Mirko Magnone

Section of Biochemistry, Department of Experimental Medicine, Center of Excellence for Biomedical Research (CEBR), University of Genova, Genoa, Italy;

View Article and Find Full Text PDF

July 2017

Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo.

Authors:

Laura Sturla Elena Mannino Sonia Scarfì Santina Bruzzone Mirko Magnone Giovanna Sociali Valeria Booz Lucrezia Guida Tiziana Vigliarolo Chiara Fresia Laura Emionite Ambra Buschiazzo Cecilia Marini Gianmario Sambuceti Antonio De Flora Elena Zocchi

Biochim Biophys Acta Mol Cell Biol Lipids 2017 Feb 15;1862(2):131-144. Epub 2016 Nov 15.

Department of Experimental Medicine and CEBR, University of Genova, Viale Benedetto XV 1, 16132 Genova, Italy.

View Article and Find Full Text PDF

February 2017

Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model.

Authors:

Giovanna Sociali Lizzia Raffaghello Mirko Magnone Federica Zamporlini Laura Emionite Laura Sturla Giovanna Bianchi Tiziana Vigliarolo Aimable Nahimana Alessio Nencioni Nadia Raffaelli Santina Bruzzone

Oncotarget 2016 Jan;7(3):2968-84

Department of Experimental Medicine, Section of Biochemistry, and CEBR, University of Genova, 16132 Genova, Italy.

View Article and Find Full Text PDF

January 2016

Abscisic Acid Stimulates Glucagon-Like Peptide-1 Secretion from L-Cells and Its Oral Administration Increases Plasma Glucagon-Like Peptide-1 Levels in Rats.

Authors:

Santina Bruzzone Mirko Magnone Elena Mannino Giovanna Sociali Laura Sturla Chiara Fresia Valeria Booz Laura Emionite Antonio De Flora Elena Zocchi

PLoS One 2015 21;10(10):e0140588. Epub 2015 Oct 21.

Department of Experimental Medicine (DIMES), Section of Biochemistry, and CEBR, University of Genova, Genova, Italy.

View Article and Find Full Text PDF

June 2016

Microgram amounts of abscisic acid in fruit extracts improve glucose tolerance and reduce insulinemia in rats and in humans.

Authors:

Mirko Magnone Pietro Ameri Annalisa Salis Gabriella Andraghetti Laura Emionite Giovanni Murialdo Antonio De Flora Elena Zocchi

FASEB J 2015 Dec 4;29(12):4783-93. Epub 2015 Aug 4.

*Department of Experimental Medicine, Section of Biochemistry and Center of Excellence for Biomedical Research, and Department of Internal Medicine, University of Genoa, Genoa, Italy; and Animal Facility, Istituto di Ricovero e Cura a Carattere Scientifico, Azienda Ospedaliera Universitaria San Martino, Istituto Scientifico Tumori, Genoa, Italy

View Article and Find Full Text PDF

December 2015

Fluridone as a new anti-inflammatory drug.

Authors:

Mirko Magnone Sonia Scarfì Laura Sturla Lucrezia Guida Salvatore Cuzzocrea Rosanna Di Paola Santina Bruzzone Annalisa Salis Antonio De Flora Elena Zocchi

Eur J Pharmacol 2013 Nov 6;720(1-3):7-15. Epub 2013 Nov 6.

Department of Experimental Medicine, University of Genova, Viale Benedetto XV 1, 16132 Genova, Italy. Electronic address:

View Article and Find Full Text PDF

November 2013

Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice.

Thromb Haemost 2014 Feb 7;111(2):308-22. Epub 2013 Nov 7.

Dr. Fabrizio Montecucco, MD, PhD, Cardiology Division, Foundation for Medical Researches, Department of Internal Medicine, University of Geneva, 64 Avenue Roseraie, 1211 Geneva, Switzerland, Tel.: +41 22 382 72 38, Fax: +41 22 382 72 45, E-mail:

View Article and Find Full Text PDF

February 2014

The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses.

Authors:

Inga Bauer Alessia Grozio Denise Lasigliè Giovanna Basile Laura Sturla Mirko Magnone Giovanna Sociali Debora Soncini Irene Caffa Alessandro Poggi Gabriele Zoppoli Michele Cea Georg Feldmann Raul Mostoslavsky Alberto Ballestrero Franco Patrone Santina Bruzzone Alessio Nencioni

J Biol Chem 2012 Nov 18;287(49):40924-37. Epub 2012 Oct 18.

Department of Internal Medicine, Section of Biochemistry and Center of Excellence for Biomedical Research (CEBR), University of Genoa, 16132 Genoa, Italy.

View Article and Find Full Text PDF

November 2012

NAD+ levels control Ca2+ store replenishment and mitogen-induced increase of cytosolic Ca2+ by Cyclic ADP-ribose-dependent TRPM2 channel gating in human T lymphocytes.

Authors:

Mirko Magnone Inga Bauer Alessandro Poggi Elena Mannino Laura Sturla Marisa Brini Elena Zocchi Antonio De Flora Alessio Nencioni Santina Bruzzone

J Biol Chem 2012 Jun 30;287(25):21067-81. Epub 2012 Apr 30.

Department of Experimental Medicine, Section of Biochemistry and Center of Excellence for Biomedical Research, University of Genova, Genova, Italy.

View Article and Find Full Text PDF

June 2012

Functional characterization of a synthetic abscisic acid analog with anti-inflammatory activity on human granulocytes and monocytes.

Authors:

Alessia Grozio Enrico Millo Lucrezia Guida Tiziana Vigliarolo Marta Bellotti Annalisa Salis Chiara Fresia Laura Sturla Mirko Magnone Andrea Galatini Gianluca Damonte Antonio De Flora Santina Bruzzone Luca Bagnasco Elena Zocchi

Biochem Biophys Res Commun 2011 Dec 6;415(4):696-701. Epub 2011 Nov 6.

Department of Experimental Medicine (DIMES), Section of Biochemistry, University of Genova, Viale Benedetto XV 1, 16132 Genova, Italy.

View Article and Find Full Text PDF

December 2011

The plant hormone abscisic acid increases in human plasma after hyperglycemia and stimulates glucose consumption by adipocytes and myoblasts.

FASEB J 2012 Mar 10;26(3):1251-60. Epub 2011 Nov 10.

Department of Experimental Medicine, University of Genova, Viale Benedetto XV, 1 16132 Genova, Italy.

View Article and Find Full Text PDF

March 2012

Autocrine abscisic acid plays a key role in quartz-induced macrophage activation.

Authors:

Mirko Magnone Laura Sturla Emanuela Jacchetti Sonia Scarfì Santina Bruzzone Cesare Usai Lucrezia Guida Annalisa Salis Gianluca Damonte Antonio De Flora Elena Zocchi

FASEB J 2012 Mar 31;26(3):1261-71. Epub 2011 Oct 31.

DIMES, Section of Biochemistry, University of Genova, Viale Benedetto XV, 1 16132 Genova, Italy.

View Article and Find Full Text PDF

March 2012

Autocrine abscisic acid mediates the UV-B-induced inflammatory response in human granulocytes and keratinocytes.

Authors:

Santina Bruzzone Giovanna Basile Elena Mannino Laura Sturla Mirko Magnone Alessia Grozio Annalisa Salis Chiara Fresia Tiziana Vigliarolo Lucrezia Guida Antonio De Flora Vanesa Tossi Raul Cassia Lorenzo Lamattina Elena Zocchi

J Cell Physiol 2012 Jun;227(6):2502-10

Department of Experimental Medicine and CEBR, University of Genova, Genova, Italy.

View Article and Find Full Text PDF

June 2012

Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells.

PLoS One 2011 27;6(7):e22739. Epub 2011 Jul 27.

Department of Internal Medicine, University of Genoa, Genoa, Italy.

View Article and Find Full Text PDF

December 2011

LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells.

Authors:

Laura Sturla Chiara Fresia Lucrezia Guida Santina Bruzzone Sonia Scarfì Cesare Usai Floriana Fruscione Mirko Magnone Enrico Millo Giovanna Basile Alessia Grozio Emanuela Jacchetti Marcello Allegretti Antonio De Flora Elena Zocchi

J Biol Chem 2009 Oct 10;284(41):28045-57. Epub 2009 Aug 10.

Department of Experimental Medicine, Section of Biochemistry, and Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV 1, Genova 16132, Italy.

View Article and Find Full Text PDF

October 2009

The plant hormone abscisic acid stimulates the proliferation of human hemopoietic progenitors through the second messenger cyclic ADP-ribose.

Authors:

Sonia Scarfì Chiara Fresia Chiara Ferraris Santina Bruzzone Floriana Fruscione Cesare Usai Federica Benvenuto Mirko Magnone Marina Podestà Laura Sturla Lucrezia Guida Ennio Albanesi Gianluca Damonte Annalisa Salis Antonio De Flora Elena Zocchi

Stem Cells 2009 Oct;27(10):2469-77

Advanced Biotechnology Center, Genova, Italy.

View Article and Find Full Text PDF

October 2009

Abscisic acid released by human monocytes activates monocytes and vascular smooth muscle cell responses involved in atherogenesis.

Authors:

Mirko Magnone Santina Bruzzone Lucrezia Guida Gianluca Damonte Enrico Millo Sonia Scarfì Cesare Usai Laura Sturla Domenico Palombo Antonio De Flora Elena Zocchi

J Biol Chem 2009 Jun 30;284(26):17808-18. Epub 2009 Mar 30.

Department of Experimental Medicine, Section of Biochemistry and Center of Excellence for Biomedical Research, University of Genova, and Vascular and Endovascular Surgery Unit, San Martino Hospital, Viale Benedetto XV 1, 16132 Genova, Italy.

View Article and Find Full Text PDF

June 2009

Ascorbic acid pre-treated quartz stimulates TNF-alpha release in RAW 264.7 murine macrophages through ROS production and membrane lipid peroxidation.

Authors:

Sonia Scarfì Mirko Magnone Chiara Ferraris Marina Pozzolini Federica Benvenuto Umberto Benatti Marco Giovine

Respir Res 2009 Mar 19;10:25. Epub 2009 Mar 19.

Department of Experimental Medicine, Section of Biochemistry, University of Genova, Genova, Italy.

View Article and Find Full Text PDF

March 2009

Abscisic acid is an endogenous stimulator of insulin release from human pancreatic islets with cyclic ADP ribose as second messenger.

Authors:

Santina Bruzzone Nicoletta Bodrato Cesare Usai Lucrezia Guida Iliana Moreschi Rita Nano Barbara Antonioli Floriana Fruscione Mirko Magnone Sonia Scarfì Antonio De Flora Elena Zocchi

J Biol Chem 2008 Nov 10;283(47):32188-97. Epub 2008 Sep 10.

Department of Experimental Medicine, Section of Biochemistry, and Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV/1, 16132 Genova, Italy.

View Article and Find Full Text PDF

November 2008

Adenylic dinucleotides produced by CD38 are negative endogenous modulators of platelet aggregation.

Authors:

Mirko Magnone Giovanna Basile Debora Bruzzese Lucrezia Guida Maria Grazia Signorello Madhu Parakkottil Chothi Santina Bruzzone Enrico Millo Ai-Dong Qi Robert A Nicholas Matthias U Kassack Giuliana Leoncini Elena Zocchi

J Biol Chem 2008 Sep 7;283(36):24460-8. Epub 2008 Jul 7.

Department of Experimental Medicine, Section of Biochemistry and Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV, 1 16132 Genova, Italy.

View Article and Find Full Text PDF

September 2008