Publications by authors named "Miriam Slavkovska"

2 Publications

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Comparison in detection of prodromal Parkinson's disease patients using original and updated MDS research criteria in two independent cohorts.

Parkinsonism Relat Disord 2021 Jun 30;87:48-55. Epub 2021 Apr 30.

Department of Neurology, P. J. Safarik University, Trieda SNP 1, 04011, Kosice, Slovak Republic; Department of Neurology, University Hospital L. Pasteur, Rastislavova 43, 04190, Kosice, Slovak Republic.

Introduction: MDS research criteria for prodromal Parkinson's disease (pPD) were published in 2015 and updated in 2019. We aimed to determine the difference in pPD patient detection rates in two cohorts recruited via gastrointestinal symptoms (PARCAS study) and the presence of a probable REM sleep behaviour disorder (PDBIOM study) using the original and updated criteria.

Methods: We evaluated all risk and prodromal markers, except genetic testing, plasma urate and physical inactivity, in both cohorts and DaT scan, diabetes mellitus type II and cognitive deficit in the PARCAS cohort. Thresholds of 50% probability for possible pPD and 80% for probable pPD were used.

Results: PPD status as identified by the original/updated criteria showed differences for probable pPD (n = 8/9; original/updated criteria) and possible pPD (n = 9/13) in the PARCAS cohort (total n = 158), as well as for probable pPD (n = 19/21) and possible pPD (n = 6/3) in the PDBIOM cohort (total n = 48). A high concordance rate was found between the two criteria sets (p < 0.001 for all groups).

Conclusion: All probable pPD cases remained in the same category after evaluation with both criteria; three possible pPD cases based on the original criteria exceeded the threshold for probable pPD based on the updated criteria, and five possible new pPD cases were detected, with only one shift in the opposite direction. The updated MDS pPD research criteria tend to identify more patients as positive, yet their accuracy needs to be determined in prospective studies.
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http://dx.doi.org/10.1016/j.parkreldis.2021.04.028DOI Listing
June 2021

The utility of set-loss error scores in the general population.

Psychol Assess 2015 Sep 2;27(3):755-62. Epub 2015 Mar 2.

Department of Psychology, Faculty of Arts, University of Pavol Jozef Safarik.

Although the measurement of cognitive performance usually relies on achievement sum scores, a growing body of research suggests that the analysis of errors made may have a predictive validity beyond that provided by the number of items correct. This study examined the validity related to one such kind of error scores--the set-loss errors--in the general population of 8- to 11-year-old children. Set-loss errors (also called rule violations) can be conceptualized as a breakdown in the adherence to task-specific rules, and in clinical populations, the propensity to make these errors has shown some specificity for identifying disorders connected with frontal lobes dysfunction. The results, however, indicate that set-loss errors derived from distinct tests could not be effectively explained by a single latent dimension; hence, they do not tap a single construct that could be called set loss or the ability to maintain set. At the same time, there were only few weak associations between various kinds of error scores as well as between the set-loss error scores and relevant constructs such as the ability to learn, attentional control, working memory, fluid and crystallized intelligence, and executive functions-related real-world behaviors, indicating an overrepresentation of construct-irrelevant variance in these kinds of scores. These indications were further accentuated by the analysis of sensitivity and specificity where any elevated number of set-loss error scores was unable to classify individuals on theoretically relevant constructs beyond chance levels. The evidence thus speaks against the use of set-loss error scores in the general population of 8- to 11-year-old children.
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http://dx.doi.org/10.1037/pas0000106DOI Listing
September 2015