Dr. Mohammad Amin Hosseini, PhD - Shiraz University of Medical Sciences - Faculty member

Dr. Mohammad Amin Hosseini

PhD

Shiraz University of Medical Sciences

Faculty member

Shiraz, Fars | Iran (Islamic Republic of)

Main Specialties: Radiation Oncology, Radiology-Diagnostic

Additional Specialties: Medical Physics

ORCID logohttps://orcid.org/0000-0002-7645-0169


Top Author

Dr. Mohammad Amin Hosseini, PhD - Shiraz University of Medical Sciences - Faculty member

Dr. Mohammad Amin Hosseini

PhD

Introduction

Mohammad Amin (MA) Hosseini recievied his PhD degree in Medical Physics at University of Turin, Italy on 2014.The major topic of his thesis focused on the accuracy of Dose Delivery System at CNAO (the first Italian National Center for Oncological Hadrontherapy). He later became a faculty member at Shiraz University of Medical Science (SUMS) in Iran. Since joining to the SUMS, his research focus on three main topics: Hadrontherapy, research and development of medical radioisotoes, and Radiation Protection & Dosimetry against ionizing and non-ionizing radiation. He has presented over 60 papers in internationally recognized journals and conferences, and, in addition to teaching specialized courses, has supervised nearly 12 master’s theses in Medical Physics and Medical Radiation Engineering. He also acts as a peer reviewer for several journals (see: https://publons.com/researcher/1244774/mohammad-amin-hosseini/ ).

Primary Affiliation: Shiraz University of Medical Sciences - Shiraz, Fars , Iran (Islamic Republic of)

Specialties:

Additional Specialties:

Research Interests:


View Dr. Mohammad Amin Hosseini’s Resume / CV

Education

Jan 2011 - Jan 2014
Universita degli Studi di Torino Scuola di Scienze della Natura
PhD
Medical Physics

Experience

May 2017
IRCT2017041233398N1, Approved clinical trials
Responsible person
The impact of Wi-Fi waves on reaction time, reasoning and short-term memory among young students of medical science university in Shiraz city
Aug 2014 - Sep 2014
Shiraz University of Medical Sciences
Faculty member
Ionizing and Non-ionizing Radiation Protection Research Center (INIRPRC)
Jan 2011
Full PhD grant
PhD student
Full PhD grant from University of Torino,Italy

Publications

22Publications

596Reads

70Profile Views

52PubMed Central Citations

EVALUATING SHORT-TERM EXPOSURE TO WI-FI SIGNALS ON STUDENTS' REACTION TIME, SHORT-TERM MEMORY AND REASONING ABILITY.

Radiat Prot Dosimetry 2019 Jun 28. Epub 2019 Jun 28.

Department of Radiology, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

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http://dx.doi.org/10.1093/rpd/ncz162DOI Listing
June 2019
109 Reads
0.913 Impact Factor

AN ASSESSMENT OF RADIATION EXPOSURE DOSES IN PATIENTS UNDERGOING PRIMARY PERCUTANEOUS CORONARY INTERVENTION BASED ON ANGIOGRAPHIC RECORDS.

Radiat Prot Dosimetry 2019 Jun;183(4):474-481

Ionizing and Non-Ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran.

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https://academic.oup.com/rpd/advance-article/doi/10.1093/rpd
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http://dx.doi.org/10.1093/rpd/ncy180DOI Listing
June 2019
46 Reads
0.913 Impact Factor

The characterization of gamma-irradiated carbon-nanostructured materials carried out using a multi-analytical approach including Raman spectroscopy

Applied Surface Science 488 (2019) 671–680

Applied Surface Science

In this experimental work, the comparative study of structural defects in gamma-irradiated carbon nanostructured materials (CNMs) including Graphene Nanoplate (GNP), Graphene Oxide (GO), Single-Walled Carbon Nanotube (SWCNT), Multi-Walled Carbon Nanotube (MWCNT), SWCNT-OH, and MWCNT-OH was investigated using Raman spectroscopy to obtain ID/IGparameter. All the samples were irradiated by 60Co in different absorbed doses of 0–100 kGy in air at ambient conditions. Also, XRD, FTIR, FESEM, and HRTEM analyses were used to characterize defects in the CNMs. FTIR analysis of GO confirmed the presence of CO, CO, and OH functional groups. Results of HRTEM analysis for GO at 30 and 50 kGy indicated bending and shrinkage of GO edges and creation of carbon onions. Raman spectroscopy of the all samples showed that there was a simultaneous competition between defect creation and graphitization in the CNMs depending on the absorbed dose and the kind of CNM; In which up to 10 kGy, due to breakage of symmetric order of the carbon atoms, the value of ID/IGwas increased, while graphitization of the carbon atoms at 100 kGy was the predominant effect, except for SWCNT. The minimum values of ID/IGparameter belonged to GO and MWCNT equaled 3.9% and 4% respectively.


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June 2019

Impact Factor 4.439

30 Reads

Reduced graphene oxide/polymethyl methacrylate (rGO/PMMA) nanocomposite for real time gamma radiation detection

Nuclear Inst. and Methods in Physics Research, A 940 (2019) 72–77

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

Novel 3 dimensional radiation sensors using reduced graphene oxide (rGO) nanoflakes in polymethyl methacrylate matrix as sensing material were synthesized and fabricated to measure the dose rate of gamma radiation. A detailed characterization of the prepared reduced graphene oxide using X-ray diffraction (XRD), thermal gravimetric analysis (TGA), atomic force microscopy (AFM), Field Emission scanning electron microscopy (FE-SEM), X-ray photoelectron spectroscopy (XPS), Fourier-transform infrared spectroscopy (FTIR) and High-resolution transmission electron microscopy (HRTEM) is presented. Reduced graphene oxide–polymethyl methacrylate composite was prepared using methylene chloride solvent-assisted dispersion of nano flakes of reduced graphene oxide in the polymer matrix. The gamma sensor mainly consists of polymethyl methacrylate/reduced graphene oxide (rGO/PMMA) nanocomposite as the sensing material and two silver coated glass electrodes to make a conductive cell. Real time dose rate information of the nanocomposite such as linearity response to dose rate and sensitivity are investigated. rGO/PMMA based gamma sensors show better performance at a standard bias voltage with respect to graphene oxide (GO) dosimeters. The response to dose rate is linear in the range of 50–130 mGy/min and the sensor array can be introduced for gamma radiation application dosimetry in diagnostic activities.

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June 2019

Impact Factor 1.336

41 Reads

68Ga@pyridine-functionalized MCM-41 mesoporous silica: a novel radio labeled composite for diagnostic applications

Radiochimica Acta. 2019 Feb 25;107(2):157-64.

Radiochimica Acta

Silica nanoparticles (SNPs) are known as intrinsic radiolabeling agents and offer a fast and reliable approach to deliver theranostic agents into targeted organs. Radiolabeled amorphous silica nanoparticles are of great interest to radiation oncology communities. In order to improve the performance of these nano materials in cancer diagnosis and treatment, their inherent properties, such as surface area and the ability to accumulate in cancer cells, should be enhanced. Pyridine functionalized mesoporous silica MCM-41 is known as a potential anticancer-drug delivery system with high suface area. In thiswork, in order to produce an image-guided drug delivery system for diagnostic applications, [68Ga] radionuclide was grafted on pyridine functionalized MCM-41. The nanoparticles were assessed with atomic force microscopy (AFM), paper chromatography, X-ray diffraction, FTIR spectroscopy, CHN and TGA/DTA analyses. The pharmacokinetic profile evaluation of the radiolabeled nano silica, [68Ga]-Py-Butyl@MCM-41, was done in Fibrosarcoma tumor-bearing mice. This labeled nanocomposite with appropriate blood circulation in body, high structural stability, high tumor/blood ID/g% ratio and fast excretion from the body can be proposed as an efficient nano engineered composite for upcoming tumor targeting/imaging nanotechnology-based applications.

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March 2019

Impact Factor 1.202

38 Reads

68Ga-5, 10, 15, 20-Tetrakis (2, 4, 6-trimethoxy phenyl) porphyrin: a novel radio-labeled porphyrin complex for positron emission tomography

J Radioanal Nucl Chem (2019) 320: 201. https://doi.org/10.1007/s10967-019-06465-1

Journal of Radioanalytical and Nuclear Chemistry

Porphyrins and 68Ga have emerged as novel synergic options for PET applications so the idea of preparation of a novel porphyrin complex using this nuclide was targeted. Herein, [68Ga(III)] labeled 5, 10, 15, 20-Tetrakis(2, 4, 6-trimethoxy phenyl) porphyrin ([68Ga(III)]-TTMPP) was developed in this work. The biodistribution of the [68Ga(III)]-TTMPP complex among vital organs of mice bearing Fibrosarcoma tumors was studied using scarification. Due to the short half-life of 68Ga, high tumor avidity and fast excretion of [68Ga(III)]-TTMPP complex, this labeled compound is demonstrated to be a potential bioprobe for positron emission tomography (PET) and photodynamic therapy (PDT).

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March 2019

Impact Factor 1.181

35 Reads

Blocking Short-Wavelength Component of the Visible Light Emitted by Smartphones' Screens Improves Human Sleep Quality.

J Biomed Phys Eng 2018 Dec 1;8(4):375-380. Epub 2018 Dec 1.

Ionizing and Non-Ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280115PMC
December 2018
58 Reads

Feasibility of Sm production using MNSR research reactor through a multi-stage approach.

Appl Radiat Isot 2018 Sep 21;139:195-200. Epub 2018 Apr 21.

Reactor Research and Nuclear Safety Department, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran.

The main objective of this study was to explore the feasibility of producing Sm radioisotope in miniature neutron source reactors (MNSRs) in Isfahan-Iran. As the first step of this study, the MNSR's geometry was created by using the MCNP6.2 simulation code and afterwards a validity check was performed by comparing the results with the experimental data. Then, by applying values obtained through simulation, the production process was followed up to 20 irradiation cycles using different irradiation and cooling periods (irradiation setups). The results showed that the proposed simulation technique has an acceptable agreement with the experiments (with a difference of nearly 6%). In spite of limitations, such as irradiation time and flux in such reactors, our results showed that by choosing the correct irradiation setup, it is possible to produces Sm up to 852.26?mCi?g in 20 successive irradiation cycles. However, after the 10th cycle, the production reached 90% of the maximum point. Nevertheless, the continuance of the irradiation process with a new target (by 10 plus 10 discrete irradiation) can double the total activity in comparison with 20 successive irradiation cycles, without any increase in the fuel consumption of the reactor. These findings increase the prospect of a large-scale production of the life-saving Sm radioisotope in MNSR reactors.

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http://dx.doi.org/10.1016/j.apradiso.2018.04.026DOI Listing
September 2018
26 Reads
1 Citation
1.056 Impact Factor

Does Exposure to Static Magnetic Fields Generated by Magnetic Resonance Imaging Scanners Raise Safety Problems for Personnel?

J Biomed Phys Eng 2018 Sep 1;8(3):333-336. Epub 2018 Sep 1.

MRI Department, Shahid Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169123PMC
September 2018
26 Reads

A Preliminary Study on the Estimation of the Number of Cancer Patients Eligible for Hadron Therapy in Iran and Fars Province.

Iran J Med Sci 2018 May;43(3):313-317

Ionizing and Non-Ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993909PMC
May 2018
95 Reads

The feasibility of 198Au production in Isfahan MNSR research reactor through a multi-stage approach

Journal of Radioanalytical and Nuclear Chemistry. 2018 May 1;316(2):435-41

Journal of Radioanalytical and Nuclear Chemistry

This study explored the feasibility to produce 198Au in the Isfahan miniature neutron source reactor (MNSR). To estimate production level, we used the MCNP simulation method, validated through empirical data. Role of different irradiation and cooling periods to maximize the produced yield was also studied. The results of our study showed that after 30 cycles, the maximum production was 812.3 mCi g−1 in the maximum flux and irradiation time. However, after the 15th cycle it reached its maximum production of 90% (740.3 mCi g−1). Also, the role of irradiation and cooling periods in the optimum fuel management was shown. Our results showed that producing 198Au is feasible in MNSRs.

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May 2018

2 Citations

Impact Factor 1.181

31 Reads

The Assessment of Mercury Released from Dental Amalgams after Exposure to Wi-Fi and X-Ray Radiation in Artificial saliva

Eurasian J Anal Chem 2018;13(2):em08

Eurasian Journal of Analytical Chemistry

Mercury is a well-known toxic element that is found in various forms in nature. Recently, dental amalgams have been recognized as a new source of mercury. This study was carried out under in vitro condition; the amount of mercury released from teeth restored with amalgams in the presence of Wi-Fi router radiation (non-ionizing radiation) and X-ray (ionizing radiation) using a protocol similar to Computed Tomography of Para-nasal Sinuses (CT) were analyzed separately, and in combination on the samples. For this reason, 50 human premolars were restored with a certain type of commercial amalgams. The samples were divided into five groups; control, only-CT, CT+ Wi-Fi, Wi-Fi+ CT and only-Wi-Fi groups, and mercury measurement were investigated at 24 and 48 hours after exposure to radiation by cold-vapor atomic absorption system. The results showed a significant difference between subgroups 24 and 48 h (p-values= 0.001 and 0.008). However, over time a significant difference was only found in CT+ Wi-Fi group (p-value= 0.043). In addition, in comparison with the control group, only the subgroup that was exposed to Wi-Fi waves showed a significant difference after 24 hours (p= 0.033). In line with some of the previous studies, our findings showed that electromagnetic waves are involved in mercury release process, and warnings about the consequences of electromagnetic waves on mercury release and subtitling it with a new compound in restorative dentistry should be taken into consideration.

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February 2018
51 Reads

The feasibility study of Lu production in Miniature Neutron Source Reactors using a multi-stage approach in Isfahan, Iran.

Appl Radiat Isot 2018 Jan 15;131:62-66. Epub 2017 Nov 15.

Reactor Research and Nuclear Safety Department, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran.

Miniature neutron source reactors (MNSRs) are among the safest and economic research reactors with potentials to be used for neutron studies. This manuscript explores the feasibility of Lu production in Isfahan MNSR reactor using direct production route. In this study, to assess the specific activity of the produced radioisotope, a simulation was carried out through the MCNPX2.6 code. The simulation was validated by irradiating a lutetium disc-like (99.98 chemical purity) at the thermal neutron flux of 5 × 10 ncms and an irradiation time of 4min. After the spectrometry of the irradiated sample, the experimental results of Lu production were compared with the simulation results. In addition, factor from the simulation was extracted by replacing it in the related equations in order to calculate specific activity through a multi-stage approach, and by using different irradiation techniques. The results showed that the simulation technique designed in this study is in agreement with the experimental approach (with a difference of approximately 3%). It was also found that the maximum Lu production at the maximum flux and irradiation time allows access to 723.5mCi/g after 27 cycles. Furthermore, the comparison of irradiation techniques showed that increasing the irradiation time is more effective in Lu production efficiency than increasing the number of irradiation cycles. In a way that increasing the irradiation time would postpone the saturation of the productions. On the other hand, it was shown that the choice of an appropriate irradiation technique for Lu production can be economically important in term of the effective fuel consumption in the reactor.

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https://linkinghub.elsevier.com/retrieve/pii/S09698043173096
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http://dx.doi.org/10.1016/j.apradiso.2017.11.019DOI Listing
January 2018
39 Reads
9 Citations
1.056 Impact Factor

Miniature Neutron Source Reactors in medical research: achievements and challenges

Journal of Radioanalytical and Nuclear Chemistry. 2017 Dec 1;314(3):1497-504.

Journal of Radioanalytical and Nuclear Chemistry

Miniature neutron source reactors (MNSRs) and their challenges were investigated. Then, MNSRs structure and operation were discussed, and conflicting usages of high enriched uranium fuel and its technical challenges were explored. By using low enriched uranium it is possible to produce 99Mo isotopes with similar quality, plus using low enriched uranium does not increase the potential risks and high does level. Furthermore, it is possible to produce several medical radioisotopes such as 99Mo/99 mTc generator, 131I, 65Zn, and 177Lu. These reactors can be employed in Boron Neutron Capture Therapy. After conversion, these reactors can be used more frequently and effectively.

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December 2017

4 Citations

Impact Factor 1.181

37 Reads

Analysis of Relative Biological Effectiveness of Proton Beams and Iso-effective Dose Profiles Using Geant4.

J Biomed Phys Eng 2017 Jun 1;7(2):95-100. Epub 2017 Jun 1.

Quchan Technical and Vocational University of Iran, Quchan, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447256PMC
June 2017
51 Reads

Does Occupational Exposure of Shahid Dastghieb International Airport Workers to Radiofrequency Radiation Affect Their Short Term Memory and Reaction Time?

J Biomed Phys Eng 2015 Sep 1;5(3):143-50. Epub 2015 Sep 1.

Ionizing and Non-ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran ; Medical Physics and Medical Engineering Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576875PMC
September 2015
30 Reads

The CNAO dose delivery system for modulated scanning ion beam radiotherapy.

Med Phys 2015 Jan;42(1):263-75

Istituto Nazionale di Fisica Nucleare, Section of Torino, Torino 10125, Italy and Centro Nazionale Adroterapia Oncologica, Pavia 27100, Italy.

Purpose: This paper describes the system for the dose delivery currently used at the Centro Nazionale di Adroterapia Oncologica (CNAO) for ion beam modulated scanning radiotherapy.

Methods: CNAO Foundation, Istituto Nazionale di Fisica Nucleare and University of Torino have designed, built, and commissioned a dose delivery system (DDS) to monitor and guide ion beams accelerated by a dedicated synchrotron and to distribute the dose with a full 3D scanning technique. Protons and carbon ions are provided for a wide range of energies in order to cover a sizable span of treatment depths. The target volume, segmented in several layers orthogonally to the beam direction, is irradiated by thousands of pencil beams which must be steered and held to the prescribed positions until the prescribed number of particles has been delivered. For the CNAO beam lines, these operations are performed by the DDS. The main components of this system are two independent beam monitoring detectors, called BOX1 and BOX2, interfaced with two control systems performing the tasks of real-time fast and slow control, and connected to the scanning magnets and the beam chopper. As a reaction to any condition leading to a potential hazard, a DDS interlock signal is sent to the patient interlock system which immediately stops the irradiation. The essential tasks and operations performed by the DDS are described following the data flow from the treatment planning system through the end of the treatment delivery.

Results: The ability of the DDS to guarantee a safe and accurate treatment was validated during the commissioning phase by means of checks of the charge collection efficiency, gain uniformity of the chambers, and 2D dose distribution homogeneity and stability. A high level of reliability and robustness has been proven by three years of system activity needing rarely more than regular maintenance and working with 100% uptime. Four identical and independent DDS devices have been tested showing comparable performances and are presently in use on the CNAO beam lines for clinical activity.

Conclusions: The dose delivery system described in this paper is one among the few worldwide existing systems to operate ion beam for modulated scanning radiotherapy. At the time of writing, it has been used to treat more than 350 patients and it has proven to guide and control the therapeutic pencil beams reaching performances well above clinical requirements. In particular, in terms of dose accuracy and stability, daily quality assurance measurements have shown dose deviations always lower than the acceptance threshold of 5% and 2.5%, respectively.

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http://doi.wiley.com/10.1118/1.4903276
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http://dx.doi.org/10.1118/1.4903276DOI Listing
January 2015
29 Reads
35 Citations
2.635 Impact Factor

Clinical performances of the dose delivery system at the Italian National center for oncological hadrontherapy (CNAO)

Romanian Reports in Physics 66 (1), 30-38

Romanian Reports in Physics

A dedicated Dose Delivery System (DDS) was developed to implement the modulated spot scanning technique at the Italian Hadrontherapy facility (CNAO). This is the highest conformal method in use with protons and carbon ions worldwide. The clinical 3 dimensional target is subdivided into several spots irradiated delivering a pencil beam for each spot. The right position of the beam is achieved using two orthogonal scanning magnets for X and Y displacements while the Z position of the Bragg peak (along the beam direction) is achieved by exploiting the ability of the synchrotron to provide the appropriate beam energy. Each spot of a slice is characterized by the number of particles and by the beam position which are managed and controlled by the DDS. The DDS drives the treatment spot by spot by exploiting the treatment planning data and the online measurements. The preliminary performances achieved by the system during clinical treatments are the object of this paper. The estimation of the dose delivery accuracy is evaluated comparing the prescribed values with the corresponding measured quantities. Results about dose distributions comparisons are based on γ-index and show a very good accuracy over single fields, single fractions and total treatments.

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January 2014

1 Citation

Impact Factor 1.582

41 Reads

SU-E-T-298: Evaluation of the CNAO Spot Scanning Technique Based on the First Clinical Deliveries.

Med Phys 2012 Jun;39(6Part14):3772

Istituto Nazionale di Fisica Nucleare, via Giuria 1, 10125 Torino, Italy.

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http://dx.doi.org/10.1118/1.4735382DOI Listing
June 2012
23 Reads
2.635 Impact Factor

Preparation and biodistribution study of 67 Ga-gallium calcitonin

Iran J Nucl Med, 19(2), pp.38-45.

Iran J Nucl Med

Introduction: In order to develop a radiolabeled calcitonin (CT) derivative for receptor imaging studies, CT was successively labeled with 67Ga-gallium chloride. Methods: The best results of the conjugation were obtained by the addition of 0.5 ml of a CT nasal pharmaceutical solution (1100 IU) to a glass tube pre-coated with DTPA-dianhydride (0.01 mg) at 25°C with continuous mild stirring for 30 min. Results: After solid phase purification of the radiolabeled hormone, instant thin layer chromatography (ITLC) showed radiochemical purity of higher than 95 % at optimized conditions (specific activity =67-134 KBq/IU, labeling efficiency 70%). 67Ga-DTPA-CT mainly accumulates in the liver. Conclusion:  Preliminary in vivo studies (ID/g%) in male wild-type rats showed significant liver uptake of the tracer after 24 hours. 67Ga-DTPA-CT can be a suitable probe for biodistribution study of CT receptors in various physiological as well as neoplastic lesions with over-expressed calcitonin receptors.

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April 2011
19 Reads

Development of a radiolabeled beta-human chorionic gonadotropin.

Acta Pharm 2009 Dec;59(4):421-9

Nuclear Medicine Research Group Agricultural Medical and Industrial, Research School (AMIRS-NSTRI), Karaj, Iran.

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http://content.sciendo.com/view/journals/acph/59/4/article-p
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http://dx.doi.org/10.2478/v10007-009-0035-6DOI Listing
December 2009
31 Reads
1.025 Impact Factor

Evaluation of [(201)Tl](III) Vancomycin in normal rats.

Nucl Med Rev Cent East Eur 2008 ;11(1):1-4

Nuclear Medicine Group, Agriculture, Medicine and Industrial Research School (AMIRS), Nuclear Science and Technology Institute, Karaj, Iran.

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March 2009
33 Reads