Publications by authors named "Mohammad A Khanfar"

35Publications

Discovery of Potent Natural-Product-Derived SIRT2 Inhibitors Using Structure-Based Exploration of SIRT2 Pharmacophoric Space Coupled With QSAR Analyses.

Anticancer Agents Med Chem 2021 Jan 12. Epub 2021 Jan 12.

Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, P.O Box 13140, Amman 11942. Jordan.

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January 2021

Metabolomic Profiling and Cytotoxic Tetrahydrofurofuran Lignans Investigations from Blanco.

Metabolites 2019 Oct 13;9(10). Epub 2019 Oct 13.

Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, Universities Zone, New Minia City 61111, Egypt.

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October 2019

Discovery of potent IRAK-4 inhibitors as potential anti-inflammatory and anticancer agents using structure-based exploration of IRAK-4 pharmacophoric space coupled with QSAR analyses.

Comput Biol Chem 2019 Apr 20;79:147-154. Epub 2019 Feb 20.

Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, P.O Box 13140, Amman 11942, Jordan.

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April 2019

Design, synthesis, and biological evaluation of novel oxadiazole- and thiazole-based histamine HR ligands.

Bioorg Med Chem 2018 08 21;26(14):4034-4046. Epub 2018 Jun 21.

Heinrich Heine University Düsseldorf, Institute of Pharmaceutical and Medicinal Chemistry, Universitaetsstr. 1, 40225 Duesseldorf, Germany. Electronic address:

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August 2018

Discovery of potent polyphosphate kinase 1 (PPK1) inhibitors using structure-based exploration of PPK1Pharmacophoric space coupled with docking analyses.

J Mol Recognit 2018 10 8;31(10):e2726. Epub 2018 May 8.

Department of Pharmaceutical Sciences, School of Pharmacy, The University of Jordan, Amman, Jordan.

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October 2018

Unsupervised pharmacophore modeling combined with QSAR analyses revealed novel low micromolar SIRT2 inhibitors.

J Mol Recognit 2017 09 15;30(9). Epub 2017 Mar 15.

Drug Discovery Unit, Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman, Jordan.

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September 2017

Discovery of Potent Bruton's Tyrosine Kinase Inhibitors Using Ligand Based Modeling.

Anticancer Agents Med Chem 2017 ;17(2):265-275

Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman 11942,Jordan.

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May 2017

Discovery of potent NEK2 inhibitors as potential anticancer agents using structure-based exploration of NEK2 pharmacophoric space coupled with QSAR analyses.

Mol Divers 2017 Feb 6;21(1):187-200. Epub 2016 Sep 6.

Department of Pharmaceutical sciences, Faculty of Pharmacy, The University of Jordan, P.O. Box 13140, Amman, 11942, Jordan.

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February 2017

Multiple Targeting Approaches on Histamine H3 Receptor Antagonists.

Front Neurosci 2016 30;10:201. Epub 2016 May 30.

Stark Lab, Institut fuer Pharmazeutische and Medizinische Chemie, Heinrich-Heine-Universitaet Duesseldorf Duesseldorf, Germany.

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June 2016

Discovery of potent adenosine A2a antagonists as potential anti-Parkinson disease agents. Non-linear QSAR analyses integrated with pharmacophore modeling.

Chem Biol Interact 2016 Jul 20;254:93-101. Epub 2016 May 20.

Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman 11942, Jordan. Electronic address:

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July 2016

Olive Oil-derived Oleocanthal as Potent Inhibitor of Mammalian Target of Rapamycin: Biological Evaluation and Molecular Modeling Studies.

Phytother Res 2015 Nov 7;29(11):1776-82. Epub 2015 Aug 7.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana, USA.

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November 2015

Design and Evaluation of 3-(Benzylthio)benzamide Derivatives as Potent and Selective SIRT2 Inhibitors.

ACS Med Chem Lett 2015 May 26;6(5):607-11. Epub 2015 Mar 26.

Department of Chemistry, Department of Molecular Biosciences, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, Northwestern University , Evanston, Illinois 60208-3113, United States.

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May 2015

The use of docking-based comparative intermolecular contacts analysis to identify optimal docking conditions within glucokinase and to discover of new GK activators.

J Comput Aided Mol Des 2014 May 8;28(5):509-47. Epub 2014 Mar 8.

Drug Discovery Unit, Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman, Jordan,

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May 2014

Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors.

Eur J Med Chem 2014 Apr 6;76:414-26. Epub 2014 Feb 6.

Department of Chemistry, Department of Molecular Biosciences, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113, USA. Electronic address:

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April 2014

Elaborate ligand-based modeling coupled with multiple linear regression and k nearest neighbor QSAR analyses unveiled new nanomolar mTOR inhibitors.

J Chem Inf Model 2013 Oct 4;53(10):2587-612. Epub 2013 Oct 4.

Drug Discovery Unit, Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan , Amman 11942, Jordan.

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October 2013

Gas chromatography/trace analysis of derivatized azelaic acid as a stability marker.

J Sep Sci 2013 Oct 21;36(19):3200-5. Epub 2013 Aug 21.

Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman, Jordan.

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October 2013

Pharmacophore modeling, homology modeling, and in silico screening reveal mammalian target of rapamycin inhibitory activities for sotalol, glyburide, metipranolol, sulfamethizole, glipizide, and pioglitazone.

J Mol Graph Model 2013 May 13;42:39-49. Epub 2013 Mar 13.

Drug Discovery Unit, Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman 11942, Jordan.

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May 2013

Design of semisynthetic analogues and 3D-QSAR study of eunicellin-based diterpenoids as prostate cancer migration and invasion inhibitors.

Eur J Med Chem 2011 Apr 28;46(4):1122-30. Epub 2011 Jan 28.

Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, LA 71201, USA.

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April 2011

Discovery of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening.

J Med Chem 2010 Dec 17;53(24):8534-45. Epub 2010 Nov 17.

Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana 71201, USA.

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December 2010

Bioactive natural, biocatalytic, and semisynthetic tobacco cembranoids.

Planta Med 2011 Mar 3;77(5):467-76. Epub 2010 Nov 3.

Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana, USA.

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March 2011

Phenylmethylene hydantoins as prostate cancer invasion and migration inhibitors. CoMFA approach and QSAR analysis.

Eur J Med Chem 2010 Nov 8;45(11):5397-405. Epub 2010 Sep 8.

Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, Louisiana 71201, USA.

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November 2010

Marine sponge-derived sipholane triterpenoids reverse P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells.

Biochem Pharmacol 2010 Nov 7;80(10):1497-506. Epub 2010 Aug 7.

Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St. John's University, Jamaica, NY 11439, USA.

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November 2010

3D-QSAR studies of latrunculin-based actin polymerization inhibitors using CoMFA and CoMSIA approaches.

Eur J Med Chem 2010 Sep 12;45(9):3662-8. Epub 2010 May 12.

Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Dr. Monroe, LA 71201, USA.

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September 2010

Semisynthetic latrunculin derivatives as inhibitors of metastatic breast cancer: biological evaluations, preliminary structure-activity relationship and molecular modeling studies.

ChemMedChem 2010 Feb;5(2):274-85

Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA.

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February 2010

Design and pharmacophore modeling of biaryl methyl eugenol analogs as breast cancer invasion inhibitors.

Bioorg Med Chem 2010 Jan 11;18(2):496-507. Epub 2009 Dec 11.

Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, 700 University Avenue, Monroe, LA 71209, USA.

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January 2010

Rational design and semisynthesis of betulinic acid analogues as potent topoisomerase inhibitors.

J Nat Prod 2009 Sep;72(9):1643-50

Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA.

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September 2009

The marine natural-derived inhibitors of glycogen synthase kinase-3beta phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling.

Bioorg Med Chem 2009 Aug 27;17(16):6032-9. Epub 2009 Jun 27.

Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, LA 71201, United States.

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August 2009