Mitch A Phelps

Mitch A Phelps

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Mitch A Phelps

Mitch A Phelps

Publications by authors named "Mitch A Phelps"

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Optimising time samples for determining area under the curve of pharmacokinetic data using non-compartmental analysis.

J Pharm Pharmacol 2019 Nov 14;71(11):1635-1644. Epub 2019 Aug 14.

School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, Australia.

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http://dx.doi.org/10.1111/jphp.13154DOI Listing
November 2019

Development of a physiologically based pharmacokinetic model for intravenous lenalidomide in mice.

Cancer Chemother Pharmacol 2019 Nov 6;84(5):1073-1087. Epub 2019 Sep 6.

School of Pharmacy and Medical Sciences, University of South Australia, North Terrace, Adelaide, 5001, Australia.

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http://dx.doi.org/10.1007/s00280-019-03941-zDOI Listing
November 2019

XRCC1-mediated DNA repair is associated with progression-free survival of multiple myeloma patients after autologous stem cell transplant.

Mol Carcinog 2019 Sep 22. Epub 2019 Sep 22.

Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, Ohio.

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http://dx.doi.org/10.1002/mc.23121DOI Listing
September 2019

Letter to the Editor: Exposure-response or clearance-response relationship in immune checkpoint therapy?-A comment on 'correlation between nivolumab exposure and treatment outcomes in non-small-cell lung cancer' by Basak et al.

Eur J Cancer 2019 Jun 19;114:25-26. Epub 2019 Apr 19.

Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH, USA; The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2019.02.017DOI Listing
June 2019

Population pharmacokinetics of lenalidomide in patients with B-cell malignancies.

Br J Clin Pharmacol 2019 May 27;85(5):924-934. Epub 2019 Feb 27.

Australian Centre for Pharmacometrics, School of Pharmacy and Medical Sciences, Division of Health Sciences, University of South Australia, Australia.

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http://dx.doi.org/10.1111/bcp.13873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475687PMC
May 2019

A Single Nucleotide Polymorphism in Was Associated With Clinical Response in Multiple Myeloma Patients.

Anticancer Res 2019 Jan;39(1):67-72

Deparment of Hematology & Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, U.S.A.

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13080DOI Listing
January 2019

Cachectic Cancer Patients: Immune to Checkpoint Inhibitor Therapy?

Clin Cancer Res 2018 12 17;24(23):5787-5789. Epub 2018 Jul 17.

Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, Ohio.

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http://clincancerres.aacrjournals.org/content/early/2018/07/
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http://clincancerres.aacrjournals.org/content/early/2018/09/
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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-1847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279566PMC
December 2018

G-CSF improves safety when you start the day after autologous transplant in multiple myeloma.

Leuk Lymphoma 2017 12 16;58(12):2947-2951. Epub 2017 May 16.

a Division of Hematology, Department of Internal Medicine, College of Medicine, t he Ohio State University , Columbus , OH , USA.

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http://dx.doi.org/10.1080/10428194.2017.1318436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607907PMC
December 2017

Plasma pharmacokinetics and bioavailability of verticillin A following different routes of administration in mice using liquid chromatography tandem mass spectrometry.

J Pharm Biomed Anal 2017 May 1;139:187-192. Epub 2017 Mar 1.

Comprehensive Cancer Center, The Ohio State University, Columbus, OH, United States; College of Pharmacy, The Ohio State University, Columbus, OH, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2017.02.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399420PMC
May 2017

Achieving the Promise of Therapeutic Extracellular Vesicles: The Devil is in Details of Therapeutic Loading.

Pharm Res 2017 05 17;34(5):1053-1066. Epub 2017 Mar 17.

Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida, USA.

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http://dx.doi.org/10.1007/s11095-017-2123-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565485PMC
May 2017

Rituximab immunotherapy: it's getting personal.

Authors:
Mitch A Phelps

Blood 2017 05;129(19):2595-2596

THE OHIO STATE UNIVERSITY.

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http://dx.doi.org/10.1182/blood-2017-03-772061DOI Listing
May 2017

In vitro immunotoxicity assessment of culture-derived extracellular vesicles in human monocytes.

J Immunotoxicol 2016 09 14;13(5):652-65. Epub 2016 Apr 14.

a Department of Veterinary Biosciences , Ohio State University , Columbus , OH , USA ;

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http://dx.doi.org/10.3109/1547691X.2016.1148089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972675PMC
September 2016

Preferential Delivery of an Opioid Antagonist to the Fetal Brain in Pregnant Mice.

J Pharmacol Exp Ther 2016 07 5;358(1):22-30. Epub 2016 May 5.

Department of Neuroscience (J.O., M.S.Y.), and College of Medicine Center for Pharmacogenomics (W.S.), Wexner Medical Center, and College of Pharmacy, Division of Pharmaceutics and Pharmaceutical Chemistry (Y.L., M.A.P.), The Ohio State University, Columbus, Ohio; and Anatomisches Institut, Anatomie und Zellbiologie (K.S.), Universität Bonn, Bonn, Germany

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http://dx.doi.org/10.1124/jpet.115.231902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931874PMC
July 2016

Discovery and Mechanism of Highly Efficient Cyclic Cell-Penetrating Peptides.

Biochemistry 2016 05 28;55(18):2601-12. Epub 2016 Apr 28.

Department of Chemistry and Biochemistry, The Ohio State University , 484 West 12th Avenue, Columbus, Ohio 43210, United States.

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http://dx.doi.org/10.1021/acs.biochem.6b00226DOI Listing
May 2016

ROR1-targeted delivery of OSU-2S, a nonimmunosuppressive FTY720 derivative, exerts potent cytotoxicity in mantle-cell lymphoma in vitro and in vivo.

Exp Hematol 2015 Sep 29;43(9):770-4.e2. Epub 2015 Apr 29.

Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH, USA; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA; Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2015.04.008DOI Listing
September 2015

Results of an abbreviated phase-II study with the Akt Inhibitor MK-2206 in Patients with Advanced Biliary Cancer.

Sci Rep 2015 Jul 10;5:12122. Epub 2015 Jul 10.

Divison of Medical Oncology, Ohio State University Comprehensive Cancer Center, 300 W 10th Ave, Columbus, OH 43210.

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http://dx.doi.org/10.1038/srep12122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894406PMC
July 2015

Reduced occurrence of tumor flare with flavopiridol followed by combined flavopiridol and lenalidomide in patients with relapsed chronic lymphocytic leukemia (CLL).

Am J Hematol 2015 Apr 25;90(4):327-33. Epub 2015 Feb 25.

Division of Hematology, Department of Internal Medicine, The Ohio State University, Comprehensive Cancer Center, The Ohio State University, College of Pharmacy, The Ohio State University, Ohio.

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http://dx.doi.org/10.1002/ajh.23946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552311PMC
April 2015

Liquid chromatography-tandem mass spectrometry assay for the simultaneous quantification of simvastatin, lovastatin, atorvastatin, and their major metabolites in human plasma.

J Chromatogr B Analyt Technol Biomed Life Sci 2015 Mar 13;983-984:18-25. Epub 2015 Jan 13.

Department of Pharmacology, College of Medicine, The Ohio State University, Columbus, OH, United States.

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http://dx.doi.org/10.1016/j.jchromb.2014.12.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324004PMC
March 2015

OSU-T315: a novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells.

Blood 2015 Jan 7;125(2):284-95. Epub 2014 Oct 7.

Department of Internal Medicine, Division of Hematology, Wexner Medical Center, Department of Medical Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH.

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http://dx.doi.org/10.1182/blood-2014-06-583518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287637PMC
January 2015

A dose escalation feasibility study of lenalidomide for treatment of symptomatic, relapsed chronic lymphocytic leukemia.

Leuk Res 2014 Sep 29;38(9):1025-9. Epub 2014 May 29.

Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA; Comprehensive Cancer Center, The Ohio State University, USA.

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http://dx.doi.org/10.1016/j.leukres.2014.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312491PMC
September 2014

Irinotecan pharmacogenetics: a finished puzzle?

J Clin Oncol 2014 Aug 23;32(22):2287-9. Epub 2014 Jun 23.

St Jude Children's Research Hospital, Memphis, TN

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http://dx.doi.org/10.1200/JCO.2014.56.3387DOI Listing
August 2014

A novel liposomal formulation of FTY720 (fingolimod) for promising enhanced targeted delivery.

Nanomedicine 2014 Feb 20;10(2):393-400. Epub 2013 Aug 20.

Division of Hematology and Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2013.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134520PMC
February 2014

A phase I trial of flavopiridol in relapsed multiple myeloma.

Cancer Chemother Pharmacol 2014 Feb 16;73(2):249-57. Epub 2013 Nov 16.

Division of Hematology, The Ohio State University, B321 Starling Loving Hall, 320 West 10th Avenue, Columbus, OH, 43210, USA,

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http://dx.doi.org/10.1007/s00280-013-2347-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946636PMC
February 2014

A phase I study of prolonged infusion of triapine in combination with fixed dose rate gemcitabine in patients with advanced solid tumors.

Invest New Drugs 2013 Jun 31;31(3):685-95. Epub 2012 Jul 31.

Division of Medical Oncology, Department of Internal Medicine, College of Medicine, The Ohio State University and The Comprehensive Cancer Center, A454 Starling-Loving Hall, 320 West 10th Ave, Columbus, OH, 43210, USA.

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http://dx.doi.org/10.1007/s10637-012-9863-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646991PMC
June 2013

Comparative cellular pharmacokinetics and pharmacodynamics of siRNA delivery by SPANosomes and by cationic liposomes.

Nanomedicine 2013 May 29;9(4):504-13. Epub 2012 Oct 29.

Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15499634120059
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http://dx.doi.org/10.1016/j.nano.2012.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633702PMC
May 2013

A pharmacokinetic/pharmacodynamic model of tumor lysis syndrome in chronic lymphocytic leukemia patients treated with flavopiridol.

Clin Cancer Res 2013 Mar 8;19(5):1269-80. Epub 2013 Jan 8.

The Comprehensive Cancer Center, College of Pharmacy, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-12-1092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845832PMC
March 2013

Pharmacokinetics and tissue disposition of lenalidomide in mice.

AAPS J 2012 Dec 7;14(4):872-82. Epub 2012 Sep 7.

Division of Pharmaceutics, College of Pharmacy, 230 Parks Hall, 500W. 12th Avenue, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1208/s12248-012-9401-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475844PMC
December 2012

Analysis of the transport of and cytotoxic effects for nalbuphine solution in corneal cells.

Am J Vet Res 2012 Dec;73(12):1987-95

Department of Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.2460/ajvr.73.12.1987DOI Listing
December 2012

Acetaminophen pediatric dose selection: caregiver satisfaction regarding the antipyretic efficacy of acetaminophen in children.

Clin Pediatr (Phila) 2012 Nov 13;51(11):1030-1. Epub 2012 Aug 13.

Southshore Hospital, Weymouth, MA, USA.

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http://dx.doi.org/10.1177/0009922812456592DOI Listing
November 2012

Pharmacokinetics of methylprednisolone acetate after intra-articular administration and subsequent suppression of endogenous hydrocortisone secretion in exercising horses.

Am J Vet Res 2012 Sep;73(9):1453-61

Comparative Orthopaedic Research Laboratory, Department of Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.2460/ajvr.73.9.1453DOI Listing
September 2012

Flavopiridol treatment of patients aged 70 or older with refractory or relapsed chronic lymphocytic leukemia is a feasible and active therapeutic approach.

Haematologica 2012 Mar 22;97(3):423-7. Epub 2012 Jan 22.

Division of Hematology, Department of Internal Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.3324/haematol.2011.047324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291598PMC
March 2012

Influence of exercise on the distribution of technetium Tc 99m medronate following intra-articular injection in horses.

Am J Vet Res 2012 Mar;73(3):418-25

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.2460/ajvr.73.3.418DOI Listing
March 2012

Pharmacogenomic testing: relevance in medical practice: why drugs work in some patients but not in others.

Cleve Clin J Med 2011 Apr;78(4):243-57

Department of Pharmacology, Division of Clinical Trials, College of Medicine, The Ohio State University, Columbus, USA.

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http://dx.doi.org/10.3949/ccjm.78a.10145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351041PMC
April 2011

Phase I clinical and pharmacokinetic study of a novel schedule of flavopiridol in relapsed or refractory acute leukemias.

Haematologica 2010 Jul 11;95(7):1098-105. Epub 2010 May 11.

Division of Hematology and Oncology and the Comprehensive Cancer Center, Department of Medicine, The Ohio State University, B310 Starling-Loving Hall, 320 West 10 Avenue, Columbus, OH 43210, USA.

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http://dx.doi.org/10.3324/haematol.2009.017103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895033PMC
July 2010

A novel liposomal formulation of flavopiridol.

Int J Pharm 2009 Jan 20;365(1-2):170-4. Epub 2008 Aug 20.

Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1016/j.ijpharm.2008.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035394PMC
January 2009

Intracellular processing of riboflavin in human breast cancer cells.

Mol Pharm 2008 Sep-Oct;5(5):839-48. Epub 2008 Aug 29.

Department of Pharmaceutical Sciences, Center for Nanomedicine and Cellular Delivery, University of Maryland, Baltimore, Maryland 21201, USA.

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http://pubs.acs.org/doi/abs/10.1021/mp800046m
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http://dx.doi.org/10.1021/mp800046mDOI Listing
December 2008

Inhibitors of tubulin assembly identified through screening a compound library.

Chem Biol Drug Des 2008 Dec;72(6):513-24

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1111/j.1747-0285.2008.00729.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677961PMC
December 2008

Antikinetoplastid antimitotic activity and metabolic stability of dinitroaniline sulfonamides and benzamides.

Bioorg Med Chem 2006 Aug 3;14(16):5699-710. Epub 2006 May 3.

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, 43210, USA.

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http://dx.doi.org/10.1016/j.bmc.2006.04.017DOI Listing
August 2006

Recognition, co-internalization, and recycling of an avian riboflavin carrier protein in human placental trophoblasts.

J Pharmacol Exp Ther 2006 May 6;317(2):465-72. Epub 2006 Jan 6.

Department of Pharmaceutical Sciences, University of Maryland, Baltimore, 20 Penn Street, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1124/jpet.105.096149DOI Listing
May 2006

Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats.

Endocrinology 2005 Nov 11;146(11):4887-97. Epub 2005 Aug 11.

Division of Pharmaceutics, College of Pharmacy and Department of Oral Biology, The Ohio State University, 500 West 12th Avenue, L. M. Parks Hall, Room 242, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1210/en.2005-0572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2039881PMC
November 2005

A novel rhodamine-riboflavin conjugate probe exhibits distinct fluorescence resonance energy transfer that enables riboflavin trafficking and subcellular localization studies.

Mol Pharm 2004 Jul-Aug;1(4):257-66

Biophysics Program and Division of Pharmaceutics, The Ohio State University, Columbus, Ohio 43210-1291, USA.

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July 2005

Topology scanning and putative three-dimensional structure of the extracellular binding domains of the apical sodium-dependent bile acid transporter (SLC10A2).

Biochemistry 2004 Sep;43(36):11380-92

Department of Pharmaceutical Sciences, University of Maryland, 20 Penn Street, Baltimore, Maryland 21201, USA.

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http://dx.doi.org/10.1021/bi049270aDOI Listing
September 2004

Favorable effects of weak acids on negative-ion electrospray ionization mass spectrometry.

Anal Chem 2004 Feb;76(3):839-47

Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.

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http://pubs.acs.org/doi/abs/10.1021/ac0351670
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http://dx.doi.org/10.1021/ac0351670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2104782PMC
February 2004

Involvement of endocytic organelles in the subcellular trafficking and localization of riboflavin.

J Pharmacol Exp Ther 2003 Aug 29;306(2):681-7. Epub 2003 Apr 29.

Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD 21202, USA.

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http://dx.doi.org/10.1124/jpet.103.051581DOI Listing
August 2003

Cytoskeletal motors and cargo in membrane trafficking: opportunities for high specificity in drug intervention.

Drug Discov Today 2003 Jun;8(11):494-502

Biophysics Program, The Ohio State University, Columbus, OH 43210-1291, USA.

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http://dx.doi.org/10.1016/s1359-6446(03)02707-7DOI Listing
June 2003

Modeling of active transport systems.

Adv Drug Deliv Rev 2002 Mar;54(3):329-54

Division of Pharmaceutics, The Ohio State University, 500 West 12th Avenue, Columbus, OH 43210-1291, USA.

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March 2002