Publications by authors named "Mohamad Hosein Lookzadeh"

9 Publications

  • Page 1 of 1

The Iranian Newborn Multiples Registry (IRNMR): a registry protocol.

J Matern Fetal Neonatal Med 2021 Jun 14:1-4. Epub 2021 Jun 14.

Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran.

Over the last decades, several twin/multiples registries have been developed worldwide, mostly concentrated in Europe and high-income countries (HICs). In Iran, we lack accurate nationwide epidemiological and biobank data on twins. We established the Iranian Newborn Multiples Registry (IRNMR) to evaluate the role of genetics and environmental factors in the variation of phenotypes among newborn monozygotic (MZ) and dizygotic (DZ) twin pairs. IRNMR is a multicenter hospital-based registry. In the pilot phase, we collected epidemiological data from multiples born in Imam Khomeini Hospital complex and Aban Hospital located in Tehran, the capital of Iran, with a population exceeding 8 million, Allameh Bohlool Gonabadi Hospital, Gonabad, Razavi Khorasan, and Shahid Sadoughi Hospital, Yazd, Iran. The IRNMR has recruited 457 sets of newborn twins and multiples so far. We hold follow-up sessions by mother and child health professionals to monitor multiples' growth, development, diseases, and mortality. We successfully developed a newborn multiples registry in Iran. This registry will create an invaluable database to study the relative influence of genes and environmental factors on various chronic diseases, growth, development, and behavioral disorders. We intend to collaborate with other centers to develop a large multicenter nationwide multiple birth registry and biobank in Iran.
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http://dx.doi.org/10.1080/14767058.2021.1875445DOI Listing
June 2021

Association of TNF- rs1800629, CASP3 rs72689236 and FCGR2A rs1801274 Polymorphisms with Susceptibility to Kawasaki Disease: A Comprehensive Meta-Analysis.

Fetal Pediatr Pathol 2021 Aug 30;40(4):320-336. Epub 2019 Dec 30.

Mother and Newborn Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: Kawasaki Disease (KD) is a multifactorial condition at the junction of infectious diseases, immunology, rheumatology, and cardiology. The aim of this study is to derive a more precise estimation of the association of TNF-α rs1800629, CASP3 rs72689236 and FCGR2A rs1801274 polymorphisms with risk of KD. PubMed, EMBASE, CNKI databases were searched to identify all relevant studies. Pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated using CMA 2.2 software. A total of 25 studies including eleven studies on TNF-α rs1800629, five studies on CASP3 rs72689236 and nine studies on FCGR2A rs1801274 were selected. Overall, pooled data revealed that CASP3 rs72689236 and FCGR2A rs1801274 polymorphisms were significantly associated with an increased risk of KD. However, there was no significant association between TNF-α rs1800629 and KD. This meta-analysis suggested that CASPS rs72689236 and FCGR2A rs1801274 polymorphisms may modulate individual susceptibility to KD.
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http://dx.doi.org/10.1080/15513815.2019.1707917DOI Listing
August 2021

Association of Fetal MTHFR 677C > T Polymorphism with Non-Syndromic Cleft Lip with or without Palate Risk: A Systematic Review and Meta-Analysis.

Fetal Pediatr Pathol 2021 Aug 27;40(4):337-353. Epub 2019 Dec 27.

Mother and Newborn Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: This study was conducted to estimate the precise association of fetal MTHFR 677 C > T polymorphism with risk of nonsyndromic cleft lip with or without cleft palate (NSCL ± P) using a large-scale meta-analysis. A comprehensive literature search was performed using studies published on PubMed, Science Direct, Scopus and CNKI databases up to November 1, 2019. A total of 38 studies with 6,525 children with NSCL ± P and 8,606 controls were selected. Overall, there was a significant association between MTHFR 677 C > T polymorphism and NSCL ± P risk. Subgroup analysis by ethnicity revealed that MTHFR 677 C > T polymorphism contributed to development of NSCL ± P in Caucasian and Mixed populations, but not in Asians. When stratified by country of origin, we found a significant association in Brazilian, Turkish and Indian populations, but not in Chinese and US-American. This meta-analysis provides strong evidence that fetal MTHFR 677 C > T polymorphism is significantly associated with NSCL ± P risk.
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http://dx.doi.org/10.1080/15513815.2019.1707918DOI Listing
August 2021

An Updated and Comprehensive Meta-Analysis of Association between VEGA -634G > C, -460T > C, +405G > C and +936C > T Polymorphisms and Retinopathy of Prematurity Risk.

Fetal Pediatr Pathol 2021 Jun 17;40(3):233-249. Epub 2019 Dec 17.

Mother and Newborn Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: Previous studies have suggested an association between VEGF-A polymorphisms and retinopathy of prematurity (ROP) risk. But the conclusions are still controversial. The aim of this meta-analysis was to evaluate the association between the VEGF-A polymorphisms and susceptibility of ROP. We searched PubMed, Scopus, WanFang and CNKI databases for all eligible case-control studies published before September 30, 2019. A total of 27 case-control studies with 5,748 ROP cases and 6,146 controls were selected. The results suggested that there was an association between VEGF-A -460T > C polymorphism and increased risk of ROP under the allele model (C vs. T: OR= 0.879, 95% CI 0.776-0.994, p = 0.040). However, VEGF-A -634G > C, +405G > C and +936C > T polymorphisms were not significantly associated with risk of ROP. The subgroup analysis demonstrated that VEGF-A +405G > C polymorphism was associated with ROP risk in Caucasians. This meta-analysis indicates that VEGF-A -460T > C polymorphism may contribute to the susceptibility for ROP.
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http://dx.doi.org/10.1080/15513815.2019.1703227DOI Listing
June 2021

The effect of Sustained Lung Inflation on Outcomes of Acute Respiratory Distress Syndrome in Preterm Infants Born in Shahid Sadoughi Hospital during 2018.

Maedica (Bucur) 2019 Sep;14(3):264-269

Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Respiratory distress syndrome is the chief reason of death in infants. Sustained lung inflation (SLI) may improve respiratory outcomes and reduce the demand for mechanical ventilation (MV). Given that only few studies have been done in this field so far, the current study aimed to evaluate the effect of SLI on outcomes of acute respiratory distress syndrome in preterm infants. This randomized trial was conducted on preterm infants with respiratory distress syndrome in Shahid Sadoughi Hospital, Yazd, Iran, during 2018. Data were extracted from medical records. Infants born at 25-30 weeks of gestation were randomized into two groups with an equal number of subjects (n=30) in each one. In group 1 (cases), patients received SLI (25 cm H2O for 15 seconds) and nasal continuous positive airway pressure (nCPAP) (5 cm H2O) after oropharynx and nasal suction. In group 2 (controls), patients received only nCPAP (5 cm H2O). Both nCPAP and SLI and were delivered through a T-piece ventilator and neonatal mask. In the current study, no serious differences were seen between case and control groups in terms of either quantitative parameters, including MV duration, Apgar score in the first minute, duration of oxygen therapy, gestational age, birth weight, nCPAP duration, and duration of hospitalization in NICU (P>0.05), or qualitative variables, including sex, pneumothorax rate, rate of intraventricular hemorrhage, need for mechanical ventilation during the first 72 hours of life, surfactant need, and mortality rate (p>0.05), except in cases of complications (p=0.019). According to the results of the current study, neither nCPAP alone, nor SLI and nCPAP had any effect on the duration, or need, or type of mechanical ventilation, while the incidence of complications in the nCPAP alone group (control group) was higher than that of combined nCPAP + SLI group (case group). It is suggested that future studies should be conducted on a larger sample size.
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http://dx.doi.org/10.26574/maedica.2019.14.3.264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861724PMC
September 2019

Association of MTHFR 1298A > C Polymorphism with Susceptibility to Non-Syndromic Cleft Lip with or without Palate: A Case-Control Study and Meta-Analysis.

Fetal Pediatr Pathol 2021 Feb 4;40(1):1-17. Epub 2019 Nov 4.

Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: Several studies have evaluated association of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene 1298A > C polymorphism with non-syndromic cleft lip with or without palate (NSCL ± P) susceptibility, however the results are inconsistent.

Materials And Methods: To address this issue, we performed a case-control study to evaluate the association of MTHFR 1298A > C polymorphism with NSCL ± P risk, followed by a meta-analysis.

Results: Including our study, a total of 22 case-control studies with 2,814 cases and 4,199 controls were selected. The results suggested that there was no significant association between MTHFR 1298A > C polymorphism and NSCL ± P risk overall. The subgroup analysis demonstrated that the polymorphism was significantly associated with NSCL ± P risk in Asians and Iranian populations, but not in Caucasians, mixed and Chinese populations.

Conclusion: This meta-analysis indicates that MTHFR 1298A > C polymorphism may not contribute to NSCL ± P risk in overall. However, the MTHFR 1298A > C polymorphism was significantly associated with an increased risk of NSCL ± P in Asians and Iranian populations.
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http://dx.doi.org/10.1080/15513815.2019.1683918DOI Listing
February 2021

ASSOCIATION OF RS2435357 AND RS1800858 POLYMORPHISMS IN RET PROTO-ONCOGENE WITH HIRSCHSPRUNG DISEASE: SYSTEMATIC REVIEW AND META-ANALYSIS.

Arq Bras Cir Dig 2019 21;32(3):e1448. Epub 2019 Oct 21.

Shahid Sadoughi University of Medical Sciences, Medical Genetics, Yazd, Yazd, Iran.

Introduction: Many published studies have estimated the association of rs2435357 and rs1800858 polymorphisms in the proto-oncogene rearranged during transfection (RET) gene with Hirschsprung disease (HSCR) risk. However, the results remain inconsistent and controversial.

Aim: To perform a meta-analysis get a more accurate estimation of the association of rs2435357 and rs1800858 polymorphisms in the RET proto-oncogene with HSCR risk.

Methods: The eligible literatures were searched by PubMed, Google Scholar, EMBASE, and Chinese National Knowledge Infrastructure (CNKI) up to June 30, 2018. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the susceptibility to HSCR.

Results: A total of 20 studies, including ten (1,136 cases 2,420 controls) for rs2435357 and ten (917 cases 1,159 controls) for rs1800858 were included. The overall results indicated that the rs2435357 (allele model: OR=0.230, 95% CI 0.178-0.298, p=0.001; homozygote model: OR=0.079, 95% CI 0.048-0.130, p=0.001; heterozygote model: OR=0.149, 95% CI 0.048-0.130, p=0.001; dominant model: OR=0.132, 95% CI 0.098-0.179, p=0.001; and recessive model: OR=0.239, 95% CI 0.161-0.353, p=0.001) and rs1800858 (allele model: OR=5.594, 95% CI 3.653-8.877, p=0.001; homozygote model: OR=8.453, 95% CI 3.783-18.890, p=0.001; dominant model: OR=3.469, 95% CI 1.881-6.396, p=0.001; and recessive model: OR=6.120, 95% CI 3.608-10.381, p=0.001) polymorphisms were associated with the increased risk of HSCR in overall.

Conclusions: The results suggest that the rs2435357 and rs1800858 polymorphisms in the RET proto-oncogene might be associated with HSCR risk.
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http://dx.doi.org/10.1590/0102-672020190001e1448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812143PMC
October 2019

Association of MTHFR 677C > T and 1298A > C polymorphisms with susceptibility to attention deficit and hyperactivity disorder.

Fetal Pediatr Pathol 2020 Oct 1;39(5):422-429. Epub 2019 Oct 1.

Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

The associations of MTHFR polymorphisms with risk of attention deficit and hyperactivity disorder (ADHD) are poorly elucidated. This study was performed to evaluate the association of MTHFR polymorphisms with ADHD risk in Iranian children. This case-control study included 214 children with ADHD and 220 healthy subjects. The MTHFR 677C > T and 1298A > C polymorphisms were genotyped by an ABI PRISMs 7500 real-time PCR System. The odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association. The MTHFR 1298A > C polymorphism CC genotype (OR= 1.526, 95% CI 1.004-2.320,  = 0.048) and C allele (OR= 1.336, 95% CI 0.1023-1.745,  = 0.034) were associated with an increased risk of ADHD. There was no significant association between MTHFR 677C > T polymorphism and increased risk of ADHD. Our results revealed that the MTHFR 1298A > C polymorphism but not the MTHFR 677 C > T is associated with increased risk of ADHD in Iranian children.
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http://dx.doi.org/10.1080/15513815.2019.1666330DOI Listing
October 2020

Association of eNOS and ACE Polymorphisms with Retinopathy of Prematurity: A Systematic Review and Meta-Analysis.

Fetal Pediatr Pathol 2020 Aug 22;39(4):334-345. Epub 2019 Aug 22.

Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.

We performed a meta-analysis to clarify the association of endothelial nitric oxide synthase (eNOS) and angiotensin I-converting enzyme (ACE) gene polymorphisms with retinopathy of prematurity (ROP) risk. PubMed, Medline, and Embase literatures up to June 01, 2019, were reviewed. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the strength of associations. Eighteen case-control studies including 14 studies (810 cases and 1754 controls) on eNOS polymorphisms and four studies (1014 cases and 1215 controls) on ACE I/D polymorphism were selected. Overall, analysis showed that infants with the ACE I/D polymorphism have an increased susceptibility to ROP. No association of eNOS 27-bp, 894 G > T and -786 T > C polymorphisms with ROP risk was found. ACE I/D polymorphism may serve as genetic biomarker of increased ROP risk. The eNOS polymorphisms do not appear to influence susceptibility to ROP.
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http://dx.doi.org/10.1080/15513815.2019.1652378DOI Listing
August 2020