Publications Authored by Mirvat El-Sibai

Phototoxicity of strained Ru(ii) complexes: is it the metal complex or the dissociating ligand?

Dalton Trans 2017 Sep;46(35):11529-11532

Department of Natural Sciences, Lebanese American University, Chouran, Beirut 1102-2801, Lebanon.

September 2017

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Antitumor activity of β-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways.

Chem Biol Interact 2017 Sep 3;275:162-170. Epub 2017 Aug 3.

Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P.O. Box 36, Byblos, Lebanon. Electronic address:

September 2017

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β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivo.

J Pharm Pharmacol 2017 Sep 5. Epub 2017 Sep 5.

Department of Pharmaceutical Sciences, School of Pharmacy, Lebanese American University, Byblos, Lebanon.

September 2017

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Erratum to: Wild carrot pentane-based fractions suppress proliferation of human HaCaT keratinocytes and protect against chemically-induced skin cancer.

BMC Complement Altern Med 2017 Mar 9;17(1):149. Epub 2017 Mar 9.

Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Byblos, Lebanon.

March 2017

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Wild carrot pentane-based fractions suppress proliferation of human HaCaT keratinocytes and protect against chemically-induced skin cancer.

BMC Complement Altern Med 2017 Jan 10;17(1):36. Epub 2017 Jan 10.

Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P.O. Box 36, Byblos, Lebanon.

January 2017

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β-2-himachalen-6-ol: A novel anticancer sesquiterpene unique to the Lebanese wild carrot.

J Ethnopharmacol 2016 Aug 27;190:59-67. Epub 2016 May 27.

School of Pharmacy, Lebanese American University, Byblos 1102 2801, Lebanon.

August 2016

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Targeting the MAP kinase pathway in astrocytoma cells using a recombinant anthrax lethal toxin as a way to inhibit cell motility and invasion.

Int J Oncol 2016 May 9;48(5):1913-20. Epub 2016 Mar 9.

Department of Natural Sciences, The Lebanese American University, Beirut 1102 2801, Lebanon.

May 2016

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Daucus carota Pentane-Based Fractions Suppress Proliferation and Induce Apoptosis in Human Colon Adenocarcinoma HT-29 Cells by Inhibiting the MAPK and PI3K Pathways.

J Med Food 2015 Jul 19;18(7):745-52. Epub 2015 Jan 19.

4 Department of Natural Sciences, School of Arts and Sciences, Lebanese American University , Beirut, Lebanon .

July 2015

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Antioxidant and hepatoprotective activities of the oil fractions from wild carrot (Daucus carota ssp. carota).

Pharm Biol 2015 9;53(9):1285-94. Epub 2015 Apr 9.

Department of Microbial and Cellular Sciences, Faculty of Health and Medical Sciences, University of Surrey , UK .

July 2015

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Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells.

J Neurooncol 2015 Mar 8;122(1):75-85. Epub 2015 Jan 8.

Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Beirut, 1102 2801, Lebanon.

March 2015

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Hepatoprotective, Antioxidant, and Anticancer Effects of the Tragopogon porrifolius Methanolic Extract.

Evid Based Complement Alternat Med 2015 28;2015:161720. Epub 2015 Jan 28.

Department of Pharmaceutical Sciences, School of Pharmacy, Lebanese American University, P.O. Box 36, Byblos 1401, Lebanon.

February 2015

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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion.

Int J Oncol 2014 Nov 3;45(5):2117-27. Epub 2014 Sep 3.

Department of Natural Sciences, Lebanese American University, Beirut 1102 2801, Lebanon.

November 2014

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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells.

BMC Complement Altern Med 2014 Oct 10;14:387. Epub 2014 Oct 10.

Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, P,O, Box 36, Byblos, Lebanon.

October 2014

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Invadopodia, regulation, and assembly in cancer cell invasion.

Cell Commun Adhes 2014 Aug 16;21(4):207-12. Epub 2014 Jun 16.

Department of Natural Sciences, The Lebanese American University , Beirut , Lebanon.

August 2014

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Daucus carota Pentane/Diethyl Ether Fraction Inhibits Motility and Reduces Invasion of Cancer Cells.

Chemotherapy 2014 13;60(5-6):302-9. Epub 2015 Jun 13.

Department of Natural Sciences, Lebanese American University, Beirut, Lebanon.

August 2014

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StarD13 is a tumor suppressor in breast cancer that regulates cell motility and invasion.

Int J Oncol 2014 May 7;44(5):1499-511. Epub 2014 Mar 7.

Department of Natural Sciences, The Lebanese American University, Beirut 1102 2801, Lebanon.

May 2014

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Palladin regulation of the actin structures needed for cancer invasion.

Cell Adh Migr 2014 1;8(1):29-35. Epub 2013 Jan 1.

Department of Natural Sciences; Lebanese American University; Beirut, Lebanon.

April 2014

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The regulation of RhoA at focal adhesions by StarD13 is important for astrocytoma cell motility.

Exp Cell Res 2014 Feb 10;321(2):109-22. Epub 2013 Dec 10.

Department of Natural Sciences, The Lebanese American University, P.O. Box: 13-5053, Chouran, Beirut 1102 2801, Lebanon. Electronic address:

February 2014

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Effect of StarD13 on colorectal cancer proliferation, motility and invasion.

Oncol Rep 2014 Jan 20;31(1):505-15. Epub 2013 Nov 20.

Department of Natural Sciences, Lebanese American University, Beirut 1102 2801, Lebanon.

January 2014

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Signaling networks of Rho GTPases in cell motility.

Cell Signal 2013 Oct 11;25(10):1955-61. Epub 2013 May 11.

Department of Natural Science, The Lebanese American University, Beirut 1102 2801, Lebanon.

October 2013

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The antioxidant and anticancer effects of wild carrot oil extract.

Phytother Res 2013 May 20;27(5):737-44. Epub 2012 Jul 20.

Faculty of Health and Medical Sciences, Department of Microbial and Cellular Sciences, University of Surrey, UK.

May 2013

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The STAR of the DLC family.

J Recept Signal Transduct Res 2013 15;33(1):10-3. Epub 2013 Jan 15.

Department of Natural Sciences, Lebanese American University, Beirut Campus, Beirut, Lebanon.

January 2013

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Deletion of the Candida albicans PIR32 results in increased virulence, stress response, and upregulation of cell wall chitin deposition.

Mycopathologia 2012 Aug 6;174(2):107-19. Epub 2012 Mar 6.

Natural Sciences Department, Lebanese American University, Byblos, Lebanon.

August 2012

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DLC2/StarD13 plays a role of a tumor suppressor in astrocytoma.

Oncol Rep 2012 Aug 17;28(2):511-8. Epub 2012 May 17.

Department of Natural Sciences, The Lebanese American University, Beirut 1102 2801, Lebanon.

August 2012

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Rho GTPases in primary brain tumor malignancy and invasion.

J Neurooncol 2012 Jul 19;108(3):333-9. Epub 2012 Apr 19.

Department of Natural Sciences, Lebanese American University, Beirut Campus, Beirut, Lebanon.

July 2012

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Influences of history, geography, and religion on genetic structure: the Maronites in Lebanon.

Eur J Hum Genet 2011 Mar 1;19(3):334-40. Epub 2010 Dec 1.

The Lebanese American University, Chouran, Beirut, Lebanon.

March 2011

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ALOX5AP gene variants show differential association with coronary artery disease in different populations.

J Community Genet 2010 Sep 18;1(3):107-15. Epub 2010 Aug 18.

The Lebanese American University, Chouran, Beirut, 1102 2801, Lebanon.

September 2010

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The I allele of the angiotensin converting enzyme I/D polymorphism confers protection against coronary artery disease.

Coron Artery Dis 2010 May;21(3):151-6

Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.

May 2010

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Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants.

Proc Natl Acad Sci U S A 2009 Dec 13;106(48):20258-63. Epub 2009 Nov 13.

Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

December 2009

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Geographical structure of the Y-chromosomal genetic landscape of the Levant: a coastal-inland contrast.

Ann Hum Genet 2009 Nov 16;73(Pt 6):568-81. Epub 2009 Aug 16.

The Lebanese American University, Chouran, Beirut 1102 2801, Lebanon.

November 2009

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Identifying genetic traces of historical expansions: Phoenician footprints in the Mediterranean.

Am J Hum Genet 2008 Nov 30;83(5):633-42. Epub 2008 Oct 30.

Lebanese American University, Chouran, Beirut 1102 2801, Lebanon.

November 2008

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RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells.

Exp Cell Res 2008 Apr 2;314(7):1540-52. Epub 2008 Feb 2.

Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

April 2008

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WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells.

J Cell Biol 2008 Mar;180(6):1245-60

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA.

March 2008

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Cofilin determines the migration behavior and turning frequency of metastatic cancer cells.

J Cell Biol 2007 Nov;179(4):777-91

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA.

November 2007

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Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells.

J Cell Sci 2007 Oct 12;120(Pt 19):3465-74. Epub 2007 Sep 12.

Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

October 2007

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The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration.

J Cell Sci 2007 Sep 14;120(Pt 17):3138-46. Epub 2007 Aug 14.

Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

September 2007

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Phospholipase C gamma negatively regulates Rac/Cdc42 activation in antigen-stimulated mast cells.

Eur J Immunol 2007 Jan;37(1):261-70

Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

January 2007

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Over-expression of the p110beta but not p110alpha isoform of PI 3-kinase inhibits motility in breast cancer cells.

Cell Motil Cytoskeleton 2004 Nov;59(3):180-8

Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

November 2004

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IL-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cells.

Mediators Inflamm 2002 Feb;11(1):39-45

Department of Physiology, Faculty of Medicine, American University of Beirut, Lebanon.

February 2002

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