Publications by authors named "Moeinadin Safavi"

49 Publications

Henoch-Schönlein Purpura (IgA Vasculitis) in Association with Thyrotoxicosis.

Case Rep Endocrinol 2021 22;2021:6669653. Epub 2021 May 22.

Pathology Department, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Graves' disease is the most common cause of hyperthyroidism, which is characterized by thyroid antibodies and the following clinical manifestations: goiter, ophthalmopathy, and pretibial myxedema. On the other hand, Henoch-Schönlein purpura is an IgA-mediated small-vessel vasculitis. Review of the literature showed a relationship between propylthiouracil overdose and the following Henoch-Schönlein purpura (IgA vasculitis) as a side effect. The patient was a 31-year-old woman with a chief complaint of tremor and significant weight loss who contracted pruritic palpable purpura during her disease course. Then, she underwent the treatment of hyperthyroidism by methimazole which intensified her cutaneous lesions. The diagnosis of Henoch-Schönlein purpura (IgA vasculitis) was confirmed after skin biopsy. Finally, she was treated with colchicine, prednisolone, and radioiodine ablation, which caused her lesions to disappear. The temporal priority of pruritic palpable skin lesions to hyperthyroidism treatment with methimazole suggested that Henoch-Schönlein purpura (IgA vasculitis) was related to hyperthyroidism and was intensified by antithyroid agents in this patient.
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http://dx.doi.org/10.1155/2021/6669653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166464PMC
May 2021

Jordans' Anomaly as a Red Flag for Neutral Lipid Storage Diseases.

Fetal Pediatr Pathol 2020 Oct 14:1-3. Epub 2020 Oct 14.

Gastroenterology Department, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Jordans' anomaly is characterized by lipid vacuoles in granulocytes which are observed in neutral lipid storage diseases like Chanarin-Dorfman syndrome. This six-year-old boy had skin ichthyosis, elevated liver enzymes, and prominent vacuoles in neutrophils, eosinophils, monocytes, and basophils (Jordans' anomaly), leading to the diagnosis of Chanarin-Dorfman Syndrome, which was successfully treated with medium-chain triglyceride oil. Jordans' anomaly is a red flag for the diagnosis of neutral lipid storage diseases especially in patients with ichthyosis and elevated liver enzymes.
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http://dx.doi.org/10.1080/15513815.2020.1831663DOI Listing
October 2020

JAK2, CALR, and MPL Mutation Profiles in BCR-ABL Negative Myeloproliferative Neoplasms, a Referral Center Experience in the Middle East.

Iran J Pathol 2021 24;16(2):190-194. Epub 2021 Jan 24.

Molecular Pathology and Cytogenetic Section, Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Background & Objective: JAK2, CALR, and MPL genes play pivotal roles in the pathogenesis of BCR-ABL negative myeloproliferative neoplasms. This study was conducted to evaluate the frequency of JAK2, CALR, and MPL mutations in BCR-ABL negative myeloproliferative neoplasms and their association with demographic data and hematologic parameters in a referral center, in the Middle East.

Methods: Seventy-one patients with BCR-ABL negative myeloproliferative neoplasms were evaluated for JAK2 V617F, CALR type 1, CALR type 2, and MPL by allele-specific PCR and conventional PCR from 2018 to 2019.

Results: Twenty-three patients were categorized as polycythemia vera, JAK2 V617F was observed in 91.3% of these cases. Thirty-eight patients were classified as essential thrombocythemia of which 52.6% showed JAK2 V617F, 18.4% demonstrated CALR type 1, 7.9% denoted CALR type 2 and there was no mutation reported in 21.1%. Seven patients were recognized as primary myelofibrosis and exhibited JAK2 V617F mutation in 57.1%, CALR type 1 in 14.3 %, CALR type 2 in 14.3% and no mutation in 14.3%. Three patients were diagnosed as MPN, unclassifiable and 33.3% revealed JAK2 V617F mutation, and no mutation was found in 66.6%. The age (59.15±13.10) and neutrophil percent (70.78±10.14) were higher in patients with JAK2 V617 mutation compared to other mutations (=0.000, and =0.03). Platelet count was significantly higher in patients with CALR type 1 mutation (1240400± 402053) (=0.000).

Conclusion: JAK2 V617F was associated with patients' higher age and higher neutrophil count in CBC. CALR mutation had an association with higher platelet count. No MPL mutation was found in this study and it seems that its frequency is lower than what is expected in this region.
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http://dx.doi.org/10.30699/IJP.2021.136458.2495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085288PMC
January 2021

Clinical Misdiagnosis of COVID-19 Infection with Confusing Clinical Course.

Case Rep Infect Dis 2021 31;2021:6629966. Epub 2021 Mar 31.

Pediatric Department, Pediatric Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Similarities in the febrile course and other manifestations of some diseases may lead to clinical misdiagnosis of COVID-19 infection. Here, we report a case in a young child with a potentially confusing clinical course. . A 29-month-old boy presented with a 2-month history of fever. His PCR test for COVID-19 was positive, and there was pleural effusion plus positive findings in the lower left lobe of the lung on computed tomography scan. Mid-sized splenomegaly was found on abdominal ultrasound, and laboratory tests disclosed pancytopenia. In light of the atypical lymphocyte counts in laboratory tests, he underwent bone marrow aspiration. The suggested diagnosis was hemophagocytic lymphohistiocytosis, and prednisolone was initiated. Subsequently, Leishman-Donovan bodies were seen in the bone marrow aspirate, and treatment was started with amphotericin, which led to clinical improvement.

Conclusion: In cases with vague clinical symptoms in tropical countries where other infectious diseases occur, possible simultaneous infection should be considered even during a pandemic. Familiarity with the possible differential diagnoses and appropriate, step-by-step consideration to rule out other possible causes are needed in all situations, and the coexistence of infectious disease should be considered in evaluating the clinical conditions of patients in tropical countries.
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http://dx.doi.org/10.1155/2021/6629966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8014250PMC
March 2021

Case Report: Encephalitis Caused by Balamuthia mandrillaris in a 3-Year-Old Iranian Girl.

Am J Trop Med Hyg 2021 Mar 15. Epub 2021 Mar 15.

1Pathology Department, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

It is about half a century since free-living amoebae were recognized as pathogenic organisms, but there is still much we should learn about these rare fatal human infectious agents. A recently introduced causative agent of granulomatous amoebic encephalitis, Balamuthia mandrillaris, has been reported in a limited number of countries around the world. A 3-year-old girl was referred to our tertiary hospital because of inability to establish a proper diagnosis. She had been experiencing neurologic complaints including ataxia, altered level of consciousness, dizziness, seizure, and left-sided hemiparesis. The patient's history, physical examination results, and laboratory investigations had led to a wide differential diagnosis. CT scan and magnetic resonance imaging analyses revealed multiple mass lesions. As a result, the patient underwent an intraoperative frozen section biopsy of the brain lesion. The frozen section study showed numerous cells with amoeba-like appearances in the background of mixed inflammatory cells. Medications for free-living amoebic meningoencephalitis were administered. PCR assay demonstrated B. mandrillaris as the pathogenic amoeba. Unfortunately, the patient died 14 days after her admission. To our knowledge, this is the first report of B. mandrillaris meningoencephalitis in the Middle East and the first time we have captured the organism during a frozen-section study.
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http://dx.doi.org/10.4269/ajtmh.20-1257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103465PMC
March 2021

Isolated primary spinal epidural hydatid cyst in a child with progressive paraparesis.

Childs Nerv Syst 2021 Mar 8. Epub 2021 Mar 8.

Department of Pediatric Neurosurgery, Children's Medical Center, Tehran University of Medical Sciences, Tehran, 1419733151, Iran.

Background: Primary spinal hydatid cyst is a rare but serious condition which occurs in about 1% of patients with hydatid disease. This disease may result in severe spinal cord compression presenting with various neurological deficits.

Case Report: A 3-year-old boy was referred to our center with progressive weakness of lower limbs, frequency, and urinary incontinence. His parents did not report back pain during child's illness. Lumbar magnetic resonance imaging (MRI) revealed an extradural well-defined thin-walled cystic lesion at L4 to S3 vertebral levels without enhancement. The cyst had compressed the thecal sac associated with bone scalloping of vertebral bodies and posterior elements. Osteoplastic laminectomy of L4-L5 and laminectomy of S1-S3 was done. Intraoperative and histopathological findings indicated an epidural hydatid cyst.

Conclusion: Although spinal hydatid cysts are rare but might be considered in the differential diagnosis of any patient with signs and symptoms of spinal cord compression. The pathophysiology, clinical manifestations, epidemiology, diagnosis, and surgical treatment of extradural hydatid cyst are discussed.
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http://dx.doi.org/10.1007/s00381-021-05100-3DOI Listing
March 2021

Photoclinic: Cryptosporidiosis in Hyper IgM Syndrome.

Arch Iran Med 2021 02 1;24(2):129-130. Epub 2021 Feb 1.

Pathology Department, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.34172/aim.2021.20DOI Listing
February 2021

Post-Chemotherapy Foamy Histiocytes in Bone Marrow Aspiration of a Child with Acute Lymphoblastic Leukemia

Turk J Haematol 2021 Feb 14;38(1):94-95. Epub 2021 Jan 14.

Tehran University of Medical Sciences, Division of Hematology and Oncology, Children’s Medical Center, Pediatrics Center of Excellence, Tehran, Iran

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http://dx.doi.org/10.4274/tjh.galenos.2021.2020.0677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927437PMC
February 2021

Spinal intravascular papillary endothelial hyperplasia in an infant.

Childs Nerv Syst 2021 03 8;37(3):733-734. Epub 2021 Jan 8.

Neurosurgery Department, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1007/s00381-021-05039-5DOI Listing
March 2021

Cytomegalovirus DNA in non-glioblastoma multiforme brain tumors of infants.

Childs Nerv Syst 2021 05 7;37(5):1581-1586. Epub 2021 Jan 7.

Cell-based Therapies Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Science, Tehran, Iran.

Purpose: CMV antigens have been detected in some brain tumors specially glioblastoma multiforme (GBM). As brain tumors in the first years of life are among the most aggressive neoplasms with poor prognosis, novel therapeutic options like targeted therapy against virus antigens are demanded. Infantile central nervous system tumors, other than GBM, have not been so far studied for CMV. To our best knowledge, this is the first study in which the presence of CMV-DNA, as a potential viral target for therapy, in non-GBM infantile brain tumors has been investigated.

Methods: The paraffin blocks of non-GBM brain neoplasms of 36 infants (age < 24 months) who were operated on between 2006 and 2016 were examined for CMV-DNA, using real-time polymerase chain reaction (PCR). Paraffin blocks of CMV infected lung tissue were used as positive control. Extraction and amplification of β2 microglobulin gene from each tumor tissue were carried as positive internal control. We also assayed 25 paraffin blocks of meningomyelocele for CMV DNA as negative tissue controls.

Results: Histopathological diagnoses consisted of 13 glial/neuroglial tumors (36.1%), 8 ependymomas (22.2%), 7 medulloblastomas (19.4%), 3 choroid plexus tumors (8.3%), 2 atypical teratoid rhabdoid tumors (5.6%), 2 embryonal CNS tumors (5.6%), and 1 germ cell tumor (2.8%). We could not detect CMV DNA in all samples examined.

Conclusion: Although CMV may be associated with GBM, no role could be proposed for this virus in development of non-GBM infantile brain tumors. Further investigations on larger series of brain tumors should be conducted to confirm or rule out our conclusion.
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http://dx.doi.org/10.1007/s00381-021-05038-6DOI Listing
May 2021

Solid-cystic cortical ependymoma: a diagnostic dilemma.

Childs Nerv Syst 2021 04 6;37(4):1033-1034. Epub 2021 Jan 6.

Neurosurgery Department, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1007/s00381-020-05010-wDOI Listing
April 2021

Pre-analytical Practices in the Molecular Diagnostic Tests, A Concise Review.

Iran J Pathol 2021 10;16(1):1-19. Epub 2020 Nov 10.

Cell-based Therapies Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Molecular assays for detection of nucleic acids in biologic specimens are valuable diagnostic tools supporting clinical diagnoses and therapeutic decisions. Pre-analytical errors, which occur before or during processing of nucleic acid extraction, contribute a significant role in common errors that take place in molecular laboratories. Certain practices in specimen collection, transportation, and storage can affect the integrity of nucleic acids before analysis. Applying best practices in these steps, helps to minimize those errors and leads to better decisions in patient diagnosis and treatment. Widely acceptable recommendations, which are for optimal molecular assays associated with pre-analytic variables, are limited. In this article, we have reviewed most of the important issues in sample handling from bed to bench before starting molecular tests, which can be used in diagnostic as well as research laboratories. We have addressed the most important pre-analytical points in performing molecular analysis in fixed and unfixed solid tissues, whole blood, serum, plasma, as well as most of the body fluids including urine, fecal and bronchial samples, as well as prenatal diagnosis samples.
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http://dx.doi.org/10.30699/ijp.2020.124315.2357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691716PMC
November 2020

Visceral Leishmaniasis: Kala-azar.

Diagn Cytopathol 2021 Mar 22;49(3):446-448. Epub 2020 Nov 22.

Department of Infectious Diseases, Pediatric's Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1002/dc.24671DOI Listing
March 2021

Cystinuria.

Postgrad Med J 2020 Nov 12. Epub 2020 Nov 12.

Pathology Department, Medical Faculty, Tehran University of Medical Sciences, Tehran, Iran

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http://dx.doi.org/10.1136/postgradmedj-2020-138483DOI Listing
November 2020

der(1)t(1;1)(p36;q10) as a Rare Variant of 1q Gain in Fanconi Anemia-Associated Myelodysplastic Syndrome.

Ann Lab Med 2021 Mar;41(2):240-242

Molecular Pathology and Cytogenetics Section, Pathology Department, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.3343/alm.2021.41.2.240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591286PMC
March 2021

What is the appropriate aganglionic bowel length on contrast enema for attempting single stage transanal endorectal pull-through in Hirschsprung disease?

J Pediatr Surg 2021 May 21;56(5):975-978. Epub 2020 Aug 21.

Department of Pathology, Pediatric center of excellence, Tehran University of Medical Sciences, Faculty of Medicine, Tehran, Iran.

Purpose: To identify influence of different values of age and abnormal bowel length in HD patients selected for single stage TERPT which affects the technique of surgery.

Methods: This observational study was carried out for over 2.5 years. All children younger than 14 years old with clinical suspicion for HD, typical transitional zone (TZ) on contrast enema (CE) distal to splenic flexure, preoperative diagnosis approved by full thickness biopsy, no previous surgical history and no urgency were included. The distance between the anus and TZ was considered as aganglionic length on CE. Biopsy was taken from distal to proximal of resected bowel to reach circumferentially normal innervated bowel. Paired sample Student's t-test, Pearson correlation test, receiver operating characteristic (ROC) analysis were performed.

Results: Forty-eight patients were enrolled in this study. Measured mean for aganglionic bowel length on CE and pathology were 33.5 ± 17.1 cm and 56.8 ± 33.5 cm, respectively (p < 0.01). Correlation coefficient (R) and coefficient of determination (R2) were 0.632 and 40%, respectively (p < 0.01). The difference between radiologic and pathologic measurements in females was higher than males (mean: 29.3 vs 21.9 cm) but was not statistically significant (p = 0.75). There was statistically significant difference between CE and pathologic results in the infants younger than 10 months (p = .004). Abnormal bowel length equal to 52 cm predicted requirement of laparoscopy assistance/laparotomy with 75% sensitivity and 85% specificity.

Conclusion: Our investigation showed it is safe to attempt for single stage TERPT when aganglionic length on CE is less than 52 cm and the child with HD is older than 10 months. Chance of requiring additional laparotomy or laparoscopy assistance is low in these patients.

Type Of Study: Study of diagnostic test.

Level Of Evidence: Level II.
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http://dx.doi.org/10.1016/j.jpedsurg.2020.08.018DOI Listing
May 2021

Photoclinic.

Arch Iran Med 2020 06 1;23(6):412-413. Epub 2020 Jun 1.

Pathology Department, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.34172/aim.2020.36DOI Listing
June 2020

Rosai-Dorfman Disease: A Rare Clinicopathological Presentation and Review of the Literature.

Head Neck Pathol 2021 Mar 5;15(1):352-360. Epub 2020 Jun 5.

Department of Radiology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Rosai-Dorfman disease (RDD) is a rare and self-limiting disease process that presents most commonly in young patients as massive, painless, cervical lymphadenopathy. Extranodal involvement may also occur. Histopathologic evaluation is the main diagnostic modality. We report an unusual presentation of RDD with cervical lymphadenopathy and an incidentally discovered sinonasal mass, clinically worrisome for malignancy. We emphasize that a high index of clinical suspicion is critical for accurate diagnosis of RDD. Clinicians and pathologists should consider RDD in a differential diagnosis of cervical lymphadenopathy, especially in young patients.
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http://dx.doi.org/10.1007/s12105-020-01183-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010025PMC
March 2021

Juvenile Polyps with Osseous Metaplasia: Report of Two Pediatric Cases and Review of the Literature.

Fetal Pediatr Pathol 2020 May 14:1-5. Epub 2020 May 14.

Pathology Department, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Osseous metaplasia is considered as a response to insults such as chronic inflammation or mucin extravasation in colorectal polyps. we report two cases of osseous metaplasia in juvenile (retention) polyps as incidental histopathological findings in a case of rectal juvenile polyposis and a patient with solitary rectal juvenile polyp. Osseous metaplasia can occur in colorectal juvenile polyps and is considered a probable response to mucin extravasation and/or chronic inflammation. The clinical and prognostic significance of osseous metaplasia in these polyps is unknown.
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http://dx.doi.org/10.1080/15513815.2020.1761916DOI Listing
May 2020

Concomitant Pulmonary Cystic Echinococcosis and Aspergillosis in a Male Child.

J Trop Pediatr 2020 12;66(6):645-647

Pathology Department, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Co-infection of cystic echinococcosis and aspergillosis is a rare finding. The patient was a 10-year-old boy complaining of chest pain and malaise with a cyst in the right lung who underwent surgical resection of the cyst. Medical therapy with albendazole was started for the patient with the initial clinical impression of cystic echinococcosis. Later, the microscopic evaluation revealed a laminated layer of cystic echinococcosis involved by acute angle branching hyaline hyphae with septate. Thus, the diagnosis of a cystic echinococcosis and aspergillosis co-infection was established. Surgery is the mainstay of treatment along with anthelminthic and anti-fungal therapy, especially in immunocompromised patients.
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http://dx.doi.org/10.1093/tropej/fmaa020DOI Listing
December 2020

Enhanced expression of Cyclin D1 and C-myc, a prognostic factor and possible mechanism for recurrence of papillary thyroid carcinoma.

Sci Rep 2020 03 20;10(1):5100. Epub 2020 Mar 20.

University of British Columbia Vancouver, Vancouver, BC, Canada.

A direct association has been shown between Cyclin D1 and C-myc gene expressions and the proliferation of human thyroid tumor cells. Our previous study showed that increased β catenin led to a reduction in disease-free probability in patients with papillary thyroid cancer. This study was designed to investigate Cyclin D1 and C-myc genes as targets for β catenin function in PTC and to determine the association between genes expression and staging, recurrence, metastasis, and disease-free survival of PTC. This study was conducted via a thorough investigation of available data from medical records as well as paraffin blocks of 77 out of 400 patients over a 10-year period. Cyclin D1 and C-myc gene expression levels were measured using real-time polymerase chain reaction (RT-PCR) and the Kaplan-Meier method was used to evaluate disease-free survival. Higher levels of Cyclin D1 and C-myc gene expressions were observed in patients with recurrence by 8.5 (P = 0.004) and 19.5 (p = 0.0001) folds, respectively. A significant positive correlation was found between Cyclin D1 expression and the cumulative dose of radioactive iodine received by patients (r = -0.2, p value = 0.03). The ten-year survival rate in the patients included in this study was 98.25% while disease-free survival was 48.1%. Higher Cyclin D1 and C-myc gene expression levels were observed in patients with recurrence/distant metastasis. Inversely, lower expression of Cyclin D1 and C-myc genes were associated with better survival of patients (SD, 0.142-0.052) (Mantel-Cox test, P = 0.002). The enhancement of Cyclin D1 and C-myc gene expression may be a potential mechanism for recurrence and aggressiveness of PTC.
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http://dx.doi.org/10.1038/s41598-020-61985-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083882PMC
March 2020

Aleukemia cutis: Clinicopathological and molecular investigation of two cases.

J Cutan Pathol 2020 Aug 12;47(8):747-754. Epub 2020 May 12.

Department of Pathology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

We describe two cases of acute myeloid leukemia (AML) who presented with cutaneous manifestations. Leukemia cutis (LC) is the cutaneous presentation of any type of leukemia and occurs in 10% to 15% of patients with AML, but cutaneous infiltration of AML rarely precedes the involvement of the bone marrow or peripheral blood and is called "aleukemia cutis." Our first case presented with facial skin thickening, a manifestation which is known as lionization and his initial clinical diagnosis was nonspecific allergic reaction. Our second case presented with urticaria-like lesions with the initial clinical and histomorphologic diagnoses of leukocytoclastic vasculitis. Histopathologic examination of skin biopsy specimens in both patients showed diffuse infiltration of the dermis with a monotonous population of intermediate-sized mononuclear cells by open chromatin and promonocytic features. Bone marrow aspiration leukocyte karyotyping showed normal cytogenetics, and molecular investigation revealed mutations of NPM1 and FLT3 genes. Somatic CEBPA gene mutation was negative in both patients. LC as the first manifestation of leukemia is very rare and could result in delayed diagnosis and affect patient prognosis.
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http://dx.doi.org/10.1111/cup.13690DOI Listing
August 2020

Trisomy 19 in Acute Megakaryocytic Leukemia.

Indian J Hematol Blood Transfus 2020 Jan 28;36(1):222-224. Epub 2019 Jun 28.

3Molecular Pathology and Cytogenetics Section, Pathology Department, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1007/s12288-019-01154-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042450PMC
January 2020

Rosai-Dorfman Disease Arising in Patella.

Arch Iran Med 2019 12 1;22(12):731-732. Epub 2019 Dec 1.

Radiology Department, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

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December 2019

A Rare Cytogenetic Variant of Monosomy 18p Syndrome as a Consequence of Whole-Arm Translocation between Chromosomes 13 and 18.

Arch Iran Med 2019 10 1;22(10):627-628. Epub 2019 Oct 1.

Molecular Pathology and Cytogenetics Division, Pathology Department, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Monosomy 18p syndrome is one of the prototypical examples of autosomal terminal deletions. This deletion can be the consequence of de novo deletions, malsegregation of a balanced parental translocation, cryptic subtelomeric deletions or ring chromosome 18. The present case is a rare cytogenetic variant of monosomy 18 as a consequence of whole-arm translocation between chromosomes 13 and 18 which has been reported only three times previously.
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October 2019

Cerebral Aspergillosis.

Arch Iran Med 2019 08 1;22(8):476-477. Epub 2019 Aug 1.

Children's Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran.

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August 2019

Chronic non-bacterial osteomyelitis of clavicle.

Postgrad Med J 2019 Dec 25;95(1130):680-681. Epub 2019 Oct 25.

Pathology Department, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran

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http://dx.doi.org/10.1136/postgradmedj-2019-137110DOI Listing
December 2019

A Rare Chromosomal Abnormality in Chronic Lymphocytic Leukemia: t(13;13)

Turk J Haematol 2020 05 14;37(2):121-122. Epub 2019 Jun 14.

Shiraz University of Medical Sciences Molecular Pathology and Cytogenetic Section, Medical Faculty, Department of Pathology, Shiraz, Iran

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http://dx.doi.org/10.4274/tjh.galenos.2019.2019.0134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236408PMC
May 2020

Chromosome 12 Rearrangement in an Adolescent with Primary Myelofibrosis.

Indian J Hematol Blood Transfus 2019 Apr 6;35(2):387-389. Epub 2018 Dec 6.

1Molecular Pathology and Cytogenetics Section, Pathology Department, Children'S Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1007/s12288-018-1055-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439120PMC
April 2019

Calcified Cerebral Hydatid Cyst Presenting with Seizure.

Arch Iran Med 2019 02 1;22(2):102-103. Epub 2019 Feb 1.

Pathology and Stem Research Center, Pathology Department, Afzalipour Medical School, Kerman University of Medical Sciences, Kerman, Iran.

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February 2019
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