Publications by authors named "Mohammad Faizan"

16 Publications

  • Page 1 of 1

Zinc oxide nanoparticles alleviates the adverse effects of cadmium stress on Oryza sativa via modulation of the photosynthesis and antioxidant defense system.

Ecotoxicol Environ Saf 2021 Sep 9;220:112401. Epub 2021 Jun 9.

Department of Botany, S.P. College, Srinagar, Jammu and Kashmir, India. Electronic address:

Cadmium (Cd) is a trace element causing severe toxicity symptoms in plants, besides posing hazardous fitness issue due to its buildup in the human body through food chain. Nanoparticles (NPs) are recently employed as a novel strategy to directly ameliorate the Cd stress and acted as nano-fertilizers. The intend of the current study was to explore the effects of zinc oxide nanoparticles (ZnO-NPs; 50 mg/L) on plant growth, photosynthetic activity, elemental status and antioxidant activity in Oryza sativa (rice) under Cd (0.8 mM) stress. To this end, the rice plants are treated by Cd stress at 15 days after sowing (DAS), and the treatment was given directly into the soil. Supply of ZnO-NPs as foliar spray was given for five consecutive days from 30 to 35 DAS, and sampling was done at 45 DAS. However, rice plants supplemented with ZnO-NPs under the Cd toxicity revealed significantly increased shoot length (SL; 34.0%), root fresh weight (RFW; 30.0%), shoot dry weight (SDW; 23.07%), and root dry weight (RDW; 12.24%). Moreover, the ZnO-NPs supplement has also positive effects on photosynthesis related parameters, SPAD value (40%), chloroplast structure, and qualitatively high fluorescence observed by confocal microscopy even under Cd stress. ZnO-NPs also substantially prevented the increases of hydrogen peroxide (HO) and malondialdehyde (MDA) triggered by Cd. Physiological and biochemical analysis showed that ZnO-NPs increased enzymatic activities of superoxide dismutase (SOD; 59%), catalase (CAT; 52%), and proline (17%) that metabolize reactive oxygen species (ROS); these increases coincided with the changes observed in the HO and MDA accumulation after ZnO-NPs application. In conclusion, ZnO-NPs application to foliage has great efficiency to improve biomass, photosynthesis, protein, antioxidant enzymes activity, mineral nutrient contents and reducing Cd levels in rice. This can be attributed mainly from reduced oxidative damage resulted due to the ZnO-NPs application.
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http://dx.doi.org/10.1016/j.ecoenv.2021.112401DOI Listing
September 2021

Role of Strigolactones: Signalling and Crosstalk with Other Phytohormones.

Open Life Sci 2020 10;15:217-228. Epub 2020 Apr 10.

Plant Physiology Section, Department of Botany, Aligarh Muslim University, Aligarh 202 002, India.

Plant hormones play important roles in controlling how plants grow and develop. While metabolism provides the energy needed for plant survival, hormones regulate the pace of plant growth. Strigolactones (SLs) were recently defined as new phytohormones that regulate plant metabolism and, in turn, plant growth and development. This group of phytohormones is derived from carotenoids and has been implicated in a wide range of physiological functions including regulation of plant architecture (inhibition of bud outgrowth and shoot branching), photomorphogenesis, seed germination, nodulation, and physiological reactions to abiotic factors. SLs also induce hyphal branching in germinating spores of arbuscular mycorrhizal fungi (AMF), a process that is important for initiating the connection between host plant roots and AMF. This review outlines the physiological roles of SLs and discusses the significance of interactions between SLs and other phytohormones to plant metabolic responses.
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http://dx.doi.org/10.1515/biol-2020-0022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8114782PMC
April 2020

Zinc oxide nanoparticles and 24-epibrassinolide alleviates Cu toxicity in tomato by regulating ROS scavenging, stomatal movement and photosynthesis.

Ecotoxicol Environ Saf 2021 May 3;218:112293. Epub 2021 May 3.

Collaborative Innovation Center of Sustainable Forestry in Southern China, College of Forest Science, Nanjing Forestry University, Nanjing 210037, China. Electronic address:

Nanoparticles (NPs) have recently emerged as potential agents for plants to ameliorate abiotic stresses by acting as nano-fertilizers. In this regard, the influence of the zinc oxide nanoparticles (ZnO-NPs) on plant responses to copper (Cu) stress has been poorly understood. Hence, the present study was executed to explore the role of ZnO-NPs (foliar) and 24-epibrassinolide (EBL; root dipping) individually or in combined form in the resilience of tomato (Solanum lycopersicum) plant to Cu stress. Tomato seeds were sown to make the nursery; and at 20 days after sowing (DAS) the plantlets were submerged in 10 M of EBL solution for 2 h, and subsequently transplanted in the soil-filled earthen pots. Cu concentration (100 mg kg) was applied to the soil at 30 DAS, whereas at 35 DAS plants were sprinkled with double distilled water (DDW; control), 50 mg/L of Zinc (Zn) and 50 mg/L of ZnO-NPs; and plant performance were evaluated at 45 DAS. It was evident that Cu-stress reduced photosynthesis (17.3%), stomatal conductance (18.1%), plant height (19.7%), and nitrate reductase (NR) activity (19.2%), but increased malondialdehyde (MDA; 29.4%), superoxide radical (O; 22.3%) and hydrogen peroxide (HO; 26.2%) content in S. lycopersicum. Moreover, ZnO-NPs and/or EBL implemented via different modes improved photosynthetic activity, stomatal aperture, growth, cell viability and activity of antioxidant enzymes and proline that augmented resilience of tomato plants to Cu stress. These observations depicted that application of ZnO-NPs and EBL could be a useful approach to assist Cu confiscation and stress tolerance against Cu in tomato plants grown in Cu contaminated sites.
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http://dx.doi.org/10.1016/j.ecoenv.2021.112293DOI Listing
May 2021

Zinc oxide nanoparticles (ZnO-NPs) induce salt tolerance by improving the antioxidant system and photosynthetic machinery in tomato.

Plant Physiol Biochem 2021 Apr 5;161:122-130. Epub 2021 Feb 5.

Collaborative Innovation Centre of Sustainable Forestry in Southern China, College of Forest Science, Nanjing Forestry University, 159 Longpan Road, Nanjing, Jiangsu, 210037, China. Electronic address:

Zinc oxide nanoparticles (ZnO-NPs) has been demonstrated to positively regulate plant tolerance to multiple environmental stresses. However, till date little information has been gained regarding the role of ZnO-NPs in the salt stress regulation in plants. Hence, the objective of our study was to investigate the role of ZnO-NPs in the regulation of salt tolerance in tomato (Lycopersicon esculentum Mill.). In this regard, the tomato plants were subjected to salt stress by using NaCl (150 mM) at the time of transplantation [15 days after sowing (DAS)]. Foliar application of ZnO-NPs at different levels viz., 10, 50 and 100 mg/L in the presence/absence of NaCl (150 mM) was carried out at 25 DAS and sampling was done at 35 DAS. Results of our study revealed that foliar spray of ZnO-NPs significantly increased shoot length (SL) and root length (RL), biomass, leaf area, chlorophyll content and photosynthetic attributes of tomato plants in the presence/absence of salt stress. Besides, the application of ZnO-NPs mitigates the negative impacts of salt stress on tomato growth, and enhanced protein content and antioxidative enzyme activity such as peroxidase (POX), superoxide dismutase (SOD) and catalase (CAT) under salt stress. In conclusion, the ZnO-NPs plays an important role in the alleviation of NaCl toxicity in tomato plants. Hence, the ZnO-NPs can be used to boost the growth performance and mitigate the adverse effects caused by NaCl in tomato.
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http://dx.doi.org/10.1016/j.plaphy.2021.02.002DOI Listing
April 2021

Zinc oxide nanoparticles help to enhance plant growth and alleviate abiotic stress: A review.

Curr Protein Pept Sci 2020 Oct 16. Epub 2020 Oct 16.

Plant Physiology Lab Department of Botany, Faculty of Life Sciences, Aligarh Muslim University, Aligarh. India.

Abiotic stresses arising from atmosphere change belie plant growth and yield, leading to food reduction. The cultivation of a large number of crops in the contaminated environment is a main concern of environmentalists in the present time. To get food safety, a highly developed nanotechnology is a useful tool for promoting food production and assuring sustainability. Nanotechnology helps to better production in agriculture by promoting the efficiency of inputs and reducing relevant losses. This review examines the research performed in the past to show how zinc oxide nanoparticles (ZnO-NPs) are influencing the negative effects of abiotic stresses. Application of ZnO-NPs is one of the most effectual options for considerable enhancement of agricultural yield globally under stressful conditions. ZnO-NPs can transform the agricultural and food industry with the help of several innovative tools in reversing oxidative stress symptoms induced by abiotic stresses. In addition, the effect of ZnO-NPs on physiological, biochemical, and antioxidative activities in various plants have also been examined properly. This review summarizes the current understanding and the future possibilities of plant-ZnO-NPs research.
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http://dx.doi.org/10.2174/1389203721666201016144848DOI Listing
October 2020

Hand tremor suppression device for patients suffering from Parkinson's disease.

J Med Eng Technol 2020 May 23;44(4):190-197. Epub 2020 Jun 23.

Department of Mechanical Engineering, Z. H. College of Engineering and Technology, Aligarh Muslim University, Aligarh, India.

In this study, a wearable device is developed as a mechanical treatment to suppress hand tremors in people with Parkinson's disease (PwPD). The biodynamic modelling of the human hand was done by considering the hand as a primary mass-spring-damper system. Dual passive vibration absorbers have been designed to match the frequencies of tremors. The performance assessment of the device was performed using the temporal response of hand tremors. The results showed that the device reduced the amplitude of the angular movement of the wrist by 57.25%. The device fabricated in the form of a bracelet was easy to wear by PwPD when needed.
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http://dx.doi.org/10.1080/03091902.2020.1759708DOI Listing
May 2020

Association Between Solid Cooking Fuels and Respiratory Disease Across Socio-Demographic Groups in India.

J Health Pollut 2019 Sep 22;9(23):190911. Epub 2019 Aug 22.

School of Humanities and Social Sciences, Indian Institute of Technology Mandi, Kamand Campus, Himachal Pradesh, India.

Background: The use of solid fuels in household cooking contributes to indoor air pollution and is the cause of more than 4 million deaths around the world annually. Solid fuel use varies with the level of development and ranges from 0% in high-income countries to more than 80% in low- and middle-income countries. Three billion people (more than 40% of the global population) are still dependent on solid fuels like firewood, dung cakes, coal, wood and agricultural residues in these countries.

Objectives: The present study aims to analyze the association of certain respiratory diseases (tuberculosis (TB), acute upper respiratory infections (AURI), chronic obstructive pulmonary diseases (COPD), and bronchial asthma) with the use of solid fuels for cooking across sociodemographic groups in India.

Methods: The 71st round of the National Sample Survey, conducted in 2014, was used. In total, 54,985 inpatients who received medical treatment from any medical institution during the last 365 days preceding the survey and who reported various diseases, such as infections, cancers, blood diseases, cardiovascular diseases, and respiratory diseases were included in the analysis. Of these inpatients, 2513 participants who reported TB, AURI, COPD and bronchial asthma were considered the dependent variables in the study. The main variable was exposure to different types of fuels used as a primary source of energy for cooking. Multinomial logistic regression was used to explain associations.

Results: The results reveal a significant association between solid fuel use and respiratory diseases in India. Overall, more than 60% of the population uses firewood and cow dung as their primary source of energy for cooking and are at a higher risk of TB, COPD and bronchial asthma. In rural areas there is a high dependence on solid fuels (80.5%) and a higher risk of respiratory diseases compared to those residing in urban areas where people are less dependent on solid fuels (22%). Among different socio-demographic groups, the dependence on solid fuels is highest among Scheduled Tribes (87.42%), followed by Scheduled Castes (74.78%) and Other Backward Classes (OBCs) (a term used by the Indian government to categorize castes that face social or educational challenges) (64.47%). Scheduled Tribes have the highest risk of TB, followed by Scheduled Castes and OBCs, respectively.

Conclusions: Exposure to solid fuels for cooking increases the potential risk of TB, COPD and bronchial asthma. Access to clean and efficient fuels for cooking is essential to reduce the burden of respiratory disease. Measures are needed to increase the availability of clean fuels for households, especially among socially disadvantaged and marginalized groups, to reduce the burden of respiratory diseases in India.

Competing Interests: The authors declare no competing financial interests.
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http://dx.doi.org/10.5696/2156-9614-9.23.190911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711332PMC
September 2019

Nanoparticles: biosynthesis, translocation and role in plant metabolism.

IET Nanobiotechnol 2019 Jun;13(4):345-352

Plant Physiology and Biochemistry Section, Department of Botany, Aligarh Muslim University, Aligarh 202002, India.

Nanotechnology is an emerging field of science that applies particles between 1 and 100 nm in size for a range of practical uses. Nano-technological discoveries have opened novel applications in biotechnology and agriculture. Many reactions involving nanoparticles (NPs) are more efficient compared to those of their respective bulk materials. NPs obtained from plant material, denoted as biogenic or phytosynthesised NPs, are preferred over chemically synthesised NPs due to their low toxicity, rapid reactions and cost-effective production. NPs impart both positive and negative impacts on plant growth and development. NPs exhibit their unique actions as a function of their size, reactivity, surface area and concentration. An insight into NP biosynthesis and translocation within the plant system will shed some light on the roles and mechanisms of NP-mediated regulation of plant metabolism. This review is a step towards that goal.
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http://dx.doi.org/10.1049/iet-nbt.2018.5251DOI Listing
June 2019

Measuring the impact of household energy consumption on respiratory diseases in India.

Glob Health Res Policy 2019 18;4:10. Epub 2019 Apr 18.

School of Humanities and Social Sciences, Indian Institute of Technology Mandi, Kamand Campus, Himachal Pradesh 175075 India.

Background: Most households in developing countries like India are not able to afford to get the services of efficient energy for cooking and lighting. Therefore, they rely mostly on solid fuels (firewood, dung cakes, crop residue, coal/coke/lignite). Such fuels cause respiratory diseases like tuberculosis, asthma respiratory cancer. Hence, this study aims to estimate the association between different types of energy used and the prevalence of respiratory diseases in India where more than 50% of the population relies on solid fuels for cooking.

Methods: The study is based on 117,752 respondents who were diagnosed with various chronic diseases such as diabetes, chronic heart diseases, leprosy, chronic renal diseases, tuberculosis, asthma etc. from District Level Household Survey (DLHS-4) which was conducted in 2012-13. Individuals who were diagnosed with a chronic illness after a proper medical examination have been considered as a dependent variable. Exposure to the type of cooking fuel is the main exposure variable, which recognises the dependence on energy. Logistic regression has been utilized to understand the association between the use of solid fuels for cooking and the prevalence of respiratory diseases.

Results: The dependence on solid fuels is very high in rural areas (72.22%) as compared to urban areas (21.43%). Among different castes, the reliance on solid fuels for cooking is highest among Scheduled Castes (61.79%) and Scheduled Tribes (70.46%). Individuals living in households where crop residue and coal/lignite is used for cooking suffer from asthma/chronic respiratory failure in the higher proportion as compared to others. Results further revealed that the use of solid fuels for cooking has a strong association with respiratory diseases. Individuals living in households where solid fuels like firewood [OR: 1.27 (0.001); C.I.: 1.19-1.35], crop residue [OR: 1.33 (0.001); C.I.:1.19-1.48], and coal [OR: 1.60 (0.001); C.I.:1.32-1.93] are used as primary fuel for cooking are 17 to 60% more likely to suffer from respiratory diseases.

Conclusion: Use of solid fuels is associated with respiratory diseases like asthma, tuberculosis and cancer of the respiratory system. Assuming these associations are causal, therefore, about 17 to 60% of the respiratory diseases in India could be prevented by providing access to clean cooking fuel to the individuals.
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http://dx.doi.org/10.1186/s41256-019-0101-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472035PMC
April 2019

Nitric oxide-mediated integrative alterations in plant metabolism to confer abiotic stress tolerance, NO crosstalk with phytohormones and NO-mediated post translational modifications in modulating diverse plant stress.

Nitric Oxide 2018 02 21;73:22-38. Epub 2017 Dec 21.

Plant Physiology Section, Department of Botany, Aligarh Muslim University, Aligarh 202002, India. Electronic address:

Nitric oxide (NO) is a major signaling biomolecule associated with signal transduction in plants. The beneficial role of NO in plants, exposed to several abiotic stresses shifted our understanding as it being not only free radical, released from the toxic byproducts of oxidative metabolism but also helps in plant sustenance. An explosion of research in plant NO biology during the last two decades has revealed that NO is a key signal associated with plant growth, germination, photosynthesis, leaf senescence, pollen growth and reorientation. NO is beneficial as well as harmful to plants in a dose-dependent manner. Exogenous application of NO at lower concentrations promotes seed germination, hypocotyl elongation, pollen development, flowering and delays senescence but at higher concentrations it causes nitrosative damage to plants. However, this review concentrates on the beneficial impact of NO in lower concentrations in the plants and also highlights the NO crosstalk of NO with other plant hormones, such as auxins, gibberellins, abscisic acid, cytokinins, ethylene, salicylic acid and jasmonic acid, under diverse stresses. While concentrating on the multidimensional role of NO, an attempt has been made to cover the role of NO-mediated genes associated with plant developmental processes, metal uptake, and plant defense responses as well as stress-related genes. More recently, several NO-mediated post translational modifications, such as S-nitrosylation, N-end rule pathway operates under hypoxia and tyrosine nitration also occurs to modulate plant physiology.
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http://dx.doi.org/10.1016/j.niox.2017.12.005DOI Listing
February 2018

Role of sugars under abiotic stress.

Plant Physiol Biochem 2016 Dec 6;109:54-61. Epub 2016 Sep 6.

Plant Physiology and Biochemistry Section, Department of Botany, Aligarh Muslim University, Aligarh, 202002, India. Electronic address:

Sugars are the most important regulators that facilitate many physiological processes, such as photosynthesis, seed germination, flowering, senescence, and many more under various abiotic stresses. Exogenous application of sugars in low concentration promote seed germination, up regulates photosynthesis, promotes flowering, delayed senescence under various unfavorable environmental conditions. However, high concentration of sugars reverses all these physiological process in a concentration dependent manner. Thus, this review focuses the correlation between sugars and their protective functions in several physiological processes against various abiotic stresses. Keeping in mind the multifaceted role of sugars, an attempt has been made to cover the role of sugar-regulated genes associated with photosynthesis, seed germination and senescence. The concentration of sugars determines the expression of these sugar-regulated genes. This review also enlightens the interaction of sugars with several phytohormones, such as abscisic acid, ethylene, cytokinins and gibberellins and its effect on their biosynthesis under abiotic stress conditions.
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http://dx.doi.org/10.1016/j.plaphy.2016.09.005DOI Listing
December 2016

Atlantic salmon (Salmo salar L.) as a marine functional source of gamma-tocopherol.

Mar Drugs 2014 Dec 9;12(12):5944-59. Epub 2014 Dec 9.

Institute of Human Nutrition and Food Science, University of Kiel, Hermann-Rodewald-Straße 6-8, D-24118 Kiel, Germany.

Gamma tocopherol (gT) exhibits beneficial cardiovascular effects partly due to its anti-inflammatory activity. Important sources of gT are vegetable oils. However, little is known to what extent gT can be transferred into marine animal species such as Atlantic salmon by feeding. Therefore, in this study we have investigated the transfer of dietary gT into salmon. To this end, fish were fed a diet supplemented with 170 ppm gT for 16 weeks whereby alpha tocopherol levels were adjusted to 190 ppm in this and the control diet. Feeding gT-rich diets resulted in a three-fold increase in gT concentrations in the liver and fillet compared to non-gT-supplemented controls. Tissue alpha tocopherol levels were not decreased indicating no antagonistic interaction between gamma- and alpha tocopherol in salmon. The concentration of total omega 3 fatty acids slightly increased in response to dietary gT. Furthermore, dietary gT significantly decreased malondialdehyde in the fillet, determined as a biomarker of lipid peroxidation. In the liver of gT fed salmon we observed an overall down-regulation of genes involved in lipid homeostasis. Additionally, gT improved the antioxidant capacity by up-regulating Gpx4a gene expression in the pyloric caeca. We suggest that Atlantic salmon may provide a marine functional source capable of enriching gT for human consumption.
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http://dx.doi.org/10.3390/md12125944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278211PMC
December 2014

Management of Idiopathic Clubfoot by Ponseti Technique in Children Presenting After One Year of Age.

J Foot Ankle Surg 2015 Sep-Oct;54(5):967-72. Epub 2014 Aug 12.

Associate Professor, Department of Orthopaedic Surgery, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

We conducted a study to determine the effectiveness of the Ponseti technique in the management of idiopathic congenital clubfoot in patients older than 1 year of age. A total of 19 patients with 28 clubfeet (16 males [84.2%], 3 females [15.8%]) were included in the present study. The mean age at presentation was 2.7 (range 1 to 3.5) years. The results of treatment using the Ponseti technique were evaluated using the Pirani and Dimeglio scoring systems. The mean precorrection total Pirani score was 4.84 (range 3.5 to 5.5) and the mean precorrection Dimeglio score was 12.96 (range 10 to 14). The mean postcorrection total Pirani score was 0.55 (range 0 to 1), and the mean postcorrection Dimeglio score was 2.32 (range 2 to 3). These differences were statistically significant (p < .001 and p < .001, respectively). In 92.8% of the feet, satisfactory correction of the deformity was achieved. The mean number of casts applied was 8 (range 5 to 12). All but 1 (3.6%) of the clubfeet required tenotomy to achieve correction. The mean follow-up duration was 2.7 (range 1.5 to 3.5) years. We have concluded that the Ponseti technique is an effective method for the management of idiopathic congenital clubfoot, even in toddlers.
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http://dx.doi.org/10.1053/j.jfas.2014.05.009DOI Listing
May 2016

A fast and validated method for the determination of malondialdehyde in fish liver using high-performance liquid chromatography with a photodiode array detector.

J Food Sci 2014 Apr 12;79(4):C484-8. Epub 2014 Mar 12.

Inst. of Human Nutrition and Food Science, Christian-Albrechts-Univ. of Kiel, Hermann-Rodewald St. 6, 24118, Kiel, Germany.

Malondialdehyde (MDA) is a biomarker of lipid peroxidation and is present in foods and biological samples such as plasma. A high-performance liquid chromatography (HPLC) method was applied to determine MDA in fish liver samples after derivatization with 2,4-dinitrophenylhydrazine (DNPH) using a ODS2 column (10 cm × 4.6 mm, 3 μm) and a photodiode array detector. The mobile phase consisted of 0.2% acetic acid (v/v) in distilled water and acetonitrile (42:58, v/v). The present method was validated in terms of linearity, lower limit of quantification, lower limit of detection, precision, accuracy, recovery, and stability of MDA according to U.S. Food and Drug Administration (FDA) guidelines. The limit of quantification of MDA was 0.39 μmol/L, which is comparable to other methods. The recovery of the spiked MDA liver samples was in the range of 92.4% to 104.2%. This newly modified HPLC method is specific, sensitive, and accurate and allows the analysis of MDA within 4 min in fish liver but also in other tissues and plasma.
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http://dx.doi.org/10.1111/1750-3841.12412DOI Listing
April 2014

Dietary alpha-tocopherol affects tissue vitamin e and malondialdehyde levels but does not change antioxidant enzymes and fatty acid composition in farmed Atlantic salmon (Salmo salar L.).

Int J Vitam Nutr Res 2013 ;83(4):238-45

Institute of Human Nutrition and Food Science, University of Kiel, Germany.

In this study the effect of increasing dietary alpha tocopherol on vitamin E tissue concentrations, lipid peroxidation (malondialdehyde), antioxidant enzymes, and fatty acid composition has been investigated in farmed Atlantic salmon. To this end fish (initial body weight ~ 193 g, n = 70 per group) were fed diets based on fish oil (27.5 %), fish meal (15.0 %), wheat gluten (20.6 %), and soy protein concentrate (24.0 %) for 14 weeks. Diets were supplemented with 0 (negative control), 150, and 400 mg/kg vitamin E as all-rac alpha-tocopheryl acetate. Dietary vitamin E did not affect feed conversion efficiency ratio but significantly (p < 0.05) increased alpha-tocopherol concentrations in salmon plasma, liver, and fillet (n = 8 per group each). The increase in fillet alpha-tocopherol was accompanied by a considerable decrease (p < 0.01) in malondialdehyde concentrations at the higher supplementation level. Furthermore, we observed an antagonistic interaction between alpha- and gamma-tocopherol in plasma at the highest supplementation level, since high dietary alpha-tocopherol reduced plasma gamma-tocopherol concentrations. Liver antioxidant enzymes, including glutathione peroxidase and superoxide dismutase, remained largely unchanged in response to dietary alpha-tocopherol. Dietary alpha-tocopherol did not affect eicosapentaenoic acid and docosahexaenoic acid concentrations in salmon fillet. Present data suggest that alpha-tocopherol supplementations beyond dietary recommendations may further improve flesh quality and nutritional value of Atlantic salmon fillet as far as malondialdehyde and vitamin E concentrations are concerned.
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http://dx.doi.org/10.1024/0300-9831/a000166DOI Listing
August 2014

Outcome of complex tibial plateau fractures treated with external fixator.

Indian J Orthop 2012 Sep;46(5):570-4

Department of Orthopaedics, NKP Salve Institute of Medical Sciences and Research Centre, Nagpur, India.

Background: Tibial plateau fractures are usually associated with communition and soft tissue injury. Percutaneous treatment of these complex fractures is intended to reduce soft issue complications and postoperative stiffness of the knee joint. We assessed the complications, clinical outcome scores, and postoperative knee range of movements, after fluoroscopic assisted closed reduction and external fixator application.

Materials And Methods: Seventy eight complex tibial plateau fractures in 78 patients were included in the study. All fractures were managed with closed reduction and external fixator application. In 28 cases with intraarticular split, we used percutaneous cancellous screw fixation for reduction and fixation of condylar parts. In nine open fractures, immediate debridement was done. In 16 cases, elevation of depressed segment and bone grafting was required, which was done from a very small incision. All patients were clinically and radiographically evaluated at a mean followup of 26.16 months (range 6-60 months).

Results: Clinical results were evaluated according to the Rasmussen's criteria. Average healing time was 13.69 weeks (range 12- 28 weeks). Mean knee range of motion was 122.60° (range 110°-130°). Forty seven results were scored as excellent, 25 good, 2 fair, and 1 as poor.

Conclusion: We believe that minimally invasive treatment by percutaneous techniques and external fixation is a fairly reasonable treatment alternative, if near anatomical reduction of joint surface can be confirmed on fluoroscopy.
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http://dx.doi.org/10.4103/0019-5413.101041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491793PMC
September 2012