Mirjam H M Heemskerk

Mirjam H M Heemskerk

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Mirjam H M Heemskerk

Mirjam H M Heemskerk

Publications by authors named "Mirjam H M Heemskerk"

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Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function.

Nat Commun 2019 Oct 1;10(1):4451. Epub 2019 Oct 1.

Institute of Immunity and Transplantation, Division of Infection and Immunity, University College London, Royal Free Hospital, London, NW3 2PF, UK.

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http://dx.doi.org/10.1038/s41467-019-12441-wDOI Listing
October 2019

Preclinical Strategies to Identify Off-Target Toxicity of High-Affinity TCRs.

Mol Ther 2018 05 23;26(5):1206-1214. Epub 2018 Feb 23.

Department of Hematology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2018.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993934PMC
May 2018

Uptake of HLA Alloantigens via CD89 and CD206 Does Not Enhance Antigen Presentation by Indirect Allorecognition.

J Immunol Res 2016 20;2016:4215684. Epub 2016 Jun 20.

Department of Nephrology, Leiden University Medical Center (LUMC), 2333 ZA Leiden, Netherlands.

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http://dx.doi.org/10.1155/2016/4215684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931073PMC
March 2017

Pulmonary immune responses against Aspergillus fumigatus are characterized by high frequencies of IL-17 producing T-cells.

J Infect 2017 01 9;74(1):81-88. Epub 2016 Nov 9.

Department of Hematology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.jinf.2016.10.010DOI Listing
January 2017

Design and validation of conditional ligands for HLA-B*08:01, HLA-B*15:01, HLA-B*35:01, and HLA-B*44:05.

Cytometry A 2015 Oct 1;87(10):967-75. Epub 2015 Jun 1.

Department of Hematology, Center for Cancer Immune Therapy, Herlev University Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1002/cyto.a.22689DOI Listing
October 2015

The molecular bases of δ/αβ T cell-mediated antigen recognition.

J Exp Med 2014 Dec 1;211(13):2599-615. Epub 2014 Dec 1.

Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity and Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Parkville, Victoria 3010, Australia Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity and Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Parkville, Victoria 3010, Australia

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http://dx.doi.org/10.1084/jem.20141764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267242PMC
December 2014

Accurate quantitation of MHC-bound peptides by application of isotopically labeled peptide MHC complexes.

J Proteomics 2014 Sep 19;109:240-4. Epub 2014 Jul 19.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2014.07.009DOI Listing
September 2014

Early cytomegalovirus reactivation leaves a specific and dynamic imprint on the reconstituting T cell compartment long-term after hematopoietic stem cell transplantation.

Biol Blood Marrow Transplant 2014 May 23;20(5):655-61. Epub 2014 Jan 23.

Department of Pediatrics, Laboratory for Immunology, Leiden University Medical Center, Leiden, The Netherlands; Pediatric HSCT unit, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.bbmt.2014.01.018DOI Listing
May 2014

Characterization of the T-cell-mediated immune response against the Aspergillus fumigatus proteins Crf1 and catalase 1 in healthy individuals.

J Infect Dis 2013 Sep 22;208(5):847-56. Epub 2013 May 22.

Department of Hematology, Leiden University Medical Center, C2-P, Albinusdreef 2, 2333 ZA Leiden, the Netherlands.

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http://dx.doi.org/10.1093/infdis/jit237DOI Listing
September 2013

The human leukocyte antigen-presented ligandome of B lymphocytes.

Mol Cell Proteomics 2013 Jul 12;12(7):1829-43. Epub 2013 Mar 12.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1074/mcp.M112.024810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708169PMC
July 2013

TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo.

Blood 2012 Apr 27;119(15):3440-9. Epub 2012 Feb 27.

Institute of Molecular Immunology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.

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http://dx.doi.org/10.1182/blood-2011-06-357939DOI Listing
April 2012

Identification of a coordinated CD8 and CD4 T cell response directed against mismatched HLA Class I causing severe acute graft-versus-host disease.

Biol Blood Marrow Transplant 2012 Feb 19;18(2):210-9. Epub 2011 Oct 19.

Laboratory of Experimental Hematology, Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.bbmt.2011.10.018DOI Listing
February 2012

Transduction of human T cells with a novel T-cell receptor confers anti-HCV reactivity.

PLoS Pathog 2010 Jul 29;6(7):e1001018. Epub 2010 Jul 29.

Division of Transplantation, Department of Surgery, Medical University of South Carolina, Hollings Cancer Center, Charleston, South Carolina, USA.

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http://dx.doi.org/10.1371/journal.ppat.1001018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912399PMC
July 2010

Mixed T cell receptor dimers harbor potentially harmful neoreactivity.

Proc Natl Acad Sci U S A 2010 Jun 1;107(24):10972-7. Epub 2010 Jun 1.

Department of Hematology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1073/pnas.1005802107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890759PMC
June 2010

Kinetic preservation of dual specificity of coprogrammed minor histocompatibility antigen-reactive virus-specific T cells.

Cancer Res 2009 Mar 17;69(5):2034-41. Epub 2009 Feb 17.

Department of Hematology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-2523DOI Listing
March 2009

Functional analysis of killer Ig-like receptor-expressing cytomegalovirus-specific CD8+ T cells.

J Immunol 2009 Jan;182(1):92-101

Department of Hematology, Laboratory of Experimental Hematology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.182.1.92DOI Listing
January 2009

Alpha beta T cell receptor transfer to gamma delta T cells generates functional effector cells without mixed TCR dimers in vivo.

J Immunol 2009 Jan;182(1):164-70

Laboratory of Experimental Hematology, Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.182.1.164DOI Listing
January 2009

Transcriptional silencing of RFXAP in MHC class II-deficiency.

Mol Immunol 2008 May 12;45(10):2920-8. Epub 2008 Mar 12.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.molimm.2008.01.026DOI Listing
May 2008

Conditional MHC class I ligands and peptide exchange technology for the human MHC gene products HLA-A1, -A3, -A11, and -B7.

Proc Natl Acad Sci U S A 2008 Mar 28;105(10):3825-30. Epub 2008 Feb 28.

Divisions of Immunology and Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0709717105
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http://dx.doi.org/10.1073/pnas.0709717105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268811PMC
March 2008

Functional human antigen-specific T cells produced in vitro using retroviral T cell receptor transfer into hematopoietic progenitors.

J Immunol 2007 Oct;179(8):4959-68

Department of Cell Biology and Histology, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.179.8.4959DOI Listing
October 2007

Strong selection of virus-specific cytotoxic CD4+ T-cell clones during primary human cytomegalovirus infection.

Blood 2006 Nov 13;108(9):3121-7. Epub 2006 Jul 13.

Department of Experimental Immunology, Division of Nephrology, Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1182/blood-2006-03-006809DOI Listing
November 2006

Rapid assessment of the antigenic integrity of tetrameric HLA complexes by human monoclonal HLA antibodies.

J Immunol Methods 2006 Aug 30;315(1-2):153-61. Epub 2006 Aug 30.

Leiden University Medical Center, Department of Immunohaematology and Bloodtransfusion, Leiden, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S002217590600219
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http://dx.doi.org/10.1016/j.jim.2006.07.020DOI Listing
August 2006

Optimizing TCR gene transfer.

Clin Immunol 2006 May 28;119(2):121-2. Epub 2006 Feb 28.

Leiden University Medical Center, Department of Hematology, C2-R, PO Box 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.clim.2006.01.006DOI Listing
May 2006

Alphabeta T-cell receptor engineered gammadelta T cells mediate effective antileukemic reactivity.

Cancer Res 2006 Mar;66(6):3331-7

Laboratory of Experimental Hematology, Department of Hematology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-4190DOI Listing
March 2006

Impact of peptides on the recognition of HLA class I molecules by human HLA antibodies.

J Immunol 2005 Nov;175(9):5950-7

Department of Immunohematology and Bloodtransfusion, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.175.9.5950DOI Listing
November 2005

Adult and cord blood T cells can acquire HA-1 specificity through HA-1 T-cell receptor gene transfer.

Haematologica 2005 Oct;90(10):1415-21

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

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October 2005

Reprogramming of virus-specific T cells into leukemia-reactive T cells using T cell receptor gene transfer.

J Exp Med 2004 Apr 29;199(7):885-94. Epub 2004 Mar 29.

Department of Hematology, Leiden University Medical Center, C2-R, P.O. Box 9600, 2300 RC, Netherlands.

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http://www.jem.org/lookup/doi/10.1084/jem.20031110
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http://dx.doi.org/10.1084/jem.20031110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211874PMC
April 2004

Functional role of alternatively spliced deoxycytidine kinase in sensitivity to cytarabine of acute myeloid leukemic cells.

Blood 2002 Feb;99(4):1373-80

Laboratory of Experimental Hematology, Department of Hematology, Leiden University Medical Center, The Netherlands.

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http://dx.doi.org/10.1182/blood.v99.4.1373DOI Listing
February 2002