C-section) subjects are not. Therefore, decreased of exposure to some environmental risk factors could be effective to reduce rate of the prevalence of asthma and wheeze.
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http://dx.doi.org/10.1007/s11356-017-0553-6DOI Listing
January 2018

Evaluation of Chronic Obstructive Pulmonary Disease (COPD) attributed to atmospheric O3, NO2, and SO2 using Air Q Model (2011-2012 year).

Environ Res 2016 Jan 21;144(Pt A):99-105. Epub 2015 Nov 21.

Environmental and Food Hygiene Laboratories (LIAA), Department of Medical, Surgical Sciences and Advanced Technologies "G.F. Ingrassia", Hygiene and Public Health, University of Catania, Via S. Sofia 87, 95123 Catania, Italy.

Chronic obstructive pulmonary disease (COPD) is an important disease worldwide characterized by chronically poor airflow. The economic burden of COPD on any society can be enormous if not managed. We applied the approach proposed by the World Health Organization (WHO) using the AirQ2.2.3 software developed by the WHO European Center for Environment and Health on air pollutants in Tabriz (Iran) (2011-2012 year). A 1h average of concentrations of ozone (O3), daily average concentrations of nitrogen dioxide (NO2) and sulfur dioxide (SO2) were used to assess human exposure and health effect in terms of attributable proportion of the health outcome and annual number of excess cases of Hospital Admissions for COPD (HA COPD). The results of this study showed that 2% (95% CI: 0.8-3.1%) of HA COPD were attributed to O3 concentrations over 10 μg/m(3). In addition, 0.7 % (95% CI: 0.1-1.8%) and 0.5% (95% CI: 0-1%) of HA COPD were attributed to NO2 and SO2 concentrations over 10 μg/m(3) respectively. In this study, we have shown that O3, NO2 and SO2 have a significant impact on COPD hospitalization. Given these results the policy decisions are needed in order to reduce the chronic pulmonary diseases caused by air pollution and furthermore better quantification studies are recommended.
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http://dx.doi.org/10.1016/j.envres.2015.10.030DOI Listing
January 2016

Degradation and biodegradability improvement of the olive mill wastewater by peroxi-electrocoagulation/electrooxidation-electroflotation process with bipolar aluminum electrodes.

Environ Sci Pollut Res Int 2015 Apr 20;22(8):6288-97. Epub 2014 Nov 20.

Department of Environmental Health Engineering, Health Sciences Research Center, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran,

Olive mill wastewater is considered as one of the most polluting effluents of the food industry and constitutes a source of important environmental problems. In this study, the removal of pollutants (chemical oxygen demand (COD), biochemical oxygen demand (BOD5), polyphenols, turbidity, color, total suspended solids (TSS), and oil and grease) from olive oil mill processing wastewater by peroxi-electrocoagulation/electrooxidation-electroflotation process with bipolar aluminum electrodes was evaluated using a pilot continuous reactor. In the electrochemical unit, aluminum (Al), stainless steel, and RuO2/Ti plates were used. The effects of pH, hydrogen peroxide doses, current density, NaCl concentrations, and reaction times were studied. Under optimal conditions of pH 4, current density of 40 mA/m(2), 1000 mg/L H2O2, 1 g/L NaCl, and 30-min reaction time, the peroxi-electrochemical method yielded very effective removal of organic pollution from the olive mill wastewater diluted four times. The treatment process reduced COD by 96%, BOD5 by 93.6%, total, polyphenols by 94.4%, color by 91.4%, turbidity by 88.7, suspended solids by 97% and oil and grease by 97.1%. The biodegradability index (BOD5/COD) increased from 0.29 to 0.46. Therefore, the peroxi-electrocoagulation/electrooxidation-electroflotation process is considered as an effective and feasible process for pre-treating olive mill wastewater, making possible a post-treatment of the effluent in a biological system.
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http://dx.doi.org/10.1007/s11356-014-3832-5DOI Listing
April 2015

Effect of exposure to O₃ , NO₂, and SO₂ on chronic obstructive pulmonary disease hospitalizations in Tabriz, Iran.

Environ Sci Pollut Res Int 2015 Feb 13;22(4):2817-23. Epub 2014 Sep 13.

Environmental Health Department of East Azerbaijan Province Health Center, Tabriz University of Medical Sciences, Tabriz, Iran,

Air pollution in cities is a serious environmental problem especially in the developing countries. We examined the associations between gaseous pollutants and hospitalizations for chronic obstructive pulmonary diseases (COPD) among people living in Tabriz, a city in north western of Iran. We used the approach proposed by the World Health Organization (WHO) using the AirQ 2.2.3 software developed by the WHO European Center for Environment and Health, Bilthoven Division. To assess human exposure and health effect, data were used for ozone as a1h average; for nitrogen dioxide and sulfur dioxide as daily average concentrations. The association between air pollution and chronic obstructive pulmonary disease (COPD) was assessed using AirQ 2.2.3 model. The results of this study showed that 3 % (95 % CI 1.2-4.8 %) of HA COPD were attributed to O3 concentrations over 10 μg/m(3). Also, 0.9 % (95 % CI 0.1-2.2 %) and 0.4 % (95 % CI 0-1.1 %) of HA COPD were attributed to NO2 and SO2 concentrations over 10 μg/m(3), respectively. For every 10 μg/m(3) increase in O3, NO2, and SO2 concentrations, the risk of HA COPD increase to about 0.58, 0.38, and 0.44 %, respectively. We found significant positive associations between the levels of all air pollution and hospital admissions COPD. Otherwise, O3, NO2, and SO2 have a significant impact on COPD hospitalization.
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http://dx.doi.org/10.1007/s11356-014-3512-5DOI Listing
February 2015

Environmental health problems and indicators in tabriz, iran.

Health Promot Perspect 2013 30;3(1):113-23. Epub 2013 Jun 30.

Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Background: Environmental Health Indicators (EHIs) are the most important criteria for evaluation of efficiency and effectiveness of the activities of the health sector. The operations and situation of the health system can be analyzed through surveying the indicators and comparing them during different times. The present study aimed to study the EHIs of Tabriz, using the common environmental health processes and national EHIs of the Ministry of Health.

Method: The required information for determination of EHIs was collected from different sources, including mainly the Environmental Health Department of the Health Center of East Azerbaijan Province, Iran and other organizations.

Results: We found some important desirable and undesirable EHIs in Tabriz,including high percentage of households with access to safe and reliable drinking water, high safety in microbiological and chemical quality of drinking water, acceptable level of BOD5 and COD in the effluent of wastewater treatment plants (WTP), lack of complete municipal wastewater collection and treatment, relatively poor sanitation and health of food markets and public places, undesirable collection,transportation and disposal of municipal solid waste, low EHIs of some school classrooms, unacceptable disposal of medical waste in some hospitals, and finally high level of noise pollution in the city.

Conclusion: Considering the poor condition of some EHIs of Tabriz, implementing proper actions for promotion of the indicators especially development of municipal wastewater collection, improvement of solid waste management,environmental health of some schools and mosques, and finally the noise pollution level of the city is recommended.
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http://dx.doi.org/10.5681/hpp.2013.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963691PMC
April 2014
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