Mitch Dowsett

Mitch Dowsett

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Mitch Dowsett

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Comparison of protein expression between formalin-fixed core-cut biopsies and surgical excision specimens using a novel multiplex approach.

Breast Cancer Res Treat 2019 Jun 22;175(2):317-326. Epub 2019 Feb 22.

Ralph Lauren Centre for Breast Cancer Research, Royal Marsden Hospital, The Royal Marsden NHS Foundation Trust, 4th Floor Wallace Wing, 203 Fulham Road, London, SW3 6JJ, UK.

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http://dx.doi.org/10.1007/s10549-019-05163-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533418PMC
June 2019

Reply to J.A. Sparano et al.

J Clin Oncol 2019 Jun 7:JCO1901147. Epub 2019 Jun 7.

2 Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1200/JCO.19.01147DOI Listing
June 2019

Beyond 5 years: enduring risk of recurrence in oestrogen receptor-positive breast cancer.

Nat Rev Clin Oncol 2019 05;16(5):296-311

Ralph Lauren Centre for Breast Cancer Research, Royal Marsden Hospital, London, UK.

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http://www.nature.com/articles/s41571-018-0145-5
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http://dx.doi.org/10.1038/s41571-018-0145-5DOI Listing
May 2019

Estimating Risk of Recurrence for Early Breast Cancer: Integrating Clinical and Genomic Risk.

J Clin Oncol 2019 Mar 11;37(9):689-692. Epub 2019 Feb 11.

Royal Marsden Hospital, London, United Kingdom.

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http://ascopubs.org/doi/10.1200/JCO.18.01412
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http://dx.doi.org/10.1200/JCO.18.01412DOI Listing
March 2019

Circulating Growth and Sex Hormone Levels and Breast Tissue Composition in Young Nulliparous Women.

Cancer Epidemiol Biomarkers Prev 2018 Dec 18;27(12):1500-1508. Epub 2018 Sep 18.

Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom.

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http://dx.doi.org/10.1158/1055-9965.EPI-18-0036DOI Listing
December 2018

Novel 18-gene signature for predicting relapse in ER-positive, HER2-negative breast cancer.

Breast Cancer Res 2018 09 4;20(1):103. Epub 2018 Sep 4.

The Breast Cancer Now Toby Robins Research Centre at the Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK.

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http://dx.doi.org/10.1186/s13058-018-1040-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122470PMC
September 2018

Abiraterone shows alternate activity in models of endocrine resistant and sensitive disease.

Br J Cancer 2018 Aug 11;119(3):313-322. Epub 2018 Jul 11.

The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW7 3RP, UK.

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http://dx.doi.org/10.1038/s41416-018-0158-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068155PMC
August 2018

Integration of Clinical Variables for the Prediction of Late Distant Recurrence in Patients With Estrogen Receptor-Positive Breast Cancer Treated With 5 Years of Endocrine Therapy: CTS5.

J Clin Oncol 2018 Jul 20;36(19):1941-1948. Epub 2018 Apr 20.

Mitch Dowsett and Andrew Dodson, Royal Marsden Hospital; Mitch Dowsett, Institute of Cancer Research; Ivana Sestak and Jack Cuzick, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, United Kingdom; Meredith M. Regan, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA; Giuseppe Viale, University of Milan; Guiseppe Viale and Marco Colleoni, European Institute of Oncology, Milan, Italy; Beat Thürlimann, Kantonsspital St Gallen, St Gallen, and International Breast Cancer Study Group and Swiss Group for Clinical Cancer Research, Berne, Switzerland.

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http://dx.doi.org/10.1200/JCO.2017.76.4258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049399PMC
July 2018

Discordance between oncotype DX recurrence score and RSPC for predicting residual risk of recurrence in ER-positive breast cancer.

Breast Cancer Res Treat 2018 Feb 11;168(1):249-258. Epub 2017 Nov 11.

Ralph Lauren Centre for Breast Cancer Research, The Royal Marsden Hospital NHS Foundation Trust, Fulham Road, London, SW3 6JJ, UK.

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http://dx.doi.org/10.1007/s10549-017-4514-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847032PMC
February 2018

Menstrual cycle characteristics and steroid hormone, prolactin, and growth factor levels in premenopausal women.

Cancer Causes Control 2017 Dec 31;28(12):1441-1452. Epub 2017 Oct 31.

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1007/s10552-017-0971-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718047PMC
December 2017

20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years.

N Engl J Med 2017 11;377(19):1836-1846

From the Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford (H.P., R.G., J. Braybrooke, C.D., C.T., P.M., R.P.), and Royal Marsden Hospital and Institute of Cancer Research, London (M.D.) - both in the United Kingdom; Sunnybrook Health Sciences Centre and the University of Toronto, Toronto (K.I.P.); Karolinska Institutet and Karolinska University Hospital, Stockholm (J. Bergh); and the University of Michigan Comprehensive Cancer Center, Ann Arbor (D.F.H.).

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http://dx.doi.org/10.1056/NEJMoa1701830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734609PMC
November 2017

Comparative Efficacy and Safety of Adjuvant Letrozole Versus Anastrozole in Postmenopausal Patients With Hormone Receptor-Positive, Node-Positive Early Breast Cancer: Final Results of the Randomized Phase III Femara Versus Anastrozole Clinical Evaluation (FACE) Trial.

J Clin Oncol 2017 Apr 23;35(10):1041-1048. Epub 2017 Jan 23.

Ian Smith and Mitch Dowsett, Royal Marsden Hospital; Institute of Cancer Research, London, United Kingdom; Denise Yardley and Howard Burris, Sarah Cannon Research Institute; Tennessee Oncology, Nashville, TN; Richard De Boer, Royal Melbourne and Western Hospitals, Melbourne, Australia; Dino Amadori, Istituto Scientifico Romagnolo per lo Studio e la Cura del Tumori Istituto di Ricovero eCura a Carattere Scientifico, Meldola; Lisa Comarella, CROS NT, Verona, Italy; Kristi McIntyre and Joyce O'Shaughnessy, Texas Oncology, US Oncology; Joyce O'Shaughnessy, Baylor University Medical Center; Baylor Charles A. Sammons Cancer Center; The US Oncology Network, Dallas, TX; Bent Ejlertsen, Danish Breast Cancer Cooperative Group, Rigshospitalet, Copenhagen, Denmark; Michael Gnant, Medical University of Vienna, Vienna, Austria; Walter Jonat, Universitätsklinikum Schleswig-Holstein, Kiel, Germany; Kathleen I. Pritchard, Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, Ontario, Canada; Lowell Hart, Florida Cancer Specialists, Fort Myers, FL; Susan Poggio and Barbara Wamil, Novartis Pharmaceuticals Corporation, East Hanover, NJ; and Herve Salomon, Novartis Pharma, Rueil-Malmaison, France.

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http://dx.doi.org/10.1200/JCO.2016.69.2871DOI Listing
April 2017

Immunohistochemical Phenotype of Breast Cancer during 25-Year Follow-up of the Royal Marsden Tamoxifen Prevention Trial.

Cancer Prev Res (Phila) 2017 Mar 18;10(3):171-176. Epub 2017 Jan 18.

Ralph Lauren Centre for Breast Cancer Research, Royal Marsden Hospital NHS Trust, London, United Kingdom.

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http://dx.doi.org/10.1158/1940-6207.CAPR-16-0247-TDOI Listing
March 2017

Childhood body size and pubertal timing in relation to adult mammographic density phenotype.

Breast Cancer Res 2017 02 7;19(1):13. Epub 2017 Feb 7.

Division of Genetics and Epidemiology, The Institute of Cancer Research, 15 Cotswold Road, London, SM2 5NG, UK.

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http://dx.doi.org/10.1186/s13058-017-0804-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297131PMC
February 2017

Comparison of EndoPredict and EPclin With Oncotype DX Recurrence Score for Prediction of Risk of Distant Recurrence After Endocrine Therapy.

J Natl Cancer Inst 2016 11 10;108(11). Epub 2016 Jul 10.

Affiliations of authors: The Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, London, UK (RB, MD); Academic Department of Biochemistry, Royal Marsden Hospital, London, UK (RB, MD); Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK (IS, JC); Sividon Diagnostics GmbH, Cologne, Germany (RK, KK, MS, CP); Institute of Pathology, Charité University Hospital and German Cancer Consortium (DKTK), Berlin, Germany (CD); Department of Surgery and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria (PD).

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http://dx.doi.org/10.1093/jnci/djw149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241904PMC
November 2016

Cross-Stratification and Differential Risk by Breast Cancer Index and Recurrence Score in Women with Hormone Receptor-Positive Lymph Node-Negative Early-Stage Breast Cancer.

Clin Cancer Res 2016 Oct 1;22(20):5043-5048. Epub 2016 Jun 1.

Molecular Pathology Unit and Centre for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-0155DOI Listing
October 2016

Plasma ESR1 Mutations and the Treatment of Estrogen Receptor-Positive Advanced Breast Cancer.

J Clin Oncol 2016 09 6;34(25):2961-8. Epub 2016 Jun 6.

Charlotte Fribbens, Ben O'Leary, Sarah Hrebien, Isaac Garcia-Murillas, Matthew Beaney, Mitch Dowsett, and Nicholas C. Turner, Institute of Cancer Research; Charlotte Fribbens, Ben O'Leary, Stephen R.D. Johnston, and Nicholas C. Turner, Royal Marsden Hospital; Lucy Kilburn and Judith M. Bliss, The Institute of Cancer Research Clinical Trials and Statistics Unit, London, UK; Massimo Cristofanilli, Thomas Jefferson University, Philadelphia, PA; Fabrice Andre, Institut Gustave Roussy, Villejuif, France; Sherene Loi, University of Melbourne, Melbourne, Australia; Sibylle Loibl, German Breast Group, Neu-Isenburg, Germany; and John Jiang, Cynthia Huang Bartlett, and Maria Koehler, Pfizer, New York, NY.

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http://dx.doi.org/10.1200/JCO.2016.67.3061DOI Listing
September 2016

Impact of type of full-field digital image on mammographic density assessment and breast cancer risk estimation: a case-control study.

Breast Cancer Res 2016 09 26;18(1):96. Epub 2016 Sep 26.

Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037867PMC
http://dx.doi.org/10.1186/s13058-016-0756-7DOI Listing
September 2016

Retrospective analysis of molecular scores for the prediction of distant recurrence according to baseline risk factors.

Breast Cancer Res Treat 2016 08 22;159(1):71-8. Epub 2016 Jul 22.

Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University, Charterhouse Square, London, EC1M 6BQ, UK.

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http://dx.doi.org/10.1007/s10549-016-3868-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010586PMC
August 2016

Incomplete Estrogen Suppression With Gonadotropin-Releasing Hormone Agonists May Reduce Clinical Efficacy in Premenopausal Women With Early Breast Cancer.

J Clin Oncol 2016 05 4;34(14):1580-3. Epub 2016 Jan 4.

University of Pittsburgh Cancer Institute and UPMC CancerCenter, Pittsburgh, PA.

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http://dx.doi.org/10.1200/JCO.2015.62.3728DOI Listing
May 2016

Changes in Expression of Genes Representing Key Biologic Processes after Neoadjuvant Chemotherapy in Breast Cancer, and Prognostic Implications in Residual Disease.

Clin Cancer Res 2016 05;22(10):2405-16

Academic Department of Biochemistry, Royal Marsden Hospital, London, United Kingdom. Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom. Breast Unit, Royal Marsden Hospital, London, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1488DOI Listing
May 2016

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.

Authors:
Alison M Dunning Kyriaki Michailidou Karoline B Kuchenbaecker Deborah Thompson Juliet D French Jonathan Beesley Catherine S Healey Siddhartha Kar Karen A Pooley Elena Lopez-Knowles Ed Dicks Daniel Barrowdale Nicholas A Sinnott-Armstrong Richard C Sallari Kristine M Hillman Susanne Kaufmann Haran Sivakumaran Mahdi Moradi Marjaneh Jason S Lee Margaret Hills Monika Jarosz Suzie Drury Sander Canisius Manjeet K Bolla Joe Dennis Qin Wang John L Hopper Melissa C Southey Annegien Broeks Marjanka K Schmidt Artitaya Lophatananon Kenneth Muir Matthias W Beckmann Peter A Fasching Isabel Dos-Santos-Silva Julian Peto Elinor J Sawyer Ian Tomlinson Barbara Burwinkel Frederik Marme Pascal Guénel Thérèse Truong Stig E Bojesen Henrik Flyger Anna González-Neira Jose I A Perez Hoda Anton-Culver Lee Eunjung Volker Arndt Hermann Brenner Alfons Meindl Rita K Schmutzler Hiltrud Brauch Ute Hamann Kristiina Aittomäki Carl Blomqvist Hidemi Ito Keitaro Matsuo Natasha Bogdanova Thilo Dörk Annika Lindblom Sara Margolin Veli-Matti Kosma Arto Mannermaa Chiu-Chen Tseng Anna H Wu Diether Lambrechts Hans Wildiers Jenny Chang-Claude Anja Rudolph Paolo Peterlongo Paolo Radice Janet E Olson Graham G Giles Roger L Milne Christopher A Haiman Brian E Henderson Mark S Goldberg Soo H Teo Cheng Har Yip Silje Nord Anne-Lise Borresen-Dale Vessela Kristensen Jirong Long Wei Zheng Katri Pylkäs Robert Winqvist Irene L Andrulis Julia A Knight Peter Devilee Caroline Seynaeve Jonine Figueroa Mark E Sherman Kamila Czene Hatef Darabi Antoinette Hollestelle Ans M W van den Ouweland Keith Humphreys Yu-Tang Gao Xiao-Ou Shu Angela Cox Simon S Cross William Blot Qiuyin Cai Maya Ghoussaini Barbara J Perkins Mitul Shah Ji-Yeob Choi Daehee Kang Soo Chin Lee Mikael Hartman Maria Kabisch Diana Torres Anna Jakubowska Jan Lubinski Paul Brennan Suleeporn Sangrajrang Christine B Ambrosone Amanda E Toland Chen-Yang Shen Pei-Ei Wu Nick Orr Anthony Swerdlow Lesley McGuffog Sue Healey Andrew Lee Miroslav Kapuscinski Esther M John Mary Beth Terry Mary B Daly David E Goldgar Saundra S Buys Ramunas Janavicius Laima Tihomirova Nadine Tung Cecilia M Dorfling Elizabeth J van Rensburg Susan L Neuhausen Bent Ejlertsen Thomas V O Hansen Ana Osorio Javier Benitez Rachel Rando Jeffrey N Weitzel Bernardo Bonanni Bernard Peissel Siranoush Manoukian Laura Papi Laura Ottini Irene Konstantopoulou Paraskevi Apostolou Judy Garber Muhammad Usman Rashid Debra Frost Louise Izatt Steve Ellis Andrew K Godwin Norbert Arnold Dieter Niederacher Kerstin Rhiem Nadja Bogdanova-Markov Charlotte Sagne Dominique Stoppa-Lyonnet Francesca Damiola Olga M Sinilnikova Sylvie Mazoyer Claudine Isaacs Kathleen B M Claes Kim De Leeneer Miguel de la Hoya Trinidad Caldes Heli Nevanlinna Sofia Khan Arjen R Mensenkamp Maartje J Hooning Matti A Rookus Ava Kwong Edith Olah Orland Diez Joan Brunet Miquel Angel Pujana Jacek Gronwald Tomasz Huzarski Rosa B Barkardottir Rachel Laframboise Penny Soucy Marco Montagna Simona Agata Manuel R Teixeira Sue Kyung Park Noralane Lindor Fergus J Couch Marc Tischkowitz Lenka Foretova Joseph Vijai Kenneth Offit Christian F Singer Christine Rappaport Catherine M Phelan Mark H Greene Phuong L Mai Gad Rennert Evgeny N Imyanitov Peter J Hulick Kelly-Anne Phillips Marion Piedmonte Anna Marie Mulligan Gord Glendon Anders Bojesen Mads Thomassen Maria A Caligo Sook-Yee Yoon Eitan Friedman Yael Laitman Ake Borg Anna von Wachenfeldt Hans Ehrencrona Johanna Rantala Olufunmilayo I Olopade Patricia A Ganz Robert L Nussbaum Simon A Gayther Katherine L Nathanson Susan M Domchek Banu K Arun Gillian Mitchell Beth Y Karlan Jenny Lester Gertraud Maskarinec Christy Woolcott Christopher Scott Jennifer Stone Carmel Apicella Rulla Tamimi Robert Luben Kay-Tee Khaw Åslaug Helland Vilde Haakensen Mitch Dowsett Paul D P Pharoah Jacques Simard Per Hall Montserrat García-Closas Celine Vachon Georgia Chenevix-Trench Antonis C Antoniou Douglas F Easton Stacey L Edwards

Nat Genet 2016 Apr 29;48(4):374-86. Epub 2016 Feb 29.

Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1038/ng.3521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938803PMC
April 2016

Risk of recurrence estimates with IHC4+C are tolerant of variations in staining and scoring: an analytical validity study.

J Clin Pathol 2016 Feb 17;69(2):128-35. Epub 2015 Aug 17.

Academic Department of Biochemistry, Royal Marsden Hospital, London, UK.

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http://jcp.bmj.com/lookup/doi/10.1136/jclinpath-2015-203212
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http://dx.doi.org/10.1136/jclinpath-2015-203212DOI Listing
February 2016

CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer.

Endocr Relat Cancer 2016 Feb 16;23(2):77-91. Epub 2015 Nov 16.

Department of Public Health and Primary CareCentre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, Cambridge CB1 8RN, UKDepartment of Genetics and Computational BiologyQIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, AustraliaWellcome Trust Centre for Human GeneticsUniversity of Oxford, Oxford OX3 7BN, UKAcademic Department of BiochemistryRoyal Marsden Hospital, London SW3 6JJ, UKDepartment of Clinical GeneticsSt George's Hospital Medical School, London SW17 0RE, UKDepartment of OncologyCentre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UKDepartment of Medical Epidemiology and BiostatisticsKarolinska Institutet, Stockholm SE-171 77, SwedenDepartment of MedicineDivision of Hematology/Oncology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USADepartment of Gynecology and ObstetricsUniversity Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, GermanyInstitute of Human GeneticsUniversity Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen 91054, GermanyGynaecology Research UnitHannover Medical School, Hannover 30625, GermanyClinics of Gynaecology and ObstetricsHannover Medical School, Hannover 30625, GermanyDepartment of GynaecologyJena University Hospital - Friedrich Schiller University, Jena 07743, GermanyVesalius Research CenterLeuven 3000, BelgiumLaboratory for Translational GeneticsDepartment of Oncology, University Hospitals Leuven, Leuven 3000, BelgiumDepartment of Obstetrics and GynecologyDivision of Gynecologic Oncology, University Hospitals, KU Leuven - University of Leuven, Leuven 3000, BelgiumDepartment of Health Sciences ResearchMayo Clinic, Rochester, Minnesota 55905, USADepartment of BiostatisticsUniversity of Kansas Medical Center, Kansas City, Kansas 66160, USADepartment of Obstetrics and GynecologyDivision of G

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http://dx.doi.org/10.1530/ERC-15-0386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697192PMC
February 2016

Microenvironmental Heterogeneity Parallels Breast Cancer Progression: A Histology-Genomic Integration Analysis.

PLoS Med 2016 Feb 16;13(2):e1001961. Epub 2016 Feb 16.

Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pmed.1001961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755617PMC
February 2016

Neoadjuvant endocrine therapy: Patient selection, treatment duration and surrogate endpoints.

Breast 2015 Nov 6;24 Suppl 2:S78-83. Epub 2015 Aug 6.

Academic Department of Biochemistry, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK; Institute of Cancer Research, Fulham Road, London SW3 6JB, UK.

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http://dx.doi.org/10.1016/j.breast.2015.07.019DOI Listing
November 2015

Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer.

Sci Transl Med 2015 Aug;7(302):302ra133

Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK. Breast Unit, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.

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http://dx.doi.org/10.1126/scitranslmed.aab0021DOI Listing
August 2015

Antiproliferative Effect of Lapatinib in HER2-Positive and HER2-Negative/HER3-High Breast Cancer: Results of the Presurgical Randomized MAPLE Trial (CRUK E/06/039).

Clin Cancer Res 2015 Jul 14;21(13):2932-40. Epub 2014 Nov 14.

The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, London, United Kingdom. Academic Department of Biochemistry, Royal Marsden NHS Foundation Trust, London, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1428DOI Listing
July 2015

Accurate Prediction and Validation of Response to Endocrine Therapy in Breast Cancer.

J Clin Oncol 2015 Jul 1;33(20):2270-8. Epub 2015 Jun 1.

Arran K. Turnbull, Laura M. Arthur, Lorna Renshaw, Alexey A. Larionov, Charlene Kay, Jeremy S. Thomas, Andrew H. Sims, J. Michael Dixon, University of Edinburgh Cancer Research UK Centre, Edinburgh; Anita K. Dunbier, Mitch Dowsett, Institute of Cancer Research, London, United Kingdom; and Anita K. Dunbier, University of Otago, Dunedin, New Zealand.

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http://dx.doi.org/10.1200/JCO.2014.57.8963DOI Listing
July 2015

Progesterone receptor A predominance is a discriminator of benefit from endocrine therapy in the ATAC trial.

Breast Cancer Res Treat 2015 Jun 28;151(2):309-18. Epub 2015 Apr 28.

Centre for Cancer Research, Westmead Millennium Institute, University of Sydney Medical School, Hawkesbury Road, Westmead, NSW, 2145, Australia.

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http://dx.doi.org/10.1007/s10549-015-3397-0DOI Listing
June 2015

Estrogen Receptor Expression in 21-Gene Recurrence Score Predicts Increased Late Recurrence for Estrogen-Positive/HER2-Negative Breast Cancer.

Clin Cancer Res 2015 Jun;21(12):2763-70

Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2842DOI Listing
June 2015

Prediction of late distant recurrence after 5 years of endocrine treatment: a combined analysis of patients from the Austrian breast and colorectal cancer study group 8 and arimidex, tamoxifen alone or in combination randomized trials using the PAM50 risk of recurrence score.

J Clin Oncol 2015 Mar 20;33(8):916-22. Epub 2014 Oct 20.

Ivana Sestak, Jack Cuzick, Queen Mary University; Mitch Dowsett, Elena Lopez-Knowles, Royal Marsden Hospital, London, United Kingdom; Martin Filipits, Peter Dubsky, Michael Gnant, Medical University of Vienna; Christian Fesl, Austrian Breast and Colorectal Cancer Study Group, Vienna, Austria; John Wayne Cowens, Sean Ferree, NanoString Technologies, Seattle, WA; and Carl Shaper, MyRAQA, Redwood Shores, CA.

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http://dx.doi.org/10.1200/JCO.2014.55.6894DOI Listing
March 2015

Reduced progesterone levels explain the reduced risk of breast cancer in obese premenopausal women: a new hypothesis.

Breast Cancer Res Treat 2015 Jan 21;149(1):1-4. Epub 2014 Nov 21.

Academic Department of Biochemistry, Royal Marsden Hospital NHS Foundation Trust, Fulham Road, London, SW3 6JJ, UK.

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http://link.springer.com/content/pdf/10.1007%2Fs10549-014-32
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http://link.springer.com/10.1007/s10549-014-3211-4
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http://dx.doi.org/10.1007/s10549-014-3211-4DOI Listing
January 2015

Differences in expression of proliferation-associated genes and RANKL across the menstrual cycle in estrogen receptor-positive primary breast cancer.

Breast Cancer Res Treat 2014 Nov 4;148(2):327-35. Epub 2014 Nov 4.

Department of Academic Biochemistry, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, UK,

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http://dx.doi.org/10.1007/s10549-014-3181-6DOI Listing
November 2014

Trastuzumab-associated cardiac events at 8 years of median follow-up in the Herceptin Adjuvant trial (BIG 1-01).

J Clin Oncol 2014 Jul 9;32(20):2159-65. Epub 2014 Jun 9.

Evandro de Azambuja and Martine J. Piccart-Genhart, Institut Jules Bordet; Evandro de Azambuja, Breast European Adjuvant Study Team; Martine J. Piccart-Gebhart, Université Libre de Bruxelles, Brussels, Belgium; Marion J. Procter and Dominique Agbor-Tarh, Frontier Science Scotland, Kincraig, Kingussie; David A. Cameron, University of Edinburgh and Western General Hospital, Edinburgh; Ian E. Smith, Royal Marsden Hospital and the Institute of Cancer Research; Mitch Dowsett, the Royal Marsden National Health Service Trust, London, United Kingdom; Dirk J. van Veldhuisen, University of Groningen, Groningen, the Netherlands; Otto Metzger-Filho and Richard D. Gelber, Dana-Farber Cancer Institute, Boston, MA; Jutta Steinseifer, F. Hoffmann-La Roche, Basel; Thomas M. Suter, Swiss Cardiovascular Center, Inselspital, Bern University Hospital, Bern, Switzerland; Michael Untch, HELIOS Klinikum Berlin, Buch; Christian Jackisch, Klinikum Offenbach, Offenbach, Germany; Luca Gianni, San Raffaele Institute, Milan, Italy; Jose Baselga, Memorial Sloan Kettering Cancer Center, New York, NY; Richard Bell, Andrew Love Cancer Centre, Geelong Hospital, Geelong, Australia; and Brian Leyland-Jones, Edith Sanford Breast Cancer Research Institute, Sioux Falls, SD.

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http://dx.doi.org/10.1200/JCO.2013.53.9288DOI Listing
July 2014

Reply to R. Bhargava et al and K. Lambein et al.

J Clin Oncol 2014 Jun 28;32(17):1857-9. Epub 2014 Apr 28.

National Cancer Institute, Bethesda, MD.

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http://dx.doi.org/10.1200/JCO.2014.55.0673DOI Listing
June 2014

Effect of aromatase inhibition on functional gene modules in estrogen receptor-positive breast cancer and their relationship with antiproliferative response.

Clin Cancer Res 2014 May 14;20(9):2485-94. Epub 2014 Mar 14.

Authors' Affiliations: Breakthrough Breast Cancer Research Centre, Institute of Cancer Research; Academic Department of Biochemistry, Royal Marsden Foundation Trust, London, United Kingdom; and Department of Biochemistry, University of Otago, Dunedin, New Zealand.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2602DOI Listing
May 2014

Interpreting plasma estrogen levels in breast cancer: caution needed.

J Clin Oncol 2014 May 14;32(14):1396-400. Epub 2014 Apr 14.

The Institute of Cancer Research; Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom.

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http://jco.ascopubs.org/content/early/2014/04/09/JCO.2013.53
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2013.53.9411
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http://dx.doi.org/10.1200/JCO.2013.53.9411DOI Listing
May 2014

Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study.

Authors:
Nichola Johnson Frank Dudbridge Nick Orr Lorna Gibson Michael E Jones Minouk J Schoemaker Elizabeth J Folkerd Ben P Haynes John L Hopper Melissa C Southey Gillian S Dite Carmel Apicella Marjanka K Schmidt Annegien Broeks Laura J Van't Veer Femke Atsma Kenneth Muir Artitaya Lophatananon Peter A Fasching Matthias W Beckmann Arif B Ekici Stefan P Renner Elinor Sawyer Ian Tomlinson Michael Kerin Nicola Miller Barbara Burwinkel Frederik Marme Andreas Schneeweiss Christof Sohn Pascal Guénel Therese Truong Emilie Cordina Florence Menegaux Stig E Bojesen Børge G Nordestgaard Henrik Flyger Roger Milne M Pilar Zamora Jose Ignacio Arias Perez Javier Benitez Leslie Bernstein Hoda Anton-Culver Argyrios Ziogas Christina Clarke Dur Hermann Brenner Heiko Müller Volker Arndt Aida Karina Dieffenbach Alfons Meindl Joerg Heil Claus R Bartram Rita K Schmutzler Hiltrud Brauch Christina Justenhoven Yon-Dschun Ko Heli Nevanlinna Taru A Muranen Kristiina Aittomäki Carl Blomqvist Keitaro Matsuo Thilo Dörk Natalia V Bogdanova Natalia N Antonenkova Annika Lindblom Arto Mannermaa Vesa Kataja Veli-Matti Kosma Jaana M Hartikainen Georgia Chenevix-Trench Jonathan Beesley Anna H Wu David Van den Berg Chiu-Chen Tseng Diether Lambrechts Dominiek Smeets Patrick Neven Hans Wildiers Jenny Chang-Claude Anja Rudolph Stefan Nickels Dieter Flesch-Janys Paolo Radice Paolo Peterlongo Bernardo Bonanni Valeria Pensotti Fergus J Couch Janet E Olson Xianshu Wang Zachary Fredericksen Vernon S Pankratz Graham G Giles Gianluca Severi Laura Baglietto Chris Haiman Jacques Simard Mark S Goldberg France Labrèche Martine Dumont Penny Soucy Soo Teo Cheng Har Yip Sze Yee Phuah Belinda K Cornes Vessela N Kristensen Grethe Grenaker Alnæs Anne-Lise Børresen-Dale Wei Zheng Robert Winqvist Katri Pylkäs Arja Jukkola-Vuorinen Mervi Grip Irene L Andrulis Julia A Knight Gord Glendon Anna Marie Mulligan Peter Devillee Jonine Figueroa Stephen J Chanock Jolanta Lissowska Mark E Sherman Per Hall Nils Schoof Maartje Hooning Antoinette Hollestelle Rogier A Oldenburg Madeleine Tilanus-Linthorst Jianjun Liu Angie Cox Ian W Brock Malcolm W R Reed Simon S Cross William Blot Lisa B Signorello Paul D P Pharoah Alison M Dunning Mitul Shah Daehee Kang Dong-Young Noh Sue K Park Ji-Yeob Choi Mikael Hartman Hui Miao Wei Yen Lim Anthony Tang Ute Hamann Asta Försti Thomas Rüdiger Hans Ulrich Ulmer Anna Jakubowska Jan Lubinski Katarzyna Jaworska-Bieniek Katarzyna Durda Suleeporn Sangrajrang Valerie Gaborieau Paul Brennan James McKay Susan Slager Amanda E Toland Celine Vachon Drakoulis Yannoukakos Chen-Yang Shen Jyh-Cherng Yu Chiun-Sheng Huang Ming-Feng Hou Anna González-Neira Daniel C Tessier Daniel Vincent Francois Bacot Craig Luccarini Joe Dennis Kyriaki Michailidou Manjeet K Bolla Jean Wang Douglas F Easton Montserrat García-Closas Mitch Dowsett Alan Ashworth Anthony J Swerdlow Julian Peto Isabel dos Santos Silva Olivia Fletcher

Breast Cancer Res 2014 May 26;16(3):R51. Epub 2014 May 26.

Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK.

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http://dx.doi.org/10.1186/bcr3662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522594PMC
May 2014

Relationship of body mass index with aromatisation and plasma and tissue oestrogen levels in postmenopausal breast cancer patients treated with aromatase inhibitors.

Eur J Cancer 2014 Apr 4;50(6):1055-64. Epub 2014 Feb 4.

Academic Department of Biochemistry, Royal Marsden Hospital, London, UK; Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1016/j.ejca.2014.01.007DOI Listing
April 2014

Estrogen receptor mutations in breast cancer--new focus on an old target.

Clin Cancer Res 2014 Apr 28;20(7):1724-6. Epub 2014 Feb 28.

Authors' Affiliations: Breakthrough Breast Cancer Research Centre at The Institute of Cancer Research and Academic Department of Biochemistry, The Royal Marsden Hospital, London, United Kingdom.

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http://clincancerres.aacrjournals.org/content/early/2014/03/
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http://clincancerres.aacrjournals.org/content/early/2014/02/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-14-0067DOI Listing
April 2014

Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update.

Arch Pathol Lab Med 2014 Feb 7;138(2):241-56. Epub 2013 Oct 7.

Antonio C. Wolff, Johns Hopkins Kimmel Comprehensive Cancer Center, Baltimore; Lisa M. McShane, National Cancer Institute, Bethesda, MD; M. Elizabeth H. Hammond, University of Utah School of Medicine and Intermountain Healthcare, Salt Lake City, UT; David G. Hicks, University of Rochester Medical Center, Rochester, NY; Mitch Dowsett, Royal Marsden Hospital, London, United Kingdom; Kimberly H. Allison, Stanford University Medical Center, Stanford; Patrick Fitzgibbons, St Jude Medical Center, Fullerton; Michael F. Press, University of Southern California, Los Angeles, CA; Donald C. Allred, Washington University School of Medicine, St Louis, MO; John M.S. Bartlett, Ontario Institute for Cancer Research; Wedad Hanna, Sunnybrook Health Sciences Center, Toronto, Ontario, Canada; Michael Bilous, University of Western Sydney and Healthscope Pathology, Sydney, New South Wales, Australia; Robert B. Jenkins, Mayo Clinic, Rochester, MN; Pamela B. Mangu, American Society of Clinical Oncology, Alexandria, VA; Soonmyung Paik, National Surgical Adjuvant Breast and Bowel Project, Pitsburgh, PA; Edith A. Perez, Mayo Clinic, Jacksonville, FL; Patricia A. Spears, North Carolina State University, Raleigh, NC; Gail H. Vance, Indiana University Medical Center, Indianapolis, IN; Giuseppe Viale, University of Milan, European Institute of Oncology, Milan, Italy; and Daniel F. Hayes, University of Michigan Comprehensive Cancer Care Center, Ann Arbor, MI.

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http://dx.doi.org/10.5858/arpa.2013-0953-SADOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086638PMC
February 2014

An international Ki67 reproducibility study.

J Natl Cancer Inst 2013 Dec 7;105(24):1897-906. Epub 2013 Nov 7.

Affiliations of authors: Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD (MCP, LMM); Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada (SCYL, DG, EM, TON); Department of Laboratory Medicine and Pathology, University of Alberta, Alberta, Canada (JCH); Division of Pathology and Laboratory Medicine, European Institute of Oncology, Milan, Italy (MGM); Division of Pathology and Laboratory Medicine, European Institute of Oncology, and University of Milan, Milan, Italy (GV); Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom (LAZ); Department of Pathology, Centre Jean Perrin, Clermont-Ferrand, and Université d'Auvergne, France (FP-L); Transformative Pathology, Ontario Institute for Cancer Research, Toronto, Ontario, Canada (JMSB); PhenoPath Laboratories, Seattle, WA (AMG); Department of Pathology, MD Anderson Cancer Center, Houston, TX (WFS); Edinburgh Cancer Research Centre, Western General Hospital, Edinburgh, United Kingdom (TP); The EMMES Corporation, Rockville, MD (RAE); Breast Oncology Program, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI (DFH); Academic Department of Biochemistry, Royal Marsden Hospital, London, United Kingdom (MD); on behalf of the International Ki67 in Breast Cancer Working Group of the Breast International Group and North American Breast Cancer Group.

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http://dx.doi.org/10.1093/jnci/djt306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888090PMC
December 2013

Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update.

J Clin Oncol 2013 Nov 7;31(31):3997-4013. Epub 2013 Oct 7.

Antonio C. Wolff, Johns Hopkins Kimmel Comprehensive Cancer Center, Baltimore; Lisa M. McShane, National Cancer Institute, Bethesda, MD; M. Elizabeth H. Hammond, University of Utah School of Medicine and Intermountain Healthcare, Salt Lake City, UT; David G. Hicks, University of Rochester Medical Center, Rochester, NY; Mitch Dowsett, Royal Marsden Hospital, London, United Kingdom; Kimberly H. Allison, Stanford University Medical Center, Stanford; Patrick Fitzgibbons, St Jude Medical Center, Fullerton; Michael F. Press, University of Southern California, Los Angeles, CA; Donald C. Allred, Washington University School of Medicine, St Louis, MO; John M.S. Bartlett, Ontario Institute for Cancer Research; Wedad Hanna, Sunnybrook Health Sciences Center, Toronto, Ontario, Canada; Michael Bilous, University of Western Sydney and Healthscope Pathology, Sydney, New South Wales, Australia; Robert B. Jenkins, Mayo Clinic, Rochester, MN; Pamela B. Mangu, American Society of Clinical Oncology, Alexandria, VA; Soonmyung Paik, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA; Edith A. Perez, Mayo Clinic, Jacksonville, FL; Patricia A. Spears, North Carolina State University, Raleigh, NC; Gail H. Vance, Indiana University Medical Center, Indianapolis, IN; Giuseppe Viale, University of Milan, European Institute of Oncology, Milan, Italy; and Daniel F. Hayes, University of Michigan Comprehensive Cancer Care Center, Ann Arbor, MI.

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http://dx.doi.org/10.1200/JCO.2013.50.9984DOI Listing
November 2013

Factors predicting late recurrence for estrogen receptor-positive breast cancer.

J Natl Cancer Inst 2013 Oct 12;105(19):1504-11. Epub 2013 Sep 12.

Affiliations of authors: Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University, London, UK (IS, JC); Academic Department of Biochemistry, Royal Marsden Hospital, London, UK (MD, LZ, EL-K); NanoString Technologies, Seattle, WA (SF, JWC).

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http://dx.doi.org/10.1093/jnci/djt244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787911PMC
October 2013

Comparison of PAM50 risk of recurrence score with oncotype DX and IHC4 for predicting risk of distant recurrence after endocrine therapy.

J Clin Oncol 2013 Aug 1;31(22):2783-90. Epub 2013 Jul 1.

Academic Department of Biochemistry, Royal Marsden Hospital, and Breakthrough Breast Cancer Centre, Institute of Cancer Research, London, SW3 6JJ, United Kingdom.

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http://dx.doi.org/10.1200/JCO.2012.46.1558DOI Listing
August 2013

Sex hormones and breast cancer risk and prognosis.

Breast 2013 Aug;22 Suppl 2:S38-43

The Academic Department of Biochemistry, The Royal Marsden NHS Foundation Trust, Wallace Wing, Fulham Road, London SW3 6JJ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.breast.2013.07.007DOI Listing
August 2013

Changes in estradiol and testosterone levels in postmenopausal women after changes in body mass index.

J Clin Endocrinol Metab 2013 Jul 10;98(7):2967-74. Epub 2013 May 10.

Division of Genetics and Epidemiology, The Institute of Cancer Research, University of London, Sutton SM2 5NG and London SW3 6JB, United Kingdom.

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http://dx.doi.org/10.1210/jc.2013-1588DOI Listing
July 2013

BCL-2: a new therapeutic target in estrogen receptor-positive breast cancer?

Cancer Cell 2013 Jul;24(1):7-9

Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.

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http://dx.doi.org/10.1016/j.ccr.2013.06.006DOI Listing
July 2013

Immunohistochemical BAG1 expression improves the estimation of residual risk by IHC4 in postmenopausal patients treated with anastrazole or tamoxifen: a TransATAC study.

Breast Cancer Res Treat 2013 Jul 13;140(2):253-62. Epub 2013 Jul 13.

Department of Academic Biochemistry, The Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, UK.

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http://dx.doi.org/10.1007/s10549-013-2628-5DOI Listing
July 2013

GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors.

Cancer Res 2013 Jun 6;73(12):3783-95. Epub 2013 May 6.

Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Department of Academic Biochemistry, The Royal Marsden Hospital; and London Research Institute, Cancer Research UK, London, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-4265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686594PMC
June 2013