Publications by authors named "Mohamed Waly"

13 Publications

  • Page 1 of 1

Economic Reliable Technique for Tunnel Grafting Using Iliac Crest Bone Graft in Two-Staged Revision Anterior Cruciate Ligament Surgery.

Arthrosc Tech 2020 Dec 21;9(12):e1917-e1925. Epub 2020 Dec 21.

Trauma and Orthopaedics, Kasr-Alainy Faculty of Medicine, Cairo University, Cairo, Egypt.

Revision anterior cruciate ligament surgery is a technically demanding procedure. Mal-positioned tunnels together with bone loss and its management are some of the difficulties and challenges faced. Two-staged procedures have successfully been used to tackle those challenges. We present a technique that is safe, reliable, reproducible, and economic in the management of bone defects faced in anterior cruciate ligament revision surgery by using iliac crest bone graft. Preoperative assessment of tunnel position and size is done by computed tomography. Tri-cortical iliac crest bone graft is harvested through a trap door. It is then shaped to fit the tunnels to be filled. It is tapered at the advancing end to facilitate introduction. Mounted on a passing pin and a drill bit, the graft is arthroscopically introduced into the femoral and tibial tunnels. The second stage is performed after the graft has incorporated, as seen on postoperative computed tomography, done at approximately 3 months after the first stage. Iliac crest provides a natural abundant reservoir for bone graft and has all the advantages of being an autograft. With good meticulous technique, complications can be avoided with less donor-site morbidity. This technique is safe, reliable, and reproducible. It provides an ample amount of graft and harvest does not rely on implants; hence, it is economic.
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http://dx.doi.org/10.1016/j.eats.2020.08.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768218PMC
December 2020

Epidemiological trends of malaria in the Western regions of Saudi Arabia: a cross sectional study.

J Infect Dev Ctries 2020 11 30;14(11):1332-1337. Epub 2020 Nov 30.

Medical Laboratory Sciences Department, College of Applied Medical Sciences, Majmaah University, Majmaah, Saudi Arabia.

Introduction: Saudi Arabia has successfully reduced malaria cases to be constrained largely in the western regions. This study aimed to determine the epidemiological trends of malaria infection in five western regions of Saudi Arabia.

Methodology: A retrospective analysis was conducted to investigate the epidemiological trends of malaria infection in the western regions, based on the published registry of the Saudi Ministry of Health, during the period from 2014 to 2017 using the appropriate statistical tools.

Results: A total of 8925 confirmed cases of malaria were reported in the western regions during the period from 2014 to 2017 with the mean of 2231 malaria cases per year. The minimum (n = 1097) and maximum (n = 4075) number of cases were reported in 2014 and 2016 respectively. The highest (n = 5919, 66.3%) number of cases were reported from Jazan region, while lowest (n = 86, 1.0%) number of cases were reported from Al-Bahah region. Plasmodium falciparum was the most frequently reported species with 7485 (83.9%) cases, while Plasmodium vivax accounted 1386 (15.5%) cases. Plasmodium malariae and mixed infections were insignificant and accounted 0.5% (n = 48) and 0.1% (n = 6) cases respectively. In relation to malaria infection and age group, malaria was predominant in > 15 age group. The highest number of malaria cases in almost all years was observed from January until March and the lowest number was reported from May until July.

Conclusions: Plasmodium falciparum was the most dominant species in this survey and Jazan was the most affected region.
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http://dx.doi.org/10.3855/jidc.13246DOI Listing
November 2020

Generalized joint hypermobility among school-aged children in Majmaah region, Saudi Arabia.

PeerJ 2020 11;8:e9682. Epub 2020 Aug 11.

Department of Physical Therapy and Health Rehabilitation, College of Applied Medical Sciences, Prince Sattam Bin Abdul Aziz University, Alkharj, Saudi Arabia.

Generalized joint hypermobility (GJH) is common among schoolchildren and usually benign. However, it may progressively lead to joint pain and developmental delay. Identifying GJH in school-aged children would facilitate the monitoring of early changes and planning for early rehabilitative intervention. Epidemiological studies addressing the prevalence of GJH among children in the Gulf region and Arab ethnicity are lacking. Hence, we aimed to determine the prevalence, pattern, and factors associated with GJH among school-aged children in the Majmaah region, Saudi Arabia. Male and female school-aged children 8-14 years of age from the Majmaah region of Saudi Arabia participated in this cross-sectional study. Beighton score was used to assess GJH. Personal characteristics such as age, height, weight, body mass index, and handedness were also collected. Descriptive statistics were obtained for personal characteristics, the point prevalence of hypermobility, frequency of Beighton score distribution, and prevalence of GJH. The associations between specific factors and the presence of GJH were analyzed using chi-square and Mann-whitney tests. Using the Beighton score cutoff ≥ 4 and ≥ 6, 15.2% and 7.6% of the school children in our study were diagnosed with GJH respectively. The prevalence of GJH was higher among females (16.8%) than among males (13.4%), but the difference was not statistically significant. The elbow joints (17.2%) were the most common hypermobile joints and the trunk (0.7%) was the least involved. The children with GJH were younger and had lesser BMI compared to children without GJH ( < 0.05). The prevalence reported in this study among school-aged children was comparable with those reported worldwide.
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http://dx.doi.org/10.7717/peerj.9682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427539PMC
August 2020

Biofeedback flutter device for managing the symptoms of patients with COPD.

Technol Health Care 2020 ;28(5):477-485

Department of Physical Therapy and Health Rehabilitation, College of Applied Medical Sciences, Prince Sattam Bin Abdul Aziz University, Alkharj, Saudi Arabia.

Background: Flutter is a device used in removing excess lung secretions. The conventional flutter lacks a biofeedback component to facilitate optimal use by the patients.

Objective: The current research aims to compare the effects of biofeedback flutter devices with the conventional flutter in managing the symptoms of patients with chronic obstructive pulmonary diseases.

Methods: One hundred and sixty-eight participants were randomly allocated into four groups: Group A (conventional), Group B (visual biofeedback), Group C (auditory biofeedback) and Group D (visual and auditory biofeedback). All groups were treated five days for 20 minutes. Outcome measures included wet sputum weight [during intervention (T1) and 1 hour after intervention (T2)], oxygen saturation and dyspnea score (before and after intervention) on all days.

Results: The wet sputum expectorated (T2) by Group B was significantly higher than Group A (P< 0.001), Group C (P< 0.001) and Group D (P< 0.05). The dyspnea score for Group B (P< 0.05), Group C (P< 0.05) and Group D (P< 0.05) was significantly lower than Group A. The post-intervention oxygen saturation level was higher in Group D followed by Groups B, C and A.

Conclusion: The use of biofeedback flutter is effective in the removal of secretion, reducing dyspnea and improving oxygen saturation when compared to conventional flutter.
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http://dx.doi.org/10.3233/THC-202222DOI Listing
January 2020

Carbetocin versus rectal misoprostol for management of third stage of labor among women with low risk of postpartum hemorrhage.

Int J Gynaecol Obstet 2020 Feb 2;148(2):238-242. Epub 2019 Dec 2.

Obstetrics and Gynecology Department, Kasr Al Aini Hospital, Cairo University, Cairo, Egypt.

Objective: To compare effectiveness and safety of carbetocin and misoprostol for prevention of postpartum hemorrhage (PPH) among low-risk women.

Methods: Randomized controlled trial among 150 pregnant women with low risk of PPH admitted for vaginal delivery at Kasr Al Ainy Hospital, Cairo, Egypt, between July 2018 and May 2019. Participants were assigned to two groups by a web-based randomization system ensuring allocation concealment. After neonatal delivery, the carbetocin group received one ampoule of carbetocin (100 μg/mL) intravenously and the misoprostol group received two rectal tablets of misoprostol (800 μg) for active management of the third stage. Blood pressure, blood loss, and hemoglobin levels were monitored. The primary outcome measure was need for additional uterotonic drugs.

Results: The carbetocin group had significantly less blood loss (P<0.001), shorter third stage (P<0.001), and less need for additional uterotonics (P=0.013) or uterine massage (P=0.007). The two drugs were hemodynamically safe. Hemoglobin levels after delivery were comparable in the two groups (P=0.475). Adverse effects were more common in the misoprostol group (P<0.001).

Conclusion: Among low-risk women, carbetocin seems to be a better alternative to misoprostol for active management of the third stage of labor; it reduced blood loss and use of additional uterotonic drugs. CLINICALTRIALS.GOV: NCT03556852.
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http://dx.doi.org/10.1002/ijgo.13056DOI Listing
February 2020

Prevalence of Intestinal Parasitic Infections among Patients of King Fahd Medical City in Riyadh Region, Saudi Arabia: A 5-Year Retrospective Study.

J Parasitol Res 2018 26;2018:8076274. Epub 2018 Jul 26.

Environmental and Occupational Health, Public Health Agency, Ministry of Health, Riyadh, Saudi Arabia.

This study is a retrospective analysis of the recorded intestinal parasitic infections for in- and outpatients visiting King Fahd Medical City, Riyadh, Saudi Arabia, from 2013 to 2017. In this study, a total of 5987 in- and outpatient were examined for intestinal parasitic infection. 30 patients out of 5987 were infected with 6 species of intestinal parasites with prevalence rate 0.5%. These parasites were (P = 0.27%), sp. (P = 0.1%), (P = 0.07%), (P = 0.03%), (P = 0.02%), and (P = 0.02%). The prevalence of infection in both males and females was 0.38% and 0.58%, respectively. Also, the prevalence of infection in different years and age groups as well as different seasons was provided. Intestinal parasitic infections are still a public health problem in Riyadh region, Saudi Arabia. Updating the epidemiologic survey of these parasites at regular intervals using the appropriate statistical methods is necessary to develop effective prevention and control strategies.
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http://dx.doi.org/10.1155/2018/8076274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083544PMC
July 2018

Work-related musculoskeletal disorders among faculty members of college of Applied Medical Sciences, Majmaah University, Saudi Arabia: A cross-sectional study.

Int J Health Sci (Qassim) 2018 Jul-Aug;12(4):18-25

Department of Physical Therapy and Health Rehabilitation, College of Applied Medical Sciences, Majmaah University, Majmaah 11952, Saudi Arabia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040859PMC
July 2018

The prevalence of transfusion-transmitted infections and nucleic acid testing among blood donors in Majmaah, Saudi Arabia.

J Infect Public Health 2018 Sep - Oct;11(5):702-706. Epub 2018 Apr 24.

Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Majmaah 11952, Saudi Arabia.

Background: Few studies discussed the prevalence of TTIs in Saudi donor blood samples. Thus, this study investigated the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), human T-lymphotropic virus (HTLV), syphilis and malaria in such samples to determine the efficacy of conducting serological and NATs on blood donors at King Khalid General Hospital in Majmaah, Saudi Arabia.

Methods: A total of 3028 donated blood units were collected from August 2015 to March 2017. Serum samples were screened for hepatitis B surface antigens (HBsAgs), HBsAbs, total anti-core antibodies (HBcAbs), HCV antigens and HIV Ab/Ag combinations. Additionally, plasma was screened for syphilis (TPHA) and HTLV. Samples were also tested for malaria with rapid malaria antigen tests. Finally, NATs were performed for the simultaneous direct detection of HBV, HCV and HIV in each sample.

Results: Out of the 3028 blood samples, 10 (0.33%) reacted to HBsAgs; 12 (0.40%) reacted to HCV antigens; 4 (0.13%) reacted to HIV Ab/Ag combinations; 6 (0.20%) reacted to HTLV antibodies; 297 (9.81%) reacted to HBcAbs and 236 (7.80%) reacted to HBsAbs. Additionally, NATs showed that 14 (0.46%) reacted to NAT-HBV; 20 (0.66%) samples were reacted to NAT-HCV and 2 (0.07%) samples reacted to NAT-HIV. Finally, 16 (0.53%) were positive for syphilis. No samples were positive for malaria.

Conclusions: The results indicated that NATs are more effective than serology tests for detecting TTIs. Moreover, correlations between standard serology tests and NATs indicated that using NATs could improve test sensitivities and decrease residual risks of TTIs and ensure safe blood transfusions.
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http://dx.doi.org/10.1016/j.jiph.2018.04.008DOI Listing
November 2018

Utilization of -acyl compounds for the synthesis of tricyclic and bridged heterocyclic compounds.

Glob J Chem 2015;1(1):21-27

N-acyl derivative was prepared via the reaction of methyl anthranilate with ethyl bromoacetate then refluxing the formed amino ester with acetic anhydride. Cyclization of in presences of sodium methoxide and methanol forming 2,4-pyrrolidindione derivative . 2,4-Quinolidinone was obtained via cyclization of in dry toluene and sodium hydride. On the other hand, indolinone derivative was obtained by cyclization of in toluene and free from alcohol due to retro Diekmann-condensation. On treatment of with sodium hydride, refluxing toluene and in presences of Crown ether gave tricyclic compound . Also, treatment of 2-pyrrolidinone with trimethylene chlorobromide produced which cyclized using base and solvent to the bridged ring derivatives . The acidic hydrolysis of afforded the corresponding amino acid . Whereas derivative was obtained by the reaction of 2-pyrrolidinone with ethyl 3-bromopropionate which on cyclization gave azabicyclo[3,2,1]octan-4,8-dione derivative . Compound underwent acidic hydrolysis to the amino ketone derivative azepanone hydrochloride .
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January 2015

Anti-parallel triplexes: Synthesis of 8-aza-7-deazaadenine nucleosides with a 3-aminopropynyl side-chain and its corresponding LNA analog.

Bioorg Med Chem 2015 May 27;23(10):2458-69. Epub 2015 Mar 27.

Department of Physics, Chemistry and Pharmacy, Nucleic Acid Center, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark. Electronic address:

The phosphoramidites of DNA monomers of 7-(3-aminopropyn-1-yl)-8-aza-7-deazaadenine (Y) and 7-(3-aminopropyn-1-yl)-8-aza-7-deazaadenine LNA (Z) are synthesized, and the thermal stability at pH 7.2 and 8.2 of anti-parallel triplexes modified with these two monomers is determined. When, the anti-parallel TFO strand was modified with Y with one or two insertions at the end of the TFO strand, the thermal stability was increased 1.2°C and 3°C at pH 7.2, respectively, whereas one insertion in the middle of the TFO strand decreased the thermal stability 1.4°C compared to the wild type oligonucleotide. In order to be sure that the 3-aminopropyn-1-yl chain was contributing to the stability of the triplex, the nucleobase X without the aminopropynyl group was inserted in the same positions. In all cases the thermal stability was lower than the corresponding oligonucleotides carrying the 3-aminopropyn-1-yl chain, especially at the end of the TFO strand. On the other hand, the thermal stability of the anti-parallel triplex was dramatically decreased when the TFO strand was modified with the LNA monomer analog Z in the middle of the TFO strand (ΔTm=-9.1°C). Also the thermal stability decreased about 6.1°C when the TFO strand was modified with Z and the Watson-Crick strand with adenine-LNA (A(L)). The molecular modeling results showed that, in case of nucleobases Y and Z a hydrogen bond (1.69 and 1.72Ǻ, respectively) was formed between the protonated 3-aminopropyn-1-yl chain and one of the phosphate groups in Watson-Crick strand. Also, it was shown that the nucleobase Y made a good stacking and binding with the other nucleobases in the TFO and Watson-Crick duplex, respectively. In contrast, the nucleobase Z with LNA moiety was forced to twist out of plane of Watson-Crick base pair which is weakening the stacking interactions with the TFO nucleobases and the binding with the duplex part.
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http://dx.doi.org/10.1016/j.bmc.2015.03.050DOI Listing
May 2015

Efficacy of a pyrimidine derivative to control spot disease on Solanum melongena caused by Alternaria alternata.

J Adv Res 2013 Jul 21;4(4):393-401. Epub 2012 Sep 21.

Botany Department, Faculty of Science, Damietta University, Egypt.

The pyrimidine derivative (4,6-dimethyl-N-phenyldiethyl pyrimidine, DPDP) was tested as a foliar spray fungicide at 50 mg l(-1) for protection of eggplant (Solanum melongena) from spot disease caused by Alternaria alternata. Varied concentrations of DPDP (10-50 mg l(-1)) differentially inhibited mycelial growth, conidial count and conidial germination of A. alternata growth in vitro; the magnitude of inhibition increased with increasing concentration. In vivo, an experiment was conducted in pots using a complete block randomized design and repeated twice with three replications and four treatments (control, A. alternata alone, DPDP alone and combination of DPDP and A. alternata) for 5 weeks (1 plant in pot × 3 pots per set (3 replications per treatment) × 4 sets (4 treatments) × 5 weeks × 2 experimental repetitions = 120 pots). In this experiment, 10-day-old eggplant seedlings were transplanted in pots and then inoculated with A. alternata, DPDP or their combination 1 week later. Leaves of the A. alternata-infected eggplant suffered from chlorosis, necrosis and brown spots during the subsequent 5 weeks. Disease intensity was obvious in infected leaves but withdrawn by DPDP. There were relationships between incidence and severity, greater in plant leaves infected A. alternata alone and diminished with the presence of DPDP. Moreover, the infection resulted in reductions in growth, decreases in contents of anthocyanins, chlorophylls, carotenoids and thiols as well as inhibitions in activities of superoxide dismutase (SOD), glutathione peroxidase (GPX) and glutathione-S-transferase (GST). Nonetheless, the application of DPDP at 50 mg led to a recovery of the infected eggplant; the infection-induced deleterious effects were mostly reversed by DPDP. However, treatment with DPDP alone seemed with no significant impacts. Due to its safe use to host and the inhibition for the pathogen, DPDP could be suggested as an efficient fungicide for protection of eggplant to control A. alternata spot disease.
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http://dx.doi.org/10.1016/j.jare.2012.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293880PMC
July 2013

One-pot Synthesis, Molecular Modeling and In Vitro Antibacterial Activity of Novel 3-(1,3,4-Oxadiazol-2-yl) Quinoxaline 1,4-Dioxide and Pyrazolyl Analogs.

Acta Chim Slov 2012 Mar;59(1):32-41

The new 1,3,4-oxadiazolylquinoxaline ring system was synthesized by the condensation of the quinoxaline 1,4-dioxide acid hydrazide 6 with acetyl chloride in one-pot synthesis. In which the hydrazide was refluxed in excess of acetyl chloride, acetic anhydride or acetic acid in the presence of phosphorus oxychloride forming the 1,3,4-oxadiazolylquinoxaline ring system. Molecular modeling studies have been performed to evaluate their recognition at the hDHFR binding-pocket as potential hDHFR inhibitors. The antibacterial properties of these compounds showed reasonable activities towards gram negative bacteria, Escherichia coli. Compound 20 performed appropriate complementarity study rather well; the conserved amino acids of hDHFR enzyme imitating the MTX docking pattern. Besides, compound 20 showed highest antibacterial activity against E. coli in comparison with the well known bacteriostatic chloramphenicol; the pyrazolyl analogues also have moderate affinity toward the applied bacteria.
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March 2012

Middle cerebral/umbilical artery resistance index ratio as sensitive parameter for fetal well-being and neonatal outcome in patients with preeclampsia: case-control study.

Croat Med J 2005 Oct;46(5):821-5

Kasr El Aini School of Medicine, Cairo University, 19 Tunis st, Maadi, PO 11435, Cairo, Egypt.

Aim: To evaluate the accuracy of middle cerebral/umbilical artery resistance index (C/U RI) ratio in predicting acidemia and low Apgar score at 5 minutes after birth in the infants of women with preeclampsia.

Methods: This prospective case-control study performed at Kasr El Aini University Hospital included 50 pregnant women with preeclampsia with or without intrauterine growth restriction (IUGR). Thirty women with uneventful pregnancies, matched for age, parity, and gestational age, served as controls. Ultrasound and Doppler studies were carried out to estimate fetal weight (EFW) and determine fetal biophysical profile and resistance indices of the middle cerebral and umbilical arteries. C/U RI <1.0 was considered abnormal. Apgar scores were assessed at 5 minutes after birth, and fetal cord blood sampling to determine blood pH was done immediately after delivery. Apgar score <6 at 5 minutes, neonatal acidemia (pH<7.2), and/or neonatal admission to neonatal intensive care unit (NICU) indicated neonatal morbidity.

Results: There were no significant differences in fetal biophysical profile, middle cerebral artery RI, or umbilical artery RI between the fetuses of women with preeclampsia and those in the control group. C/U RI <1.0 was found in significantly more fetuses of women with preeclampsia than in their controls (0.7-/+0.3 and 1.3-/+0.7, respectively; P<0.001). In the preeclampsia group, C/U RI was abnormal in 32 out of 38 fetuses with IUGR, and in only 5 out of 12 of fetuses without IUGR. Neonatal acidemia was found in 30 out of 38 newborns with IUGR and in 3 out of 12 of newborns without IUGR. Preeclampsia and C/U RI <1.0 carried a relative risk of 1.4 for neonatal morbidity (neonatal academia pH<7.2, 5-minute Apgar score <6, and/or admission to NICU). C/U RI had 64.1% sensitivity, 72.7% specificity, 89.2% positive predictive value, and 36.3% negative predictive value for neonatal morbidity.

Conclusion: There was a strong correlation between the C/U RI and neonatal outcome in women with preeclampsia. C/U RI <1.0 may be helpful in the identification of newborns at risk of morbidity, irrespective of whether they are small or appropriate for their gestational age.
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October 2005