Publications

Evidence for a Derangement of the Microvascular System in Patients with a Very Early Diagnosis of Systemic Sclerosis.
J Rheumatol 2017 Aug 15;44(8):1190-1197. Epub 2017 May 15.
From the Department of Internal Medicine, São João Hospital Center, Al Prof Hernâni Monteiro; I3S, Instituto de Investigação e Inovação em Saúde, University of Porto; Departamento de Biomedicina, Unidade de Bioquímica, Faculty of Medicine, University of Porto; Nobre Laboratory, Faculty of Medicine, University of Porto, Porto, Portugal; Department of Experimental and Clinical Medicine, Division of Rheumatology, Azienda Ospedaliero-Universitaria Careggi (AOUC), University of Florence; Department of Experimental and Clinical Medicine, Section of Anatomy and Histology, University of Florence, Florence; Department of Translational Medical Sciences, Centre for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy.

Angiogenic T cell expansion correlates with severity of peripheral vascular damage in systemic sclerosis.
PLoS One 2017 10;12(8):e0183102. Epub 2017 Aug 10.
Department of Experimental and Clinical Medicine, Section of Internal Medicine, Azienda Ospedaliero-Universitaria Careggi (AOUC), University of Florence, Florence, Italy.

The "myth" of loss of angiogenesis in systemic sclerosis: a pivotal early pathogenetic process or just a late unavoidable event?
Arthritis Res Ther 2017 Jul 6;19(1):162. Epub 2017 Jul 6.
Department of Experimental and Clinical Medicine, Division of Rheumatology and Scleroderma Unit, Azienda Ospedaliera Universitaria Careggi, University of Florence, Viale Pieraccini 18, 50139, Florence, Italy.

Endothelial-to-mesenchymal transition contributes to endothelial dysfunction and dermal fibrosis in systemic sclerosis.
Ann Rheum Dis 2017 May 6;76(5):924-934. Epub 2017 Jan 6.
Department of Experimental and Clinical Medicine, Section of Internal Medicine, Rheumatology Unit, Azienda Ospedaliero-Universitaria Careggi (AOUC), University of Florence, Florence, Italy.

Proangiogenic effects of soluble α-Klotho on systemic sclerosis dermal microvascular endothelial cells.
Arthritis Res Ther 2017 Feb 10;19(1):27. Epub 2017 Feb 10.
Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, AOUC, Largo Brambilla 3, 50134, Florence, Italy.

Decreased expression of neuropilin-1 as a novel key factor contributing to peripheral microvasculopathy and defective angiogenesis in systemic sclerosis.
Ann Rheum Dis 2016 Aug 10;75(8):1541-9. Epub 2015 Sep 10.
Department of Experimental and Clinical Medicine, Division of Rheumatology, Azienda Ospedaliero-Universitaria Careggi (AOUC), University of Florence, Florence, Italy.

Bosentan blocks the antiangiogenic effects of sera from systemic sclerosis patients: an in vitro study.
Clin Exp Rheumatol 2015 Jul-Aug;33(4 Suppl 91):S148-52. Epub 2015 Jun 19.
Department of Experimental and Clinical Medicine, Section of Internal Medicine and Division of Rheumatology, Azienda Ospedaliero-Universitaria Careggi (AOUC), University of Florence, Florence, Italy.

Plexin-D1/Semaphorin 3E pathway may contribute to dysregulation of vascular tone control and defective angiogenesis in systemic sclerosis.
Arthritis Res Ther 2015 Aug 21;17:221. Epub 2015 Aug 21.
Department of Experimental and Clinical Medicine, Division of Rheumatology, Azienda Ospedaliero-Universitaria Careggi (AOUC), University of Florence, Viale Pieraccini 18, I-50139, Florence, Italy.


Disease activity improvement in rheumatoid arthritis treated with tumor necrosis factor-α inhibitors correlates with increased soluble Fas levels.
J Rheumatol 2014 Oct 1;41(10):1961-5. Epub 2014 Sep 1.
From the Department of Experimental and Clinical Medicine, Section of Internal Medicine; Division of Rheumatology, Azienda Ospedaliero-Universitaria Careggi; DENOthe Centre; Department of Experimental and Clinical Medicine, Section of Anatomy and Histology, University of Florence, Florence, Italy.E. Romano, PhD; R. Terenzi, MD; F. Peruzzi, MD; G. Fiori, MD; F. Nacci, MD; S. Bellando-Randone, MD, PhD; M. Matucci-Cerinic, MD, PhD; S. Guiducci, MD, PhD, Department of Experimental and Clinical Medicine, Section of Internal Medicine, Division of Rheumatology, Azienda Ospedaliero-Universitaria Careggi; DENOthe Centre; M. Manetti, PhD; Department of Experimental and Clinical Medicine, Section of Anatomy and Histology, University of Florence.

Inactivation of urokinase-type plasminogen activator receptor (uPAR) gene induces dermal and pulmonary fibrosis and peripheral microvasculopathy in mice: a new model of experimental scleroderma?
Ann Rheum Dis 2014 Sep 12;73(9):1700-9. Epub 2013 Jul 12.
Department of Experimental and Clinical Medicine, Section of Internal Medicine and Division of Rheumatology, Azienda Ospedaliero-Universitaria Careggi, University of Florence, Florence, Italy.

Differential expression of junctional adhesion molecules in different stages of systemic sclerosis.
Arthritis Rheum 2013 Jan;65(1):247-57
Azienda Ospedaliero-Universitaria Careggi (AOUC), Excellence Centre for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies (DENOthe), Department of Anatomy, Histology, and Forensic Medicine, University of Florence, Florence, Italy.





Bone marrow-derived mesenchymal stem cells from early diffuse systemic sclerosis exhibit a paracrine machinery and stimulate angiogenesis in vitro.
Ann Rheum Dis 2011 Nov 6;70(11):2011-21. Epub 2011 Aug 6.
Department of Biomedicine, Division of Rheumatology, AOUC, Excellence Centre for Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy.






HLA-B27 transgenic rat: an animal model mimicking gut and joint involvement in human spondyloarthritides.
Ann N Y Acad Sci 2009 Sep;1173:570-4
Department of Biomedicine, Division of Rheumatology-DENOTHE, Center for the Study at the Molecular and Clinical Level of Chronic, Degenerative, and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Florence, Italy.

Analysis of vascular gene expression in arthritic synovium by laser-mediated microdissection.
Arthritis Rheum 2007 Apr;56(4):1094-105
Department of Medicine and Rheumatology, Justus-Liebig-University of Giessen, Giessen, and University Hospital Regensburg, Germany.




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