Mohamed Ali Hakimi

Mohamed Ali Hakimi

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Mohamed Ali Hakimi

Mohamed Ali Hakimi

Publications by authors named "Mohamed Ali Hakimi"

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Metal-captured inhibition of pre-mRNA processing activity by CPSF3 controls infection.

Sci Transl Med 2019 Nov;11(517)

Institute for Advanced Biosciences (IAB), Host-Pathogen Interactions and Immunity to Infection, INSERM U1209, CNRS UMR 5309, University Grenoble Alpes, 38000 Grenoble, France.

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http://dx.doi.org/10.1126/scitranslmed.aax7161DOI Listing
November 2019

Sustained Egr-1 Response via p38 MAP Kinase Signaling Modulates Early Immune Responses of Dendritic Cells Parasitized by .

Front Cell Infect Microbiol 2019 11;9:349. Epub 2019 Oct 11.

Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.

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http://dx.doi.org/10.3389/fcimb.2019.00349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797980PMC
October 2019

The Toxoplasma effector TEEGR promotes parasite persistence by modulating NF-κB signalling via EZH2.

Nat Microbiol 2019 07 29;4(7):1208-1220. Epub 2019 Apr 29.

Team Host-Pathogen Interactions and Immunity to Infection, Institute for Advanced Biosciences, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, Grenoble, France.

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http://dx.doi.org/10.1038/s41564-019-0431-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591128PMC
July 2019

Characterization of a effector uncovers an alternative GSK3/β-catenin-regulatory pathway of inflammation.

Elife 2018 10 15;7. Epub 2018 Oct 15.

Team Host-pathogen interactions & immunity to infection, University of Grenoble Alpes, Inserm, CNRS, IAB, Grenoble, France.

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http://dx.doi.org/10.7554/eLife.39887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214654PMC
October 2018

Toxoplasma Parasite Twisting Motion Mechanically Induces Host Cell Membrane Fission to Complete Invasion within a Protective Vacuole.

Cell Host Microbe 2018 07 28;24(1):81-96.e5. Epub 2018 Jun 28.

Institute for Advanced Biosciences (IAB), Team Membrane Dynamics of Parasite-Host Cell Interactions, CNRS UMR5309, INSERM U1209, Université Grenoble Alpes, Grenoble 38700, France. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2018.06.003DOI Listing
July 2018

Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis.

Structure 2017 10 31;25(10):1495-1505.e6. Epub 2017 Aug 31.

Molecular Medicine - Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi 110067, India. Electronic address:

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http://dx.doi.org/10.1016/j.str.2017.07.015DOI Listing
October 2017

Effectors Targeting Host Signaling and Transcription.

Clin Microbiol Rev 2017 07;30(3):615-645

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

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http://dx.doi.org/10.1128/CMR.00005-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5475222PMC
July 2017

Dual role of the Toxoplasma gondii clathrin adaptor AP1 in the sorting of rhoptry and microneme proteins and in parasite division.

PLoS Pathog 2017 Apr 21;13(4):e1006331. Epub 2017 Apr 21.

Centre d'Infection et d'Immunité de Lille, Université de Lille, Inserm U1019, CNRS UMR 8204, CHU Lille, Institut Pasteur de Lille, Lille, France.

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http://dx.doi.org/10.1371/journal.ppat.1006331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415223PMC
April 2017

Targeting CPSF3 as a new approach to control toxoplasmosis.

EMBO Mol Med 2017 03;9(3):385-394

Institute for Advanced Biosciences (IAB), Team Host-Pathogen Interactions & Immunity to Infection, INSERM U1209, CNRS UMR 5309, Université Grenoble Alpes, Grenoble, France

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http://dx.doi.org/10.15252/emmm.201607370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331205PMC
March 2017

Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist.

Structure 2017 01 23;25(1):16-26. Epub 2016 Nov 23.

IAB, Team Host-Pathogen Interactions & Immunity to Infection, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, 38700 Grenoble, France. Electronic address:

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http://dx.doi.org/10.1016/j.str.2016.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222587PMC
January 2017

A Critical Role for Toxoplasma gondii Vacuolar Protein Sorting VPS9 in Secretory Organelle Biogenesis and Host Infection.

Sci Rep 2016 12 14;6:38842. Epub 2016 Dec 14.

Laboratory of Cellular and Molecular Biology of Toxoplasma, Université de Lille, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, INSERM U 1019, CNRS UMR 8204, 59000, Lille, France.

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http://dx.doi.org/10.1038/srep38842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155228PMC
December 2016

Evidence for ARGONAUTE4-DNA interactions in RNA-directed DNA methylation in plants.

Genes Dev 2016 12 16;30(23):2565-2570. Epub 2016 Dec 16.

Laboratoire Génome et Développement des Plantes (LGDP), UMR5096, Centre National de la Recherche Scientifique (CNRS), Université de Perpignan via Domitia (UPVD), 66860 Perpignan, France.

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http://dx.doi.org/10.1101/gad.289553.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5204349PMC
December 2016

Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.

Antimicrob Agents Chemother 2016 10 23;60(10):5817-27. Epub 2016 Sep 23.

European Molecular Biology Laboratory, Grenoble Outstation, Grenoble, France, and University Grenoble Alpes-CNRS-EMBL International Unit (UMI 3265) for Virus Host-Cell Interactions, UMI 3265, Grenoble, France

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http://dx.doi.org/10.1128/AAC.00873-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038320PMC
October 2016

Toxoplasma gondii TgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-γ-mediated host defenses.

J Exp Med 2016 08 8;213(9):1779-98. Epub 2016 Aug 8.

Institute for Advanced Biosciences (IAB), Team Host-Pathogen Interactions and Immunity to Infection, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, F-38700 Grenoble, France

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http://dx.doi.org/10.1084/jem.20160340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995087PMC
August 2016

The aspartyl protease TgASP5 mediates the export of the Toxoplasma GRA16 and GRA24 effectors into host cells.

Cell Microbiol 2016 Feb 6;18(2):151-67. Epub 2015 Sep 6.

Laboratoire Adaptation et Pathogénie des Microorganismes, Centre National de la Recherche Scientifique, UMR5163, F-38041, Grenoble, France.

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http://dx.doi.org/10.1111/cmi.12498DOI Listing
February 2016

Toxoplasma's ways of manipulating the host transcriptome via secreted effectors.

Curr Opin Microbiol 2015 Aug 24;26:24-31. Epub 2015 Apr 24.

CNRS, UMR5163, LAPM, 38041 Grenoble, France; Université Joseph Fourier, 38000 Grenoble, France.

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http://dx.doi.org/10.1016/j.mib.2015.04.003DOI Listing
August 2015

Recombinant expression, purification, and crystallization of the glutaminyl-tRNA synthetase from Toxoplasma gondii.

Protein Expr Purif 2015 Jun 28;110:115-21. Epub 2015 Feb 28.

European Molecular Biology Laboratory, 38000 Grenoble, France.

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http://dx.doi.org/10.1016/j.pep.2015.02.017DOI Listing
June 2015

Structure of Prolyl-tRNA Synthetase-Halofuginone Complex Provides Basis for Development of Drugs against Malaria and Toxoplasmosis.

Structure 2015 May 26;23(5):819-829. Epub 2015 Mar 26.

Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Road, New Delhi 110067, India. Electronic address:

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http://www.cell.com/structure/pdf/S0969-2126(15)00074-X.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S096921261500074
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http://dx.doi.org/10.1016/j.str.2015.02.011DOI Listing
May 2015

Toxoplasma exports dense granule proteins beyond the vacuole to the host cell nucleus and rewires the host genome expression.

Cell Microbiol 2014 Mar 20;16(3):334-43. Epub 2014 Jan 20.

CNRS, UMR5163, LAPM, Grenoble, 38041, France; Université Joseph Fourier, Grenoble, 38000, France.

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http://dx.doi.org/10.1111/cmi.12255DOI Listing
March 2014

Lysine acetyltransferase GCN5b interacts with AP2 factors and is required for Toxoplasma gondii proliferation.

PLoS Pathog 2014 Jan 2;10(1):e1003830. Epub 2014 Jan 2.

Department of Pharmacology & Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America ; Microbiology & Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1003830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879359PMC
January 2014

Flexible synthesis and evaluation of diverse anti-Apicomplexa cyclic peptides.

J Org Chem 2013 Apr 4;78(8):3655-75. Epub 2013 Apr 4.

Département de Pharmacochimie Moléculaire, Université Joseph Fourier-Grenoble 1, CNRS UMR 5063, CNRS ICMG FR 2607, bâtiment André Rassat, 470 rue de la Chimie, F-38041 Grenoble Cedex 9, France.

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http://dx.doi.org/10.1021/jo4001492DOI Listing
April 2013

Apicomplexan parasites and subversion of the host cell microRNA pathway.

Trends Parasitol 2011 Nov 15;27(11):481-6. Epub 2011 Aug 15.

Unité Mixte de Recherche 5163, Laboratoire Adaptation et Pathogénie des Micro-organismes, Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier Grenoble 1, BP 170, F-38042 Grenoble CEDEX 9, France.

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http://dx.doi.org/10.1016/j.pt.2011.07.001DOI Listing
November 2011

How Fitch-Margoliash Algorithm can Benefit from Multi Dimensional Scaling.

Evol Bioinform Online 2011 7;7:61-85. Epub 2011 Jun 7.

UMR INSERM unité U722 and Université Denis Diderot-Paris 7, Faculté de médecine, site Xavier Bichat, 16 rue Henri Huchard, 75870 Paris cedex 18, France.

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http://dx.doi.org/10.4137/EBO.S7048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118699PMC
July 2011

Toxoplasma gondii peroxiredoxin promotes altered macrophage function, caspase-1-dependent IL-1β secretion enhances parasite replication.

Vet Res 2011 Jun 27;42:80. Epub 2011 Jun 27.

School of Veterinary Medicine & Science, Faculty of Medicine and Health Sciences, University of Nottingham, Sutton Bonington Campus, Leicestershire, LE12 5RD, UK.

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http://dx.doi.org/10.1186/1297-9716-42-80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141401PMC
June 2011

Activity of the histone deacetylase inhibitor FR235222 on Toxoplasma gondii: inhibition of stage conversion of the parasite cyst form and study of new derivative compounds.

Antimicrob Agents Chemother 2010 Nov 16;54(11):4843-50. Epub 2010 Aug 16.

Parasitology-Mycology Laboratory, Département des Agents Infectieux, Centre Hospitalier Universitaire, Grenoble cedex 09, France.

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http://dx.doi.org/10.1128/AAC.00462-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976123PMC
November 2010

Chromatin modifications: implications in the regulation of gene expression in Toxoplasma gondii.

Cell Microbiol 2010 Apr 26;12(4):413-23. Epub 2010 Jan 26.

Laboratoire Adaptation et Pathogénie des Micro-organismes, CNRS UMR 5163 - ATIP+ Group, Université Joseph Fourier, BP 170, F-38042 Grenoble cedex 9, France.

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http://dx.doi.org/10.1111/j.1462-5822.2010.01446.xDOI Listing
April 2010

Epigenetic mechanisms regulate stage differentiation in the minimized protozoan Giardia lamblia.

Mol Microbiol 2010 Apr 1;76(1):48-67. Epub 2010 Feb 1.

Institute of Parasitology, University of Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1111/j.1365-2958.2010.07062.xDOI Listing
April 2010

A Toxoplasma type 2C serine-threonine phosphatase is involved in parasite growth in the mammalian host cell.

Microbes Infect 2009 Oct 27;11(12):935-45. Epub 2009 Jun 27.

Institut Cochin, Université Paris Descartes, CNRS UMR 8104, Paris, France.

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http://dx.doi.org/10.1016/j.micinf.2009.06.002DOI Listing
October 2009

The small ubiquitin-like modifier (SUMO)-conjugating system of Toxoplasma gondii.

Int J Parasitol 2009 Jan 12;39(1):81-90. Epub 2008 Aug 12.

Laboratoire Adaptation et Pathogénie des Micro-organismes, Université Joseph Fourier, France.

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http://dx.doi.org/10.1016/j.ijpara.2008.07.009DOI Listing
January 2009

The histone methylase KMTox interacts with the redox-sensor peroxiredoxin-1 and targets genes involved in Toxoplasma gondii antioxidant defences.

Mol Microbiol 2009 Jan 5;71(1):212-26. Epub 2008 Nov 5.

Laboratoire Adaptation et Pathogénie des Micro-organismes, Université Joseph Fourier GRENOBLE 1, BP 170, F-38042 Grenoble cedex 9, France.

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http://dx.doi.org/10.1111/j.1365-2958.2008.06519.xDOI Listing
January 2009

Intraplastidial trafficking of a phage-type RNA polymerase is mediated by a thylakoid RING-H2 protein.

Proc Natl Acad Sci U S A 2008 Jul 20;105(26):9123-8. Epub 2008 Jun 20.

Laboratoire Plastes et Differénciation Cellulaire, Université Joseph Fourier and Centre National de la Recherche Scientifique, B.P. 53, F-38041 Grenoble Cedex 9, France.

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http://dx.doi.org/10.1073/pnas.0800909105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2449375PMC
July 2008

Reiterated WG/GW motifs form functionally and evolutionarily conserved ARGONAUTE-binding platforms in RNAi-related components.

Genes Dev 2007 Oct;21(20):2539-44

Laboratoire Génome et Développement de Plantes, Centre National de la Recherche Scientifique/Institut de Recherche pour le Développement/Université de Perpignan 5096, 66860 Perpignan Cedex, France.

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http://www.genesdev.org/cgi/doi/10.1101/gad.451207
Publisher Site
http://dx.doi.org/10.1101/gad.451207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2000319PMC
October 2007

Epigenetics in Apicomplexa: control of gene expression during cell cycle progression, differentiation and antigenic variation.

Curr Opin Microbiol 2007 Aug 23;10(4):357-62. Epub 2007 Aug 23.

UMR5163/CNRS-UJF, Jean-Roget Institute, Grenoble, France.

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http://dx.doi.org/10.1016/j.mib.2007.07.005DOI Listing
August 2007

Fission yeast homologs of human histone H3 lysine 4 demethylase regulate a common set of genes with diverse functions.

J Biol Chem 2006 Nov 21;281(47):35983-8. Epub 2006 Sep 21.

Laboratory of Molecular Cell Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1074/jbc.M606349200DOI Listing
November 2006

Functional interplay between histone demethylase and deacetylase enzymes.

Mol Cell Biol 2006 Sep;26(17):6395-402

The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1128/MCB.00723-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592851PMC
September 2006

Histone mediated gene activation in Toxoplasma gondii.

Mol Biochem Parasitol 2006 Aug 18;148(2):109-16. Epub 2006 Apr 18.

Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, MS A-525, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1016/j.molbiopara.2006.03.010DOI Listing
August 2006

Recruitment of MLL by HMG-domain protein iBRAF promotes neural differentiation.

Nat Cell Biol 2005 Nov;7(11):1113-7

The Wistar Institute, 3601 Spruce St., Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1038/ncb1312DOI Listing
November 2005

A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.

J Biol Chem 2003 Feb 18;278(9):7234-9. Epub 2002 Dec 18.

Wistar Institute, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M208992200DOI Listing
February 2003

Characterization of Arabidopsis plastid sigma-like transcription factors SIG1, SIG2 and SIG3.

Plant Mol Biol 2003 Feb;51(3):385-99

Laboratoire de Génétique Moléculaire des Plantes, 'Plastes et différenciation cellulaire', Université Joseph Fourier and Centre National de la Recherche Scientifique, B.P. 53, 38041 Grenoble, France.

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http://dx.doi.org/10.1023/a:1022095017355DOI Listing
February 2003

The motor protein kinesin-1 links neurofibromin and merlin in a common cellular pathway of neurofibromatosis.

J Biol Chem 2002 Oct 20;277(40):36909-12. Epub 2002 Aug 20.

Wistar Institute, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.C200434200DOI Listing
October 2002

A chromatin remodelling complex that loads cohesin onto human chromosomes.

Nature 2002 Aug;418(6901):994-8

The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/nature01024DOI Listing
August 2002