Mitchell J Weiss

Mitchell J Weiss

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Mitchell J Weiss

Mitchell J Weiss

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Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1.

N Engl J Med 2019 04;380(16):1525-1534

From the Departments of Bone Marrow Transplantation and Cellular Therapy (E.M., B.T., W.J., S.G.), Hematology (S.Z., Z.M., J.C., J.D., X.T., B.Y.R., M.J.W., B.P.S.), Therapeutics Production and Quality (T.L., M.M.M.), Immunology (H.A., B.Y.), Pharmaceutical Sciences (S.J.C.), Biostatistics (G.K., C.L.), and Infectious Diseases (G.M.), St. Jude Children's Research Hospital, Memphis, TN; the Allergy and Clinical Immunology Division, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru (J.C.A.B.); the Department of Pediatrics, Allergy-Immunology Division, Children's Hospital Los Angeles, Los Angeles (J.A.C.), and the Department of Pediatrics, Division of Pediatric Allergy-Immunology-Bone Marrow Transplantation, University of California, San Francisco (UCSF) Benioff Children's Hospital, San Francisco (J.R.L.-B., J.M.P., M.J.C.) - both in California; the Department of Pediatrics, Pediatric Allergy and Immunology, University of New Mexico, Albuquerque (E.D.); University of Oklahoma Health Sciences Center, Tulsa (J.T.L.); Departamento de Pediatria da Universidade de Taubaté, Conselho Nacional de Medicina, São Paulo (A.C.M.A.); Copperfield Childcare, Claremont, South Africa (H.W.); and the Genetic Immunotherapy Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (S.S.D.R., H.L.M.).

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http://www.nejm.org/doi/10.1056/NEJMoa1815408
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http://dx.doi.org/10.1056/NEJMoa1815408DOI Listing
April 2019

Children with sickle cell anemia and APOL1 genetic variants develop albuminuria early in life.

Haematologica 2019 Mar 19. Epub 2019 Mar 19.

Division Pediatric Hematology and Oncology, University of Alabama at Birmingham, USA

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http://dx.doi.org/10.3324/haematol.2018.212779DOI Listing
March 2019

Complexities of genetic diagnosis illustrated by an atypical case of congenital hypoplastic anemia.

Cold Spring Harb Mol Case Stud 2018 Dec 17;4(6). Epub 2018 Dec 17.

Department of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1101/mcs.a003384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318771PMC
December 2018

Testicular endothelial cells are a critical population in the germline stem cell niche.

Nat Commun 2018 10 22;9(1):4379. Epub 2018 Oct 22.

Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1038/s41467-018-06881-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197186PMC
October 2018

Generation of a human Juvenile myelomonocytic leukemia iPSC line, CHOPi001-A, with a mutation in CBL.

Stem Cell Res 2018 08 5;31:157-160. Epub 2018 Jul 5.

Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, United States; Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, United States. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2018.07.001DOI Listing
August 2018

Nonspecific inhibition of erythropoiesis by short hairpin RNAs.

Blood 2018 Jun 4;131(24):2733-2736. Epub 2018 May 4.

Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN.

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http://dx.doi.org/10.1182/blood-2018-03-841304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032891PMC
June 2018

A Cell Culture Model of Resistance Arteries.

J Vis Exp 2017 09 8(127). Epub 2017 Sep 8.

Department of Molecular Physiology and Biophysics, University of Virginia School of Medicine; Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine;

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http://dx.doi.org/10.3791/55992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752193PMC
September 2017

Platelet dense granules begin to selectively accumulate mepacrine during proplatelet formation.

Blood Adv 2017 Aug;1(19):1478-1490

Dept. of Pathology & Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.

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http://dx.doi.org/10.1182/bloodadvances.2017006726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604861PMC
August 2017

Welcoming a new age for gene therapy in hematology.

Blood 2016 05 6;127(21):2523-4. Epub 2016 Apr 6.

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN.

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http://dx.doi.org/10.1182/blood-2016-03-678714DOI Listing
May 2016

Unlinking an lncRNA from Its Associated cis Element.

Mol Cell 2016 Apr 31;62(1):104-10. Epub 2016 Mar 31.

Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.02.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877494PMC
April 2016

The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development.

Mol Cell Biol 2016 01 2;36(2):304-19. Epub 2015 Nov 2.

Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA Division of Hematology and Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA

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http://mcb.asm.org/content/36/2/304.full.pdf
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http://mcb.asm.org/lookup/doi/10.1128/MCB.00936-15
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http://dx.doi.org/10.1128/MCB.00936-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719296PMC
January 2016

Dynamics of GATA1 binding and expression response in a GATA1-induced erythroid differentiation system.

Genom Data 2015 Jun;4:1-7

Center for Comparative Genomics and Bioinformatics, Pennsylvania State University, University Park, Pennsylvania 16802, USA ; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S22135960150001
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http://dx.doi.org/10.1016/j.gdata.2015.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338950PMC
June 2015

Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility.

Epigenetics Chromatin 2015 23;8:16. Epub 2015 Apr 23.

Center for Comparative Genomics and Bioinformatics, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 304 Wartik Laboratory, University Park, PA 16802 USA.

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http://dx.doi.org/10.1186/s13072-015-0009-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432502PMC
May 2015

Hematopoietic differentiation of pluripotent stem cells in culture.

Methods Mol Biol 2014 ;1185:181-94

Department of Pathology and Laboratory Medicine and Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/978-1-4939-1133-2_12DOI Listing
March 2015

Anemia: progress in molecular mechanisms and therapies.

Nat Med 2015 Mar;21(3):221-30

Department of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1038/nm.3814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452951PMC
March 2015

MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome.

Blood 2015 Feb 22;125(8):1292-301. Epub 2014 Dec 22.

Childhood Leukemia Research Institute, Cancer Research Center, Sheba Medical Center, Ramat-Gan, Israel; Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel;

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http://dx.doi.org/10.1182/blood-2014-06-581892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335082PMC
February 2015

Dynamic shifts in occupancy by TAL1 are guided by GATA factors and drive large-scale reprogramming of gene expression during hematopoiesis.

Genome Res 2014 Dec 15;24(12):1945-62. Epub 2014 Oct 15.

Center for Comparative Genomics and Bioinformatics, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA;

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http://dx.doi.org/10.1101/gr.164830.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248312PMC
December 2014

Immune hemolytic anemia with drug-induced antibodies to carboplatin and vincristine in a pediatric patient with an optic pathway glioma.

Transfusion 2014 Nov 27;54(11):2901-5. Epub 2014 May 27.

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://doi.wiley.com/10.1111/trf.12729
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http://dx.doi.org/10.1111/trf.12729DOI Listing
November 2014

A comparative encyclopedia of DNA elements in the mouse genome.

Authors:
Feng Yue Yong Cheng Alessandra Breschi Jeff Vierstra Weisheng Wu Tyrone Ryba Richard Sandstrom Zhihai Ma Carrie Davis Benjamin D Pope Yin Shen Dmitri D Pervouchine Sarah Djebali Robert E Thurman Rajinder Kaul Eric Rynes Anthony Kirilusha Georgi K Marinov Brian A Williams Diane Trout Henry Amrhein Katherine Fisher-Aylor Igor Antoshechkin Gilberto DeSalvo Lei-Hoon See Meagan Fastuca Jorg Drenkow Chris Zaleski Alex Dobin Pablo Prieto Julien Lagarde Giovanni Bussotti Andrea Tanzer Olgert Denas Kanwei Li M A Bender Miaohua Zhang Rachel Byron Mark T Groudine David McCleary Long Pham Zhen Ye Samantha Kuan Lee Edsall Yi-Chieh Wu Matthew D Rasmussen Mukul S Bansal Manolis Kellis Cheryl A Keller Christapher S Morrissey Tejaswini Mishra Deepti Jain Nergiz Dogan Robert S Harris Philip Cayting Trupti Kawli Alan P Boyle Ghia Euskirchen Anshul Kundaje Shin Lin Yiing Lin Camden Jansen Venkat S Malladi Melissa S Cline Drew T Erickson Vanessa M Kirkup Katrina Learned Cricket A Sloan Kate R Rosenbloom Beatriz Lacerda de Sousa Kathryn Beal Miguel Pignatelli Paul Flicek Jin Lian Tamer Kahveci Dongwon Lee W James Kent Miguel Ramalho Santos Javier Herrero Cedric Notredame Audra Johnson Shinny Vong Kristen Lee Daniel Bates Fidencio Neri Morgan Diegel Theresa Canfield Peter J Sabo Matthew S Wilken Thomas A Reh Erika Giste Anthony Shafer Tanya Kutyavin Eric Haugen Douglas Dunn Alex P Reynolds Shane Neph Richard Humbert R Scott Hansen Marella De Bruijn Licia Selleri Alexander Rudensky Steven Josefowicz Robert Samstein Evan E Eichler Stuart H Orkin Dana Levasseur Thalia Papayannopoulou Kai-Hsin Chang Arthur Skoultchi Srikanta Gosh Christine Disteche Piper Treuting Yanli Wang Mitchell J Weiss Gerd A Blobel Xiaoyi Cao Sheng Zhong Ting Wang Peter J Good Rebecca F Lowdon Leslie B Adams Xiao-Qiao Zhou Michael J Pazin Elise A Feingold Barbara Wold James Taylor Ali Mortazavi Sherman M Weissman John A Stamatoyannopoulos Michael P Snyder Roderic Guigo Thomas R Gingeras David M Gilbert Ross C Hardison Michael A Beer Bing Ren

Nature 2014 Nov;515(7527):355-64

Ludwig Institute for Cancer Research and University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1038/nature13992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266106PMC
November 2014

Post-translational transformation of methionine to aspartate is catalyzed by heme iron and driven by peroxide: a novel subunit-specific mechanism in hemoglobin.

J Biol Chem 2014 Aug 17;289(32):22342-57. Epub 2014 Jun 17.

From the Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892,

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http://dx.doi.org/10.1074/jbc.M114.568980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862693PMC
August 2014

Erythro-megakaryocytic transcription factors associated with hereditary anemia.

Blood 2014 May 20;123(20):3080-8. Epub 2014 Mar 20.

Children's Hospital of Philadelphia, Philadelphia, PA.

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http://dx.doi.org/10.1182/blood-2014-01-453167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023417PMC
May 2014

Personalized platelet transfusions: one step closer to the clinic.

Cell Stem Cell 2014 Apr;14(4):425-6

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.03.012DOI Listing
April 2014

Iron-laden macrophage in autoimmune disease.

Blood 2014 Jan;123(4):469

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January 2014

Update on the diagnosis and management of thalassemia.

Authors:
Mitchell J Weiss

Clin Adv Hematol Oncol 2014 Jan;12(1):56-9

The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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January 2014

Long noncoding RNAs in biology and hematopoiesis.

Blood 2013 Jun 3;121(24):4842-6. Epub 2013 May 3.

Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2013-03-45
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http://dx.doi.org/10.1182/blood-2013-03-456111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682336PMC
June 2013

Congenital dyserythropoietic anemias: III's a charm.

Blood 2013 Jun;121(23):4614-5

University of Pennsylvania, USA;

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http://dx.doi.org/10.1182/blood-2013-05-497602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674662PMC
June 2013

The calcineurin-NFAT pathway negatively regulates megakaryopoiesis.

Blood 2013 Apr 27;121(16):3205-15. Epub 2013 Feb 27.

Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1182/blood-2012-04-421172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630833PMC
April 2013

Hemoglobin variants: biochemical properties and clinical correlates.

Cold Spring Harb Perspect Med 2013 Mar 1;3(3):a011858. Epub 2013 Mar 1.

Cell and Molecular Biology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1101/cshperspect.a011858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579210PMC
March 2013

α-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of α-subunits of human HbA with hydrogen peroxide.

J Biol Chem 2013 Feb 21;288(6):4288-98. Epub 2012 Dec 21.

Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20852, USA.

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http://dx.doi.org/10.1074/jbc.M112.412064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567680PMC
February 2013

miR-451 regulates dendritic cell cytokine responses to influenza infection.

J Immunol 2012 Dec 19;189(12):5965-75. Epub 2012 Nov 19.

Seattle Biomedical Research Institute, Seattle, WA 98109, USA.

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http://dx.doi.org/10.4049/jimmunol.1201437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528339PMC
December 2012

α-Hemoglobin-stabilizing protein is a sensitive and specific marker of erythroid precursors.

Am J Surg Pathol 2012 Oct;36(10):1538-47

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1097/PAS.0b013e31825fa501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445287PMC
October 2012

An encyclopedia of mouse DNA elements (Mouse ENCODE).

August 2012

SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models.

Blood 2012 Jul 18;120(2):404-14. Epub 2012 May 18.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, 513 Stellar-Chance Laboratories, 422 Curie Blvd., Philadelphia, PA 19104-6100, USA.

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http://dx.doi.org/10.1182/blood-2011-11-389551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398753PMC
July 2012

What's in a name?

J Clin Invest 2012 Jul 18;122(7):2346-9. Epub 2012 Jun 18.

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http://dx.doi.org/10.1172/JCI63989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386834PMC
July 2012

CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis.

J Clin Invest 2012 Jun 1;122(6):2257-66. Epub 2012 May 1.

Division of Cancer Pathobiology, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, Philadelphia 19104-4399, Pennsylvania, USA.

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http://dx.doi.org/10.1172/JCI45851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366393PMC
June 2012

Loss of the miR-144/451 cluster impairs ischaemic preconditioning-mediated cardioprotection by targeting Rac-1.

Cardiovasc Res 2012 May 21;94(2):379-90. Epub 2012 Feb 21.

Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0575, USA.

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http://dx.doi.org/10.1093/cvr/cvs096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331614PMC
May 2012

Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia.

Blood 2012 May 16;119(22):5265-75. Epub 2012 Mar 16.

Cell and Molecular Biology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-12-39
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http://dx.doi.org/10.1182/blood-2011-12-397729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3369615PMC
May 2012

Insights into hemoglobin assembly through in vivo mutagenesis of α-hemoglobin stabilizing protein.

J Biol Chem 2012 Mar 27;287(14):11325-37. Epub 2012 Jan 27.

Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M111.313205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322894PMC
March 2012

Functional regulation of pre-B-cell leukemia homeobox interacting protein 1 (PBXIP1/HPIP) in erythroid differentiation.

J Biol Chem 2012 Feb 20;287(8):5600-14. Epub 2011 Dec 20.

Molecular and Cellular Oncology Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad-500046, India.

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http://dx.doi.org/10.1074/jbc.M111.289843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285334PMC
February 2012

A new 'Linc' between noncoding RNAs and blood development.

Genes Dev 2011 Dec;25(24):2555-8

Division of Hematology/Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1101/gad.183020.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248677PMC
December 2011

Identification of distal cis-regulatory elements at mouse mitoferrin loci using zebrafish transgenesis.

Mol Cell Biol 2011 Apr 19;31(7):1344-56. Epub 2011 Jan 19.

Department of Medicine, Division of Hematology, Brigham and Women’s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.01010-10
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http://dx.doi.org/10.1128/MCB.01010-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135305PMC
April 2011

AHSP (α-haemoglobin-stabilizing protein) stabilizes apo-α-haemoglobin in a partially folded state.

Biochem J 2010 Dec;432(2):275-82

School of Molecular Bioscience, University of Sydney, Sydney, NSW 2006, Australia.

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http://dx.doi.org/10.1042/BJ20100642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384432PMC
December 2010

Protein quality control during erythropoiesis and hemoglobin synthesis.

Hematol Oncol Clin North Am 2010 Dec;24(6):1071-88

Cell and Molecular Biology Graduate Group, The Combined Degree Program, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.hoc.2010.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136498PMC
December 2010

MicroRNAs in erythropoiesis.

Curr Opin Hematol 2010 May;17(3):155-62

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1097/MOH.0b013e328337ba6cDOI Listing
May 2010

The role of alpha-hemoglobin stabilizing protein in redox chemistry, denaturation, and hemoglobin assembly.

Antioxid Redox Signal 2010 Feb;12(2):219-31

Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77251-1892, USA.

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http://www.liebertpub.com/doi/10.1089/ars.2009.2780
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http://dx.doi.org/10.1089/ars.2009.2780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821148PMC
February 2010

Getting by with a little help from our friends.

Authors:
Mitchell J Weiss

Curr Opin Pediatr 2010 Feb;22(1)

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http://dx.doi.org/10.1097/MOP.0b013e3283353d7bDOI Listing
February 2010

A cis-proline in alpha-hemoglobin stabilizing protein directs the structural reorganization of alpha-hemoglobin.

J Biol Chem 2009 Oct 25;284(43):29462-9. Epub 2009 Aug 25.

School of Molecular and Microbial Biosciences, University of Sydney, New South Wales 2006, Australia.

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http://dx.doi.org/10.1074/jbc.M109.027045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785579PMC
October 2009

Stem cells unscramble yolk sac hematopoiesis.

Blood 2009 Aug;114(8):1455-6

The Children's Hospital of Philadelphia, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2009-06-22
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http://dx.doi.org/10.1182/blood-2009-06-226209DOI Listing
August 2009

Chaperoning erythropoiesis.

Blood 2009 Mar 24;113(10):2136-44. Epub 2008 Dec 24.

Division of Hematology, The Children's Hospital of Philadelphia, PA, USA.

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http://dx.doi.org/10.1182/blood-2008-09-115238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652363PMC
March 2009

Transcriptional enhancement by GATA1-occupied DNA segments is strongly associated with evolutionary constraint on the binding site motif.

Genome Res 2008 Dec 25;18(12):1896-905. Epub 2008 Sep 25.

Center for Comparative Genomics and Bioinformatics of the Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.

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http://www.genome.org/cgi/doi/10.1101/gr.083089.108
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http://dx.doi.org/10.1101/gr.083089.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593580PMC
December 2008

An iron responsive element-like stem-loop regulates alpha-hemoglobin-stabilizing protein mRNA.

J Biol Chem 2008 Oct 2;283(40):26956-64. Epub 2008 Aug 2.

Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M802421200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2555993PMC
October 2008

A GATA-1-regulated microRNA locus essential for erythropoiesis.

Proc Natl Acad Sci U S A 2008 Mar 26;105(9):3333-8. Epub 2008 Feb 26.

Division of Hematology, Children's Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.0712312105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265118PMC
March 2008

STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice.

J Clin Invest 2007 Dec;117(12):3890-9

Department of Medicine, Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

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http://content.the-jci.org/articles/view/33010
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http://dx.doi.org/10.1172/JCI33010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096448PMC
December 2007

Diseased red blood cells topple iron balance.

Nat Med 2007 Sep;13(9):1020-1

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http://dx.doi.org/10.1038/nm0907-1020DOI Listing
September 2007

An erythroid chaperone that facilitates folding of alpha-globin subunits for hemoglobin synthesis.

J Clin Invest 2007 Jul;117(7):1856-65

Cell and Molecular Biology Graduate Program, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1172/JCI31664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904324PMC
July 2007