Publications by authors named "Mohamad Zare"

10 Publications

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The correlation between cluster seizures and findings of magnetic resonance imaging in drug refractory epilepsy patients.

Am J Clin Exp Immunol 2020 15;9(3):47-52. Epub 2020 Jun 15.

Department of Emergency, Abadan University of Medical Science Abadan, Iran.

Background: Epilepsy is a chronic neurologic condition and affects peoples at all ages. Seizure clusters are generally referred to seizures that occur at close intervals with complete recovery between attacks. Various studies have reported a variety of frequencies and risk factors for this condition.

Method: We designed a study to determine the frequency of seizure cluster and to determine neuroimaging findings in these patients and also to evaluate the Correlation between Cluster Seizures and Findings of Magnetic Resonance Imaging in Drug Refractory Epilepsy patients.

Results: After analyzing data from 568 refractory epilepsy patients, we found that the prevalence of cluster seizure variant is 14.43%. 29.26% of patients with a history of cluster seizure had no obvious abnormal MRI findings whereas 14.40 % of patients without history of cluster seizure had no obvious abnormal MRI findings (-value <0.05). Compared to Drug Refractory Epilepsy patients without history of seizure clusters, patients with a history of seizure clusters had less abnormal MRI findings, less Mesial Temporal Sclerosis, and more Focal Cortical Dysplasia in Magnetic Resonance Imaging ( value <0.05).

Conclusions: Seizure cluster has a significant negative impact on the quality of life of patients. According to results of this study it seems that brain MRI findings of drug refractory epilepsy patients with a history of seizure clusters are different from brain MRI findings of drug refractory epilepsy patients without a history of seizure clusters. mesial temporal sclerosis is less frequent and focal cortical dysplasia is more frequent in brain MRI of drug refractory epilepsy patients with a history of seizure clusters compared to drug refractory epilepsy patients without a history of seizure clusters.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364372PMC
June 2020

Frequency of Seizure Clusters and Their Associated Risk Factors in Adult Patients with Epilepsy Referred to Epilepsy Center of Kashani Hospital in Isfahan from 2011 to 2016.

Int J Prev Med 2020 17;11:19. Epub 2020 Feb 17.

Department of Emergency, Abadan University of Medical Science, Abadan, Iran.

Background: Epilepsy is a chronic neurologic condition and affects people of all ages. Seizure clusters are generally referred to seizures that occur at close intervals with complete recovery between attacks. Various studies have reported a variety of frequencies and risk factors for this condition.

Methods: We designed a study to determine the frequency of seizure cluster and their associated risk factors in Iranian population for the first time.

Results: Among 40 variables analyzed, 18 of them were significantly associated with seizure clustering. Risk factors including educational level, age of onset, number of drugs, seizure types, perinatal complication, developmental delay, other illnesses, parental consanguinity, systemic diseases, number of drugs used, mentation, motor signs, sensory signs, cranial nerves signs, cerebellar signs, seizure duration, existence of magnetic resonance imaging (MRI) lesion, and type of MRI pathology are significantly associated with clustering of seizures. When associated risk factors were analyzed with multivariate analysis, age of onset of seizures, number of antiepileptic drugs currently used, lack of seizure-free periods, seizure frequency, and type of MRI pathology are significantly defining for anticipating clustering of seizures.

Conclusions: Seizure cluster has a significant negative impact on the quality of life of patients. Important risk factors that are found to be associated are age of onset, parental consanguinity, frequency of seizure, lack of have seizure-free period or periods, pathologies in neurological examination, and MRI findings.
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http://dx.doi.org/10.4103/ijpvm.IJPVM_238_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050217PMC
February 2020

The Role of Interictal Epileptiform Discharges in Epilepsy Surgery Outcome.

Int J Prev Med 2019 7;10:101. Epub 2019 Jun 7.

Department of Neurology, Medical School, Mazandaran University of Medical Sciences, Sari, Iran.

Background: Epilepsy surgery is a fundamental treatment in refractory epilepsy. Video electroencephalographic (v-EEG) monitoring plays an essential role in presurgical evaluation of patients. However there are reports of favorable outcome based on interictal and magnetic resonance imaging (MRI) findings without any need for v-EEG monitoring in patients with temporal lobe epilepsy (TLE). This study aimed to investigate the prognostic effect of concordance between interictal findings and ictal and MRI data on postsurgical outcome of TLE and extratemporal lobe epilepsy (ETLE).

Methods: A retrospective study was conducted on 199 patients with refractory focal epilepsy who were admitted for presurgical evaluation. The concordance between irritative zone (IZ) and seizure onset zone (SOZ) and also IZ and MRI lesion was registered, and subsequently the prognostic effect of relevancy on 1-year follow-up result based on Engel criteria was investigated.

Results: In TLE and ETLE regarding relevancy between IZ and SOZ, 77.8% and 73.2% were concordant, 2.5% and 0% were discordant, and 19.6% and 26.8% had overlap, respectively. Concordance between IZ and MRI lesion was found in 76.6% and 51.2% of patients with TLE and ETLE while discordance was recorded in 2.5% and 12.2% and overlap registered in 20.9% and 36.6%, respectively. The concordance of interictal findings had no effect on postsurgical outcome of patients with TLE and ETLE.

Conclusions: Our study showed that concordance of IZ with SOZ and MRI has no independent effect on postsurgical outcome of patients with TLE and ETLE. We suggest that excluding exceptional cases, v-EEG monitoring should be considered as the mainstay of presurgical evaluation.
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http://dx.doi.org/10.4103/ijpvm.IJPVM_237_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592222PMC
June 2019

Novel Green Biomimetic Approach for Synthesis of ZnO-Ag Nanocomposite; Antimicrobial Activity against Food-borne Pathogen, Biocompatibility and Solar Photocatalysis.

Sci Rep 2019 06 5;9(1):8303. Epub 2019 Jun 5.

School of Mechanical Engineering, Beijing Institute of Technology, 100081, Beijing, China.

A simple, eco-friendly, and biomimetic approach using Thymus vulgaris (T. vulgaris) leaf extract was developed for the formation of ZnO-Ag nanocomposites (NCs) without employing any stabilizer and a chemical surfactant. T. vulgaris leaf extract was used for the first time, in a novel approach, for green fabrication of ZnO-Ag NCs as a size based reducing agent via the hydrothermal method in a single step. Presence of phenols in T. vulgaris leaf extract has served as both reducing and capping agents that play a critical role in the production of ZnO-Ag NCs. The effect of silver nitrate concentration in the formation of ZnO-Ag NCs was studied. The in-vitro Antimicrobial activity of NCs displayed high antimicrobial potency on selective gram negative and positive foodborne pathogens. Antioxidant activity of ZnO-Ag NCs was evaluated via (2,2-diphenyl-1-picrylhydrazyl) DPPH method. Photocatalytic performance of ZnO-Ag NCs was appraised by degradation of phenol under natural sunlight, which exhibited efficient photocatalytic activity on phenol. Cytotoxicity of the NCs was evaluated using the haemolysis assay. Results of this study reveal that T. vulgaris leaf extract, containing phytochemicals, possess reducing property for ZnO-Ag NCs fabrication and the obtained ZnO-Ag NCs could be employed effectively for biological applications in food science. Therefore, the present study offers a promising way to achieve high-efficiency photocatalysis based on the hybrid structure of semiconductor/metal.
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http://dx.doi.org/10.1038/s41598-019-44309-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549174PMC
June 2019

Prognostic value of ictal onset patterns in postsurgical outcome of temporal lobe epilepsy.

Iran J Neurol 2017 Oct;16(4):185-191

Isfahan University of Medical Sciences, Isfahan, Iran.

To investigate ictal onset patterns (IOP) in scalp electroencephalography (EEG) of patients with temporal lobe epilepsy (TLE) and their prognostic effect on the postoperative outcome. We conducted a retrospective cohort study between 2011 and 2015 in our referral Epilepsy Surgery Center enrolling adult patients with refractory TLE and a visible epileptogenic lesion in magnetic resonance imaging (MRI), who underwent epilepsy surgery. Demographic, clinical and MRI findings were collected and ictal findings during video-EEG monitoring were reviewed in detail. The correlation between preoperative findings and the postsurgical outcome was analyzed. We reviewed 303 seizures in 93 patients. Rhythmic theta and rhythmic spike/sharp and wave were respectively the most common initial ictal pattern and late significant discharges. Engel class I outcome was observed in 88.2% of patients. Female sex, aura, the absence of secondary generalization, rhythmic theta as initial ictal pattern and concordance of ictal-interictal EEG findings were correlated with favorable 1-year postsurgical outcome. Preoperative clinical and EEG findings can provide valuable information regarding postsurgical prognosis in TLE patients.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937004PMC
October 2017

Comparison of different doses of subconjunctival sunitinib with bevacizumab in the treatment of corneal neovascularization in experimental rats.

J Res Med Sci 2017 16;22:16. Epub 2017 Feb 16.

Isfahan Eye Research Center, Feiz Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: To compare the efficacy of subconjunctival administration of bevacizumab and different doses of sunitinib malate in reducing corneal neovascularization (CNV).

Materials And Methods: In this experimental study, central corneal cauterization was created in the right eye of fifty male Sprague-Dawley rats. On day 1 (1 week after cauterization), rats were randomly assigned into five treatment groups. Group control ( = 10) received subconjunctival injection of 0.02 ml of base saline solution. Group 1 ( = 10) received 0.02 ml of bevacizumab (25 mg/ml). Group 2, 3, and 4 ( = 10 for each group) were treated with 0.02 ml of sunitinib malate (10, 20, and 50 μg/ml, respectively). On days 1, 7, and 14, digital photographs of the cornea were taken, and the area of CNV was measured.

Results: During the 2-week follow-up, CNV area in treatment groups was less than in control group ( < 0.05). On day 7, corneal avascular area was highest in Group 3 at 63%. On day 14, the area of CNV in Groups 2 and 3 was less than in Group 1 ( = 0.031 and 0.011, respectively), but the difference between Groups 2 and 3 was not statistically significant ( = 0.552). The decreased CNV area on day 14 in Group 4 was significant in comparison to bevacizumab, but it was not significant on day 7 ( = 0.25 on day 7 and 0.002 on day 14).

Conclusion: Subconjunctival sunitinib malate is more effective than bevacizumab in regressing CNV. This effect is more prominent on day 14.
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http://dx.doi.org/10.4103/1735-1995.200266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367213PMC
February 2017

A COMPARATIVE STUDY BETWEEN POVIDONE-IODINE AND MANUGEL 85 ON SURGICAL SCRUB.

Mater Sociomed 2016 Oct 17;28(5):348-352. Epub 2016 Oct 17.

Department of Nursing, School of Nursing and Midwifery, ShahreKord University of Medical Sciences, Shahrekord, Iran.

Background: Direct transmission through skin contact is one of ways for disease transmission. Medical staffs have contact with many patients, so their hand can be a factor for the transmission of disease. Surgical scrub is a process that leads to destruction immigrant and stable microbus of hands and arms through friction washing by use of antiseptic solution prior to surgery. The aim of this study was to compare the effectiveness of disinfection of Povidone-Iodine and Manugel 85 in surgical scrub.

Methods: This study was a clinical trial that done before and after Surgical scrub. 33 person of surgical team in hospital were surveyed during. Four samples were done for every person: first before surgical scrub with Povidone-Iodine solution, second immediately after surgical scrub, then after one week third test done before surgical scrub with Manugel 85, and forth one immediately after surgical scrub. Paired t-test was used for statistical analysis and SPSS analysis.

Results: Data analysis showed that the effect of Povidone-Iodine and Manugel 85, separately, before and after surgical scrub on number of colonies is significant. But the effect of these two solutions on behalf of number of colonies was not significant. The 100% grown cultures before surgical scrub with Povidone-Iodine solution and 90.91% before surgical scrub with Manugel 85 were staphylococcus.

Conclusion: The disinfection effect of Povidone-Iodine and Manuge l85 on surgical scrub is the same.
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http://dx.doi.org/10.5455/msm.2016.28.348-352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5149428PMC
October 2016

Effects of Vitamin E on seizure frequency, electroencephalogram findings, and oxidative stress status of refractory epileptic patients.

Adv Biomed Res 2016 16;5:36. Epub 2016 Mar 16.

Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Oxidative stress has been a frequent finding in epileptic patients receiving antiepileptic drugs (AEDs). In this study, the influence of Vitamin E on the antiseizure activity and redox state of patients treated with carbamazepine, sodium valproate, and levetiracetam has been investigated.

Materials And Methods: This double-blind, placebo-controlled trial was carried out on 65 epileptic patients with chronic antiepileptic intake. The subjects received 400 IU/day of Vitamin E or placebo for 6 months. Seizure frequency, electroencephalogram (EEG), and redox state markers were measured monthly through the study.

Results: Total antioxidant capacity, catalase and glutathione were significantly higher in Vitamin E received group compared with controls (P < 0.05) whereas malodialdehyde levels did not differ between two groups (P < 0.07). Vitamin E administration also caused a significant decrease in the frequency of seizures (P < 0.001) and improved EEG findings (P = 0.001). Of 32 patients in case group, the positive EEG decreased in 16 patients (50%) whereas among 33 patients in control group only 4 patients (12.1%) showed decreased positive EEG.

Conclusion: The results of this preliminary study indicate that coadministration of antioxidant Vitamin E with AEDs improves seizure control and reduces oxidative stress.
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http://dx.doi.org/10.4103/2277-9175.178780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815530PMC
April 2016

A Study of Patients and Nurses' Perception of the Quality of Pain Management in the Patients Undergoing Surgery in the Departments of Surgery of Rasht Hospitals in 2013.

Glob J Health Sci 2015 Mar 26;7(7 Spec No):55-61. Epub 2015 Mar 26.

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Purpose & Field: More than one hundred million people around the world undergo a surgery annually. Although, the surgery itself is a treatment method to relieve pain and discomfort, it can be considered as one of the important factors to make a pain too. Perception and diagnosis of the pain is the most important duty of nurses. Effective pain management after surgery facilitates the patient's recovery, decreases the length of hospitalization and increases the patient satisfaction. This study aims to investigate the patients and nurses' perception of the quality of pain management in the patients undergoing an abdominal surgery.

Materials & Methods: The current study is a descriptive research that has been conducted on 204 candidate patients for the abdominal surgery and the nurses who care them in the departments of surgery of Rasht hospitals by using the Simple Random Sampling method. The necessary tools in gathering data for the questionnaire consist of demographic characteristics. Idval,E et al's Questionnaire for evaluation and pain perception, numerical and visual evaluation tools for the patient and nurse satisfaction with pain relief. Statistical analysis has been made through the 16 version of SPSS software by using descriptive statistics, average and standard deviation.

Findings: The results show that the level of patient satisfaction with providing necessary care to relieve pain was 29.1% (maximum), 20.8% (minimum) and 78.7% to the confidence, environment and all areas, respectively. For the nurses, this level was 32.4% (maximum), 16.4% (minimum) and 77.1% to the performance, environment and all areas, respectively. The maximum level of patient perception of satisfaction with pain relief was 49.1% and for the nurses, it was 37.7% (good level).

Conclusions: The results indicated that the patients' perception of providing necessary cares to relieve pain and their satisfaction with the pain relief are more than the nurses and in a good level.
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http://dx.doi.org/10.5539/gjhs.v7n7p55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803996PMC
March 2015

Splenic artery pseudoaneurysm: learning from errors.

BMJ Case Rep 2012 Jun 28;2012. Epub 2012 Jun 28.

Emergency Department, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1136/bcr.10.2011.4903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448361PMC
June 2012