Publications

A novel inhibitor of farnesyltransferase with a zinc site recognition moiety and a farnesyl group.
Bioorg Med Chem Lett 2017 Aug 20;27(16):3862-3866. Epub 2017 Jun 20.
Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. Electronic address:

The SETD8/PR-Set7 Methyltransferase Functions as a Barrier to Prevent Senescence-Associated Metabolic Remodeling.
Cell Rep 2017 Feb;18(9):2148-2161
Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Agency for Medical Research and Development (AMED), Tokyo 100-0004, Japan. Electronic address:


HMGA2 promotes adipogenesis by activating C/EBPβ-mediated expression of PPARγ.
Biochem Biophys Res Commun 2016 Apr 8;472(4):617-23. Epub 2016 Mar 8.
Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, 860-0811, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Agency for Medical Research and Development, Tokyo, Japan. Electronic address:


Endoplasmic Reticulum (ER) Stress Induces Sirtuin 1 (SIRT1) Expression via the PI3K-Akt-GSK3β Signaling Pathway and Promotes Hepatocellular Injury.
J Biol Chem 2015 Dec 23;290(51):30366-74. Epub 2015 Oct 23.
From the Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, 862-0973, Japan,

H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation.
Mol Cell 2015 Nov;60(4):584-96
Division of Metabolic Medicine, The University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan; The Translational Systems Biology and Medicine Initiative (TSBMI), Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655, Japan. Electronic address:



The actin family protein ARP6 contributes to the structure and the function of the nucleolus.
Biochem Biophys Res Commun 2015 Aug 9;464(2):554-60. Epub 2015 Jul 9.
Laboratory of Molecular Biology, Graduate School of Agricultural Science, Tohoku University, Tsutsumidori-Amamiyamachi 1-1, Aoka-ku, Sendai 981-8555, Japan. Electronic address:

STAT5 Orchestrates Local Epigenetic Changes for Chromatin Accessibility and Rearrangements by Direct Binding to the TCRγ Locus.
J Immunol 2015 Aug 20;195(4):1804-14. Epub 2015 Jul 20.
Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan;

Lysine-specific demethylase 2 suppresses lipid influx and metabolism in hepatic cells.
Mol Cell Biol 2015 Apr 26;35(7):1068-80. Epub 2015 Jan 26.
Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo, Japan

Lysine Demethylase LSD1 Coordinates Glycolytic and Mitochondrial Metabolism in Hepatocellular Carcinoma Cells.
Cancer Res 2015 Apr 3;75(7):1445-56. Epub 2015 Feb 3.
Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo, Japan.

A cluster of noncoding RNAs activates the ESR1 locus during breast cancer adaptation.
Nat Commun 2015 Apr 29;6:6966. Epub 2015 Apr 29.
1] Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan [2] Program for Leading Graduate Schools 'HIGO (Health life science: Interdisciplinary and Glocal Oriented) Program', Kumamoto University, Kumamoto 860-8556, Japan [3] Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0076, Japan.

Sall1 maintains nephron progenitors and nascent nephrons by acting as both an activator and a repressor.
J Am Soc Nephrol 2014 Nov 17;25(11):2584-95. Epub 2014 Apr 17.
Departments of Kidney Development and CREST, Japan Science and Technology Agency, Saitama, Japan

Computational image analysis of colony and nuclear morphology to evaluate human induced pluripotent stem cells.
Sci Rep 2014 Nov 11;4:6996. Epub 2014 Nov 11.
1] Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan [2] Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo, Japan.

Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.
J Biol Chem 2014 Jun 15;289(26):18137-51. Epub 2014 May 15.
From the Division of Neurology, Department of Neuroscience and Sensory Organs, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.

IGF2 DMR0 methylation, loss of imprinting, and patient prognosis in esophageal squamous cell carcinoma.
Ann Surg Oncol 2014 Apr 7;21(4):1166-74. Epub 2013 Dec 7.
Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto City, Kumamoto, Japan.

Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1.
Nat Commun 2014 Apr 14;5:3634. Epub 2014 Apr 14.
Department of Molecular Biology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan.

LINE-1 hypomethylation, DNA copy number alterations, and CDK6 amplification in esophageal squamous cell carcinoma.
Clin Cancer Res 2014 Mar 14;20(5):1114-24. Epub 2014 Jan 14.
Authors' Affiliations: Department of Gastroenterological Surgery, Graduate School of Medical Sciences; Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka; and Department of Biostatistics and Epidemiology, Yokohama City University Medical Center, Yokohama, Japan.

Quantitative assessment of higher-order chromatin structure of the INK4/ARF locus in human senescent cells.
Aging Cell 2012 Jun 12;11(3):553-6. Epub 2012 Mar 12.
Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Global Center of Excellence Cell Fate Regulation Research and Education Unit, Kumamoto University, Kumamoto 860-0811, Japan.


Higher-order chromatin regulation and differential gene expression in the human tumor necrosis factor/lymphotoxin locus in hepatocellular carcinoma cells.
Mol Cell Biol 2012 Apr 21;32(8):1529-41. Epub 2012 Feb 21.
Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, and the Global Center of Excellence Cell Fate Regulation Research and EducationUnit,Kumamoto University, Kumamoto, Japan.

Hmga1 is differentially expressed and mediates silencing of the CD4/CD8 loci in T cell lineages and leukemic cells.
Cancer Sci 2012 Mar 28;103(3):439-47. Epub 2011 Dec 28.
Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, and Global Center of Excellence Cell Fate Regulation Research and Education Unit, Kumamoto University, Kumamoto, Japan.

FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure.
Nat Commun 2012 Mar 27;3:758. Epub 2012 Mar 27.
Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, the Global Center of Excellence 'Cell Fate Regulation Research and Education Unit', Kumamoto University, 860-0811, Japan.

CRMP5-associated GTPase (CRAG) protein protects neuronal cells against cytotoxicity of expanded polyglutamine protein partially via c-Fos-dependent activator protein-1 activation.
J Biol Chem 2011 Sep 8;286(39):33879-89. Epub 2011 Aug 8.
Laboratory of Molecular Biochemistry, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, USA.

Promyelocytic leukemia protein induces apoptosis due to caspase-8 activation via the repression of NFkappaB activation in glioblastoma.
Neuro Oncol 2009 Apr 23;11(2):132-41. Epub 2008 Sep 23.
Department of Neurosurgery, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Tokushima, Japan.


Overlapping roles of the methylated DNA-binding protein MBD1 and polycomb group proteins in transcriptional repression of HOXA genes and heterochromatin foci formation.
J Biol Chem 2007 Jun 11;282(22):16391-400. Epub 2007 Apr 11.
Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Graduate School of Medical Sciences, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan.

The regulation of human beta-defensin 2 by the ETS transcription factor MEF (myeloid Elf-1-like factor) is enhanced by promyelocytic leukemia protein.
J Pharmacol Sci 2004 Aug 31;95(4):466-70. Epub 2004 Jul 31.
Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan.

Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein.
J Biol Chem 2004 Apr 19;279(18):19091-8. Epub 2004 Feb 19.
Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan.

Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin.
Proc Natl Acad Sci U S A 2003 Oct 10;100(22):12859-64. Epub 2003 Oct 10.
Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan.

Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression.
J Biol Chem 2003 Jun 23;278(26):24132-8. Epub 2003 Apr 23.
Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan.

Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response.
J Biol Chem 2002 Feb 19;277(5):3599-605. Epub 2001 Nov 19.
Department of Tumor Genetics and Biology and Department of Internal Medicine I, Kumamoto University School of Medicine, 2-2-1 Honjo, Kumamoto 860-0811, Japan.

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