Mohammad A Khanfar

Heinrich Heine University Düsseldorf, Institute of Pharmaceutical and Medicinal Chemistry, Universitaetsstr. 1, 40225 Duesseldorf, Germany. Electronic address:

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August 2018

Discovery of potent polyphosphate kinase 1 (PPK1) inhibitors using structure-based exploration of PPK1Pharmacophoric space coupled with docking analyses.

Authors:

Rasha M Bashatwah Mohammad A Khanfar Sanaa K Bardaweel

J Mol Recognit 2018 10 8;31(10):e2726. Epub 2018 May 8.

Department of Pharmaceutical Sciences, School of Pharmacy, The University of Jordan, Amman, Jordan.

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October 2018

Unsupervised pharmacophore modeling combined with QSAR analyses revealed novel low micromolar SIRT2 inhibitors.

Authors:

Mohammad A Khanfar Mutasem O Taha

J Mol Recognit 2017 09 15;30(9). Epub 2017 Mar 15.

Drug Discovery Unit, Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman, Jordan.

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September 2017

Discovery of Potent Bruton's Tyrosine Kinase Inhibitors Using Ligand Based Modeling.

Authors:

Wafa A Mera Malek Alzihlif Mutasem O Taha Mohammad A Khanfar

Anticancer Agents Med Chem 2017 ;17(2):265-275

Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman 11942,Jordan.

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May 2017

Discovery of potent NEK2 inhibitors as potential anticancer agents using structure-based exploration of NEK2 pharmacophoric space coupled with QSAR analyses.

Authors:

Mohammad A Khanfar Fahmy Banat Shada Alabed Saja Alqtaishat

Mol Divers 2017 Feb 6;21(1):187-200. Epub 2016 Sep 6.

Department of Pharmaceutical sciences, Faculty of Pharmacy, The University of Jordan, P.O. Box 13140, Amman, 11942, Jordan.

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February 2017

Multiple Targeting Approaches on Histamine H3 Receptor Antagonists.

Authors:

Mohammad A Khanfar Anna Affini Kiril Lutsenko Katarina Nikolic Stefania Butini Holger Stark

Front Neurosci 2016 30;10:201. Epub 2016 May 30.

Stark Lab, Institut fuer Pharmazeutische and Medizinische Chemie, Heinrich-Heine-Universitaet Duesseldorf Duesseldorf, Germany.

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June 2016

Discovery of potent adenosine A2a antagonists as potential anti-Parkinson disease agents. Non-linear QSAR analyses integrated with pharmacophore modeling.

Authors:

Mohammad A Khanfar Saja Al-Qtaishat Maha Habash Mutasem O Taha

Chem Biol Interact 2016 Jul 20;254:93-101. Epub 2016 May 20.

Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman 11942, Jordan. Electronic address:

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July 2016

Olive Oil-derived Oleocanthal as Potent Inhibitor of Mammalian Target of Rapamycin: Biological Evaluation and Molecular Modeling Studies.

Authors:

Mohammad A Khanfar Sanaa K Bardaweel Mohamed R Akl Khalid A El Sayed

Phytother Res 2015 Nov 7;29(11):1776-82. Epub 2015 Aug 7.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana, USA.

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November 2015

Design and Evaluation of 3-(Benzylthio)benzamide Derivatives as Potent and Selective SIRT2 Inhibitors.

Authors:

Mohammad A Khanfar Luisa Quinti Hua Wang Johnathan Nobles Aleksey G Kazantsev Richard B Silverman

ACS Med Chem Lett 2015 May 26;6(5):607-11. Epub 2015 Mar 26.

Department of Chemistry, Department of Molecular Biosciences, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, Northwestern University , Evanston, Illinois 60208-3113, United States.

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May 2015

Combining docking-based comparative intermolecular contacts analysis and k-nearest neighbor correlation for the discovery of new check point kinase 1 inhibitors.

Authors:

Nour Jamal Jaradat Mohammad A Khanfar Maha Habash Mutasem Omar Taha

J Comput Aided Mol Des 2015 Jun 9;29(6):561-81. Epub 2015 May 9.

Faculty of Pharmacy, Zarqa University, Zarqa, Jordan.

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June 2015

Discovery of nanomolar phosphoinositide 3-kinase gamma (PI3Kγ) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis.

Authors:

Mutasem O Taha Mahmoud A Al-Sha'er Mohammad A Khanfar Afaf H Al-Nadaf

Eur J Med Chem 2014 Sep 18;84:454-65. Epub 2014 Jul 18.

Department of Pharmaceutical Chemistry, Applied Science University, Amman, Jordan.

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September 2014

The use of docking-based comparative intermolecular contacts analysis to identify optimal docking conditions within glucokinase and to discover of new GK activators.

Authors:

Mutasem O Taha Maha Habash Mohammad A Khanfar

J Comput Aided Mol Des 2014 May 8;28(5):509-47. Epub 2014 Mar 8.

Drug Discovery Unit, Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman, Jordan,

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May 2014

Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors.

Authors:

Mohammad A Khanfar Luisa Quinti Hua Wang Soo Hyuk Choi Aleksey G Kazantsev Richard B Silverman

Eur J Med Chem 2014 Apr 6;76:414-26. Epub 2014 Feb 6.

Department of Chemistry, Department of Molecular Biosciences, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113, USA. Electronic address:

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April 2014

Discovery of novel urokinase plasminogen activator (uPA) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis.

Authors:

Mahmoud A Al-Sha'er Mohammad A Khanfar Mutasem O Taha

J Mol Model 2014 Jan 28;20(1):2080. Epub 2014 Jan 28.

Faculty of Pharmacy, Zarqa University, Zarqa, 13132, Jordan.

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January 2014

Elaborate ligand-based modeling coupled with multiple linear regression and k nearest neighbor QSAR analyses unveiled new nanomolar mTOR inhibitors.

Authors:

Mohammad A Khanfar Mutasem O Taha

J Chem Inf Model 2013 Oct 4;53(10):2587-612. Epub 2013 Oct 4.

Drug Discovery Unit, Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan , Amman 11942, Jordan.

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October 2013

Synthesis and characterization of new derivatives of alginic acid and evaluation of their iron(III)-crosslinked beads as potential controlled release matrices.

Authors:

Samer R Abulateefeh Mohammad A Khanfar Ramia Z Al Bakain Mutasem O Taha

Pharm Dev Technol 2014 Nov 13;19(7):856-67. Epub 2013 Sep 13.

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy .

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November 2014

Gas chromatography/trace analysis of derivatized azelaic acid as a stability marker.

Authors:

Muhammed Alzweiri Ruba Tarawneh Mohammad A Khanfar

J Sep Sci 2013 Oct 21;36(19):3200-5. Epub 2013 Aug 21.

Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman, Jordan.

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October 2013

Protective activity of (1S,2E,4R,6R,7E,11E)-2,7,11-cembratriene-4,6-diol analogues against diisopropylfluorophosphate neurotoxicity: preliminary structure-activity relationship and pharmacophore modeling.

Authors:

Vesna A Eterović Angelie Del Valle-Rodriguez Dinely Pérez Marimée Carrasco Mohammad A Khanfar Khalid A El Sayed Pedro A Ferchmin

Bioorg Med Chem 2013 Aug 24;21(15):4678-86. Epub 2013 May 24.

Department of Biochemistry, School of Medicine, Universidad Central del Caribe, Bayamón, PR 00960, USA.

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August 2013

Pharmacophore modeling, homology modeling, and in silico screening reveal mammalian target of rapamycin inhibitory activities for sotalol, glyburide, metipranolol, sulfamethizole, glipizide, and pioglitazone.

Authors:

Mohammad A Khanfar Majed M AbuKhader Saja Alqtaishat Mutasem O Taha

J Mol Graph Model 2013 May 13;42:39-49. Epub 2013 Mar 13.

Drug Discovery Unit, Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman 11942, Jordan.

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May 2013

Design of semisynthetic analogues and 3D-QSAR study of eunicellin-based diterpenoids as prostate cancer migration and invasion inhibitors.

Authors:

Hossam M Hassan Ahmed Y Elnagar Mohammad A Khanfar Asmaa A Sallam Rabab Mohammed Lamiaa A Shaala Diaa T A Youssef Mohamed S Hifnawy Khalid A El Sayed

Eur J Med Chem 2011 Apr 28;46(4):1122-30. Epub 2011 Jan 28.

Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, LA 71201, USA.

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April 2011

Discovery of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening.

Authors:

Mohammad A Khanfar Ronald A Hill Amal Kaddoumi Khalid A El Sayed

J Med Chem 2010 Dec 17;53(24):8534-45. Epub 2010 Nov 17.

Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana 71201, USA.

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December 2010

Bioactive natural, biocatalytic, and semisynthetic tobacco cembranoids.

Authors:

Hany N Baraka Mohammad A Khanfar John C Williams Emad M El-Giar Khalid A El Sayed

Planta Med 2011 Mar 3;77(5):467-76. Epub 2010 Nov 3.

Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana, USA.

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March 2011

Phenylmethylene hydantoins as prostate cancer invasion and migration inhibitors. CoMFA approach and QSAR analysis.

Authors:

Mohammad A Khanfar Khalid A El Sayed

Eur J Med Chem 2010 Nov 8;45(11):5397-405. Epub 2010 Sep 8.

Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, Louisiana 71201, USA.

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November 2010