Publications by authors named "Mohamed S Traoré"

2 Publications

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Antiplasmodial Oleanane Triterpenoids from Root Bark.

J Nat Prod 2021 Mar 5;84(3):666-675. Epub 2021 Mar 5.

Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.

Phytochemical investigation of the -BuOH extract of the roots of Sc. Elliot (Combretaceae) led to the isolation and identification of 10 oleanane triterpenoids (-), among which six new compounds, i.e., albidanoside A (), albidic acid A (), albidinolic acid (), albidienic acid (), albidolic acid (), and albidiolic acid (), and two triterpenoid aglycones, i.e., albidic acid B () and albidic acid C (), were isolated here for the first time from a natural source, along with two known compounds. The structures of these constituents were established by means of 1D and 2D NMR spectroscopy and ESI mass spectrometry. The isolated compounds were evaluated for their antiplasmodial and antimicrobial activity against the chloroquine-resistant strain K1, , and . Compounds -, , , and showed moderate antiplasmodial activity with IC values between 5 and 15 μM. None of the tested compounds were active against or . These findings emphasize the potential of as a source for discovery of new antiplasmodial compounds.
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March 2021

In vitro antiprotozoal, antimicrobial and antitumor activity of Pavetta crassipes K. Schum leaf extracts.

J Ethnopharmacol 2010 Aug 31;130(3):529-35. Epub 2010 May 31.

Département de Pharmacie, Faculté de Médecine, Pharmacie et Odontostomatologie, Université de Conakry, Conakry, Guinea.

Aim Of The Study: To study the potential benefit of the traditional medicinal plant Pavetta crassipes K. Schum (Rubiaceae), which is widely distributed throughout West Africa, the methanol and dichloromethane extracts were isolated from the plant leaves to determine if they exhibited antiprotozoal, antibacterial, antifungal or antitumor activity in vitro.

Materials And Methods: The methanol and dichloromethane extracts and their specific fractions were obtained using bioassay-guided fractionation and investigated for antiproliferative activity in vitro in microorganisms (Staphylococcus aureus, Escherichia coli and Candida albicans), protozoans (Trypanosoma cruzi, Trypanosoma brucei, Leishmania infantum and Plasmodium falciparum), and cancer (U373, PC3, MXT and A549) and normal cell lines (NHDF and MRC-5).

Results: Most of the alkaloid fractions investigated exhibited antiproliferative activity in all the cancer cell lines, microorganisms and protozoans studied.

Conclusions: The benefit of Pavetta crassipes as a traditional medicinal remedy was confirmed using antiprotozoal and cytotoxicity assays in vitro. These analyses revealed that the components present in the alkaloid extract of Pavetta crassipes are responsible for its antiprotozoal and cytotoxic efficacy.
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August 2010