Publications Authored by Mitsuyoshi Nakao

Activation of Sp1-mediated transcription by Rta of Epstein-Barr virus via an interaction with MCAF1.

Nucleic Acids Res 2017 May;45(8):5009

Department of Microbiology and Immunology, Chang Gung University Taoyuan, Taiwan.

May 2017

Download Full Paper

Roles of long noncoding RNAs in chromosome domains.

Wiley Interdiscip Rev RNA 2017 Mar 3;8(2). Epub 2016 Aug 3.

Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.

March 2017

Download Full Paper

Analysis of estrogen receptor β gene methylation in autistic males in a Chinese Han population.

Metab Brain Dis 2017 Mar 16. Epub 2017 Mar 16.

Department of Child and Adolescent Health, School of Public Health, Harbin Medical University, No.157 Baojian Road, Harbin, 150081, China.

March 2017

Download Full Paper

The SETD8/PR-Set7 Methyltransferase Functions as a Barrier to Prevent Senescence-Associated Metabolic Remodeling.

Cell Rep 2017 Feb;18(9):2148-2161

Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Agency for Medical Research and Development (AMED), Tokyo 100-0004, Japan. Electronic address:

February 2017

Download Full Paper

The Glucocorticoid Receptor Regulates the ANGPTL4 Gene in a CTCF-Mediated Chromatin Context in Human Hepatic Cells.

PLoS One 2017 5;12(1):e0169225. Epub 2017 Jan 5.

Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.

January 2017

Download Full Paper

DNA methylation-independent removable insulator controls chromatin remodeling at the HOXA locus via retinoic acid signaling.

Hum Mol Genet 2016 Dec;25(24):5383-5394

Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.

December 2016

Download Full Paper

Potential Neuroprotective Effects of an LSD1 Inhibitor in Retinal Ganglion Cells via p38 MAPK Activity.

Invest Ophthalmol Vis Sci 2016 Nov;57(14):6461-6473

Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.

November 2016

Download Full Paper

Histone demethylase LSD1 controls the phenotypic plasticity of cancer cells.

Cancer Sci 2016 Sep 1;107(9):1187-92. Epub 2016 Sep 1.

Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.

September 2016

Download Full Paper

UHRF1 regulates global DNA hypomethylation and is associated with poor prognosis in esophageal squamous cell carcinoma.

Oncotarget 2016 Sep;7(36):57821-57831

Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan.

September 2016

Download Full Paper

Application of targeted enrichment to next-generation sequencing of retroviruses integrated into the host human genome.

Sci Rep 2016 Jun 20;6:28324. Epub 2016 Jun 20.

Center for AIDS Research, Kumamoto University, Japan.

June 2016

Download Full Paper

Loss of the integral nuclear envelope protein SUN1 induces alteration of nucleoli.

Nucleus 2016 10;7(1):68-83. Epub 2016 Mar 10.

a Osaka University , Graduate School of Medicine and Health Science , Suita City , Osaka , Japan.

April 2016

Download Full Paper

HMGA2 promotes adipogenesis by activating C/EBPβ-mediated expression of PPARγ.

Biochem Biophys Res Commun 2016 Apr 8;472(4):617-23. Epub 2016 Mar 8.

Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, 860-0811, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Agency for Medical Research and Development, Tokyo, Japan. Electronic address:

April 2016

Download Full Paper

The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome.

Proc Natl Acad Sci U S A 2016 Mar 29;113(11):3054-9. Epub 2016 Feb 29.

Section of Virology, Division of Infectious Diseases, Imperial College, London W2 1PG, United Kingdom;

March 2016

Download Full Paper

Lysine-specific demethylase-1 contributes to malignant behavior by regulation of invasive activity and metabolic shift in esophageal cancer.

Int J Cancer 2016 Jan 17;138(2):428-39. Epub 2015 Aug 17.

Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan.

January 2016

Download Full Paper

Endoplasmic Reticulum (ER) Stress Induces Sirtuin 1 (SIRT1) Expression via the PI3K-Akt-GSK3β Signaling Pathway and Promotes Hepatocellular Injury.

J Biol Chem 2015 Dec 23;290(51):30366-74. Epub 2015 Oct 23.

From the Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, 862-0973, Japan,

December 2015

Download Full Paper

H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation.

Mol Cell 2015 Nov;60(4):584-96

Division of Metabolic Medicine, The University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan; The Translational Systems Biology and Medicine Initiative (TSBMI), Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan. Electronic address:

November 2015

Download Full Paper

TET family proteins and 5-hydroxymethylcytosine in esophageal squamous cell carcinoma.

Oncotarget 2015 Sep;6(27):23372-82

Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Japan.

September 2015

Download Full Paper

Novel metal chelating molecules with anticancer activity. Striking effect of the imidazole substitution of the histidine-pyridine-histidine system.

Bioorg Med Chem 2015 Sep 29;23(17):5476-82. Epub 2015 Jul 29.

Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. Electronic address:

September 2015

Download Full Paper

Retinoblastoma protein promotes oxidative phosphorylation through upregulation of glycolytic genes in oncogene-induced senescent cells.

Aging Cell 2015 Aug 25;14(4):689-97. Epub 2015 May 25.

Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.

August 2015

Download Full Paper

The actin family protein ARP6 contributes to the structure and the function of the nucleolus.

Biochem Biophys Res Commun 2015 Aug 9;464(2):554-60. Epub 2015 Jul 9.

Laboratory of Molecular Biology, Graduate School of Agricultural Science, Tohoku University, Tsutsumidori-Amamiyamachi 1-1, Aoka-ku, Sendai 981-8555, Japan. Electronic address:

August 2015

Download Full Paper

STAT5 Orchestrates Local Epigenetic Changes for Chromatin Accessibility and Rearrangements by Direct Binding to the TCRγ Locus.

J Immunol 2015 Aug 20;195(4):1804-14. Epub 2015 Jul 20.

Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan;

August 2015

Download Full Paper

Lysine-specific demethylase 2 suppresses lipid influx and metabolism in hepatic cells.

Mol Cell Biol 2015 Apr 26;35(7):1068-80. Epub 2015 Jan 26.

Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo, Japan

April 2015

Download Full Paper

Lysine Demethylase LSD1 Coordinates Glycolytic and Mitochondrial Metabolism in Hepatocellular Carcinoma Cells.

Cancer Res 2015 Apr 3;75(7):1445-56. Epub 2015 Feb 3.

Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo, Japan.

April 2015

Download Full Paper

Identification of HSP70-inducing activity in Arnica montana extract and purification and characterization of HSP70-inducers.

J Dermatol Sci 2015 Apr 4;78(1):67-75. Epub 2015 Feb 4.

Department of Drug Discovery and Development, Faculty of Pharmacy, Keio University, Tokyo 105-8512, Japan. Electronic address:

April 2015

Download Full Paper

A cluster of noncoding RNAs activates the ESR1 locus during breast cancer adaptation.

Nat Commun 2015 Apr 29;6:6966. Epub 2015 Apr 29.

1] Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan [2] Program for Leading Graduate Schools 'HIGO (Health life science: Interdisciplinary and Glocal Oriented) Program', Kumamoto University, Kumamoto 860-8556, Japan [3] Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0076, Japan.

April 2015

Download Full Paper

Sall1 maintains nephron progenitors and nascent nephrons by acting as both an activator and a repressor.

J Am Soc Nephrol 2014 Nov 17;25(11):2584-95. Epub 2014 Apr 17.

Departments of Kidney Development and CREST, Japan Science and Technology Agency, Saitama, Japan

November 2014

Download Full Paper

Computational image analysis of colony and nuclear morphology to evaluate human induced pluripotent stem cells.

Sci Rep 2014 Nov 11;4:6996. Epub 2014 Nov 11.

1] Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan [2] Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo, Japan.

November 2014

Download Full Paper

Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.

J Biol Chem 2014 Jun 15;289(26):18137-51. Epub 2014 May 15.

From the Division of Neurology, Department of Neuroscience and Sensory Organs, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.

June 2014

Download Full Paper

IGF2 DMR0 methylation, loss of imprinting, and patient prognosis in esophageal squamous cell carcinoma.

Ann Surg Oncol 2014 Apr 7;21(4):1166-74. Epub 2013 Dec 7.

Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto City, Kumamoto, Japan.

April 2014

Download Full Paper

Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1.

Nat Commun 2014 Apr 14;5:3634. Epub 2014 Apr 14.

Department of Molecular Biology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan.

April 2014

Download Full Paper

LINE-1 hypomethylation, DNA copy number alterations, and CDK6 amplification in esophageal squamous cell carcinoma.

Clin Cancer Res 2014 Mar 14;20(5):1114-24. Epub 2014 Jan 14.

Authors' Affiliations: Department of Gastroenterological Surgery, Graduate School of Medical Sciences; Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka; and Department of Biostatistics and Epidemiology, Yokohama City University Medical Center, Yokohama, Japan.

March 2014

Download Full Paper

The transcriptional cofactor MCAF1/ATF7IP is involved in histone gene expression and cellular senescence.

PLoS One 2013 30;8(7):e68478. Epub 2013 Jul 30.

Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.

August 2013

Download Full Paper

Metabolism-epigenome crosstalk in physiology and diseases.

J Hum Genet 2013 Jul 30;58(7):410-5. Epub 2013 May 30.

Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.

July 2013

Download Full Paper

[Epigenomic modification as therapeutic targets of cancer].

Nihon Rinsho 2012 Nov;70 Suppl 8:91-7

Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University.

November 2012

Download Full Paper

Quantitative assessment of higher-order chromatin structure of the INK4/ARF locus in human senescent cells.

Aging Cell 2012 Jun 12;11(3):553-6. Epub 2012 Mar 12.

Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Global Center of Excellence Cell Fate Regulation Research and Education Unit, Kumamoto University, Kumamoto 860-0811, Japan.

June 2012

Download Full Paper

The role of methyl-binding proteins in chromatin organization and epigenome maintenance.

Brief Funct Genomics 2012 May 19;11(3):251-64. Epub 2011 Dec 19.

Institut National du Cancer (INCa), CNRS UMR7216/Université Paris Diderot, Paris, France.

May 2012

Download Full Paper

Rb/E2F1 regulates the innate immune receptor Toll-like receptor 3 in epithelial cells.

Mol Cell Biol 2012 Apr 6;32(8):1581-90. Epub 2012 Feb 6.

Division of Hematopoiesis, Center for AIDS Research, Kumamoto University, Kumamoto, Japan.

April 2012

Download Full Paper

Higher-order chromatin regulation and differential gene expression in the human tumor necrosis factor/lymphotoxin locus in hepatocellular carcinoma cells.

Mol Cell Biol 2012 Apr 21;32(8):1529-41. Epub 2012 Feb 21.

Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, and the Global Center of Excellence Cell Fate Regulation Research and EducationUnit,Kumamoto University, Kumamoto, Japan.

April 2012

Download Full Paper

Hmga1 is differentially expressed and mediates silencing of the CD4/CD8 loci in T cell lineages and leukemic cells.

Cancer Sci 2012 Mar 28;103(3):439-47. Epub 2011 Dec 28.

Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, and Global Center of Excellence Cell Fate Regulation Research and Education Unit, Kumamoto University, Kumamoto, Japan.

March 2012

Download Full Paper

The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.

Mol Biol Cell 2012 Mar 19;23(6):1115-28. Epub 2012 Jan 19.

Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan.

March 2012

Download Full Paper

FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure.

Nat Commun 2012 Mar 27;3:758. Epub 2012 Mar 27.

Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, the Global Center of Excellence 'Cell Fate Regulation Research and Education Unit', Kumamoto University, 860-0811, Japan.

March 2012

Download Full Paper

CRMP5-associated GTPase (CRAG) protein protects neuronal cells against cytotoxicity of expanded polyglutamine protein partially via c-Fos-dependent activator protein-1 activation.

J Biol Chem 2011 Sep 8;286(39):33879-89. Epub 2011 Aug 8.

Laboratory of Molecular Biochemistry, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, USA.

September 2011

Download Full Paper

MCAF1 and synergistic activation of the transcription of Epstein-Barr virus lytic genes by Rta and Zta.

Nucleic Acids Res 2010 Aug 12;38(14):4687-700. Epub 2010 Apr 12.

Department of Biochemical Science and Technology, College of Life Science, National Taiwan University, Taipei, Taiwan.

August 2010

Download Full Paper

Sequence-specific recognition of methylated DNA by human zinc-finger proteins.

Nucleic Acids Res 2010 Aug 19;38(15):5015-22. Epub 2010 Apr 19.

CNRS UMR7216, Université Paris-Diderot, Paris, France.

August 2010

Download Full Paper

The p150 subunit of CAF-1 causes association of SUMO2/3 with the DNA replication foci.

Biochem Biophys Res Commun 2010 Jan 15;391(1):407-13. Epub 2009 Nov 15.

Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, Kumamoto 860-8555, Japan.

January 2010

Download Full Paper

HMGA1 is induced by Wnt/beta-catenin pathway and maintains cell proliferation in gastric cancer.

Am J Pathol 2009 Oct 3;175(4):1675-85. Epub 2009 Sep 3.

Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan.

October 2009

Download Full Paper

Simian virus 40 large T antigen targets the microtubule-stabilizing protein TACC2.

J Cell Sci 2009 Sep 11;122(Pt 17):3190-8. Epub 2009 Aug 11.

Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Honjo, Kumamoto, Japan.

September 2009

Download Full Paper

Architectural roles of multiple chromatin insulators at the human apolipoprotein gene cluster.

EMBO J 2009 May 26;28(9):1234-45. Epub 2009 Mar 26.

Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.

May 2009

Download Full Paper

Promyelocytic leukemia protein induces apoptosis due to caspase-8 activation via the repression of NFkappaB activation in glioblastoma.

Neuro Oncol 2009 Apr 23;11(2):132-41. Epub 2008 Sep 23.

Department of Neurosurgery, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Tokushima, Japan.

April 2009

Download Full Paper

Human T-cell leukemia virus type 1 bZIP factor selectively suppresses the classical pathway of NF-kappaB.

Blood 2009 Mar 8;113(12):2755-64. Epub 2008 Dec 8.

Laboratory of Virus Control, Institute for Virus Research, Kyoto University, Kyoto, Japan.

March 2009

Download Full Paper

HMGA2 maintains oncogenic RAS-induced epithelial-mesenchymal transition in human pancreatic cancer cells.

Am J Pathol 2009 Mar 29;174(3):854-68. Epub 2009 Jan 29.

Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan.

March 2009

Download Full Paper

MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity.

J Biol Chem 2009 Feb 23;284(8):5165-74. Epub 2008 Dec 23.

Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan.

February 2009

Download Full Paper

Polycomb group protein-associated chromatin is reproduced in post-mitotic G1 phase and is required for S phase progression.

J Biol Chem 2008 Jul 2;283(27):18905-15. Epub 2008 May 2.

Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan.

July 2008

Download Full Paper

Cohesin mediates transcriptional insulation by CCCTC-binding factor.

Nature 2008 Feb 30;451(7180):796-801. Epub 2008 Jan 30.

Research Institute of Molecular Pathology, Dr. Bohr Gasse 7, 1030 Vienna, Austria.

February 2008

Download Full Paper

High mobility group protein HMGA1 inhibits retinoblastoma protein-mediated cellular G0 arrest.

Cancer Sci 2007 Dec 17;98(12):1893-901. Epub 2007 Sep 17.

Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University 2-2-1 Honjo, Kumamoto 860-0811, Japan.

December 2007

Download Full Paper

Overlapping roles of the methylated DNA-binding protein MBD1 and polycomb group proteins in transcriptional repression of HOXA genes and heterochromatin foci formation.

J Biol Chem 2007 Jun 11;282(22):16391-400. Epub 2007 Apr 11.

Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Graduate School of Medical Sciences, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan.

June 2007

Download Full Paper

Dynamic changes in the epigenomic state and nuclear organization of differentiating mouse embryonic stem cells.

Genes Cells 2007 Apr;12(4):447-60

Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Ten-noudai, Tsukuba, Ibaraki 305-8572, Japan.

April 2007

Download Full Paper

Inhibition of DNA binding of Sox2 by the SUMO conjugation.

Biochem Biophys Res Commun 2006 Dec 2;351(4):920-6. Epub 2006 Nov 2.

Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan.

December 2006

Download Full Paper

[Nuclear organelles in the interchromosomal region].

Tanpakushitsu Kakusan Koso 2006 Nov;51(14 Suppl):1957-63

November 2006

Download Full Paper

[Epigenetics and nuclear reprogramming: overview].

Tanpakushitsu Kakusan Koso 2006 Nov;51(14 Suppl):2024-6

November 2006

Download Full Paper

Nuclear and chromatin reorganization in the MHC-Oct3/4 locus at developmental phases of embryonic stem cell differentiation.

Dev Biol 2006 Oct 21;298(2):354-67. Epub 2006 Apr 21.

Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, The 21st Century COE, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan.

October 2006

Download Full Paper

SUMO down-regulates the activity of Elf4/myeloid Elf-1-like factor.

Biochem Biophys Res Commun 2006 Sep 1;348(3):880-8. Epub 2006 Aug 1.

Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan.

September 2006

Download Full Paper

CTCF-dependent chromatin insulator is linked to epigenetic remodeling.

Mol Cell 2006 Sep;23(5):733-42

Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan.

September 2006

Download Full Paper

Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation.

J Biol Chem 2006 Aug 5;281(32):23180-90. Epub 2006 Jun 5.

Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan.

August 2006

Download Full Paper

In situ SUMOylation analysis reveals a modulatory role of RanBP2 in the nuclear rim and PML bodies.

Exp Cell Res 2006 May;312(8):1418-30

Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Kumanmoto 860-0811, Japan.

May 2006

Download Full Paper

[Nuclear and chromatin dynamics].

Tanpakushitsu Kakusan Koso 2006 Apr;51(4):302-9

April 2006

Download Full Paper

Loss of expression of type IV collagen alpha5 and alpha6 chains in colorectal cancer associated with the hypermethylation of their promoter region.

Am J Pathol 2006 Mar;168(3):856-65

Department of Surgical Pathology, Kumamoto University School of Medicine, Japan.

March 2006

Download Full Paper

Activation of Sp1-mediated transcription by Rta of Epstein-Barr virus via an interaction with MCAF1.

Nucleic Acids Res 2005 28;33(20):6528-39. Epub 2005 Nov 28.

Faculty of Biological Medicine and Environmental Biology and Graduate Institute of Biochemistry, Kaohsiung Medical University, Kaohsiung, Taiwan.

November 2005

Download Full Paper

Halogenated thymidine analogues restore the expression of silenced genes without demethylation.

Cancer Res 2005 Aug;65(15):6927-33

Laboratory of Virus Immunology, Institute for Virus Research, Kyoto University, Kyoto, Japan.

August 2005

Download Full Paper

Epigenetic silencing of the imprinted gene ZAC by DNA methylation is an early event in the progression of human ovarian cancer.

Int J Cancer 2005 Jul;115(5):690-700

Department of Molecular Genetics, Division of Molecular and Cell Therapeutics, Medical Institute of Bioregulation, Kyusyu University, Oita, Japan.

July 2005

Download Full Paper

Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria.

J Biol Chem 2005 May 7;280(19):19166-76. Epub 2005 Mar 7.

Department of Tumor Genetics and Biology, Graduate School of Medical Sciences, Kumamoto University, Honjo, Kumamoto 860-8556, Japan.

May 2005

Download Full Paper

Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins.

J Biol Chem 2005 Apr 2;280(14):13928-35. Epub 2005 Feb 2.

Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan.

April 2005

Download Full Paper

[Aging and DNA methylation].

Nihon Ronen Igakkai Zasshi 2005 Mar;42(2):137-43

March 2005

Download Full Paper

Overproduction of eukaryotic SUMO-1- and SUMO-2-conjugated proteins in Escherichia coli.

Anal Biochem 2004 Aug;331(1):204-6

Department of Regeneration Medicine, Institute of Molecular Embryology Genetics, Kumamoto University, Kumamoto, 860-0811, Japan.

August 2004

Download Full Paper

The regulation of human beta-defensin 2 by the ETS transcription factor MEF (myeloid Elf-1-like factor) is enhanced by promyelocytic leukemia protein.

J Pharmacol Sci 2004 Aug 31;95(4):466-70. Epub 2004 Jul 31.

Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan.

August 2004

Download Full Paper

Epigenetic system: a pathway to malignancies and a therapeutic target.

Int J Hematol 2004 Aug;80(2):103-7

Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan.

August 2004

Download Full Paper

Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein.

J Biol Chem 2004 Apr 19;279(18):19091-8. Epub 2004 Feb 19.

Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan.

April 2004

Download Full Paper

Generation of SUMO-1 modified proteins in E. coli: towards understanding the biochemistry/structural biology of the SUMO-1 pathway.

FEBS Lett 2004 Apr;564(1-2):85-90

Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan.

April 2004

Download Full Paper

Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin.

Proc Natl Acad Sci U S A 2003 Oct 10;100(22):12859-64. Epub 2003 Oct 10.

Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan.

October 2003

Download Full Paper

Nedd4 regulates egress of Ebola virus-like particles from host cells.

J Virol 2003 Sep;77(18):9987-92

Division of Molecular Virology, Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita-ku, Sapporo 060-0815, Japan.

September 2003

Download Full Paper

Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression.

J Biol Chem 2003 Jun 23;278(26):24132-8. Epub 2003 Apr 23.

Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan.

June 2003

Download Full Paper

Serum response factor is modulated by the SUMO-1 conjugation system.

Biochem Biophys Res Commun 2003 Jun;306(1):32-8

Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, 860-0811, Kumamoto, Japan.

June 2003

Download Full Paper

MCAF mediates MBD1-dependent transcriptional repression.

Mol Cell Biol 2003 Apr;23(8):2834-43

Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Kumamoto University, Kumamoto 860-0811, Japan.

April 2003

Download Full Paper

PML-nuclear bodies are involved in cellular serum response.

Genes Cells 2003 Mar;8(3):275-86

Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan.

March 2003

Download Full Paper

The aryl hydrocarbon receptor nuclear transporter is modulated by the SUMO-1 conjugation system.

J Biol Chem 2002 Nov 26;277(48):46576-85. Epub 2002 Sep 26.

Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan.

November 2002

Download Full Paper

Functional involvement of a novel Nedd4-like ubiquitin ligase on retrovirus budding.

EMBO Rep 2002 Jul;3(7):636-40

Division of Molecular Virology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan.

July 2002

Download Full Paper

Visualization of transcription-dependent association of imprinted genes with the nuclear matrix.

Exp Cell Res 2002 Apr;274(2):189-96

Faculty of Bioresources, Mie University, 1515 Kamihama, Tsu, 514-8507, Japan.

April 2002

Download Full Paper

Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response.

J Biol Chem 2002 Feb 19;277(5):3599-605. Epub 2001 Nov 19.

Department of Tumor Genetics and Biology and Department of Internal Medicine I, Kumamoto University School of Medicine, 2-2-1 Honjo, Kumamoto 860-0811, Japan.

February 2002

Download Full Paper