Publications by authors named "Mohamed Said"

200 Publications

Physical activity, sedentary behaviors, and breakfast eating as factors influencing BMI in Saudi students, aged 10 to 15 years.

Ann Med 2022 Dec;54(1):1459-1472

Department of Physical Education, College of Education, King Faisal University, Al-Ahsa, Saudi Arabia.

Background: Eating less and moving more are the simplest and most common strategies to combat excessive weight. Several other lifestyle factors can also contribute to maintaining a healthy weight.

Objectives: The present study examined the effects of breakfast frequency, duration and quality of sleep, daily physical activity, sedentary behaviours, and school transportation on the BMI of Saudi students, aged 10-15 years.

Materials And Methods: This study included 981 students (240 girls (24.46%) [66 children (27.5%) and 174 adolescents (72.5%)] and 741 boys (75.54%) [441 children (59.51%) and 300 adolescents (40.49%)]). For each participant, height, weight, and body composition were obtained using bioelectric impedance analysis. A questionnaire focussing on lifestyle behaviours over the last seven days was also completed by each student. Multiple comparisons were performed to test for significant differences between the groups, stratified by sex, age, and BMI. Stepwise multiple regression analysis was used to determine the variables that significantly affected BMI.

Results: The overall prevalence of overweight and obesity in boys was 12.82% and 25.1%, and in girls, 10.42% and 5.42%, respectively. Most participants used cars or buses as transportation to and from school (100% of girls and 83% of boys). Breakfast was skipped mainly by male participants. Boys tended to sleep more than girls during school days (488.90 ± 74.33 vs. 467.76 ± 78.75 min. night). They were more active (2.58 ± 0.69 vs. 2.34 ± 0.82), used laptops more frequently (2.46 ± 1.51 vs. 1.90 ± 1.63), and played more video games (3.12 ± 1.43 vs. 1.2875 ± 1.36) than girls. However, girls were less sedentary (2.63 ± 0.76 vs. 2.9±.79), watched more TV (3.65 ± 1.155 vs. 2.73 ± 1.48) and used their smartphones more (3.6625 ± 1.3 vs. 3.28 ± 1.44) than boys.

Conclusions: This study revealed significant associations between BMI and breakfast intake, physical activities, and sedentary behaviours. Of these, using laptops and playing video games were the key sedentary activities that influenced BMI.Key messagesA significantly higher prevalence of overweight and obesity was noted among boys compared to girls in private school students, aged 10-15 years, in Al-Ahsa governorate, Eastern Province of Saudi Arabia.Boys slept more than girls on school days, and they were more active, used laptops more frequently, and played more video games than girls. Girls were less sedentary, watched television more often, and used smartphones more frequently than boys.Among private school students aged 10-15 years in Al-Ahsa governorate, Eastern Province of Saudi Arabia, BMI was significantly associated with breakfast intake frequency, physical activity, and sedentary behaviours, among which using laptops and playing video games were the sedentary activities that most influenced BMI.
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http://dx.doi.org/10.1080/07853890.2022.2077429DOI Listing
December 2022

Variation Range of Different Inductor Topologies with Shields for RF and Inductive Sensing Applications.

Sensors (Basel) 2022 May 5;22(9). Epub 2022 May 5.

Sensors, Microsystems and Actuators Laboratory of Louvain (SMALL), Université Catholique de Louvain, Place du Levant 3, 1348 Louvain-la-Neuve, Belgium.

In this study, different planar inductor topologies were studied to evaluate their characteristic parameters' variation range upon approaching Fe- and Cu-based shield plates. The use of such materials can differently alter the electrical properties of planar inductors such as the inductance, resonant frequency, resistance, and quality factor, which could be useful in multiple devices, particularly in inductive sensing and radio-frequency (or RF) applications. To reach an optimal design, five different square topologies, including spiral, tapered, non-spiral, meander, and fractal, were built on a printed circuit board (PCB) and assessed experimentally. At the working frequency of 1 MHz, the results showed a decrease in the inductance value when approaching a Cu-based plate and an increase with Fe-based plates. The higher variation range was noticeable for double-layer topologies, which was about 60% with the Cu-based plate. Beyond an intrinsic deflection frequency, the inductance value began to decrease when approaching the ferromagnetic plate because of the ferromagnetic resonance (FMR). It has been shown that the FMR frequency depends on the inductor topology and is larger for the double-layer spiral one. The -factor was decreasing for all topologies but was much faster when using ferromagnetic plates because of the FMR, which intensely increases the track resistance. The resonant frequency was increasing for all double-layer topologies and decreasing for single-layer ones, which was mainly due to the percentage change in the stray capacitance compared to the inductance variation. The concept of varying inductors by metal shielding plates has great potential in a wide range of nondestructive sensing and RF applications.
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http://dx.doi.org/10.3390/s22093514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101558PMC
May 2022

A patent review of anticancer CDK2 inhibitors (2017-present).

Expert Opin Ther Pat 2022 May 18. Epub 2022 May 18.

School of Biotechnology, Badr University in Cairo, Badr City, Cairo 11829, Egypt.

Introduction: : The success of the CDK4/6 inhibitor Ibrance™ (Palbociclib) as an anticancer agent inspired and directed more efforts towards the discovery of selective cyclin-dependent kinase (CDKs) inhibitors. CDK2 is a member of the CDKs family that plays an important role in regulating the progression of cells into both S- and M-phases of the cell cycle. Studies suggest that overexpression of CDK2 may be implicated in tumor growth in cancer.

Areas Covered: : This review covers the patent literature of CDK2 inhibitors published between 2017 and 2021. We searched the online databases of the European Patent Office, American Chemical Society, and Google patents.

Expert Opinion: Developing selective CDK2 inhibitors is challenging due to the absence of a previously approved selective CDK2 inhibitor. However, ongoing efforts by Incyte Corporation and Pfizer Inc., which are reported herein, may stand out as a new starting point and bring novel information critical for the medicinal chemistry and drug design scientists in the field of CDK2 inhibitors development.
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http://dx.doi.org/10.1080/13543776.2022.2078193DOI Listing
May 2022

Structural, optical and photocatalytic properties of mesoporous CuO nanoparticles with tunable size and different morphologies.

RSC Adv 2021 Nov 24;11(60):37801-37813. Epub 2021 Nov 24.

Physics Department, Faculty of Science, Assiut University 71516 Assiut Egypt.

Nanomaterials with controllable particle size and shape have fascinating properties. Herein, CuO nanoparticles (NPs) with controlled particle size and morphology are obtained a simple co-precipitation approach. Variation of the reaction medium composition steers the variation of both particle size and morphology of the CuO NPs. The reaction was performed in ethanol-water solutions with different volume to volume ratios (v/v%) 0, 25, 50, and 100%. XRD of the obtained samples revealed a drop in their particle size from ∼13 to ∼7 nm when the aqueous medium is entirely replaced by the ethanolic medium. TEM and HR-TEM investigations have pointed to the formation of CuO NPs with rod-like shapes in water (diameter = 15 nm and length = 200 nm). Whereas, spherical NPs with a diameter of 7.2 nm are obtained in ethanol. Structural analysis of CuO samples obtained in different media was done applying the Rietveld method. The volume of the monoclinic unit cell of CuO is increased to 81.869 Å when water (81.207 Å) is completely substituted by ethanol. Moreover, the internal local strain () and the dislocation density () values increase from 2.78 × 10 to 4.64 × 10 and 0.592 × 10 to 1.93 × 10 line per m, respectively by changing from aqueous to ethanolic medium. The optical band gap ( ) determined using Tauc's equation for the direct transition is increased from 2.2 to 2.65 eV when water is totally replaced by ethanol. The feasibility of both CuO samples as photocatalysts for the degradation of Congo red was tested. CuO prepared in pure water showed remarkably high efficiency during the first 25 min of illumination. Both samples showed complete dye removal after 35 min. Ultimately, this work presents a simple and green approach for the preparation of CuO NPs with tunable particle size, varied morphological shapes, high surface area, and different structural and optical properties merely through controlling the ethanol content in water.
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http://dx.doi.org/10.1039/d1ra04780aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043742PMC
November 2021

Using Different Low-Profile Abutments for Assisting Mandibular Implant Overdenture: A Split-Mouth Study.

Int J Dent 2022 9;2022:8738220. Epub 2022 Apr 9.

Department of Prosthodontics, Mansoura University, Mansoura, Egypt.

Background: Using a pair of different low-profile abutments to assist mandibular implant overdenture (MIOD) in limited restorative space is questionable due to the different morphology.

Objective: To investigate the marginal bone level (MBL) change and peri-implant-tissue health (PITH) around a pair of OT Equator and Locator suprastructures assisting MIOD.

Methods: Seventeen edentulous patients received MIOD assisted by OT Equator and Locator. MBL change was investigated at the implant loading (T1), after six months (T2) and twelve months (T3) of implant loading. PITH was evaluated at T2 and T3.

Results: There was within abutment significant difference in MBL change after T2 and T3 of loading for Locator (0.05 ± 0.02 and 0.32 ± 0.08, respectively) (=0.01); and for Equator (0.11 ± 0.08 and 0.21 ± 0.09, respectively) (=0.01). Also, there was a significant difference between Locator and Equator on the modified plaque index (MPI) after T3 (=0.01). The significant results were recorded for the MPI at T2 and T3 for Locator (0.92 ± 0.26 and 1.5 ± 0.51, respectively) (=0.01) and for Equator (0.82 ± 0.26 and 1.42 ± 0.51, respectively) (=0.003). For modified bleeding index, there was significant difference at T2 and T3 for Locator (0.57 ± 0.19 and 1.14 ± 0.41, respectively) (=0.03) and for Equator (0.46 ± 0.22 and 1.07 ± 0.41, respectively) (=0.01). For gingival index, there was significant difference at T2 and T3 for Locator (0.57 ± 0.11 and 1.28 ± 0.35, respectively) (=0.001) and for Equator (0.35 ± 0.21 and 1.1 ± 0.46, respectively) (=0.001).

Conclusions: Using different pairs of the low-profile OT Equator and Locator abutments to assist MIOD is clinically acceptable based on the MBL change and PITH outcomes.
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http://dx.doi.org/10.1155/2022/8738220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9013306PMC
April 2022

Collaborative Impact of Compost and Beneficial Rhizobacteria on Soil Properties, Physiological Attributes, and Productivity of Wheat Subjected to Deficit Irrigation in Salt Affected Soil.

Plants (Basel) 2022 Mar 25;11(7). Epub 2022 Mar 25.

Department of Botany, Faculty of Agriculture, Suez Canal University, Ismailia 41522, Egypt.

Plant growth and crop productivity under unfavorable environmental challenges require a unique strategy to scavenge the severely negative impacts of these challenges such as soil salinity and water stress. Compost and plant growth-promoting rhizobacteria (PGPR) have many beneficial impacts, particularly in plants exposed to different types of stress. Therefore, a field experiment during two successive seasons was conducted to investigate the impact of compost and PGPR either separately or in a combination on exchangeable sodium percentage (ESP), soil enzymes (urease and dehydrogenase), wheat physiology, antioxidant defense system, growth, and productivity under deficient irrigation and soil salinity conditions. Our findings showed that exposure of wheat plants to deficit irrigation in salt-affected soil inhibited wheat growth and development, and eventually reduced crop productivity. However, these injurious impacts were diminished after soil amendment using the combined application of compost and PGPR. This combined application enhanced soil urease and dehydrogenase, ion selectivity, chlorophylls, carotenoids, stomatal conductance, and the relative water content (RWC) whilst reducing ESP, proline content, which eventually increased the yield-related traits of wheat plants under deficient irrigation conditions. Moreover, the coupled application of compost and PGPR reduced the uptake of Na and resulted in an increment in superoxide dismutase (SOD), catalase (CAT), and peroxidase (POX) activities that lessened oxidative damage and improved the nutrient uptake (N, P, and K) of deficiently irrigated wheat plants under soil salinity. It was concluded that to protect wheat plants from environmental stressors, such as water stress and soil salinity, co-application of compost with PGPR was found to be effective.
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http://dx.doi.org/10.3390/plants11070877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9002696PMC
March 2022

Outbreak and control of Achromobacter denitrificans at an academic hospital in Pretoria, South Africa.

Infect Control Hosp Epidemiol 2022 Mar 28:1-7. Epub 2022 Mar 28.

Department of Medical Microbiology, University of Pretoria, Pretoria, Gauteng, South Africa.

Objective: In this study, we sought to determine the source of an outbreak of Achromobacter denitrificans infections in patients at a tertiary-care academic hospital.

Design: Outbreak report study with intervention. The study period extended from February 2018 to December 2018.

Setting: The study was conducted at a tertiary-care academic hospital in Pretoria, South Africa.

Patients And Participants: All patients who cultured A. denitrificans from any site were included in this study. During the study period, 43 patients met this criterion.

Interventions: Once an outbreak was confirmed, the microbiology laboratory compiled a list of affected patients. A common agent, chlorhexidine-and-water solution, was used as a disinfectant-antiseptic for all affected patients. The laboratory proceeded to culture this solution. Environmental and surface swabs were also cultured from the hospital pharmacy area where this solution was prepared. Repetitive-element, sequence-based, polymerase chain reaction (rep-PCR) was performed on the initial clinical isolates to confirm the relatedness of the isolates.

Results: In total, 43 isolates of A. denitrificans were cultured from patient specimens during the outbreak. The laboratory cultured A. denitrificans from all bottles of chlorhexidine-and-water solutions sampled from the wards and the pharmacy. The culture of the dispenser device used to prepare this solution also grew A. denitrificans. The rep-PCR confirmed the clonality of the clinical isolates with 2 genotypes dominating.

Conclusions: Contaminated chlorhexidine-and-water solutions prepared at the hospital pharmacy was determined to be the source of the outbreak. Once this item was removed from the hospital, the laboratory did not culture any further A. denitrificans isolates from patient specimens.
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http://dx.doi.org/10.1017/ice.2022.52DOI Listing
March 2022

Anthropometry, body composition, and athletic performance in specific field tests in Paralympic athletes with different disabilities.

Heliyon 2022 Mar 25;8(3):e09023. Epub 2022 Feb 25.

Faculty of Sciences, Bizerte, Tunisia.

Purpose: The structural appearance of each disabled athlete or the shape of their body, as determined by their individual genotype and influenced by the environment, considerably affects their technical and physical performance. This study sought to examine the morphological characteristics of elite track and field athletes with different disabilities, including their possible effects on physical and physiological performance.

Methods: A total of 66 male elite athletes with cerebral palsy (n = 12), upper arm amputation (n = 12), short stature (n = 20), or intellectual disability (n = 22) were included. For each athlete, height, weight, sitting height, arm span and four skin folds were assessed; ape index, body mass index, body fat percentage, fat mass, fat mass index and fat-free mass values were calculated; and vertical jump, drop jump, countermovement jump, squat jump, repeated sprint ability and Yo-Yo Intermittent Recovery Level 1 tests were performed.

Results: Significant differences were noticed between short stature and the other groups concerning morphological characteristics, however, the best motor performance was observed in amputees and, to a lesser degree, in short stature. In the top performing athletes, physical performance was significantly correlated with body mass index and fat mass index for amputees, and with arm span, ape index, body fat percentage and fat mass index for short stature. Regression analysis revealed that regardless of disability type, physical and physiological performance (except maximum heart rate) were significantly influenced primarily by adipose tissue-specific variables. A significant effect of height, weight, fat free mass, arm span, sitting height, and ape index on drop jump performance with left leg, maximal oxygen consumption, and maximum heart rate was also noticed. The type of disability affects performance in the squat jump and vertical jump tests, and to a lesser extent in the countermovement jump test.
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http://dx.doi.org/10.1016/j.heliyon.2022.e09023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889346PMC
March 2022

Efficacy of fine motor and balance exercises on fine motor skills in children with sensorineural hearing loss.

Restor Neurol Neurosci 2022 ;40(1):43-52

Basic Sciences Department, Faculty of Physical Therapy, Benha University, Egypt.

Background: Childhood hearing impairment is a major disability associated with delayed motor development. The affected Fine motor performance in children with sensorineural hearing loss (SNHL) could be due to dynamic balance deficits and visual-motor incoordination.

Objective: This study was designed to investigate the effects of fine motor exercises with or without balancing exercises on fine motor skills in children with SNHL.

Methods: One hundred and eighty (180) children their age ranged from 8 to 18 years old diagnosed with SNHL were selected. They were divided into three groups, 60 children (control group) practiced only their ordinary activities of daily living, 60 children (fine motor exercises group) practiced fine motor exercises, and 60 children (fine motor and balance exercise) group practiced fine motor and balance exercises. The outcomes were assessed by the Bruininks Oseretsky Test of the motor proficiency second edition scale (BOT-2).

Results: Generally, there was a statistically significant difference between control group and fine motor exercises group where (p < 0.05), besides, there was a statistically significant difference between control group and fine motor and balance exercises group where (p < 0.05). But, there was no statistically significant difference between fine motor exercises group and fine motor and balance exercises group where (p > 0.05).

Conclusions: The Fine Motor performance of children with SNHL has been improved by Fine motor with or without balancing exercises according to (BOT-2).
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http://dx.doi.org/10.3233/RNN-211156DOI Listing
April 2022

Design, Synthesis, Chemical and Biochemical Insights Into Novel Hybrid Spirooxindole-Based p53-MDM2 Inhibitors With Potential Bcl2 Signaling Attenuation.

Front Chem 2021 14;9:735236. Epub 2021 Dec 14.

Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.

The tumor resistance to p53 activators posed a clinical challenge. Combination studies disclosed that concomitant administration of Bcl2 inhibitors can sensitize the tumor cells and induce apoptosis. In this study, we utilized a rapid synthetic route to synthesize two novel hybrid spirooxindole-based p53-MDM2 inhibitors endowed with Bcl2 signaling attenuation. The adducts mimic the thematic features of the chemically stable potent spiro [3-indole-3,2'-pyrrolidin]-2(1)-ones p53-MDM2 inhibitors, while installing a pyrrole ring a carbonyl spacer inspired by the natural marine or synthetic products that efficiently inhibit Bcl2 family functions. A chemical insight into the two synthesized spirooxindoles including single crystal x-ray diffraction analysis unambiguously confirmed their structures. The synthesized spirooxindoles and were preliminarily tested for cytotoxic activities against normal cells, MDA-MB 231, HepG-2, and Caco-2 MTT assay. was superior to 5-fluorouracil. Mechanistically, induced apoptosis-dependent anticancer effect (43%) higher than that of 5-fluorouracil (34.95%) in three studied cancer cell lines, activated p53 (47%), downregulated the Bcl2 gene (1.25-fold), and upregulated p21 (2-fold) in the treated cancer cells. Docking simulations declared the possible binding modes of the synthesized compounds within MDM2.
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http://dx.doi.org/10.3389/fchem.2021.735236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713455PMC
December 2021

Resuming post living donor liver transplantation in the COVID-19 pandemic: real-life experience, single-center experience.

Egypt Liver J 2021 20;11(1):92. Epub 2021 Dec 20.

Pediatrics Department, Liver Transplantation Unit, Cairo University, Cairo, Egypt.

Background: Solid organ transplantation (SOT) service has been disrupted during the current coronavirus disease 2019 (COVID-19) pandemic, which deferred the service in most centers worldwide. As the pandemic persists, there will be an urgency to identify the best and safest practices for resuming activities as areas re-open. Resuming activity is a difficult issue, in particular, the decision of reopening after a period of slowing down or complete cessation of activities.

Objectives: To share our experience in resuming living donor liver transplantation (LDLT) in the context of the COVID-19 pandemic in the Liver Transplantation Unit of El-Manial Specialized Hospital, Cairo University, Egypt, and to review the obstacles that we have faced.

Material And Methods: This study is a single-center study. We resumed LDLT by the 26th of August 2020 after a period of closure from the 1st of March 2020. We have taken a lot of steps in order to prevent COVID-19 transmission among transplant patients and healthcare workers (HCWs).

Results: In our study, we reported three LDLT recipients, once resuming the transplantation till now. All our recipients and donors tested negative for SARS-CoV-2 by nasopharyngeal RT-PCR a day before the transplantation. Unfortunately, one of them developed COVID-19 infection. We managed rapidly to isolate him in a single room, restricting one team of HCWs to deal with him with strict personal protective measures. Finally, the patient improved and was discharged in a good condition. The second patient ran a smooth course apart from FK neurotoxicity which improved with proper management. The third patient experienced a sharp rise in bilirubin and transaminases on day 14 that was attributed to drug toxicity vs. rejection and managed by discontinuing the offending drugs and pulse steroids. In addition, one of our head nurses tested positive for SARS-CoV-2 that was manageable with self-isolation.

Conclusion: Careful patient, donor, personnel screening is mandatory. Adequate supply of personal protective equipments, effective infection control policies, and appropriate administrative modifications are needed for a safe return of LDLT practice.
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http://dx.doi.org/10.1186/s43066-021-00153-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8686346PMC
December 2021

A case report of Nocardia asiatica constrictive pericarditis in a patient with Human Immunodeficiency Virus.

Cardiovasc Pathol 2022 May-Jun;58:107403. Epub 2021 Dec 22.

Department of Medical Microbiology, University of Pretoria, Pretoria, South Africa; Department of Medical Microbiology, Tshwane Academic Division, National Health Laboratory Service, Pretoria, South Africa.

Nocardiosis commonly affects the respiratory system and is a rare cause of purulent pericarditis. Invasive nocardial infections occur more frequently in patients with immunosuppression. A misdiagnosis as tuberculosis infection is not uncommon, especially in the context of immunosuppression in high burden tuberculosis settings. The risk factors and clinical features of the two disease entities overlap substantially. Misdiagnosis may lead to a delay in appropriate treatment and may result in poor outcomes. It is important to note that these conditions may also co-exist in the same patient. We describe, to the best of our knowledge, the first case of Nocardia asiatica pericarditis in a 32-year-old man with Human Immunodeficiency Virus infection. The patient was initially diagnosed in September 2020 with a lower respiratory tract infection and pulmonary tuberculosis was suspected. A chest radiograph, performed at admission, revealed a pericardial effusion and N. asiatica was cultured from a pericardial fluid specimen that was collected 5 days following admission. Despite a good initial clinical response to a combination of trimethoprim/sulfamethoxazole and imipenem/cilastatin, the patient demised after 16 weeks of treatment. Previous reports of laboratory confirmed nocardial pericarditis are also reviewed and summarized.
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http://dx.doi.org/10.1016/j.carpath.2021.107403DOI Listing
March 2022

Radical versus conservative surgical treatment of liver hydatid cysts: A paired comparison analysis.

Am J Surg 2021 Dec 16. Epub 2021 Dec 16.

Department of Gastrointestinal Surgery, Sahloul Hospital, Sousse, Tunisia. Electronic address:

Background: The management of liver hydatid cysts (LHC) is complex and includes surgery, percutaneous drainage, chemotherapy and observation. Broadly, there are two types of surgical treatment for LHC - conservative surgery (CS) and radical surgery (RS). The purpose of this study was to compare the outcome of RS and CS.

Methods: Data from all patients with LHC treated in Sahloul Hospital, between January 2000 and December 2019, were retrieved. To minimize selection bias, paired comparison analysis (PCA) was performed.

Results: A total of 914 patients were included in this study. RS and CS were performed in 284 and 630 patients, respectively. After PCA, 206 patients were included in each group. The incidence of intraoperative bleeding was significantly higher in the RS group. The overall morbidity was significantly lower in the RS group. Thity-four patients developed recurrence with significantly higher recurrence in CS group.

Conclusion: RS is associated with fewer postoperative complications and lower recurrence rate compared to CS. RS may be the preferred procedure for LHC if the expertise is available.
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http://dx.doi.org/10.1016/j.amjsurg.2021.12.014DOI Listing
December 2021

Corrigendum: Brucellosis - Laboratory workers' nightmare come true: A case study.

Afr J Lab Med 2021 22;10(1):1690. Epub 2021 Nov 22.

National Health Laboratory Services, Tshwane Academic Division, Pretoria, South Africa.

[This corrects the article DOI: 10.4102/ajlm.v9i1.1114.].
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http://dx.doi.org/10.4102/ajlm.v10i1.1690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8661401PMC
November 2021

Modification of Xanthan Gum for a High-Temperature and High-Salinity Reservoir.

Polymers (Basel) 2021 Dec 1;13(23). Epub 2021 Dec 1.

Department of Petroleum Engineering, King Fahd University of Petroleum & Minerals, Dhahran 31261, Saudi Arabia.

Tertiary oil recovery, commonly known as enhanced oil recovery (EOR), is performed when secondary recovery is no longer economically viable. Polymer flooding is one of the EOR methods that improves the viscosity of injected water and boosts oil recovery. Xanthan gum is a relatively cheap biopolymer and is suitable for oil recovery at limited temperatures and salinities. This work aims to modify xanthan gum to improve its viscosity for high-temperature and high-salinity reservoirs. The xanthan gum was reacted with acrylic acid in the presence of a catalyst in order to form xanthan acrylate. The chemical structure of the xanthan acrylate was verified by FT-IR and NMR analysis. The discovery hybrid rheometer (DHR) confirmed that the viscosity of the modified xanthan gum was improved at elevated temperatures, which was reflected in the core flood experiment. Two core flooding experiments were conducted using six-inch sandstone core plugs and Arabian light crude oil. The first formulation-the xanthan gum with 3% NaCl solution-recovered 14% of the residual oil from the core. In contrast, the modified xanthan gum with 3% NaCl solution recovered about 19% of the residual oil, which was 5% higher than the original xanthan gum. The xanthan gum acrylate is therefore more effective at boosting tertiary oil recovery in the sandstone core.
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http://dx.doi.org/10.3390/polym13234212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659541PMC
December 2021

Production, Titration, Neutralisation, Storage and Lyophilisation of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Lentiviral Pseudotypes.

Bio Protoc 2021 Nov 5;11(21):e4236. Epub 2021 Nov 5.

Viral Pseudotype Unit (VPU Kent), Medway School of Pharmacy, University of Kent and Greenwich at Medway, Chatham Maritime, Kent, UK.

This protocol details a rapid and reliable method for the production and titration of high-titre viral pseudotype particles with the SARS-CoV-2 spike protein (and D614G or other variants of concern, VOC) on a lentiviral vector core, and use for neutralisation assays in target cells expressing angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2). It additionally provides detailed instructions on substituting in new spike variants via gene cloning, lyophilisation and storage/shipping considerations for wide deployment potential. Results obtained with this protocol show that SARS-CoV-2 pseudotypes can be produced at equivalent titres to SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV) pseudotypes, neutralised by human convalescent plasma and monoclonal antibodies, and stored at a range of laboratory temperatures and lyophilised for distribution and subsequent application.
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http://dx.doi.org/10.21769/BioProtoc.4236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595416PMC
November 2021

Molecular hybridization design and synthesis of novel spirooxindole-based MDM2 inhibitors endowed with BCL2 signaling attenuation; a step towards the next generation p53 activators.

Bioorg Chem 2021 12 13;117:105427. Epub 2021 Oct 13.

Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia. Electronic address:

Despite the achieved progress in developing efficient MDM2-p53 protein-protein interaction inhibitors (MDM2 inhibitors), the acquired resistance of tumor cells to such p53 activators posed an argument about the druggability of the pathway. Combination studies disclosed that concomitant inhibition of MDM2 and BCL2 functions can sensitize the tumor cells and synergistically induce apoptosis. Herein, we employed a rapid combinatorial approach to generate a novel series of hybrid spirooxindole-based MDM2 inhibitors (5a-s) endowed with BCL2 signaling attenuation. The adducts were designed to mimic the thematic features of the chemically stable potent spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-ones MDM2 inhibitors while installing a pyrrole ring on the core via a carbonyl spacer inspired by the natural product marinopyrrole A that efficiently inhibits BCL2 family functions by various mechanisms. NCI 60 cell-line panel screening revealed their promising broad-spectrum antiproliferative activities. The NCI-selected derivatives were screened for cytotoxic activities against normal fibroblasts, MDA-MB 231, HepG-2, and Caco-2 cells via MTT assay, subjected to mechanistic apoptosis studies for assessment of p53, BCL2, p21, and caspase 3/7 status, then evaluated for potential MDM2 inhibition utilizing MST assay. The most balanced potent and safe derivatives; 5i and 5q were more active than 5-fluorouracil, exhibited low μmrange MDM2 binding (K=1.32and 1.72 μm, respectively), induced apoptosis-dependent anticancer activities up to 50%, activated p53 by 47-63%, downregulated the BCL2 gene to 59.8%, and reduced its protein level (13.75%) in the treated cancer cells. Further downstream p53 signaling studies revealed > 2 folds p21 upregulation and > 3 folds caspase 3/7 activation. Docking simulations displayed that the active MDM2 inhibitors resided well into the p53 binding sites of MDM2, and shared key interactions with the co-crystalized inhibitor posed by the indolinone scaffold (5i, 5p, and 5q), the halogen substituents (5r), or the installed spiro ring (5s). Finally, in silico ADMET profiling predicted acceptable drug-like properties with full accordance to Lipinski's, Veber's, and Muegge's bioavailability parameters for 5i and a single violation for 5q.
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http://dx.doi.org/10.1016/j.bioorg.2021.105427DOI Listing
December 2021

Does arthroscopic patellar denervation with high tibial osteotomy improve anterior knee pain?

J Exp Orthop 2021 Nov 9;8(1):104. Epub 2021 Nov 9.

Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.

Purpose: Patellofemoral (PF) joint osteoarthritis (OA) is a major cause of anterior knee pain. Combined PF and medial tibiofemoral (TF) OA is common in older adults. We evaluated the effect of arthroscopic patellar denervation (PD) in patients with combined TF and PFOA after malalignment correction.

Methods: Forty-five patients [females/males, 27/18; age, 30-59 years (45.5 ± 8.50); mean body mass index, 25.15 ± 3.04 kg/m] were treated in our department from March 2017 to March 2019. The patients were randomised into 2 groups: group A included 22 patients who underwent open-wedge high tibial osteotomy (OWHTO) and arthroscopic PD and group B included 23 patients who underwent OWHTO without denervation. The effect of denervation was statistically and clinically evaluated using the Knee injury and Osteoarthritis Outcome Score (KOOS) and Kujala (anterior knee pain score) score.

Results: After 24 months, 40 patients were available for the final follow-up. The final values of KOOS and the Kujala score were significantly different between the groups (p < 0.001). For group A, the average KOOS improved from 42.73 to 72.38 (p < 0.001) and the Kujala score improved from 42 to 74.1 (p < 0.001), whereas in group B, the average KOOS improved from 39.22 to 56.84 (p < 0.001) and the Kujala score improved from 39.7 to 56.4 (p < 0.001).

Conclusion: Adding arthroscopic PD to OWHTO relieves anterior knee pain in patients with combined TF and PFOA and improves knee joint function and quality of life.

Level Of Evidence: Level I prospective randomised control clinical trial.
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http://dx.doi.org/10.1186/s40634-021-00411-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575725PMC
November 2021

The effect of direct acting antiviral agents on vascular endothelial function in Egyptian patients with chronic hepatitis C virus infection.

Saudi Pharm J 2021 Oct 4;29(10):1120-1128. Epub 2021 Aug 4.

Lecturer of Clinical Pharmacy, Clinical Pharmacy & Pharmacy Practice Department, Faculty of Pharmacy, Damanhour University, Damanhour City, Egypt.

Chronic hepatitis C virus (HCV) infection is correlated with cerebrovascular and cardiovascular disease (CVD). This study aimed to assess the effect of treatment with DAAs on vascular endothelial function in cirrhotic and non-cirrhotic HCV infected patients without any CVD risk factors. Fifty chronic HCV genotype 4 infected patients, without cardiovascular risks who have been listed to receive sofosbuvir/daclatasvir with ribavirin combination as triple therapy for 3 months were prospectively recruited. Endothelial dysfunction markers as soluble vascular cell adhesion molecule-1 (sVCAM-1) and Von willebrand factor (vWf) and inflammation marker (IL6) were estimated at baseline and 3 months post the end of therapy (SVR). All patients achieved SVR. VCAM1 level was significantly improved after HCV clearance with DAA in cirrhotic HCV patients (P = 0.002) compared to patients with mild liver fibrosis (P = 0.006). Levels of vWF also decreased significantly in cirrhosis and non-cirrhosis groups after SVR (P < 0.001 and P = 0.011, respectively). Systemic inflammatory marker (IL6) showed significant decrease in cirrhotic patients (P = 0.001). While, IL6 level did not change significantly in non-cirrhotic group (P = 0.061). Also at SVR, noninvasive liver fibrosis indices have been reduced significantly in the two groups (P < 0.001). HCV clearance by new DAA treatment improves the vascular endothelial dysfunction in Egyptian HCV infected patients with different levels of liver fibrosis and with no risk factors for endothelial dysfunction or CVD.
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http://dx.doi.org/10.1016/j.jsps.2021.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523355PMC
October 2021

Spinal epidural abscess caused by Aspergillus spp masquerading as spinal tuberculosis in a person with HIV.

Lancet Infect Dis 2021 11 29;21(11):e356-e362. Epub 2021 Sep 29.

Department of Medical Microbiology, University of Pretoria, Pretoria, South Africa; Tshwane Academic Division, National Health Laboratory Service, Pretoria, South Africa.

Spinal epidural abscess caused by Aspergillus spp is a debilitating form of invasive aspergillosis that can easily be misdiagnosed as spinal tuberculosis due to shared risk factors and clinical features. In this Grand Round, we describe a case of thoracic aspergillus spinal epidural abscess in a patient with underlying HIV infection. The initial diagnostic consideration was that of spinal tuberculosis. Consequently, despite positive microbiological cultures of Aspergillus fumigatus, antifungal therapy was delayed until histopathological evaluation of the affected tissue confirmed the presence of fungal hyphae. The patient showed an initial favourable response after surgical removal of the infected focus, but unfortunately never returned to premorbid functioning. This case highlights the importance of early diagnosis, urgent surgery, and prompt antifungal therapy for the management of aspergillus spinal epidural abscesses. Associated morbidity and mortality can be substantially increased if physicians fail to recognise this condition and do not institute appropriate and timely surgical and medical treatment.
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http://dx.doi.org/10.1016/S1473-3099(20)30979-8DOI Listing
November 2021

Partial discharge detection with on-chip spiral inductor as a loop antenna.

Rev Sci Instrum 2021 Sep;92(9):094701

Systems Integration & Emerging Energies (SI2E), National Engineering School of Sfax, University of Sfax, Route Soukra, BP 1173, 3038 Sfax, Tunisia.

In this paper, a pioneer partial discharge (PD) loop antenna sensor is presented and examined. It is made of a 70-turn square planar inductor with a side length of 1.8 mm, which is fabricated on top of a silicon substrate in complementary metal oxide semiconductor technology. The microsensor ability to detect corona PD is demonstrated once connected in series with a 60 dB gain amplifier. The behavior is studied at different separation distances from the line through which the PD pulses flow. At 5 cm away, a damped sinusoidal induced voltage with an amplitude of about 100 mV has been measured. The output signal spectrum is highly concentrated around a central resonance frequency of ∼5 MHz. The microsensor response is compared with those of other industrial sensors from Techimp, i.e., horn antennas and high-frequency current transformer sensors. The presented on-chip sensor can be considered a non-intrusive competing solution compared with other heavy and expensive commercial sensors due to its lightweight, compact size, and low cost. In addition, it shows an acceptable signal to noise ratio compared with other commercial electromagnetic wave-based sensors.
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http://dx.doi.org/10.1063/5.0051419DOI Listing
September 2021

Surgical management of giant hepatic hemangioma: A 10-year single center experience.

Ann Med Surg (Lond) 2021 Sep 6;69:102542. Epub 2021 Jul 6.

Department of Digestive Surgery, Sahloul Hospital, Sousse, Tunisia.

Background: Hepatic hemangiomas are the most typical benign mesenchymal lesions of the liver. Most of these lesions are asymptomatic. Giant hepatic hemangiomas (GHH) (>10 cm) are often symptomatic and require surgical intervention. This study aimed to describe the clinical findings, risk factors, diagnostic approach and management of GHH.

Methods: We performed a retrospective analysis of patients with GHH treated at our hospital from January 2008 to December 2018. The medical records of each patient were reviewed to obtain the clinical and surgical data.

Results: Twelve patients with GHH were treated during the study period. 9 were female and 3 were male. The mean age of diagnosis was 48,2 years. The most common presenting symptom was abdominal pain. Eight patients presented an abdominal mass. Indications for surgical resections were rupture (n = 2), Kasabach-Merritt syndrome (n = 1) and abdominal pain (n = 9). Right hepatectomy was done in four patients, left lobectomy in four patients, and enucleation in four patients. Embolization was performed in 4 patients, but due to the persistence of symptoms or bleeding, surgery was indicated. The mean operative time was 3.5 h, and median blood loss was 870 ml. The median hospital stay was 5.3 days. For four patients, we registered postoperative complications causing death in one case. All alive patients were asymptomatic at a median follow-up of 55 months.

Conclusion: Despite limitations and alternative modalities, surgery remains the only effective curative treatment for GHH.
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http://dx.doi.org/10.1016/j.amsu.2021.102542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379432PMC
September 2021

Diagnostic accuracy of the BioFire FilmArray blood culture identification panel when used in critically ill patients with sepsis.

J Microbiol Methods 2021 10 17;189:106303. Epub 2021 Aug 17.

Department of Medical Microbiology, University of Pretoria, Pretoria, South Africa; Tshwane Academic Division, National Health Laboratory Service, Pretoria, South Africa.

Sepsis accounts for high mortality rates in critical care units. Prompt and accurate identification of causative pathogens and initiation of appropriate antimicrobial therapy is critical for the appropriate management of patients in order to optimise clinical outcomes. The BioFire FilmArray blood culture identification (BCID) panel is a US Food and Drug Administration (FDA) approved rapid, multiplex polymerase chain reaction (PCR) assay that is able to identify a variety of bacteria, fungi and antimicrobial resistance determinants directly from positive blood cultures. The aim of this study was to evaluate the diagnostic performance of the BioFire FilmArray BCID panel against the gold standard of blood cultures. Seventy-eight positive blood cultures obtained from critically ill patients suspected of having sepsis were included in the study. Each bottle was processed with the BioFire FilmArray BCID panel as well as conventional culture methods. Diagnostic accuracy of the BioFire FilmArray BCID panel was determined. The assay demonstrated a high sensitivity and specificity for pathogen identification of 96.5% (95% CI, 91.3-99.0) and 99.7% (95% CI, 99.3-99.9), respectively. The findings of this study support the role of the BioFire FilmArray BCID panel in the management of critically ill patients with sepsis.
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http://dx.doi.org/10.1016/j.mimet.2021.106303DOI Listing
October 2021

Clinical utility of the BioFire FilmArray Blood Culture Identification panel in the adjustment of empiric antimicrobial therapy in the critically ill septic patient.

PLoS One 2021 9;16(7):e0254389. Epub 2021 Jul 9.

Department of Medical Microbiology, University of Pretoria, Pretoria, South Africa.

Sepsis and septic shock are key contributors to mortality in critically ill patients and thus prompt recognition and management thereof is central to achieving improved patient outcomes. Early initiation of appropriate antimicrobial therapy constitutes a crucial component of the management strategy and thus early identification of the causative pathogen is essential in informing antimicrobial therapeutic choices. The BioFire FilmArray blood culture identification (BCID) panel is a US Food and Drug Administration (FDA) approved rapid, multiplex polymerase chain reaction assay for use on positive blood cultures. This study evaluated its clinical utility in the intensive care unit (ICU) setting, in terms of amendment of empiric antimicrobial therapy in critically ill patients with sepsis. The assay proved useful in this setting as final results were made available to clinicians significantly earlier than with conventional culture methods. This, in turn, allowed for modification of empirical antimicrobial therapy to more appropriate agents in 32% of patients. Additionally, the use of the BioFire FilmArray BCID panel permitted the prompt implementation of additional infection prevention and control practices in a sizeable proportion (14%) of patients in the study who were harbouring multidrug resistant pathogens. These findings support the use of the BioFire FilmArray BCID panel as a valuable adjunct to conventional culture methods for the diagnosis and subsequent management of critically ill patients with sepsis.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254389PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270117PMC
November 2021

CXCR4 as a prognostic marker in Egyptian chronic lymphocytic leukemia patients.

Egypt J Immunol 2021 07;28(3):114-126

Department of Clinical Pathology, Faculty of Medicine, Assiut University, Egypt.

Chronic lymphocytic leukemia (CLL) has variable clinical presentations, and molecular and biological prognostic markers. The C-X-C chemokine receptor 4 (CXCR4) and its ligand stromal cell-derived factor-1 (SDF-1) play an important role in trafficking of lymphocytes and monocytes. The aim was to study lymphocyte expression of CXCR4 and its prognostic value in CLL. A case control study was carried out on 30 newly diagnosed CLL cases and 30 healthy controls. Fludarabine, cyclophosphamide, and rituximab (FCR) was the standard treatment. Flowcytometric measurement of CXCR4 expression on lymphocytes was done. CXCR4 was significantly higher in patients than controls (81.67 ± 17.95 vs. 11.78 ± 2.78; P< 0.001). CXCR4 was significantly higher (P<0.001) in high risk CLL (93.63 ± 6.78) vs. intermediate risk (82.50 ± 7.13) and low risk (75.84 ± 12.23). CXCR4 was significantly higher (P<0.001) in non-responders (91.63 ± 6.98) vs. partial responders (83.11 ± 5.55) and complete responders (70.11 ± 4.44). CXCR4 was significantly lower in survivors vs. non-survivors (80.89 ± 5.09 vs. 85.43 ± 5.51; P< 0.001. CXCR4 had significant positive correlation with WBCs (r=0.45, P=0.01) and lymphocytes (r=0.40, P=0.01) measured at diagnosis. In conclusions, expression of CXCR4 in newly diagnosed CLL is significantly high. CXCR4 increased expression is associated with poor prognosis and resistance to the therapy.so it can be used as prognostic tool.
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July 2021

Rheumatoid arthritis serotype and synthetic disease-modifying anti-rheumatic drugs in patients with periodontitis: A case-control study.

PLoS One 2021 21;16(6):e0252859. Epub 2021 Jun 21.

Faculty of Dentistry, Department of Restorative Dentistry, Unit of Periodontology, Universiti Kebangsaaan Malaysia, Kuala Lumpur, Malaysia.

Patients with rheumatoid arthritis (RA) experience a higher prevalence of periodontitis. This study aimed to examine the variation of periodontitis experienced with different serotypes suffered by RA patients and to examine the relationship between the different medications taken for RA that may influence this relationship. Two hundred and sixty RA and control participants underwent standardized periodontal examinations. Medical, serological and radiological (Sharp/van der Heijde) records were assessed. Functional status was assessed using the administered Health Assessment Questionnaire. Moreover, disease parameters, including disease activity (DAS28-ESR) and anti-citrullinated protein antibodies (ACPA) and rheumatoid factor (RF) seropositivity were evaluated. Periodontitis was higher in RA (71.54%) compared with controls (54.62%). The stage of periodontitis experienced by ACPA-positive participants were higher than APCA-negative participants. The probing pocket depth and recession experienced by RF-positive participants were higher than those who were RF-negative. RA participants on methotrexate had lower clinical attachment loss and lower periodontal probing depth compared with participants on a combination methotrexate and other disease-modifying antirheumatic drugs. Participants taking corticosteroids had lower gingival index scores. The association between seropositivity and the type of medications taken with periodontal health parameters in this group of patients suggests that both seropositivity and medications taken are important modifiers in the relationship between periodontitis and RA.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0252859PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8216515PMC
November 2021

Diverticular disease of the small bowel: a rare cause of the duodenojejunal flexure obstruction (a case report).

Pan Afr Med J 2021 24;38:213. Epub 2021 Feb 24.

Gastroenterology Department, Fattouma Bourguiba Hospital, Monastir, Tunisia.

The small bowel is the least common site for diverticula in the entire gastrointestinal tract. Chronic upper intestinal obstruction due to diverticula is very rare. We report a case of multiple small bowel diverticula causing mechanical obstruction of the duodenojejunal flexure.
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http://dx.doi.org/10.11604/pamj.2021.38.213.27575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140677PMC
June 2021

Synthesis, molecular modeling, selective aldose reductase inhibition and hypoglycemic activity of novel meglitinides.

Bioorg Chem 2021 06 20;111:104909. Epub 2021 Apr 20.

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University, P.O. 41522 Ismailia, Egypt.

In the present study, a novel generation of selective aldose reductase ALR2 inhibitors with significant hypoglycemic activities was designed and modulated based on rhodanine scaffold joined to an acetamide linker in between two lipophilic moieties. The synthesis of the novel compounds was accomplished throughout simple chemical pathways. Molecular docking was performed on B-cell membrane protein SUR1, aldehyde reductase ALR1 and aldose reductase ALR2 active sites. Compounds 10B, 11B, 12B, 15C, 16C, 26F and 27F displayed the highest hypoglycemic activities with 80.7, 85.2, 87, 82.3, 83.5, 81.4 and 85.3% reduction in blood glucose levels, respectively. They were more potent than the standard hypoglycemic agent repaglinide with 65.4% reduction in blood glucose level. Compounds 12B and 15C with IC 0.29 and 0.35 µM were more potent than the standard ALR2 inhibitor epalrestat with IC 0.40 µM. They were selective towards ALR2 over ALR1 134 and 116 folds, respectively. Molecular docking studies matched with the in-vitro and in-vivo results to elucidate the dual activities of both compounds 12B and 15C as potent antagonists for ALR2 over ALR1 and good agonists for the SUR1 protein.
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http://dx.doi.org/10.1016/j.bioorg.2021.104909DOI Listing
June 2021

Aerobic training, resistance training, or their combination as a means to fight against excess weight and metabolic syndrome in obese students - which is the most effective modality? A randomized controlled trial.

Appl Physiol Nutr Metab 2021 Aug 25;46(8):952-963. Epub 2021 Feb 25.

Physical Education Department, College of Education, King Faisal University, Saudi Arabia.

This study aimed to determine the effects of either aerobic training (AT) or resistance training (RT) or both (A+RT) on obesity and its comorbidities in young adults. A total of 61 participants, aged 21.74 ± 1.42 years and with a body mass (BM) index (BMI) of 36.21 ± 2.43 kg/m, were randomized for 12 weeks into control (CONT, = 15), AT ( = 15), RT ( = 16), and A+RT ( = 15) groups. BM, body composition, and cardiovascular disease risk factors were assessed before and after intervention. BM did not change in the CONT and RT groups but decreased significantly by 7.5 kg in the AT ( ≤ 0.05) and 8.82 kg in the A+RT ( ≤ 0.05) groups, respectively. Significant reductions were also noted in waist circumference, BMI, and body fat percentage in the exercising groups. The most significant variations were in the A+RT group. High-density lipoprotein cholesterol (HDL-C) concentrations were increased after A+RT by 2.39 mg/dL. Significant reductions were also noted in very-low-density lipoprotein cholesterol (VLDL-C) concentrations (-2.84 mg/dL) in the A+RT group. AT alone is effective in improving BM and body composition, while RT alone improves the body composition and A+RT ensures better outcomes concerning BM, body composition, HDL-C, and VLDL-C. Aerobic training alone is effective in improving BM and body composition. Resistance training alone improves the body composition. The combination of aerobic and resistance exercises ensures better outcomes for BM, body composition, HDL-C, and VLDL-C.
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http://dx.doi.org/10.1139/apnm-2020-0972DOI Listing
August 2021

Multifunctional Hydroxyapatite/Silver Nanoparticles/Cotton Gauze for Antimicrobial and Biomedical Applications.

Nanomaterials (Basel) 2021 Feb 8;11(2). Epub 2021 Feb 8.

Chemistry Department, Faculty of Science, Helwan University, Helwan, Cairo 11795, Egypt.

Medical textiles have played an increasingly important protection role in the healthcare industry. This study was aimed at improving the conventional cotton gauze for achieving advanced biomedical specifications (coloration, UV-protection, anti-inflammation, and antimicrobial activities). These features were obtained by modifying the cotton gauze fabrics via in-situ precipitation of hydroxyapatite nanoparticles (HAp NP), followed by in-situ photosynthesis of silver (Ag) NPs with ginger oil as a green reductant with anti-inflammation properties. The HAp-Ag NPs coating provides good UV-protection properties. To further improve the HAp and Ag NPs dispersion and adhesion on the surface, the cotton gauze fabrics were modified by cationization with chitosan, or by partial carboxymethylation (anionic modification). The influence of the cationic and anionic modifications and HAp and Ag NPs deposition on the cotton gauze properties (coloration, UV-protection, antimicrobial activities, and water absorption) was thoroughly assessed. Overall, the results indicate that chemical (anionic and cationic) modification of the cotton gauze enhances HAp and Ag NPs deposition. Chitosan can increase biocompatibility and promotes wound healing properties of cotton gauze. Ag NP deposition onto cotton gauze fabrics brought high antimicrobial activities against Candida albicans, Gram-positive and Gram-negative bacteria, and improved UV protection.
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http://dx.doi.org/10.3390/nano11020429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915402PMC
February 2021
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