Mr Lars Robert, RN - Government - Legislative office

Mr Lars Robert

RN

Government

Legislative office

Cotonu, Cotonu | Benin

Main Specialties: Other

Additional Specialties: Legislative

Mr Lars Robert, RN - Government - Legislative office

Mr Lars Robert

RN
Introduction

Primary Affiliation: Government - Cotonu, Cotonu , Benin

Specialties:

Additional Specialties:

Metrics

100

Publications

441

Profile Views

202

Reads

1537

PubMed Central Citations

Top co-authors
Yasuhiro Kazuki
Yasuhiro Kazuki

Institute of Regenerative Medicine and Biofunction

44
Toshiaki Inoue
Toshiaki Inoue

School of Life Sciences

21
Mitsuhiko Osaki
Mitsuhiko Osaki

Tottori University

18
Motonobu Katoh
Motonobu Katoh

School of Life Sciences

15
Hiroyuki Kugoh
Hiroyuki Kugoh

Institute of Regenerative Medicine and Biofunction

12
Masaharu Hiratsuka
Masaharu Hiratsuka

School of Life Sciences

12
Masato Takiguchi
Masato Takiguchi

NTT Basic Research Laboratories

10
Satoshi Abe
Satoshi Abe

Fukushima Medical University

10
Hisao Ito
Hisao Ito

Tottori University

8
Narumi Uno
Narumi Uno

Institute of Regenerative Medicine and Biofunction

7

Publications

100Publications

202Reads

1537PubMed Central Citations

Comparison of Genomic and Epigenomic Expression in Monozygotic Twins Discordant for Rett Syndrome.

PLoS One 2013 21;8(6):e66729. Epub 2013 Jun 21.

Department of Epigenetic Medicine, Faculty of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Japan.

View Article
October 2017
1 Read
16 PubMed Central Citations(source)
3.23 Impact Factor

A novel system for simultaneous or sequential integration of multiple gene-loading vectors into a defined site of a human artificial chromosome.

PLoS One 2014 10;9(10):e110404. Epub 2014 Oct 10.

Stem Cell Project, Tokyo Metropolitan Institute of Medical Science, Kamikitazawa, Setagaya-ku, Tokyo, Japan; Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo, Japan.

View Article
December 2015
10 PubMed Central Citations(source)
3.23 Impact Factor

Decreased PITX1 gene expression in human cutaneous malignant melanoma and its clinicopathological significance.

Eur J Dermatol 2013 May-Jun;23(3):344-9

Division of Molecular Genetics and Biofunction, Institute of Regenerative Medicine and Biofunction.

View Article
November 2015
8 Reads
6 PubMed Central Citations(source)
1.99 Impact Factor

Recurrent micronucleation through cell cycle progression in the presence of microtubule inhibitors.

Cell Struct Funct 2015 9;40(1):51-9. Epub 2015 Jan 9.

Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University.

View Article
November 2015
2 PubMed Central Citations(source)
1.68 Impact Factor

Dual-color fluorescence imaging to monitor CYP3A4 and CYP3A7 expression in human hepatic carcinoma HepG2 and HepaRG cells.

PLoS One 2014 7;9(8):e104123. Epub 2014 Aug 7.

Chromosome Engineering Research Center, Tottori University, Yonago, Japan.

View Article
April 2015
2 PubMed Central Citations(source)
3.23 Impact Factor

miR-19b regulates hTERT mRNA expression through targeting PITX1 mRNA in melanoma cells.

Sci Rep 2015 Feb 3;5:8201. Epub 2015 Feb 3.

1] Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Yonago, Tottori 683-8503, Japan [2] Chromosome Engineering Research Center, Tottori University, Yonago, Tottori 683-8503, Japan.

View Article
February 2015
12 PubMed Central Citations(source)
5.08 Impact Factor

A pathway from chromosome transfer to engineering resulting in human and mouse artificial chromosomes for a variety of applications to bio-medical challenges.

Chromosome Res 2015 Feb;23(1):111-33

Chromosome Engineering Research Center, Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan,

View Article
February 2015
3 Reads
19 PubMed Central Citations(source)
2.48 Impact Factor

A human artificial chromosome recapitulates the metabolism of native telomeres in mammalian cells.

PLoS One 2014 18;9(2):e88530. Epub 2014 Feb 18.

Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, Japan.

View Article
January 2015
1 PubMed Central Citation(source)
3.23 Impact Factor

Highly sensitive luciferase reporter assay using a potent destabilization sequence of calpain 3.

J Biotechnol 2015 Jan 18;194:115-23. Epub 2014 Dec 18.

Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, Kagawa 761-0395, Japan. Electronic address:

View Article
January 2015
10 Reads
3 PubMed Central Citations(source)
2.87 Impact Factor

A novel and stable mouse artificial chromosome vector.

ACS Synth Biol 2014 Dec 17;3(12):903-14. Epub 2012 Oct 17.

Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University , 86 Nishi-cho, Yonago, Tottori 683-8503, Japan.

View Article
December 2014
2 Reads
16 PubMed Central Citations(source)
3.95 Impact Factor

Deacetylation of the mitotic checkpoint protein BubR1 at lysine 250 by SIRT2 and subsequent effects on BubR1 degradation during the prometaphase/anaphase transition.

Biochem Biophys Res Commun 2014 Oct 5;453(3):588-94. Epub 2014 Oct 5.

Division of Human Genome Science, Department of Molecular and Cellular Biology, School of Life Sciences, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan; Chromosome Engineering Research Center, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan. Electronic address:

View Article
October 2014
3 Reads
6 PubMed Central Citations(source)
2.30 Impact Factor

Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies.

Sci Rep 2014 Aug 27;4:6136. Epub 2014 Aug 27.

1] Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan; Tel: +81-859-38-6219 [2] Chromosome Engineering Research Center (CERC), Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan.

View Article
August 2014
10 Reads
7 PubMed Central Citations(source)
5.08 Impact Factor

Effects on asthma and induction of interleukin-8 caused by Asian dust particles collected in western Japan.

J Asthma 2014 Aug 27;51(6):595-602. Epub 2014 Mar 27.

Department of Respiratory Medicine and Rheumatology, Faculty of Medicine, Tottori University , Yonago , Tottori .

View Article
August 2014
8 Reads
6 PubMed Central Citations(source)
1.83 Impact Factor

A novel transchromosomic system: stable maintenance of an engineered Mb-sized human genomic fragment translocated to a mouse chromosome terminal region.

Transgenic Res 2014 Jun 2;23(3):441-53. Epub 2014 Feb 2.

Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan.

View Article
June 2014
2 Reads
1 PubMed Central Citation(source)
2.32 Impact Factor

SIRT2 knockdown increases basal autophagy and prevents postslippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors.

FEBS J 2014 Jun 30;281(11):2623-37. Epub 2014 Apr 30.

Division of Human Genome Science, Department of Molecular and Cellular Biology, School of Life Sciences, Faculty of Medicine, Tottori University, Japan; Chromosome Engineering Research Center, Tottori University, Japan.

View Article
June 2014
8 PubMed Central Citations(source)
4.00 Impact Factor

[Challenge toward gene-therapy using iPS cells for Duchenne muscular dystrophy].

Rinsho Shinkeigaku 2012 ;52(11):1139-42

Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University.

View Article
April 2014
1 Read

PITX1 is a reliable biomarker for predicting prognosis in patients with oral epithelial dysplasia.

Oncol Lett 2014 Mar 24;7(3):750-754. Epub 2013 Dec 24.

Division of Molecular Genetics and Biofunction, Institute of Regenerative Medicine and Biofunction, Tottori University Graduate School of Medical Science, Yonago, Tottori 683-8503, Japan.

View Article
March 2014
4 PubMed Central Citations(source)
0.99 Impact Factor

Bi-HAC vector system toward gene and cell therapy.

ACS Synth Biol 2014 Feb 9;3(2):83-90. Epub 2014 Jan 9.

Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University , 86 Nishi-cho, Yonago, Tottori 683-8503, Japan.

View Article
February 2014
1 Read
3 PubMed Central Citations(source)
3.95 Impact Factor

Highly stable maintenance of a mouse artificial chromosome in human cells and mice.

Biochem Biophys Res Commun 2013 Dec 9;442(1-2):44-50. Epub 2013 Nov 9.

Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan; Chromosome Engineering Research Center, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan.

View Article
December 2013
1 Read
9 PubMed Central Citations(source)
2.30 Impact Factor

The transfer of human artificial chromosomes via cryopreserved microcells.

Cytotechnology 2013 Oct 15;65(5):803-9. Epub 2013 Mar 15.

Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan.

View Article
October 2013
3 Reads
6 PubMed Central Citations(source)
1.75 Impact Factor

Knockout of mouse Cyp3a gene enhances synthesis of cholesterol and bile acid in the liver.

J Lipid Res 2013 Aug 24;54(8):2060-8. Epub 2013 May 24.

Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.

View Article
August 2013
5 Reads
4 PubMed Central Citations(source)
4.42 Impact Factor

Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans.

Hum Mol Genet 2013 Feb 2;22(3):578-92. Epub 2012 Nov 2.

Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan.

View Article
February 2013
7 Reads
17 PubMed Central Citations(source)
6.39 Impact Factor

An induced pluripotent stem cell-mediated and integration-free factor VIII expression system.

Biochem Biophys Res Commun 2013 Feb 3;431(2):336-41. Epub 2013 Jan 3.

Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Tottori, Japan.

View Article
February 2013
1 Read
7 PubMed Central Citations(source)
2.30 Impact Factor

Organization of synthetic alphoid DNA array in human artificial chromosome (HAC) with a conditional centromere.

ACS Synth Biol 2012 Dec;1(12):590-601

Laboratories of Molecular Pharmacology, National Cancer Institute, Bethesda, MD 20892, USA.

View Article
December 2012
2 Reads
16 PubMed Central Citations(source)
3.95 Impact Factor

Replication timing in a single human chromosome 11 transferred into the Chinese hamster ovary (CHO) cell line.

Gene 2012 Nov 3;510(1):1-6. Epub 2012 Sep 3.

Department of Laboratory Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, Japan.

View Article
November 2012
1 PubMed Central Citation(source)
2.14 Impact Factor

Cysteine-rich protein 61 suppresses cell invasion via down-regulation of matrix metalloproteinase-7 expression in the human gastric carcinoma cell line MKN-45.

Mol Med Rep 2010 Jul-Aug;3(4):711-5

Division of Molecular Genetics and Biofunction, Department of Biomedical Science, Tottori University Graduate School of Medical Science, Tottori University, Tottori 683-8503, Japan.

View Article
October 2012
1 Read
2 PubMed Central Citations(source)
1.48 Impact Factor

Prognostic significance of sirtuin 2 protein nuclear localization in glioma: an immunohistochemical study.

Oncol Rep 2012 Sep 19;28(3):923-30. Epub 2012 Jun 19.

Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, and Department of Surgical Pathology, Toyama University Hospital, Yonago, Tottori 683-8503, Japan.

View Article
September 2012
4 Reads
4 PubMed Central Citations(source)
2.19 Impact Factor

Bioluminescence imaging of bone formation using hairless osteocalcin-luciferase transgenic mice.

Bone 2012 Sep 23;51(3):369-75. Epub 2012 Jun 23.

Division of Molecular Biology, School of Life Sciences, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8503, Japan.

View Article
September 2012
1 Read
4 PubMed Central Citations(source)

Hybridization of testis-derived stem cells with somatic cells and embryonic stem cells in mice.

Biol Reprod 2012 Jun 14;86(6):178. Epub 2012 Jun 14.

Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

View Article
June 2012
3.32 Impact Factor

Methyl CpG-binding protein isoform MeCP2_e2 is dispensable for Rett syndrome phenotypes but essential for embryo viability and placenta development.

J Biol Chem 2012 Apr 28;287(17):13859-67. Epub 2012 Feb 28.

Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira 187-8502, Japan.

View Article
April 2012
2 Reads
17 PubMed Central Citations(source)
4.57 Impact Factor

Integration-free iPS cells engineered using human artificial chromosome vectors.

PLoS One 2011 5;6(10):e25961. Epub 2011 Oct 5.

Division of Molecular and Cell Genetics, Department of Molecular and Cellular Biology, School of Life Sciences, Faculty of Medicine, Tottori University, Yonago, Japan.

View Article
February 2012
5 Reads
25 PubMed Central Citations(source)
3.23 Impact Factor

Establishment and characterization of a transgenic mouse model for in vivo imaging of Bmp4 expression in the pancreas.

PLoS One 2011 15;6(9):e24956. Epub 2011 Sep 15.

Division of Molecular Biology, School of Life Sciences, Faculty of Medicine, Tottori University, Yonago, Japan.

View Article
February 2012
2 PubMed Central Citations(source)
3.23 Impact Factor

Dysregulation of gene expression in the artificial human trisomy cells of chromosome 8 associated with transformed cell phenotypes.

PLoS One 2011 29;6(9):e25319. Epub 2011 Sep 29.

Laboratory of Radiation Biology, Research Reactor Institute, Kyoto University, Osaka, Japan.

View Article
January 2012
13 PubMed Central Citations(source)
3.23 Impact Factor

Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells.

Proc Natl Acad Sci U S A 2011 Dec 28;108(50):20048-53. Epub 2011 Nov 28.

Laboratories of Molecular Pharmacology, National Cancer Institute, Bethesda, MD 20892, USA.

View Article
December 2011
2 Reads
26 PubMed Central Citations(source)
9.81 Impact Factor

[Toward gene and cell therapy using human artificial chromosome].

Nihon Rinsho 2011 Dec;69(12):2142-7

Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University.

View Article
December 2011

A new chromosome 14-based human artificial chromosome (HAC) vector system for efficient transgene expression in human primary cells.

Biochem Biophys Res Commun 2011 Nov 22;415(3):439-44. Epub 2011 Oct 22.

Innovative Drug Research Laboratories, Research Division, Kyowa Hakko Kirin Co., Ltd., 3-6-6 Asahimachi, Machida, Tokyo 194-8533, Japan.

View Article
November 2011
3 Reads
5 PubMed Central Citations(source)
2.30 Impact Factor

Neuron-specific impairment of inter-chromosomal pairing and transcription in a novel model of human 15q-duplication syndrome.

Hum Mol Genet 2011 Oct 1;20(19):3798-810. Epub 2011 Jul 1.

Frontier Science Organization, Kanazawa University, 13-1 Takaramachi, Kanazawa, Japan.

View Article
October 2011
1 Read
26 PubMed Central Citations(source)
6.39 Impact Factor

Human artificial chromosomes for gene delivery and the development of animal models.

Mol Ther 2011 Sep 12;19(9):1591-601. Epub 2011 Jul 12.

Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Yonago, Japan.

View Article
September 2011
1 Read
37 PubMed Central Citations(source)
6.23 Impact Factor

Gene dosage imbalance of human chromosome 21 in mouse embryonic stem cells differentiating to neurons.

Gene 2011 Aug 27;481(2):93-101. Epub 2011 Apr 27.

Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Shatin, New Territories.

View Article
August 2011
1 PubMed Central Citation(source)
2.14 Impact Factor

Stem cell-mediated transfer of a human artificial chromosome ameliorates muscular dystrophy.

Sci Transl Med 2011 Aug;3(96):96ra78

Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, 20132 Milan, Italy.

View Article
August 2011
12 Reads
57 PubMed Central Citations(source)
15.84 Impact Factor

MicroRNA-143 regulates human osteosarcoma metastasis by regulating matrix metalloprotease-13 expression.

Mol Ther 2011 Jun 22;19(6):1123-30. Epub 2011 Mar 22.

Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.

View Article
June 2011
3 Reads
74 PubMed Central Citations(source)
6.23 Impact Factor

Deleted in Esophageal Cancer 1(DEC1) is down-regulated and contributes to migration in head and neck squamous cell carcinoma cell lines.

ORL J Otorhinolaryngol Relat Spec 2011 26;73(1):17-23. Epub 2010 Oct 26.

Division of Otolaryngology, Head and Neck Surgery, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine, Tottori, Japan.

View Article
May 2011
1 PubMed Central Citation(source)
0.67 Impact Factor

Identification of PITX1 as a TERT suppressor gene located on human chromosome 5.

Mol Cell Biol 2011 Apr 7;31(8):1624-36. Epub 2011 Feb 7.

Department of Biomedical Science, Graduate School of Medical Science, Tottori University, 86 Nishicho, Yonago 683-8503, Japan.

View Article
April 2011
3 Reads
28 PubMed Central Citations(source)
4.78 Impact Factor

A method for producing transgenic cells using a multi-integrase system on a human artificial chromosome vector.

PLoS One 2011 Feb 24;6(2):e17267. Epub 2011 Feb 24.

Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University, Yonago, Japan.

View Article
February 2011
2 Reads
30 PubMed Central Citations(source)
3.23 Impact Factor

SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis.

Genes Cells 2011 Jan 9;16(1):34-45. Epub 2010 Nov 9.

Division of Human Genome Science, Department of Molecular and Cellular Biology, School of Life Sciences, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan.

View Article
January 2011
29 PubMed Central Citations(source)
2.81 Impact Factor

Human artificial chromosome with a conditional centromere for gene delivery and gene expression.

DNA Res 2010 Oct 26;17(5):293-301. Epub 2010 Aug 26.

Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University, Nishi-cho, Yonago, Tottori, Japan.

View Article
October 2010
1 Read
28 PubMed Central Citations(source)
5.48 Impact Factor

[Advantages and applications of human artificial chromosome vector].

Seikagaku 2010 Sep;82(9):846-52

Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan.

View Article
September 2010

Human chromosome 5 carries a transcriptional regulator of human telomerase reverse transcriptase (hTERT).

Biochem Biophys Res Commun 2010 Aug 16;398(4):695-701. Epub 2010 Jul 16.

Department of Biomedical Science, Graduate School of Medical Science, and Chromosome Engineering Research Center, Tottori University, 86 Nishicho, Yonago 683-8503, Japan.

View Article
August 2010
2 Reads
3 PubMed Central Citations(source)
2.30 Impact Factor

Development of evaluation system for bioactive substances using human artificial chromosome-mediated osteocalcin gene expression.

J Biochem 2010 Jul 17;148(1):29-34. Epub 2010 Mar 17.

Department of Molecular Biology, School of Life Sciences, Faculty of Medicine, Tottori University, Nishi-cho, Yonago 683-8503, Japan.

View Article
July 2010
2 Reads
4 PubMed Central Citations(source)
2.58 Impact Factor

Localization of an hTERT repressor region on human chromosome 3p21.3 using chromosome engineering.

Genome Integr 2010 May 26;1(1). Epub 2010 May 26.

Department of Biomedical Science, Graduate School of Medical Science, and Chromosome Engineering Research Center, Tottori University, 86 Nishicho, Yonago 683-8503, Japan.

View Article
May 2010
6 PubMed Central Citations(source)

Exploitation of the interaction of measles virus fusogenic envelope proteins with the surface receptor CD46 on human cells for microcell-mediated chromosome transfer.

BMC Biotechnol 2010 May 6;10:37. Epub 2010 May 6.

Chromosome Engineering Research Center, Tottori University, Yonago 683-8503, Japan.

View Article
May 2010
15 PubMed Central Citations(source)
2.03 Impact Factor

A gene delivery system with a human artificial chromosome vector based on migration of mesenchymal stem cells towards human glioblastoma HTB14 cells.

Neurol Res 2010 May 8;32(4):429-37. Epub 2009 Jul 8.

Department of Neurosurgery, Faculty of Medicine, Tottori University, Tottori, Japan.

View Article
May 2010
2 Reads
9 PubMed Central Citations(source)
1.45 Impact Factor

Complete genetic correction of ips cells from Duchenne muscular dystrophy.

Mol Ther 2010 Feb 8;18(2):386-93. Epub 2009 Dec 8.

Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Yonago, Japan.

View Article
February 2010
1 Read
76 PubMed Central Citations(source)
6.23 Impact Factor

Effects of Tritrichomonas muris on the mouse intestine: a proteomic analysis.

Exp Anim 2009 Oct;58(5):537-42

Division of Laboratory Animal Science, Research Center for Bioscience and Technology, Tottori University, Yonago, Tottori, Japan.

View Article
October 2009
2 Reads
3 PubMed Central Citations(source)

Genetic reconstruction of mouse spermatogonial stem cell self-renewal in vitro by Ras-cyclin D2 activation.

Cell Stem Cell 2009 Jul;5(1):76-86

Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.

View Article
July 2009
43 PubMed Central Citations(source)

Aberrant promoter methylation and expression of the imprinted PEG3 gene in glioma.

Proc Jpn Acad Ser B Phys Biol Sci 2009 ;85(4):157-65

Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University, Japan.

View Article
June 2009
1 Read
11 PubMed Central Citations(source)
2.65 Impact Factor

Introduction of a normal human chromosome 8 corrects abnormal phenotypes of Werner syndrome cells immortalized by expressing an hTERT gene.

J Radiat Res 2009 May 25;50(3):253-9. Epub 2009 Apr 25.

Radiation Biology Laboratory, Radiation Research Center, Frontier Science Innovation Center, Organization for University-Industry-Government Cooperation, Osaka Prefecture University, Sakai, Osaka, Japan.

View Article
May 2009
2 Reads
1.69 Impact Factor

SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest.

Cell Cycle 2009 Apr 19;8(8):1279-91. Epub 2009 Apr 19.

Division of Human Genome Science, Department of Molecular and Cellular Biology, School of Life Sciences, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan.

View Article
April 2009
17 PubMed Central Citations(source)

A noncoding RNA gene on chromosome 10p15.3 may function upstream of hTERT.

BMC Mol Biol 2009 Feb 2;10. Epub 2009 Feb 2.

Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8503, Japan.

View Article
February 2009
2 Reads
7 PubMed Central Citations(source)
2.19 Impact Factor

Enhanced apoptosis during early neuronal differentiation in mouse ES cells with autosomal imbalance.

Cell Res 2009 Feb;19(2):247-58

Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan.

View Article
February 2009
2 Reads
8 PubMed Central Citations(source)
12.41 Impact Factor

A highly stable and nonintegrated human artificial chromosome (HAC) containing the 2.4 Mb entire human dystrophin gene.

Mol Ther 2009 Feb 25;17(2):309-17. Epub 2008 Nov 25.

Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Yonago, Japan.

View Article
February 2009
2 Reads
33 PubMed Central Citations(source)
6.23 Impact Factor

Identification of the human homolog of the imprinted mouse Air non-coding RNA.

Genomics 2008 Dec 2;92(6):464-73. Epub 2008 Oct 2.

Ce-M-M-Research Center for Molecular Medicine of the Austrian Academy of Science, Vienna Biocenter, Dr. Bohr-Gasse 9/4, A1030 Vienna, Austria.

View Article
December 2008
3 Reads
16 PubMed Central Citations(source)
2.28 Impact Factor

Genetic instability caused by loss of MutS homologue 3 in human colorectal cancer.

Cancer Res 2008 Oct;68(20):8465-72

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.

View Article
October 2008
3 Reads
53 PubMed Central Citations(source)
9.33 Impact Factor

DLX5 expression is monoallelic and Dlx5 is up-regulated in the Mecp2-null frontal cortex.

J Cell Mol Med 2008 Aug 5;12(4):1188-91. Epub 2008 Jun 5.

Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA.

View Article
August 2008
3 Reads
9 PubMed Central Citations(source)

Changes in expression of imprinted genes following treatment of human cancer cell lines with non-mutagenic or mutagenic carcinogens.

Int J Oncol 2008 Aug;33(2):351-60

Oral and Maxillofacial Surgery, The Nippon Dental University Hospital at Tokyo, Tokyo 102-8158, Japan.

View Article
August 2008
2 PubMed Central Citations(source)
3.02 Impact Factor

CTCFL/BORIS is a methylation-independent DNA-binding protein that preferentially binds to the paternal H19 differentially methylated region.

Cancer Res 2008 Jul;68(14):5546-51

Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.

View Article
July 2008
17 PubMed Central Citations(source)
9.33 Impact Factor

Introduction of a CD40L genomic fragment via a human artificial chromosome vector permits cell-type-specific gene expression and induces immunoglobulin secretion.

J Hum Genet 2008 6;53(5):447-53. Epub 2008 Mar 6.

Division of Human Genome Science, Department of Molecular and Cellular Biology, Faculty of Medicine, Tottori University, 86, Nishi-cho, Yonago 683-8503, Japan.

View Article
July 2008
2 Reads
6 PubMed Central Citations(source)
2.46 Impact Factor

Telomerase-mediated life-span extension of human primary fibroblasts by human artificial chromosome (HAC) vector.

Biochem Biophys Res Commun 2008 May 5;369(3):807-11. Epub 2008 Mar 5.

Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University, 86 Nishimachi, Yonago, Tottori 683-8503, Japan.

View Article
May 2008
1 Read
5 PubMed Central Citations(source)
2.30 Impact Factor

Transfer of human artificial chromosome vectors into stem cells.

Reprod Biomed Online 2008 Jan;16(1):57-69

Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, 86 Nishicho, Yonago, Tottori 683-8503, Japan.

View Article
January 2008
14 PubMed Central Citations(source)
3.02 Impact Factor

Apoptotic pathway induced by transduction of RUNX3 in the human gastric carcinoma cell line MKN-1.

Cancer Sci 2008 Jan 22;99(1):23-30. Epub 2007 Oct 22.

Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8503, Japan.

View Article
January 2008
6 PubMed Central Citations(source)

Suggestive evidence for chromosomal localization of non-coding RNA from imprinted LIT1.

J Hum Genet 2007 5;52(11):926-33. Epub 2007 Oct 5.

Department of Biomedical Science, Graduate School of Medical Science, Tottori University, 86 Nishicho, Yonago 683-8503, Japan.

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January 2008
13 PubMed Central Citations(source)
2.46 Impact Factor

Production of knockout mice by gene targeting in multipotent germline stem cells.

Dev Biol 2007 Dec 26;312(1):344-52. Epub 2007 Sep 26.

Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-ku, Kyoto 606-8501, Japan.

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December 2007
1 Read
14 PubMed Central Citations(source)
3.55 Impact Factor

Telomeric DNA length in cerebral gray and white matter is associated with longevity in individuals aged 70 years or older.

Exp Gerontol 2007 Oct 21;42(10):944-50. Epub 2007 May 21.

Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.

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October 2007
3 Reads
13 PubMed Central Citations(source)
3.48 Impact Factor

MAD1 (mitotic arrest deficiency 1) is a candidate for a tumor suppressor gene in human stomach.

Virchows Arch 2007 Oct 3;451(4):771-9. Epub 2007 Aug 3.

Division of Molecular Genetics and Biofunction, Department of Biomedical Science, Graduate School of Medicine, Tottori University, 86, Nishi-cho, Yonago 683-8503, Japan.

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October 2007
1 Read
5 PubMed Central Citations(source)
2.65 Impact Factor

Imprinting status of paternally imprinted DLX5 gene in Japanese patients with Rett syndrome.

Brain Dev 2007 Sep 23;29(8):491-5. Epub 2007 Mar 23.

Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University, 86 Nishicho, Yonago, Tottori 683-8503, Japan.

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September 2007
1 Read
3 PubMed Central Citations(source)
1.54 Impact Factor

Transmission of genomic instability from a single irradiated human chromosome to the progeny of unirradiated cells.

Radiat Res 2007 Jun;167(6):675-81

Division of Radiation Life Science, Department of Radiation Life Science and Radiation Medical Science, Kyoto University Research Reactor Institute, Osaka, Japan.

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June 2007
2 PubMed Central Citations(source)
2.91 Impact Factor

The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation.

Cell Cycle 2007 May 30;6(9):1011-8. Epub 2007 May 30.

Division of Human Genome Science, Department of Molecular and Cellular Biology, School of Life Sciences, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan.

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May 2007
53 PubMed Central Citations(source)

Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks.

J Biol Chem 2007 Apr 1;282(14):10138-45. Epub 2007 Feb 1.

Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, 86 Nishimachi, Yonago, Tottori 683-8503, Japan.

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April 2007
4 Reads
10 PubMed Central Citations(source)
4.57 Impact Factor

Human artificial chromosome vectors meet stem cells: new prospects for gene delivery.

Stem Cell Rev 2006 ;2(1):43-50

Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction,Tottori University, 86 Nishicho,Yonago, Tottori 683-8503, Japan.

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February 2007
2 Reads
10 PubMed Central Citations(source)
2.77 Impact Factor

A comparison study in the proteomic signatures of multipotent germline stem cells, embryonic stem cells, and germline stem cells.

Biochem Biophys Res Commun 2007 Feb 13;353(2):259-67. Epub 2006 Dec 13.

Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Yonago, Tottori 683-8503, Japan.

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February 2007
4 PubMed Central Citations(source)
2.30 Impact Factor

Antigen-mediated growth control of hybridoma cells via a human artificial chromosome.

Biochim Biophys Acta 2007 Feb 6;1770(2):206-12. Epub 2006 Nov 6.

Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

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February 2007
1 Read
3 PubMed Central Citations(source)

Delayed onset of beating and decreased expression of T-type Ca2+ channel in mouse ES cell-derived cardiocytes carrying human chromosome 21.

Biochem Biophys Res Commun 2006 Dec 12;351(1):126-32. Epub 2006 Oct 12.

Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science, 86 Nishi-cho, Yonago 683-8503, Japan.

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December 2006
2 Reads
2.30 Impact Factor

Expression profile of LIT1/KCNQ1OT1 and epigenetic status at the KvDMR1 in colorectal cancers.

Cancer Sci 2006 Nov 5;97(11):1147-54. Epub 2006 Sep 5.

Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, 86 Nishimachi, Yonago, Tottori 683-8503, Japan.

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November 2006
25 PubMed Central Citations(source)

Exogenous gene expression and growth regulation of hematopoietic cells via a novel human artificial chromosome.

J Hum Genet 2006 7;51(2):147-50. Epub 2005 Dec 7.

Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan.

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October 2006
1 Read
3 PubMed Central Citations(source)
2.46 Impact Factor

Telomere shortening with aging in the human pancreas.

Exp Gerontol 2006 Sep 24;41(9):882-6. Epub 2006 Jul 24.

Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo 173-0015, Japan.

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September 2006
1 Read
19 PubMed Central Citations(source)
3.48 Impact Factor

A novel expression system for genomic DNA loci using a human artificial chromosome vector with transformation-associated recombination cloning.

J Hum Genet 2005 18;50(11):592-9. Epub 2005 Oct 18.

Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan.

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June 2006
2 Reads
5 PubMed Central Citations(source)
2.46 Impact Factor

Production of knockout mice by random or targeted mutagenesis in spermatogonial stem cells.

Proc Natl Acad Sci U S A 2006 May 5;103(21):8018-23. Epub 2006 May 5.

Department of Molecular Genetics, Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan. tshinoha2virus.kyoto-u.ac.jp

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May 2006
1 Read
34 PubMed Central Citations(source)
9.81 Impact Factor

Phage phiC31 integrase-mediated genomic integration of the common cytokine receptor gamma chain in human T-cell lines.

J Gene Med 2006 May;8(5):646-53

Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.

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May 2006
2 Reads
12 PubMed Central Citations(source)
2.47 Impact Factor

A novel human artificial chromosome vector provides effective cell lineage-specific transgene expression in human mesenchymal stem cells.

Stem Cells 2005 Nov-Dec;23(10):1608-16. Epub 2005 Sep 1.

Department of Molecular and Cell Genetics, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Yonago, Tottori 683-8503, Japan.

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March 2006
9 PubMed Central Citations(source)
6.52 Impact Factor

Generation of chromosome-specific monoclonal antibodies using in vitro-differentiated transchromosomic mouse embryonic stem cells.

Stem Cells 2005 Nov-Dec;23(10):1479-88. Epub 2005 Aug 4.

Pharmaceutical Research Laboratory, Pharmaceutical Division, Kirin Brewery Co., Ltd., Takasaki-shi, Gunma 370-1295, Japan.

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March 2006
2 Reads
6.52 Impact Factor

Evidence for a role of Collapsin response mediator protein-2 in signaling pathways that regulate the proliferation of non-neuronal cells.

Biochem Biophys Res Commun 2006 Feb 5;340(4):1244-50. Epub 2006 Jan 5.

Department of Genetic Medicine and Regenerative Therapeutics, Graduate School of Medical Science, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan.

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February 2006
12 PubMed Central Citations(source)
2.30 Impact Factor

Heat-regulated production and secretion of insulin from a human artificial chromosome vector.

Biochem Biophys Res Commun 2006 Feb 27;340(4):1053-61. Epub 2005 Dec 27.

Department of Human Genome Science, Graduate School of Medical Science, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan.

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February 2006
4 Reads
3 PubMed Central Citations(source)
2.30 Impact Factor

Topoisomerase II cleavage activity within the human D11Z1 and DXZ1 alpha-satellite arrays.

Chromosome Res 2005 21;13(6):637-48. Epub 2005 Sep 21.

Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK.

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January 2006
2 Reads
10 PubMed Central Citations(source)
2.48 Impact Factor

Genetic and epigenetic properties of mouse male germline stem cells during long-term culture.

Development 2005 Sep 17;132(18):4155-63. Epub 2005 Aug 17.

Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.

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September 2005
7 Reads
60 PubMed Central Citations(source)
6.46 Impact Factor
Top co-authors
Yasuhiro Kazuki
Yasuhiro Kazuki

Institute of Regenerative Medicine and Biofunction

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Toshiaki Inoue
Toshiaki Inoue

School of Life Sciences

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Mitsuhiko Osaki
Mitsuhiko Osaki

Tottori University

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Motonobu Katoh
Motonobu Katoh

School of Life Sciences

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Hiroyuki Kugoh
Hiroyuki Kugoh

Institute of Regenerative Medicine and Biofunction

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Masaharu Hiratsuka
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Masato Takiguchi
Masato Takiguchi

NTT Basic Research Laboratories

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Satoshi Abe
Satoshi Abe

Fukushima Medical University

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Hisao Ito
Hisao Ito

Tottori University

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Narumi Uno
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Institute of Regenerative Medicine and Biofunction

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