Publications by authors named "Mohamed R Akl"

25Publications

(-)-Oleocanthal Combined with Lapatinib Treatment Synergized against HER-2 Positive Breast Cancer In Vitro and In Vivo.

Nutrients 2019 Feb 15;11(2). Epub 2019 Feb 15.

School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, LA 71201, USA.

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February 2019

Usnic Acid Benzylidene Analogues as Potent Mechanistic Target of Rapamycin Inhibitors for the Control of Breast Malignancies.

J Nat Prod 2017 04 28;80(4):932-952. Epub 2017 Feb 28.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe , Monroe, Louisiana 71209, United States.

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April 2017

The marine-derived pachycladin diterpenoids as novel inhibitors of wild-type and mutant EGFR.

Biochem Pharmacol 2017 Feb 8;126:51-68. Epub 2016 Dec 8.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, LA 71201, United States. Electronic address:

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February 2017

Novel c-Met inhibitory olive secoiridoid semisynthetic analogs for the control of invasive breast cancer.

Eur J Med Chem 2016 08 8;118:299-315. Epub 2016 Aug 8.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, LA, 71201, USA. Electronic address:

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August 2016

The oleocanthal-based homovanillyl sinapate as a novel c-Met inhibitor.

Oncotarget 2016 May;7(22):32247-73

Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana, USA.

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May 2016

Norstictic Acid Inhibits Breast Cancer Cell Proliferation, Migration, Invasion, and In Vivo Invasive Growth Through Targeting C-Met.

Phytother Res 2016 Apr 6;30(4):557-66. Epub 2016 Jan 6.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana, 71201, USA.

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April 2016

Molecular and clinical profiles of syndecan-1 in solid and hematological cancer for prognosis and precision medicine.

Oncotarget 2015 Oct;6(30):28693-715

Genomics and Biomarkers Program, The John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ, USA.

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October 2015

Olive Oil-derived Oleocanthal as Potent Inhibitor of Mammalian Target of Rapamycin: Biological Evaluation and Molecular Modeling Studies.

Phytother Res 2015 Nov 7;29(11):1776-82. Epub 2015 Aug 7.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana, USA.

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November 2015

Araguspongine C induces autophagic death in breast cancer cells through suppression of c-Met and HER2 receptor tyrosine kinase signaling.

Mar Drugs 2015 Jan 8;13(1):288-311. Epub 2015 Jan 8.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, LA 71201, USA.

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January 2015

3-O-[N-(p-fluorobenzenesulfonyl)-carbamoyl]-oleanolic acid, a semisynthetic analog of oleanolic acid, induces apoptosis in breast cancer cells.

Eur J Pharmacol 2014 Oct 18;740:209-17. Epub 2014 Jul 18.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, LA 71201, USA. Electronic address:

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October 2014

Discovery, optimization, and pharmacophore modeling of oleanolic acid and analogues as breast cancer cell migration and invasion inhibitors through targeting Brk/Paxillin/Rac1 axis.

Chem Biol Drug Des 2015 Feb 16;85(2):231-43. Epub 2014 Jul 16.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA, 71201, USA; Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Helwan, Cairo, 11795, Egypt.

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February 2015

Olive phenolics as c-Met inhibitors: (-)-Oleocanthal attenuates cell proliferation, invasiveness, and tumor growth in breast cancer models.

PLoS One 2014 21;9(5):e97622. Epub 2014 May 21.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana, United States of America.

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January 2015

The marine-derived sipholenol A-4-O-3',4'-dichlorobenzoate inhibits breast cancer growth and motility in vitro and in vivo through the suppression of Brk and FAK signaling.

Mar Drugs 2014 Apr 14;12(4):2282-304. Epub 2014 Apr 14.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana, 1800 Bienville Drive, Monroe, LA 71201, USA.

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April 2014

Tumor cell transformation using antisense oligonucleotide.

Methods Mol Biol 2014 ;1139:259-68

College of Pharmacy, University of Louisiana at Monroe, Monroe, LA, USA.

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November 2014

Optimization, pharmacophore modeling and 3D-QSAR studies of sipholanes as breast cancer migration and proliferation inhibitors.

Eur J Med Chem 2014 Feb 12;73:310-24. Epub 2013 Dec 12.

Department of Basic Pharmaceutical Sciences of College of Pharmacy, University of Louisiana at Monroe, USA. Electronic address:

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February 2014

Potential role of tocotrienols in the treatment and prevention of breast cancer.

Biofactors 2014 Jan-Feb;40(1):49-58. Epub 2013 Jun 27.

Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA, USA.

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October 2014

Optimization of tocotrienols as antiproliferative and antimigratory leads.

Eur J Med Chem 2013 Jan 23;59:329-41. Epub 2012 Nov 23.

Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, LA 71201, USA.

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January 2013