Mireille Khacho

Mireille Khacho

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Mireille Khacho

Mireille Khacho

Publications by authors named "Mireille Khacho"

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Linking mitochondrial dynamics, cristae remodeling and supercomplex formation: How mitochondrial structure can regulate bioenergetics.

Mitochondrion 2019 11 15;49:259-268. Epub 2019 Jun 15.

Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology (OISB), Center for Neuromuscular Disease, University of Ottawa, Ottawa, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15677249193002
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http://dx.doi.org/10.1016/j.mito.2019.06.003DOI Listing
November 2019

Mitochondria as central regulators of neural stem cell fate and cognitive function.

Nat Rev Neurosci 2019 01;20(1):34-48

Department of Cellular and Molecular Medicine, University of Ottawa Brain and Mind Research Institute, Ottawa, Ontario, Canada.

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http://www.nature.com/articles/s41583-018-0091-3
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http://dx.doi.org/10.1038/s41583-018-0091-3DOI Listing
January 2019

Mitochondrial dynamics in the regulation of neurogenesis: From development to the adult brain.

Dev Dyn 2018 01 13;247(1):47-53. Epub 2017 Jul 13.

Department of Cellular and Molecular Medicine, University of Ottawa Brain and Mind Research Institute, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1002/dvdy.24538DOI Listing
January 2018

Mitochondrial activity in the regulation of stem cell self-renewal and differentiation.

Curr Opin Cell Biol 2017 12 22;49:1-8. Epub 2017 Nov 22.

Department of Cellular and Molecular Medicine, University of Ottawa Brain and Mind Research Institute, 451 Smyth Rd, Ottawa, Ontario K1H 8M5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2017.11.003DOI Listing
December 2017

Mitochondrial dysfunction underlies cognitive defects as a result of neural stem cell depletion and impaired neurogenesis.

Hum Mol Genet 2017 09;26(17):3327-3341

Department of Cellular and Molecular Medicine, University of Ottawa Brain and Mind Research Institute, Ottawa, ON K1H 8M5, Canada.

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http://dx.doi.org/10.1093/hmg/ddx217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886206PMC
September 2017

Mitochondrial and Reactive Oxygen Species Signaling Coordinate Stem Cell Fate Decisions and Life Long Maintenance.

Antioxid Redox Signal 2017 Jul 31. Epub 2017 Jul 31.

Department of Cellular and Molecular Medicine, Brain and Mind Research Institute, University of Ottawa , Ottawa, Canada .

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http://dx.doi.org/10.1089/ars.2017.7228DOI Listing
July 2017

Adaptation to Stressors by Systemic Protein Amyloidogenesis.

Dev Cell 2016 10 6;39(2):155-168. Epub 2016 Oct 6.

Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada; Department of Urology, University of Miami Miller School of Medicine, Miami, FL 33136, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2016.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098424PMC
October 2016

Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program.

Cell Stem Cell 2016 08 26;19(2):232-247. Epub 2016 May 26.

Department of Cellular and Molecular Medicine, University of Ottawa Brain and Mind Research Institute, Ottawa, ON K1H 8M5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.04.015DOI Listing
August 2016

Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival.

Nat Commun 2014 Apr 1;5:3550. Epub 2014 Apr 1.

Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.

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http://dx.doi.org/10.1038/ncomms4550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988820PMC
April 2014

LKB1-regulated adaptive mechanisms are essential for neuronal survival following mitochondrial dysfunction.

Hum Mol Genet 2013 Mar 27;22(5):952-62. Epub 2012 Nov 27.

Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.

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http://dx.doi.org/10.1093/hmg/dds500DOI Listing
March 2013

Subcellular dynamics of the VHL tumor suppressor: on the move for HIF degradation.

Future Oncol 2009 Feb;5(1):85-95

Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ontario, Canada.

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http://dx.doi.org/10.2217/14796694.5.1.85DOI Listing
February 2009

eEF1A is a novel component of the mammalian nuclear protein export machinery.

Mol Biol Cell 2008 Dec 17;19(12):5296-308. Epub 2008 Sep 17.

Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada.

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http://dx.doi.org/10.1091/mbc.e08-06-0562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592675PMC
December 2008

Cancer-causing mutations in a novel transcription-dependent nuclear export motif of VHL abrogate oxygen-dependent degradation of hypoxia-inducible factor.

Mol Cell Biol 2008 Jan 29;28(1):302-14. Epub 2007 Oct 29.

Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.01044-07
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http://dx.doi.org/10.1128/MCB.01044-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223288PMC
January 2008

Identification of a common subnuclear localization signal.

Mol Biol Cell 2007 Oct 25;18(10):3966-77. Epub 2007 Jul 25.

Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ONT, Canada, K1H 8M5.

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http://dx.doi.org/10.1091/mbc.e07-03-0295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995723PMC
October 2007

Restriction of rRNA synthesis by VHL maintains energy equilibrium under hypoxia.

Cell Cycle 2006 Oct 16;5(20):2401-13. Epub 2006 Oct 16.

Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.4161/cc.5.20.3387DOI Listing
October 2006

Regulation of ubiquitin ligase dynamics by the nucleolus.

J Cell Biol 2005 Aug;170(5):733-44

Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.

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http://dx.doi.org/10.1083/jcb.200506030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171338PMC
August 2005

Oxygen sensing by H+: implications for HIF and hypoxic cell memory.

Cell Cycle 2004 Aug 7;3(8):1027-9. Epub 2004 Aug 7.

Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.

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August 2004