Publications by authors named "Mitchell P Levesque"

100Publications

The Tumor Profiler Study: integrated, multi-omic, functional tumor profiling for clinical decision support.

Authors:
Anja Irmisch Ximena Bonilla Stéphane Chevrier Kjong-Van Lehmann Franziska Singer Nora C Toussaint Cinzia Esposito Julien Mena Emanuela S Milani Ruben Casanova Daniel J Stekhoven Rebekka Wegmann Francis Jacob Bettina Sobottka Sandra Goetze Jack Kuipers Jacobo Sarabia Del Castillo Michael Prummer Mustafa A Tuncel Ulrike Menzel Andrea Jacobs Stefanie Engler Sujana Sivapatham Anja L Frei Gabriele Gut Joanna Ficek Nicola Miglino Rudolf Aebersold Marina Bacac Niko Beerenwinkel Christian Beisel Bernd Bodenmiller Reinhard Dummer Viola Heinzelmann-Schwarz Viktor H Koelzer Markus G Manz Holger Moch Lucas Pelkmans Berend Snijder Alexandre P A Theocharides Markus Tolnay Andreas Wicki Bernd Wollscheid Gunnar Rätsch Mitchell P Levesque

Cancer Cell 2021 Jan 20. Epub 2021 Jan 20.

University Hospital Zurich, Department of Dermatology, University of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland. Electronic address:

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January 2021

Evaluation of the Interplay between the ADAR Editome and Immunotherapy in Melanoma.

Authors:
Marina Tusup Phil F Cheng Ernesto Picardi Austeja Raziunaite Reinhard Dummer Mitchell P Levesque Lars E French Emmanuella Guenova Thomas M Kundig Steve Pascolo

Noncoding RNA 2021 Jan 12;7(1). Epub 2021 Jan 12.

Department of Dermatology, University Hospital of Zürich, Gloriastrasse 31, 8091 Zürich, Switzerland.

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January 2021

Blood-based kinase activity profiling: a potential predictor of response to immune checkpoint inhibition in metastatic cancer.

Authors:
Daan P Hurkmans Els M E Verdegaal Sabrina A Hogan Rik de Wijn Lies Hovestad Dianne M A van den Heuvel Rob Ruijtenbeek Marij J P Welters Mandy van Brakel Edwin A Basak Herbert M Pinedo Cor H J Lamers Harmen J G van de Werken John P Groten Reno Debets Mitchell P Levesque Reinhard Dummer Ellen Kapiteijn Ron H J Mathijssen Joachim G J V Aerts Sjoerd H van der Burg

J Immunother Cancer 2020 Dec;8(2)

Department of Medical Oncology, Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands

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December 2020

Serum CD73 is a prognostic factor in patients with metastatic melanoma and is associated with response to anti-PD-1 therapy.

Authors:
Roberta Turiello Mariaelena Capone Diana Giannarelli Elva Morretta Maria Chiara Monti Gabriele Madonna Domenico Mallardo Lucia Festino Rosa Azzaro Mitchell P Levesque Laurence Imhof Benjamin Weide Teresa Amaral Marc Chevrier Antje Sucker Piotr Rutkowski Dirk Schadendorf Celeste Lebbe Jason John Luke Kilian Wistuba-Hamprecht Reinhard Dummer Aldo Pinto Silvana Morello Paolo A Ascierto

J Immunother Cancer 2020 Dec;8(2)

Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Campania, Italy

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December 2020

Sustained androgen receptor signaling is a determinant of melanoma cell growth potential and tumorigenesis.

Authors:
Min Ma Soumitra Ghosh Daniele Tavernari Atul Katarkar Andrea Clocchiatti Luigi Mazzeo Anastasia Samarkina Justine Epiney Yi-Ru Yu Ping-Chih Ho Mitchell P Levesque Berna C Özdemir Giovanni Ciriello Reinhard Dummer G Paolo Dotto

J Exp Med 2021 Feb;218(2)

Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.

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February 2021

Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state.

Authors:
Daniela Cerezo-Wallis Marta Contreras-Alcalde Kevin Troulé Xavier Catena Cynthia Mucientes Tonantzin G Calvo Estela Cañón Cristina Tejedo Paula C Pennacchi Sabrina Hogan Peter Kölblinger Héctor Tejero Andrew X Chen Nuria Ibarz Osvaldo Graña-Castro Lola Martinez Javier Muñoz Pablo Ortiz-Romero José L Rodriguez-Peralto Gonzalo Gómez-López Fátima Al-Shahrour Raúl Rabadán Mitchell P Levesque David Olmeda María S Soengas

Nat Med 2020 12 19;26(12):1865-1877. Epub 2020 Oct 19.

Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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December 2020

Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity.

Authors:
Felicity Newell James S Wilmott Peter A Johansson Katia Nones Venkateswar Addala Pamela Mukhopadhyay Natasa Broit Carol M Amato Robert Van Gulick Stephen H Kazakoff Ann-Marie Patch Lambros T Koufariotis Vanessa Lakis Conrad Leonard Scott Wood Oliver Holmes Qinying Xu Karl Lewis Theresa Medina Rene Gonzalez Robyn P M Saw Andrew J Spillane Jonathan R Stretch Robert V Rawson Peter M Ferguson Tristan J Dodds John F Thompson Georgina V Long Mitchell P Levesque William A Robinson John V Pearson Graham J Mann Richard A Scolyer Nicola Waddell Nicholas K Hayward

Nat Commun 2020 10 16;11(1):5259. Epub 2020 Oct 16.

QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

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October 2020

The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress.

Authors:
Michael Bauer Zuzana Nascakova Anca-Irina Mihai Phil F Cheng Mitchell P Levesque Simon Lampart Robert Hurwitz Lennart Pfannkuch Jana Dobrovolna Melanie Jacobs Sina Bartfeld Anders Dohlman Xiling Shen Alevtina A Gall Nina R Salama Antonia Töpfer Achim Weber Thomas F Meyer Pavel Janscak Anne Müller

Nat Commun 2020 10 9;11(1):5117. Epub 2020 Oct 9.

Institute of Molecular Cancer Research, University of Zurich, 8057, Zurich, Switzerland.

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October 2020

Retrospective Analysis of Treatment and Complications of Immune Checkpoint Inhibitor-Associated Colitis: Histological Ulcerations as Potential Predictor for a Steroid-Refractory Disease Course.

Authors:
Julian Burla Sena Bluemel Luc Biedermann Marjam J Barysch Reinhard Dummer Mitchell P Levesque Christoph Gubler Bernhard Morell Gerhard Rogler Michael Scharl

Inflamm Intest Dis 2020 Aug 26;5(3):109-116. Epub 2020 May 26.

Division of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

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August 2020

NRAS melanoma tumor formation is reduced by p38-MAPK14 activation in zebrafish models and NRAS-mutated human melanoma cells.

Authors:
Ishani Banik Phil F Cheng Christopher M Dooley Jana Travnickova Munise Merteroglu Reinhard Dummer Elizabeth E Patton Elisabeth M Busch-Nentwich Mitchell P Levesque

Pigment Cell Melanoma Res 2020 Sep 10. Epub 2020 Sep 10.

University Hospital Zurich, University of Zurich, Zurich, Switzerland.

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September 2020

Toxicity of combined targeted therapy and concurrent radiotherapy in metastatic melanoma patients: a single-center retrospective analysis.

Authors:
Johanna S Ziegler Stephanie Kroeze Marie-Luise Hilbers Laurence Imhof Matthias Guckenberger Mitchell P Levesque Reinhard Dummer Phil Cheng Joanna Mangana

Melanoma Res 2020 12;30(6):552-561

Department of Dermatology, University Hospital of Zurich, University of Zurich, Gloriastrasse.

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December 2020

SPANX Control of Lamin A/C Modulates Nuclear Architecture and Promotes Melanoma Growth.

Authors:
Ikrame Lazar Bertrand Fabre Yongmei Feng Ali Khateb Patrick Turko Julia M Martinez Gomez Dennie T Frederick Mitchell P Levesque Lea Feld Gao Zhang Tongwu Zhang Brian James Jeny Shklover Emily Avitan-Hersh Ido Livneh Marzia Scortegagna Kevin Brown Ola Larsson Ivan Topisirovic Haguy Wolfenson Meenhard Herlyn Keith Flaherty Reinhard Dummer Ze'ev A Ronai

Mol Cancer Res 2020 10 22;18(10):1560-1573. Epub 2020 Jun 22.

Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California.

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October 2020

The EMT Transcription Factor ZEB2 Promotes Proliferation of Primary and Metastatic Melanoma While Suppressing an Invasive, Mesenchymal-Like Phenotype.

Authors:
Niels Vandamme Geertrui Denecker Kenneth Bruneel Gillian Blancke Özden Akay Joachim Taminau Jordy De Coninck Eva De Smedt Nicolas Skrypek Wouter Van Loocke Jasper Wouters David Nittner Corinna Köhler Douglas S Darling Phil F Cheng Marieke I G Raaijmakers Mitchell P Levesque Udupi Girish Mallya Mairin Rafferty Balazs Balint William M Gallagher Lieve Brochez Danny Huylebroeck Jody J Haigh Vanessa Andries Florian Rambow Pieter Van Vlierberghe Steven Goossens Joost J van den Oord Jean-Christophe Marine Geert Berx

Cancer Res 2020 07 5;80(14):2983-2995. Epub 2020 Jun 5.

Molecular and Cellular Oncology Laboratory, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.

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July 2020

Targeting PHGDH Upregulation Reduces Glutathione Levels and Resensitizes Resistant NRAS-Mutant Melanoma to MAPK Kinase Inhibition.

Authors:
Mai Q Nguyen Jessica L F Teh Timothy J Purwin Inna Chervoneva Michael A Davies Katherine L Nathanson Phil F Cheng Mitchell P Levesque Reinhard Dummer Andrew E Aplin

J Invest Dermatol 2020 Nov 7;140(11):2242-2252.e7. Epub 2020 May 7.

Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Electronic address:

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November 2020

Radiomics, Tumor Volume, and Blood Biomarkers for Early Prediction of Pseudoprogression in Patients with Metastatic Melanoma Treated with Immune Checkpoint Inhibition.

Authors:
Lucas Basler Hubert S Gabryś Sabrina A Hogan Matea Pavic Marta Bogowicz Diem Vuong Stephanie Tanadini-Lang Robert Förster Ken Kudura Martin W Huellner Reinhard Dummer Matthias Guckenberger Mitchell P Levesque

Clin Cancer Res 2020 Aug 6;26(16):4414-4425. Epub 2020 Apr 6.

Department of Dermatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

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August 2020

Temporal activation of WNT/β-catenin signaling is sufficient to inhibit SOX10 expression and block melanoma growth.

Authors:
Rexhep Uka Christian Britschgi Anja Krättli Claudia Matter Daniela Mihic Michal J Okoniewski Marco Gualandi Roger Stupp Paolo Cinelli Reinhard Dummer Mitchell P Levesque Olga Shakhova

Oncogene 2020 05 1;39(20):4132-4154. Epub 2020 Apr 1.

Department of Medical Oncology and Hematology, University Hospital Zurich, University of Zurich, Wagistrasse 14, 8952, Schlieren, UK.

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May 2020

Lipoconstruct surface topography grating size influences vascularization onset in the dorsal skinfold chamber model.

Authors:
Michelle McLuckie Francesco Robotti Nadia Sanchez-Macedo Dominik Enderlin Laura Frese Phil F Cheng Mitchell P Levesque José T Egaña Dimos Poulikakos Aldo Ferrari Nicole Lindenblatt

Acta Biomater 2020 04 8;106:136-144. Epub 2020 Feb 8.

Division of Plastic Surgery and Hand Surgery, University Hospital Zurich, Raemistrasse 100, Zurich 8091, Switzerland. Electronic address:

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April 2020

Inhibition of p38/MK2 Signaling Prevents Vascular Invasion of Melanoma.

Authors:
Judith Wenzina Silvio Holzner Emmi Puujalka Phil F Cheng Agnes Forsthuber Karin Neumüller Klaudia Schossleitner Beate M Lichtenberger Mitchell P Levesque Peter Petzelbauer

J Invest Dermatol 2020 04 14;140(4):878-890.e5. Epub 2019 Oct 14.

Skin and Endothelium Research Division, Department of Dermatology, Medical University of Vienna, Vienna, Austria. Electronic address:

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April 2020

A genome-wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS-mutant melanoma.

Authors:
Adi Nagler David W Vredevoogd Michal Alon Phil F Cheng Sophie Trabish Shelly Kalaora Rand Arafeh Victoria Goldin Mitchell P Levesque Daniel S Peeper Yardena Samuels

Pigment Cell Melanoma Res 2020 03 10;33(2):334-344. Epub 2019 Oct 10.

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

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March 2020

Morpho-Molecular Assessment Indicates New Prognostic Aspects and Personalized Therapeutic Options in Sinonasal Melanoma.

Authors:
Sandra N Freiberger Grégoire B Morand Patrick Turko Ulrich Wager Reinhard Dummer Martin Hüllner David Holzmann Niels J Rupp Mitchell P Levesque

Cancers (Basel) 2019 Sep 7;11(9). Epub 2019 Sep 7.

University of Zurich, 8006 Zurich, Switzerland.

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September 2019