Publications by authors named "Mobin Khoshbin"

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Association of gene polymorphisms and serum E-Selectin level with risk of coronary artery disease in lur population of Iran.

Arch Physiol Biochem 2020 Oct 6:1-6. Epub 2020 Oct 6.

Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khorramabad, Iran.

Background: Adhesion molecules like E-selectin have important role in pathogenesis of atherosclerosis. and polymorphisms of gene and E-selectin serum level may affect the risk of coronary artery disease (CAD).

Methods: A total of 145 normal individuals and 154 patients diagnosed with CAD from the Lur population of Iran undergoing coronary angiography were enrolled. Genetic polymorphisms of were determined using PCR-RFLP. Serum level of soluble E-selectin was measured using Elisa.

Results: T allele in polymorphism was significantly associated with an increased risk of atherosclerosis ( = 0.018). No significant association was observed for polymorphism. The mean serum level of soluble E-selectin in the patient group was significantly higher than the control group ( < 0.001).

Conclusions: Allele type in polymorphism plays a role in increasing the risk of developing CAD. Furthermore, since serum E-selectin level is associated with systemic inflammation, it contributes to the increased risk of the disease.
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October 2020