Mitchell P Levesque

Mitchell P Levesque

UNVERIFIED PROFILE

Are you Mitchell P Levesque?   Register this Author

Register author
Mitchell P Levesque

Mitchell P Levesque

Publications by authors named "Mitchell P Levesque"

Are you Mitchell P Levesque?   Register this Author

83Publications

2008Reads

34Profile Views

Inhibition of p38/MK2 signaling prevents vascular invasion of melanoma.

J Invest Dermatol 2019 Oct 14. Epub 2019 Oct 14.

Skin and Endothelium Research Division, Department of Dermatology, Medical University of Vienna, Vienna, Austria. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jid.2019.08.451DOI Listing
October 2019

A genome-wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS-mutant melanoma.

Pigment Cell Melanoma Res 2019 Sep 24. Epub 2019 Sep 24.

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pcmr.12825DOI Listing
September 2019

Bioinformatics for precision oncology.

Brief Bioinform 2019 05;20(3):778-788

Department of Biosystems Science and Engineering of ETH Zurich in Basel, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bib/bbx143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585151PMC
May 2019

EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation.

Cancer Cell 2018 07 28;34(1):69-84.e14. Epub 2018 Jun 28.

Stem Cell Biology, Institute of Anatomy, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2018.06.001DOI Listing
July 2018

Methadone-Not a magic bullet in melanoma therapy.

Exp Dermatol 2018 06;27(6):694-696

Department of Dermatology, Zurich University Hospital, Zurich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13543DOI Listing
June 2018

Embryonic bone morphogenetic protein and nodal induce invasion in melanocytes and melanoma cells.

Biol Open 2018 Jun 7;7(6). Epub 2018 Jun 7.

Section of Dermato-Oncology, Department of Dermatology, Tuebingen University Hospital, Liebermeisterstrasse 25, 72076 Tuebingen, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/bio.032656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031345PMC
June 2018

Melanoma Immunotherapy: Next-Generation Biomarkers.

Front Oncol 2018 29;8:178. Epub 2018 May 29.

Department of Dermatology, UniversitätsSpital Zürich, Gloriastrasse, Zurich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2018.00178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986946PMC
May 2018

Wnt-signaling enhances neural crest migration of melanoma cells and induces an invasive phenotype.

Mol Cancer 2018 02 17;17(1):59. Epub 2018 Feb 17.

Center for Dermatooncology, Department of Dermatology, University Hospital Tübingen, University of Tübingen, Liebermeisterstr.25, 72076, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12943-018-0773-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816360PMC
February 2018

Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer.

Nat Chem Biol 2018 Jan 30;14(1):94-101. Epub 2017 Oct 30.

Department of Clinical Science, University of Bergen, Bergen, Norway.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nchembio.2510DOI Listing
January 2018

low neurotrophin receptor CD271 regulates phenotype switching in melanoma.

Nat Commun 2017 12 7;8(1):1988. Epub 2017 Dec 7.

University of Zürich, Institute of Anatomy, Winterthurerstrasse 190, 8057, Zürich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-017-01573-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719420PMC
December 2017

HLA-A*26 Is Correlated With Response to Nivolumab in Japanese Melanoma Patients.

J Invest Dermatol 2017 11 21;137(11):2443-2444. Epub 2017 Jul 21.

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jid.2017.06.023DOI Listing
November 2017

Multicenter, real-life experience with checkpoint inhibitors and targeted therapy agents in advanced melanoma patients in Switzerland.

Melanoma Res 2017 08;27(4):358-368

aDepartment of Dermatology, University Hospital Zurich bUniversity of Zurich cHorten Centre for Patient Oriented Research and Knowledge Transfer, University of Zurich, Zurich dDepartment of Internal Medicine, Cantonal Hospital Aarau, Aarau eDepartment of Oncology, Cantonal Hospital Graubünden, Chur fService of Medical Oncology, Department of Oncology, University Hospital of Lausanne, Lausanne, Switzerland gUniversity of Vienna, Vienna, Austria.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CMR.0000000000000359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633326PMC
August 2017

MEK inhibition and immune responses in advanced melanoma.

Oncoimmunology 2017 10;6(8):e1335843. Epub 2017 Aug 10.

University Hospital Zurich, Department Dermatology, Zürich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/2162402X.2017.1335843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593717PMC
August 2017

Metastatic melanoma moves on: translational science in the era of personalized medicine.

Cancer Metastasis Rev 2017 03;36(1):7-21

Department of Dermatology, University of Zurich, University of Zurich Hospital, Gloriastrasse 31, CH-8091, Zurich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10555-017-9658-0DOI Listing
March 2017

Data mining The Cancer Genome Atlas in the era of precision cancer medicine.

Swiss Med Wkly 2015 16;145:w14183. Epub 2015 Sep 16.

Dermatology Clinic, University Hospital Zurich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4414/smw.2015.14183DOI Listing
June 2016

A Transcriptionally Inactive ATF2 Variant Drives Melanomagenesis.

Cell Rep 2016 05 19;15(9):1884-92. Epub 2016 May 19.

Tumor Initiation and Maintenance Program, Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2016.04.072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889472PMC
May 2016

Romidepsin and Azacitidine Synergize in their Epigenetic Modulatory Effects to Induce Apoptosis in CTCL.

Clin Cancer Res 2016 Apr 9;22(8):2020-31. Epub 2015 Dec 9.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-15-1435DOI Listing
April 2016

Proteomics approaches to understanding mitogen-activated protein kinase inhibitor resistance in melanoma.

Curr Opin Oncol 2016 Mar;28(2):172-9

aDepartment of Dermatology, Medical University of Vienna, Vienna, Austria bInstitute of Molecular Systems Biology, ETH Zurich, Switzerland cDepartment of Dermatology, University of Zurich Hospital, University of Zurich, Zurich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCO.0000000000000261DOI Listing
March 2016

Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy.

Cancer Cell 2016 Mar;29(3):270-284

Manchester Cancer Research Centre, Wellcome Trust Centre for Cell-Matrix Research, The University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2016.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796027PMC
March 2016

Perturbing resistance: a network perspective.

Pigment Cell Melanoma Res 2016 Jan;29(1):5-7

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pcmr.12431DOI Listing
January 2016

Melanoma's next top model, it is in the air.

Exp Dermatol 2015 Sep 4;24(9):659-60. Epub 2015 Jun 4.

Department of Dermatology, University Hospital of Zürich and University of Zürich, Zürich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.12757DOI Listing
September 2015

A Floor-Plate Extracellular Protein-Protein Interaction Screen Identifies Draxin as a Secreted Netrin-1 Antagonist.

Cell Rep 2015 Jul 16;12(4):694-708. Epub 2015 Jul 16.

Max Planck Institute for Developmental Biology, Genetics, Spemannstraße 35, 72076 Tübingen, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2015.06.047DOI Listing
July 2015

A new live-cell biobank workflow efficiently recovers heterogeneous melanoma cells from native biopsies.

Exp Dermatol 2015 May;24(5):377-80

Department of Dermatology, University Hospital Zürich and University of Zurich, Zürich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.12683DOI Listing
May 2015

Hedgehog signaling in basal cell carcinoma.

J Dermatol Sci 2015 May 23;78(2):95-100. Epub 2015 Feb 23.

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jdermsci.2015.02.007DOI Listing
May 2015

Curing advanced melanoma by 2025.

Curr Opin Oncol 2015 Mar;27(2):125-7

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCO.0000000000000168DOI Listing
March 2015

Heterogeneity across the dorso-ventral axis in zebrafish EVL is regulated by a novel module consisting of sox, snail1a and max genes.

Mech Dev 2012 Mar-Jun;129(1-4):13-23. Epub 2012 Apr 12.

Max-Planck Institut für Entwicklungsbiologie, Department of Genetics, Tuebingen, Germany.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09254773120002
Publisher Site
http://dx.doi.org/10.1016/j.mod.2012.03.003DOI Listing
September 2014

To B-(RAF) or not to be.

J Invest Dermatol 2014 May;134(5):1200-1201

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/jid.2014.62DOI Listing
May 2014

Novel therapies for cutaneous T-cell lymphoma: what does the future hold?

Expert Opin Investig Drugs 2014 Apr 8;23(4):457-67. Epub 2014 Jan 8.

University Hospital of Zürich, Department of Dermatology , Gloriastrasse 31, 8091 Zürich , Switzerland +41 44 255 5528 ;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1517/13543784.2014.876407DOI Listing
April 2014

Hypoxia contributes to melanoma heterogeneity by triggering HIF1α-dependent phenotype switching.

J Invest Dermatol 2013 Oct 8;133(10):2436-2443. Epub 2013 Mar 8.

Department of Dermatology, University Hospital of Zürich, Zürich, Switzerland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/jid.2013.115DOI Listing
October 2013

Mutations in c10orf11, a melanocyte-differentiation gene, cause autosomal-recessive albinism.

Am J Hum Genet 2013 Mar 7;92(3):415-21. Epub 2013 Feb 7.

Applied Human Molecular Genetics, Kennedy Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajhg.2013.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591853PMC
March 2013

New tools for the identification of developmentally regulated enhancer regions in embryonic and adult zebrafish.

Zebrafish 2013 Mar 5;10(1):21-9. Epub 2013 Mar 5.

Department of Genetics, Max-Planck-Institut für Entwicklungsbiologie, Tübingen, Germany .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/zeb.2012.0775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670562PMC
March 2013

Melanoma immunotherapy: historical precedents, recent successes and future prospects.

Immunotherapy 2013 Feb;5(2):169-82

Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, CH-8091 Zurich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/imt.12.162DOI Listing
February 2013

Real-life experience with pegylated interferon and conventional interferon in adjuvant melanoma therapy.

J Immunother 2013 Jan;36(1):52-6

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CJI.0b013e31827809c7DOI Listing
January 2013

Centrosome loss or amplification does not dramatically perturb global gene expression in Drosophila.

Biol Open 2012 Oct 17;1(10):983-93. Epub 2012 Aug 17.

Sir William Dunn School of Pathology, University of Oxford , South Parks Road, Oxford OX1 3RE , UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/bio.20122238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507170PMC
October 2012

Sorafenib in melanoma.

Expert Opin Investig Drugs 2012 Apr 7;21(4):557-68. Epub 2012 Mar 7.

University Hospital of Zurich, Department of Dermatology, Gloriastrasse 31, Zurich, 8091, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1517/13543784.2012.665872DOI Listing
April 2012

Lgl2 executes its function as a tumor suppressor by regulating ErbB signaling in the zebrafish epidermis.

PLoS Genet 2009 Nov 13;5(11):e1000720. Epub 2009 Nov 13.

Department of Genetics, Max-Planck Institut für Entwicklungsbiologie, Tuebingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1000720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771016PMC
November 2009

The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability.

Development 2008 Jun 23;135(11):2013-22. Epub 2008 Apr 23.

Tübingen University, Center for Plant Molecular Biology, Department of Developmental Genetics, Auf der Morgenstelle 3-5, 72076 Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dev.020743DOI Listing
June 2008

An evolutionarily conserved mechanism delimiting SHR movement defines a single layer of endodermis in plants.

Science 2007 Apr;316(5823):421-5

Department of Biology and Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1139531DOI Listing
April 2007

Whole-genome analysis of the SHORT-ROOT developmental pathway in Arabidopsis.

PLoS Biol 2006 May 2;4(5):e143. Epub 2006 May 2.

Department of Biology and Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pbio.0040143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1450008PMC
May 2006

Systems biology.

Curr Biol 2004 Mar;14(5):R179-80

Biology Department, Duke University, Box 91000, Durham, North Carolina 27708, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cub.2004.02.012DOI Listing
March 2004