Publications by authors named "Mohamed Soufiaoui"

3 Publications

  • Page 1 of 1

1-(3-p-Tolyl-isoxazol-5-yl)cyclo-hexa-nol.

Acta Crystallogr Sect E Struct Rep Online 2009 Nov 4;65(Pt 12):o2971. Epub 2009 Nov 4.

The title compound, C(16)H(19)NO(2), contains two mol-ecules in the asymmetric unit. Each mol-ecule is composed of three inter-connected rings, two essentially planar rings, viz. the isoxazole and the methyl-benzyl aromatic ring [maximum deviations of 0.0027 (13) and 0.0031 (19) Å from the isoxazole and methylbenzyl ring planes, respectively, in the first molecule, 0.0018 (12) and 0.019 (2) Å in the second molecule], and one cyclo-hexa-nol ring having a chair conformation. Although the two mol-ecules have similar bond distances and angles, they differ in the orientation of the cyclo-hexa-nol ring with respect to the tolyl-isoxazole unit. In the first mol-ecule, the dihedral angle between the isoxazole and methyl-benzyl rings is 22.03 (8)° and between the isoxazole and cyclo-hexa-nol rings is 30.15 (8)°. The corresponding values in the second mol-ecule are 6.13 (10) and 88.44 (8)°, respectively. In the crystal, the molecules are linked by O-H⋯O and O-H⋯N hydrogen bonds, building up a zigzag chain parallel to the a axis.
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http://dx.doi.org/10.1107/S1600536809044900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972041PMC
November 2009

Synthesis and studies of modified oligonucleotides-directed triple helix formation at the purine-pyrimidine interrupted site.

Nucleosides Nucleotides Nucleic Acids 2003 May-Aug;22(5-8):1277-80

Laboratoire de Chimie des Plantes et de Synthèse Organique et Bioorganique, Universitè des Sciences, Rabat, Morocco.

Triple helix formation is still restricted to oligopurine-oligopyrimidine double stranded DNA target. Herein we focus on our progress achieved in nucleobase and oligonucleotide modifications area to address the chemical challenge to circumvent the recognition of a purine-pyrimidine base pair interruption in an oligopyrimidine-oligopurine DNA sequence.
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http://dx.doi.org/10.1081/NCN-120022945DOI Listing
December 2003

Triterpenoid saponins from the shells of Argania spinosa seeds.

J Agric Food Chem 2002 Jul;50(16):4600-3

Laboratoire de Chimie des Plantes et de Synthèse Organique et Bioorganique, Faculté des Sciences, University of Rabat, B.P. 1041, RP Rabat, Morocco.

Two new oleanene saponins were isolated from the MeOH extract of the shell of Argania spinosa. They possess protobassic acid and 16alpha-protobassic acid as aglycons. The disaccharide moiety linked to C-3 of the aglycon is made up of two glucose units; the pentasaccharide moiety linked to C-28 is made up of arabinose, xylose, and three rhamnose units. Their structures were elucidated by 1D and 2D NMR experiments including (1)H-(1)H (DQF-COSY, 1D TOCSY, and 2D HOHAHA) and (1)H-(13)C (HSQC and HMBC) spectroscopy along with mass spectrometry.
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http://dx.doi.org/10.1021/jf0200117DOI Listing
July 2002
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