Publications by authors named "Mohamed Goda"

7 Publications

  • Page 1 of 1

Zirconium Oxide Sulfate-Carbon (ZrOSO@C) Derived from Carbonized UiO-66 for Selective Production of Dimethyl Ether.

ACS Appl Mater Interfaces 2020 Jan 24;12(1):646-653. Epub 2019 Dec 24.

Methanol dehydration process to dimethyl ether (DME) has been considered as one of the main routes to produce clean fuel, that is, DME. Thus, efficient catalysts are highly required for selective production of DME. Herein, UiO-66 was used as a precursor for the synthesis of zirconium oxide sulfate embedded carbon (ZrOSO@C). The synthesis method involves a one-step carbonization of UiO-66 in the presence of sulfuric acid (10 wt %). Material characterizations using X-ray diffraction, X-ray photoelectron spectroscopy, Fourier transform infrared, and Raman spectroscopy approve the formation of the high crystalline phase of ZrOSO@C. Nitrogen adsorption-desorption isotherms and high-resolution transmission electron microscopy confirm the mesopore structure of the materials. Acidity analysis using pyridine temperature-programmed desorption and isopropanol dehydration corroborates that ZrOSO@C has weak and intermediate acidic sites making ZrOSO@C an effective catalyst for methanol dehydration to DME. The materials offered full conversion (100%) with excellent selectivity (100%) at a relatively low temperature (250 °C). The catalyst exhibited a long-term stability for 120 h. Based on these results, DME is produced efficiently in terms of conversion, selectivity, and long-term stability.
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http://dx.doi.org/10.1021/acsami.9b17520DOI Listing
January 2020

Potential role of circulating microRNAs (486-5p, 497, 509-5p and 605) in metabolic syndrome Egyptian male patients.

Diabetes Metab Syndr Obes 2019 6;12:601-611. Epub 2019 May 6.

Clinical Pharmacy Department, Faculty of Pharmacy (boys), Al-Azhar University, Nasr City, Cairo 13465, Egypt.

This study aims to evaluate the expression pattern of circulating microRNAs (miR)-486-5p, miR-497, miR-509-5p, and miR-605 in the serum of metabolic syndrome (MetS) Egyptian male patients. In this study, the circulating miR-486-5p, miR-497, miR509-5p, and miR-605 were amplified and quantitatively detected by quantitative real-time polymerase chain reaction in sera of 55 MetS male patients in comparison to 20 male controls. The level of fasting plasma glucose and triacylglycerol (TAG) were measured using calorimetric assay. Blood pressure was measured using mercuric sphygmomanometer. Anthropometric measurements were done to each individual. Furthermore, MetS patients were defined according to the criteria proposed by the American Heart Association and divided into three groups according to MetS index. The study was performed on three groups and a control group defined as follows: group 1: 15 MetS patients who fulfilled all diagnostic criteria of MetS; group 2: 20 MetS patients with normal blood pressure; group 3: 20 MetS patients with normal TAG levels.The levels of miRs are expressed as [median (IQR)]. miR-486-5-p and miR-497 expression were elevated in group 1 [31.9(49), 0.0001; 73.1(42.5), 0.0001], group 2 [36.4(15.7), 0.0001; 68.3(54.8), 0.0001], and group (3) [10.8(18.9), 0.0014; 27.5(39.7), 0.0012]. MiR-509-5p was elevated in groups 1 and 2 [501(468), 0.0001], [309(436), 0.0006], respectively, while normally expressed in group 3 [0.93(0.077), 0.0001]. miR-605 was elevated in groups 1 and 3 [25.4(20.0), 0.0018], [54.8(65.8), 0.0001], while normally expressed in group 2 [0.84(0.67), 0.0001]. miRs (486-5p, 497, 509-5p, and 605) serum levels were higher in MetS patients than in healthy control subjects; therefore, these serum miRs can serve as early biomarkers and can be used to follow-up the prognosis of MetS.
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http://dx.doi.org/10.2147/DMSO.S187422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511614PMC
May 2019

Redo Scoring for Prediction of Success of Redo-Percutaneous Balloon Mitral Valvuloplasty in Patients with Mitral Restenosis.

J Heart Valve Dis 2017 09;26(5):537-546

Cardiology Department, Zagazig University Hospital, Zagazig, Egypt.

Background: Echocardiographic predictors of redo-percutaneous balloon mitral valvuloplasty (redo-PBMV) have not been well studied, and indications are based mainly on Wilkins score. The study aim was to evaluate the immediate results of redo-PMBV and to introduce a simplified redo-score to predict the success of redo-PBMV.

Methods: Two cohorts of symptomatic patients (derivation group, n = 218; validation group, n = 100) who had undergone redo-PBMV at a mean of 8.1 ± 2.9 years after a first successful PBMV were enrolled in the study. The mean Wilkins scores were 8.5 ± 1.7 in the derivation group and 8.4 ± 1.8 in the validation group. PBMV was performed using a multi-track technique. Independent echocardiographic predictors of outcome were assigned a points value: mitral valve area ≤1.0 cm2 (2 points), posterior mitral valve leaflet length (PMVL)/anterior mitral valve leaflet length (AMVL) ratio ≤1/2 (2 points), doming distance ≤12 mm (3 points), mitral annular calcification (mild = 1 point; moderate = 2 points; severe = 3 points), commissural status (no fusion = 0 points; uni-fusion = 2 points; bi-fusion = 3 points) and chordal length ≤10 mm (2 points).

Results: The minimum score was 5 and the maximum was 13. A receiver operating curve analysis showed the redo score to be highly significant in predicting redo-PBMV immediate results. The cut-off value of redo score to predict a favorable outcome was ≤8, with a sensitivity of 96% and specificity of 85% in the derivation cohort, and a sensitivity of 95% and specificity of 83% in the validation cohort. A Wilkins score ≤8 had a sensitivity of 71% and a specificity of 59% in the derivation cohort, while sensitivity was 70% and specificity 62% in the validation cohort.

Conclusions: The described scoring system was significantly more predictive than the Wilkins score, and was particularly valuable in predicting outcome in patients with a prior PBMV. It may serve as a satisfactory scoring system for correctly selecting patients with mitral restenosis for PBMV.
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September 2017

Epstein-Barr virus infection and breast invasive ductal carcinoma in Egyptian women: A single center experience.

J Egypt Natl Canc Inst 2017 Jun 24;29(2):77-82. Epub 2017 Apr 24.

Department of Clinical and Radiation Oncology, Sohag University, Faculty of Medicine, Egypt. Electronic address:

Background: A controversy of the role of Epstein-Barr virus (EBV) infection in breast carcinomas has been reported in the literature.

Objectives: We carried on this research to explore possible association between EBV infection and breast invasive ductal carcinoma (IDC) in Egyptian women attending our center.

Study Design: This study carried out at Sohag university hospital on 84 paraffin embedded samples of breast tissue, of them 42 breast IDC as the case group and 42 breast fibroadenomas as the control group. Nested PCRand immunohistochemistry (IHC) done separately for all samples to identify the Epstein-Barr nuclear antigen-1 (EBNA-1) gene and EBV latent membrane protein-1 (LMP-1) respectively, in breast cancer cells and controls.

Results: Specimen considered positive when both (EBNA-1) gene and LMP-1 were detected using PCR and IHC separately for the same sample, this was achieved by 10/42 (23.81%) of breast IDC (case group) and 6/42 (14.29%) of breast fibro-adenomas (control group) (P-value=0.4). Nodal involvement was the only parameter that demonstrated a significant statistical relationship with EBV presence in cancerous tissue with p-value=0.003.

Conclusion: Our research could not find a significant statistical association between EBV infection and breast IDC in Egyptian women attending our center, but, there might be an association between the existence of EBV and tumor aggressiveness.
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http://dx.doi.org/10.1016/j.jnci.2017.02.002DOI Listing
June 2017

Higher Grades and Repeated Recurrence of Hepatic Encephalopathy May Be Related to High Serum Manganese Levels.

Biol Trace Elem Res 2016 Feb 2;169(2):153-8. Epub 2015 Jul 2.

Emergency Department, Senbelawein Central Hospital, Egyptian Ministry of Health, Senbelawein, Egypt.

Hepatic encephalopathy is a serious complication of liver failure. Until now, the precise pathophysiologic mechanisms are not fully determined. It has been demonstrated that manganese plays an important role in the pathogenesis of hepatic encephalopathy. Therefore, we studied manganese levels in serum of cirrhotic patients with hepatic encephalopathy in relation to grading and recurrence of hepatic encephalopathy. One hundred persons were enrolled in the study, 80 cirrhotic patients with or without encephalopathy and 20 healthy controls. Hepatic encephalopathy was diagnosed clinically and by laboratory findings. Serum manganese levels were measured in all participants. The grading of hepatic encephalopathy was significantly correlated to the severity of liver dysfunction. The mean serum manganese level was significantly higher in cirrhotic patients than in controls and in cirrhotic patients with encephalopathy than in those without encephalopathy. It was also significantly higher in patients with advanced grading of hepatic encephalopathy. Serum manganese level was positively correlated to number of recurrences of encephalopathy during a 6-month follow-up period. Serum manganese levels were able to predict recurrence of hepatic encephalopathy within 6 months following the episode. Serum manganese levels are positively correlated to the modified Child-Pugh score of cirrhosis as well as grading and number of recurrences of hepatic encephalopathy. Higher manganese levels seem to be related to worsening of the condition, and its measurement may be used as a predictor of repeated recurrences.
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http://dx.doi.org/10.1007/s12011-015-0405-5DOI Listing
February 2016

Relation of left atrial stiffness to insulin resistance in obese children: Doppler strain imaging study.

Echocardiography 2015 Jul 1;32(7):1157-63. Epub 2014 Nov 1.

Cardiology Department, Zagazig University Hospital, Zagazig, Egypt.

Background: The main objective of the study was to assess the strain measures (peak systolic longitudinal strain [LAS] and stiffness index [LASt]) and their relation to insulin resistance in obese children.

Methods And Results: Eighty obese children (body mass index was 28.2 ± 3.1) and 60 age-matched healthy nonobese children were recruited. Conventional, tissue Doppler imaging LAS and LASt were measured for all children using 2D speckle tracking imaging (2DSI). Insulin resistance was assessed for obese children. Mean LAS was lower, and mean LASt was higher in obese children as compared to control group (11.3 + 2.2 vs. 38.2 + 11.6, P < 0.001, and 1.12 ± 0.23 vs. 0.21 ± 0.11, P < 0.001, respectively). LASt was significantly correlated with insulin resistance (P < 0.0001), and a value of >1.0 of LASt was the best cutoff value which can predict insulin resistance in obese children with a sensitivity of 92% and specificity of 86%.

Conclusions: LAS and LASt differed significantly in obese and nonobese children, in spite of normal left ventricular systolic and diastolic functions. LAS and LASt were associated with insulin resistance in obese children.
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http://dx.doi.org/10.1111/echo.12824DOI Listing
July 2015

Delayed blood pressure recovery ratio and its relation to endothelial function and left ventricular diastolic function in prediabetics.

Echocardiography 2014 Aug 20;31(7):858-64. Epub 2013 Dec 20.

Department of Cardiology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Background: Endothelial function plays a key role in determining the clinical manifestations of established atherosclerotic lesions and has shown to be associated with suppressed sympathetic tone. Abnormal heart rate recovery (HRR) and systolic blood pressure (SBP) response during recovery has been found to have diagnostic role for detecting cardiovascular risk.

Aim: To investigate whether with abnormal HRR and delayed SBP recovery ratio after exercise could predict endothelial dysfunction in prediabetic subjects.

Methods: Ninety-two prediabetic patients underwent brachial artery flow-mediated dilatation (FMD) test and a maximal exercise stress test. Seventy-eight healthy subjects served as a control group. HRR at 1 minute (HRR1 ) and SBP recovery ratio (SBPRR3 ) was defined as the SBP at minute 3 of recovery divided by SBP at peak exercise. Left ventricular diastolic function was assessed utilizing both conventional and tissue Doppler echocardiography.

Results: Flow-mediated dilatation was significantly decreased in prediabetics versus controls (P < 0.0001). Isovolumetric relaxation time and E/E' were significantly increased in prediabetics (P < 0.01 and <0.001). Delayed SBPRR3 was significantly correlated with impaired endothelial function and (E/E') in prediabetics (r = 0.62, P < 0.001 and r = 0.56, P < 0.001, respectively). Stepwise linear regression analysis revealed that HRR1 and SBPRR3 were significant predictors of endothelial dysfunction (r = 0.61, r(2) = 0.37, P < 0.01 and r = 0.51; r(2) = 27; P < 0.0001).

Conclusions: Abnormal HRR1 and delayed SBP response detected during recovery imply a significant correlation with impaired endothelial function and diastolic dysfunction in prediabetics.
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http://dx.doi.org/10.1111/echo.12489DOI Listing
August 2014