Publications by authors named "Mohamed M Bassiouny"

3 Publications

  • Page 1 of 1

Value of electroencephalographic monitoring in newborns with hypoxic-ischemic encephalopathy treated with hypothermia.

J Pediatr Neurosci 2016 Oct-Dec;11(4):309-315

Department of Radiology, Benha University, Banha, Egypt.

Background: The values of electroencephalography (EEG) in neonatal hypoxic-ischemic encephalopathy (HIE) during therapeutic hypothermia (TH) are still uncertain.

Aims: The aim of this study is to detect EEG background, the prevalence of seizures during cooling, and to determine different EEG patterns that can predict brain injury in magnetic resonance imaging (MRI).

Patients And Methods: Thirty-nine newborns with HIE were subjected to TH. Continuous monitoring by video-EEG was carried out throughout cooling and during rewarming. MRI was done for all newborns after rewarming. The predictive value of EEG background for MRI brain injury was evaluated at 6-h intervals during cooling and rewarming.

Results: At all-time intervals, normal EEG was associated with no or mild MRI brain injury. At the beginning of cooling, normal background was more predictive of a favorable MRI outcome than at later time points. After 24 h of monitoring, diffuse burst suppression and depressed patterns had the greatest prognostic value. In most patients, a discontinuous pattern was not associated with poor prognosis. Thirty-one percent developed electrical seizures, and 8% developed status epilepticus. Seizures were subclinical in 42%. There is a significant association between duration of seizure patterns detected on the EEG and severity of brain injury on MRI.

Conclusions: Continuous EEG monitoring in newborns with HIE under cooling has a prognostic value about early MRI brain injury and identifies electrographic seizures, approximately 50% of which are subclinical. Treatment of clinical and subclinical seizure results in a reduction of the total duration of seizure pattern supports the hypothesis that subclinical seizures should be treated.
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http://dx.doi.org/10.4103/1817-1745.199467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314843PMC
February 2017

Heart-type fatty acid-binding protein as a predictor of cardiac ischemia in intractable seizures in children.

J Pediatr Neurosci 2016 Jul-Sep;11(3):175-181

Department of Clinical Pathology, Al-Azhar University, Cairo, Egypt.

Background: Children with intractable epilepsy have chronic dysfunction of the autonomic nervous system causing myocardial ischemia. Heart-type fatty acid-binding protein (H-FABP) is a sensitive biomarker for myocardial ischemia.

Aims: We aimed to evaluate serum levels of H-FABP during seizures compared to their interictal levels and healthy controls and changes in heart rate (HR) and HR variability (HRV) in epileptic children with intractable seizures.

Materials And Methods: We included 30 epileptic seizures in 25 children with intractable epilepsy and 30 matched controls. They were subjected to video-electroencephalography monitoring simultaneously with Holter electrocardiogram and measurement of H-FABP.

Results: Mean serum levels of H-FABP were increased significantly in patients either in the ictal or interictal periods compared to that in the controls ( < 0.001 and P< 0.01, respectively). There is no significant difference in serum levels of the H-FABP in the ictal and interictal periods. The basal time domain measures of HRV were significantly lower in the patient group compared to the control group.

Conclusion: H-FABP might suggest a degree of myocardial ischemia in intractable epilepsy. HRV is impaired in patients with refractory seizures.
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http://dx.doi.org/10.4103/1817-1745.193364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108116PMC
November 2016

Effects of antenatal magnesium sulfate therapy on cerebral and systemic hemodynamics in preterm newborns.

Acta Obstet Gynecol Scand 2010 Jun;89(6):801-6

Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Assiut, Egypt.

Objectives: To investigate whether antenatal magnesium sulfate (MgSO(4)) exposure has an influence on cerebral blood flow and systemic hemodynamics in preterm infants during the first few days of life.

Design: Prospective case-control study.

Setting: University affiliated referral hospital.

Population: A total of 48 women who delivered preterm (30-34 weeks) and their offspring.

Methods: Mothers and newborns were divided into two groups based on maternal exposure to MgSO(4) (n = 28) or not (n = 20). Cerebral blood flow velocity measurements were obtained from the neonatal anterior cerebral artery and right and left middle cerebral arteries.

Main Outcome Measures: Neonatal Doppler examinations of the brain circulation, heart rate, systemic blood pressure and echocardiographic assessment of ductus arteriosus shunting during the first week of life.

Results: Maternal MgSO(4) had a significant lowering effect on neonatal cerebral blood flow. Peak systolic velocity was significantly lower in anterior cerebral artery and right and left middle cerebral arteries (p = 0.031, 0.027 and 0.039, respectively), as was end-diastolic velocity (p = 0.035, 0.012 and 0.025, respectively) and mean velocity (p = 0.036, 0.024 and 0.003, respectively). The resistance index and relative vascular resistance in the three cerebral arteries showed no significant difference between the two studied groups.

Conclusion: Antenatal MgSO(4) exposure before preterm birth has potent systemic vascular effects in the preterm offspring, which is reflected in decreased neonatal cerebral perfusion during the critical first few days of life. This is associated with an increased incidence of patent ductus arteriosus, which may require operative intervention.
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http://dx.doi.org/10.3109/00016341003739542DOI Listing
June 2010