Publications by authors named "Miriam Erlacher"

44Publications

Inhibition of the anti-apoptotic protein MCL-1 severely suppresses human hematopoiesis.

Haematologica 2020 Nov 26;Online ahead of print. Epub 2020 Nov 26.

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Germany; German Cancer Consortium (DKTK), Freiburg, Germany and German Cancer Research Center (DKFZ), Heidelberg.

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http://dx.doi.org/10.3324/haematol.2020.252130DOI Listing
November 2020

BCL-XL expression is essential for human erythropoiesis and engraftment of hematopoietic stem cells.

Cell Death Dis 2020 01 6;11(1). Epub 2020 Jan 6.

Faculty of Medicine, Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1038/s41419-019-2203-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944703PMC
January 2020

Checkpoint kinase 1 is essential for fetal and adult hematopoiesis.

EMBO Rep 2019 08 17;20(8):e47026. Epub 2019 Jun 17.

Division of Developmental Immunology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.15252/embr.201847026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680171PMC
August 2019

Impaired human hematopoiesis due to a cryptic intronic splicing mutation.

J Exp Med 2019 05 26;216(5):1050-1060. Epub 2019 Mar 26.

Division of Hematology/Oncology, The Manton Center for Orphan Disease Research, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

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http://www.jem.org/lookup/doi/10.1084/jem.20181625
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http://dx.doi.org/10.1084/jem.20181625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504223PMC
May 2019

Azacitidine is effective for targeting leukemia-initiating cells in juvenile myelomonocytic leukemia.

Leukemia 2019 07 24;33(7):1805-1810. Epub 2019 Jan 24.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1038/s41375-018-0343-2DOI Listing
July 2019

and evaluation of possible pro-survival activities of PGE2, EGF, TPO and FLT3L on human hematopoiesis.

Haematologica 2019 04 15;104(4):669-677. Epub 2018 Nov 15.

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg

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http://www.haematologica.org/lookup/doi/10.3324/haematol.201
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http://dx.doi.org/10.3324/haematol.2018.191569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442978PMC
April 2019

Concise Review: Cheating Death for a Better Transplant.

Stem Cells 2018 11 1;36(11):1646-1654. Epub 2018 Oct 1.

Faculty of Medicine, Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1002/stem.2901DOI Listing
November 2018

Transient apoptosis inhibition in donor stem cells improves hematopoietic stem cell transplantation.

J Exp Med 2017 Oct 7;214(10):2967-2983. Epub 2017 Sep 7.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

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http://dx.doi.org/10.1084/jem.20161721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626392PMC
October 2017

Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology.

Am J Med Genet A 2017 Apr 7;173(4):1017-1037. Epub 2017 Feb 7.

Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1002/ajmg.a.38142DOI Listing
April 2017

Impact of tofacitinib treatment on human B-cells in vitro and in vivo.

J Autoimmun 2017 02 26;77:55-66. Epub 2016 Oct 26.

Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1016/j.jaut.2016.10.005DOI Listing
February 2017

Long-term serial xenotransplantation of juvenile myelomonocytic leukemia recapitulates human disease in Rag2-/-γc-/- mice.

Haematologica 2016 05 17;101(5):597-606. Epub 2016 Feb 17.

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University Medical Center, Freiburg, Germany The German Cancer Consortium, Heidelberg, Germany

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http://dx.doi.org/10.3324/haematol.2015.138545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004370PMC
May 2016

Bcl-2 proteins in development, health, and disease of the hematopoietic system.

FEBS J 2016 08 21;283(15):2779-810. Epub 2016 Mar 21.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Medical Center of Freiburg, Germany.

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http://dx.doi.org/10.1111/febs.13683DOI Listing
August 2016

Missing Cells: Pathophysiology, Diagnosis, and Management of (Pan)Cytopenia in Childhood.

Front Pediatr 2015 13;3:64. Epub 2015 Jul 13.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Medical Center of Freiburg , Freiburg , Germany.

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http://dx.doi.org/10.3389/fped.2015.00064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500095PMC
July 2015

Reversible pancytopenia and immunodeficiency in a patient with hereditary folate malabsorption.

Pediatr Blood Cancer 2015 Jun 11;62(6):1091-4. Epub 2014 Dec 11.

Department of Pediatrics and Adolescent Medicine, University Medical Center, Freiburg, Germany.

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http://dx.doi.org/10.1002/pbc.25364DOI Listing
June 2015

Patients with T⁺/low NK⁺ IL-2 receptor γ chain deficiency have differentially-impaired cytokine signaling resulting in severe combined immunodeficiency.

Eur J Immunol 2014 Oct 28;44(10):3129-40. Epub 2014 Aug 28.

Center for Chronic Immunodeficiency (CCI), University Medical Center and University of Freiburg, Freiburg, Germany; Faculty of Biology, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1002/eji.201444689DOI Listing
October 2014

hTERT: another brick in the wall of cancer cells.

Mutat Res 2013 Apr-Jun;752(2):119-28. Epub 2012 Dec 31.

Freiburg University Medical Centre, Department of Environmental Health Sciences, Breisacher Str. 115 b, 79106 Freiburg i.Br., Germany. Electronic address:

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http://dx.doi.org/10.1016/j.mrrev.2012.12.005DOI Listing
April 2015

Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development.

J Exp Med 2008 Mar 25;205(3):641-55. Epub 2008 Feb 25.

Division of Developmental Immunology, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria.

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http://dx.doi.org/10.1084/jem.20071658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275386PMC
March 2008

Preclinical studies of treosulfan demonstrate potent activity in Ewing's sarcoma.

Cancer Chemother Pharmacol 2008 Jun 1;62(1):19-31. Epub 2007 Sep 1.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Albert-Ludwigs-University, Mathildenstr. 1, 79106, Freiburg, Germany.

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http://dx.doi.org/10.1007/s00280-007-0566-9DOI Listing
June 2008

Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction.

J Exp Med 2006 Dec 18;203(13):2939-51. Epub 2006 Dec 18.

Division of Developmental Immunology, Biocenter, Innsbruck Medical University, A-6020 Innsbruck, Austria.

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http://dx.doi.org/10.1084/jem.20061552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118188PMC
December 2006

FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal.

J Exp Med 2006 Jul 26;203(7):1657-63. Epub 2006 Jun 26.

The Campbell family Institute for Breast Cancer Research, University Health Network, Toronto, Ontario M5G 2C1, Canada.

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http://dx.doi.org/10.1084/jem.20060353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118330PMC
July 2006

TCR signaling inhibits glucocorticoid-induced apoptosis in murine thymocytes depending on the stage of development.

Eur J Immunol 2005 Nov;35(11):3287-96

Division of Experimental Pathophysiology and Immunology, Biocenter, Innsbruck Medical University, Austria.

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http://doi.wiley.com/10.1002/eji.200526279
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http://dx.doi.org/10.1002/eji.200526279DOI Listing
November 2005

BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.

Blood 2005 Dec 23;106(13):4131-8. Epub 2005 Aug 23.

Division of Experimental Pathophysiology & Immunology, Biocenter, Innsbruck Medical University, A-6020 Innsbruck, Austria.

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http://dx.doi.org/10.1182/blood-2005-04-1595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895232PMC
December 2005

Death squads enlisted by the tumour suppressor p53.

Biochem Biophys Res Commun 2005 Jun;331(3):786-98

The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0500706
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http://dx.doi.org/10.1016/j.bbrc.2005.03.183DOI Listing
June 2005

The Bcl-2 protein family and its role in the development of neoplastic disease.

Exp Gerontol 2004 Aug;39(8):1125-35

Institute of Pathophysiology, University of Innsbruck Medical School, Fritz-Pregl-Str. 3, A-6020 Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.exger.2004.04.011DOI Listing
August 2004