Mireia Sospedra

Mireia Sospedra

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Mireia Sospedra

Mireia Sospedra

Publications by authors named "Mireia Sospedra"

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Effects of natalizumab therapy on intrathecal antiviral antibody responses in MS.

Neurol Neuroimmunol Neuroinflamm 2019 Nov 25;6(6). Epub 2019 Sep 25.

From the Neuroimmunology and Multiple Sclerosis Research Section (F.L., Ivan Jelcic, M.S., R.M., Ilijas Jelcic), Department of Neurology, University Hospital of Zurich, Switzerland; and Institute for Neuroimmunology and Multiple Sclerosis (inims) (C.H.), Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000621DOI Listing
November 2019

Detailed Characterization of T Cell Receptor Repertoires in Multiple Sclerosis Brain Lesions.

Front Immunol 2018 19;9:509. Epub 2018 Mar 19.

Neuroimmunology and MS Research (nims), Department of Neurology, University Zurich, Zürich, Switzerland.

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http://dx.doi.org/10.3389/fimmu.2018.00509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867461PMC
April 2019

Prevention and therapy of JC polyomavirus-mediated progressive multifocal leukoencephalopathy - a realistic possibility?

Swiss Med Wkly 2017 31;147:w14520. Epub 2017 Oct 31.

Neuroimmunology and Multiple Sclerosis Research Section, Department of Neurology, University of Zurich, University Hospital Zurich, Switzerland.

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http://doi.emh.ch/smw.2017.14520
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http://dx.doi.org/10.4414/smw.2017.14520DOI Listing
July 2018

B cells in multiple sclerosis.

Authors:
Mireia Sospedra

Curr Opin Neurol 2018 06;31(3):256-262

Neuroimmunology and MS Research (nims), Department of Neurology, University Zurich, Zürich, Switzerland.

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http://dx.doi.org/10.1097/WCO.000000000000563DOI Listing
June 2018

Phenotypic and functional complexity of brain-infiltrating T cells in Rasmussen encephalitis.

Neurol Neuroimmunol Neuroinflamm 2018 Jan 8;5(1):e419. Epub 2017 Dec 8.

Neuroimmunology and Multiple Sclerosis Research Section (F.A.N., I.J., C.K., M.S., R.M.), Department of Neurology, University Hospital Zurich, Switzerland; Neuropediatric Clinic and Clinic for Neurorehabilitation (T.P.), Epilepsy Center for Children and Adolescents, Schoen Klinik Vogtareuth, Germany; and Institute of Neuropathology (H.B.), University Hospital Zurich, Switzerland.

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http://dx.doi.org/10.1212/NXI.0000000000000419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733246PMC
January 2018

Current multiple sclerosis treatments have improved our understanding of MS autoimmune pathogenesis.

Eur J Immunol 2016 09;46(9):2078-90

Theodor Kocher Institute, University of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1002/eji.201646485DOI Listing
September 2016

OMIP-033: A comprehensive single step staining protocol for human T- and B-cell subsets.

Cytometry A 2016 07 8;89(7):629-32. Epub 2016 Jun 8.

Neuroimmunology and Multiple Sclerosis Research Section, Department of Neurology, University Hospital Zurich, 8091, Switzerland.

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http://dx.doi.org/10.1002/cyto.a.22889DOI Listing
July 2016

Immunology of Multiple Sclerosis.

Semin Neurol 2016 Apr 26;36(2):115-27. Epub 2016 Apr 26.

Section of Neuroimmunology and MS Research, Neurology Clinic, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1055/s-0036-1579739DOI Listing
April 2016

Mechanisms of immune escape in central nervous system infection with neurotropic JC virus variant.

Ann Neurol 2016 Mar 13;79(3):404-18. Epub 2016 Feb 13.

Neuroimmunology and Multiple Sclerosis Research Section, Department of Neurology University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1002/ana.24574DOI Listing
March 2016

Immunology of progressive multifocal leukoencephalopathy.

J Neurovirol 2015 Dec 5;21(6):614-22. Epub 2015 Mar 5.

Neuroimmunology and Multiple Sclerosis Research Section, Department of Neurology, University Hospital Zurich, 8091, Zurich, Switzerland.

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http://link.springer.com/10.1007/s13365-014-0294-y
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http://dx.doi.org/10.1007/s13365-014-0294-yDOI Listing
December 2015

Broadly neutralizing human monoclonal JC polyomavirus VP1-specific antibodies as candidate therapeutics for progressive multifocal leukoencephalopathy.

Sci Transl Med 2015 Sep 23;7(306):306ra150. Epub 2015 Sep 23.

Neuroimmunology and Multiple Sclerosis Research Section, Department of Neurology, University of Zurich, University Hospital Zurich, 8091 Zurich, Switzerland.

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http://dx.doi.org/10.1126/scitranslmed.aac8691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820754PMC
September 2015

Central role of Th2/Tc2 lymphocytes in pattern II multiple sclerosis lesions.

Ann Clin Transl Neurol 2015 Sep 8;2(9):875-93. Epub 2015 Jun 8.

Neuroimmunology and MS Research (nims), Department of Neurology, University Zurich Frauenklinikstrasse 26, 8091, Zürich, Switzerland.

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http://dx.doi.org/10.1002/acn3.218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574806PMC
September 2015

Antibody responses following induction of antigen-specific tolerance with antigen-coupled cells.

Mult Scler 2015 Apr 8;21(5):651-5. Epub 2014 Sep 8.

Clinical Department of Neurology, Innsbruck Medical University, Austria/Neuroimmunology and Multiple Sclerosis Research, Department of Neurology, University Hospital Zurich, Switzerland

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http://journals.sagepub.com/doi/10.1177/1352458514549405
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http://dx.doi.org/10.1177/1352458514549405DOI Listing
April 2015

Treating progressive multifocal leukoencephalopathy with interleukin 7 and vaccination with JC virus capsid protein VP1.

Clin Infect Dis 2014 Dec 11;59(11):1588-92. Epub 2014 Sep 11.

Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany Neuroimmunology and Multiple Sclerosis Research, Department of Neurology, University of Zurich, Switzerland.

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http://dx.doi.org/10.1093/cid/ciu682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650775PMC
December 2014

Sphingosine-1 phosphate and central nervous system.

Curr Top Microbiol Immunol 2014 ;378:149-70

Neuroimmunology and Multiple Sclerosis Research, Clinic for Neurology, University Hospital Zurich, University Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland,

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http://dx.doi.org/10.1007/978-3-319-05879-5_7DOI Listing
July 2014

Long-term safety and efficacy of natalizumab in relapsing-remitting multiple sclerosis: impact on quality of life.

Patient Relat Outcome Meas 2014 4;5:25-33. Epub 2014 Apr 4.

Neuroimmunology and MS Research, Department of Neurology, University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.2147/PROM.S41768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983075PMC
June 2014

Boswellic acids reduce Th17 differentiation via blockade of IL-1β-mediated IRAK1 signaling.

Eur J Immunol 2014 Apr 16;44(4):1200-12. Epub 2014 Feb 16.

Institute for Neuroimmunology and Clinical Multiple Sclerosis Research (INIMS) and Clinic for Neurology, Center for Molecular Neurobiology, Universitätsklinikum Hamburg Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1002/eji.201343629DOI Listing
April 2014

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

Authors:
Ashley H Beecham Nikolaos A Patsopoulos Dionysia K Xifara Mary F Davis Anu Kemppinen Chris Cotsapas Tejas S Shah Chris Spencer David Booth An Goris Annette Oturai Janna Saarela Bertrand Fontaine Bernhard Hemmer Claes Martin Frauke Zipp Sandra D'Alfonso Filippo Martinelli-Boneschi Bruce Taylor Hanne F Harbo Ingrid Kockum Jan Hillert Tomas Olsson Maria Ban Jorge R Oksenberg Rogier Hintzen Lisa F Barcellos Cristina Agliardi Lars Alfredsson Mehdi Alizadeh Carl Anderson Robert Andrews Helle Bach Søndergaard Amie Baker Gavin Band Sergio E Baranzini Nadia Barizzone Jeffrey Barrett Céline Bellenguez Laura Bergamaschi Luisa Bernardinelli Achim Berthele Viola Biberacher Thomas M C Binder Hannah Blackburn Izaura L Bomfim Paola Brambilla Simon Broadley Bruno Brochet Lou Brundin Dorothea Buck Helmut Butzkueven Stacy J Caillier William Camu Wassila Carpentier Paola Cavalla Elisabeth G Celius Irène Coman Giancarlo Comi Lucia Corrado Leentje Cosemans Isabelle Cournu-Rebeix Bruce A C Cree Daniele Cusi Vincent Damotte Gilles Defer Silvia R Delgado Panos Deloukas Alessia di Sapio Alexander T Dilthey Peter Donnelly Bénédicte Dubois Martin Duddy Sarah Edkins Irina Elovaara Federica Esposito Nikos Evangelou Barnaby Fiddes Judith Field Andre Franke Colin Freeman Irene Y Frohlich Daniela Galimberti Christian Gieger Pierre-Antoine Gourraud Christiane Graetz Andrew Graham Verena Grummel Clara Guaschino Athena Hadjixenofontos Hakon Hakonarson Christopher Halfpenny Gillian Hall Per Hall Anders Hamsten James Harley Timothy Harrower Clive Hawkins Garrett Hellenthal Charles Hillier Jeremy Hobart Muni Hoshi Sarah E Hunt Maja Jagodic Ilijas Jelčić Angela Jochim Brian Kendall Allan Kermode Trevor Kilpatrick Keijo Koivisto Ioanna Konidari Thomas Korn Helena Kronsbein Cordelia Langford Malin Larsson Mark Lathrop Christine Lebrun-Frenay Jeannette Lechner-Scott Michelle H Lee Maurizio A Leone Virpi Leppä Giuseppe Liberatore Benedicte A Lie Christina M Lill Magdalena Lindén Jenny Link Felix Luessi Jan Lycke Fabio Macciardi Satu Männistö Clara P Manrique Roland Martin Vittorio Martinelli Deborah Mason Gordon Mazibrada Cristin McCabe Inger-Lise Mero Julia Mescheriakova Loukas Moutsianas Kjell-Morten Myhr Guy Nagels Richard Nicholas Petra Nilsson Fredrik Piehl Matti Pirinen Siân E Price Hong Quach Mauri Reunanen Wim Robberecht Neil P Robertson Mariaemma Rodegher David Rog Marco Salvetti Nathalie C Schnetz-Boutaud Finn Sellebjerg Rebecca C Selter Catherine Schaefer Sandip Shaunak Ling Shen Simon Shields Volker Siffrin Mark Slee Per Soelberg Sorensen Melissa Sorosina Mireia Sospedra Anne Spurkland Amy Strange Emilie Sundqvist Vincent Thijs John Thorpe Anna Ticca Pentti Tienari Cornelia van Duijn Elizabeth M Visser Steve Vucic Helga Westerlind James S Wiley Alastair Wilkins James F Wilson Juliane Winkelmann John Zajicek Eva Zindler Jonathan L Haines Margaret A Pericak-Vance Adrian J Ivinson Graeme Stewart David Hafler Stephen L Hauser Alastair Compston Gil McVean Philip De Jager Stephen J Sawcer Jacob L McCauley

Nat Genet 2013 Nov 29;45(11):1353-60. Epub 2013 Sep 29.

1] John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA. [2].

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http://dx.doi.org/10.1038/ng.2770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832895PMC
November 2013

JC virus granule cell neuronopathy and GCN-IRIS under natalizumab treatment.

Ann Neurol 2013 Oct 16;74(4):622-6. Epub 2013 Sep 16.

Neuroimmunology and Multiple Sclerosis Research Section, Department of Neurology, University Hospital Zurich, Zurich; Department of Neurology, University Hospital Zurich, Zurich.

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http://dx.doi.org/10.1002/ana.23973DOI Listing
October 2013

Gender differences in circulating levels of neutrophil extracellular traps in serum of multiple sclerosis patients.

J Neuroimmunol 2013 Aug 2;261(1-2):108-19. Epub 2013 Jun 2.

Institute for Neuroimmunology and Clinical MS Research (INiMS), Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Falkenried 94, 20251 Hamburg, Germany.

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http://dx.doi.org/10.1016/j.jneuroim.2013.05.004DOI Listing
August 2013

HLA-DR15-derived self-peptides are involved in increased autologous T cell proliferation in multiple sclerosis.

Brain 2013 Jun;136(Pt 6):1783-98

Institute for Neuroimmunology and Clinical Multiple Sclerosis Research, Centre for Molecular Neurobiology Hamburg, University Medical Centre Eppendorf, 20251 Hamburg, Germany.

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http://dx.doi.org/10.1093/brain/awt108DOI Listing
June 2013

TCR bias and HLA cross-restriction are strategies of human brain-infiltrating JC virus-specific CD4+ T cells during viral infection.

J Immunol 2012 Oct 31;189(7):3618-30. Epub 2012 Aug 31.

Institute for Neuroimmunology and Clinical Multiple Sclerosis Research, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.

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http://dx.doi.org/10.4049/jimmunol.1201612DOI Listing
October 2012

T lymphocyte priming by neutrophil extracellular traps links innate and adaptive immune responses.

J Immunol 2012 Apr 20;188(7):3150-9. Epub 2012 Feb 20.

Institute for Neuroimmunology and Clinical Multiple Sclerosis Research, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.

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http://dx.doi.org/10.4049/jimmunol.1103414DOI Listing
April 2012

Displacement chromatography as first separating step in online two-dimensional liquid chromatography coupled to mass spectrometry analysis of a complex protein sample--the proteome of neutrophils.

J Chromatogr A 2012 Apr 18;1232:288-94. Epub 2012 Feb 18.

Institute of Clinical Chemistry, University Medical Center Hamburg-Eppendorf (UKE), Martinistraße 52, D-20246 Hamburg, Germany.

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http://dx.doi.org/10.1016/j.chroma.2012.02.029DOI Listing
April 2012

Natalizumab treatment perturbs memory- and marginal zone-like B-cell homing in secondary lymphoid organs in multiple sclerosis.

Eur J Immunol 2012 Mar 27;42(3):790-8. Epub 2011 Dec 27.

Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology Hamburg, University Medical Center-Eppendorf, Hamburg, UKE, Germany.

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http://doi.wiley.com/10.1002/eji.201142108
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http://dx.doi.org/10.1002/eji.201142108DOI Listing
March 2012

Neutrophils in multiple sclerosis are characterized by a primed phenotype.

J Neuroimmunol 2012 Jan 9;242(1-2):60-71. Epub 2011 Dec 9.

Institute for Neuroimmunology and Clinical MS Research (inims), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center-Eppendorf, Falkenried 94, 20251 Hamburg (UKE), Germany.

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http://dx.doi.org/10.1016/j.jneuroim.2011.11.009DOI Listing
January 2012

Central role of JC virus-specific CD4+ lymphocytes in progressive multi-focal leucoencephalopathy-immune reconstitution inflammatory syndrome.

Brain 2011 Sep;134(Pt 9):2687-702

Department of Clinical Neuroimmunology and Multiple Sclerosis Research, Neurology Clinic, University Hospital Zürich, University of Zürich, Frauenklinikstrasse 26, 8091 Zürich, Switzerland.

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http://dx.doi.org/10.1093/brain/awr206DOI Listing
September 2011

Combining positional scanning peptide libraries, HLA-DR transfectants and bioinformatics to dissect the epitope spectrum of HLA class II cross-restricted CD4+ T cell clones.

J Immunol Methods 2010 Feb 28;353(1-2):93-101. Epub 2009 Dec 28.

Cellular Immunology Section, Neuroimmunology Branch, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00221759090037
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http://dx.doi.org/10.1016/j.jim.2009.12.006DOI Listing
February 2010

Antigen-specific therapies in MS - Current concepts and novel approaches.

J Neurol Sci 2008 Nov 3;274(1-2):18-22. Epub 2008 Jul 3.

Institute for Neuroimmunology and Clinical MS Research (inims), Center for Molecular Neurobiology Hamburg, University Medical Center Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1016/j.jns.2008.05.021DOI Listing
November 2008

Cerebrospinal fluid-infiltrating CD4+ T cells recognize Borrelia burgdorferi lysine-enriched protein domains and central nervous system autoantigens in early lyme encephalitis.

Infect Immun 2007 Jan 23;75(1):243-51. Epub 2006 Oct 23.

Neuroimmunology Branch, Cellular Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1128/IAI.01110-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828376PMC
January 2007

When T cells recognize a pattern, they might cause trouble.

Curr Opin Immunol 2006 Dec 28;18(6):697-703. Epub 2006 Sep 28.

Institucio Catalana de Recerca i Estudis Avançats (ICREA), Institut de Recerca, Unitat de Neuroimmunologia Clinica, Hospital Universitari Vall D'Hebron, Passeig Vall D'Hebron 119-129, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.coi.2006.09.006DOI Listing
December 2006

Infections in MS: beneficial or harmful?

Authors:
Mireia Sospedra

Int MS J 2006 May;13(2):39-40

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May 2006

Clonotypic analysis of cerebrospinal fluid T cells during disease exacerbation and remission in a patient with multiple sclerosis.

J Neuroimmunol 2006 Feb 18;171(1-2):177-83. Epub 2005 Nov 18.

Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bldg. 10, Room 5B16, 10 Center Dr MSC1400 Bethesda, MD 20892-1400, USA.

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http://dx.doi.org/10.1016/j.jneuroim.2005.10.002DOI Listing
February 2006

Antigen-specific therapies in multiple sclerosis.

Int Rev Immunol 2005 Sep-Dec;24(5-6):393-413

Unitat de Neuroimmunologia Clínica, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

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http://dx.doi.org/10.1080/08830180500371256DOI Listing
February 2006

Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 haplotype.

J Immunol 2006 Feb;176(3):1951-61

Cellular Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746197PMC
http://dx.doi.org/10.4049/jimmunol.176.3.1951DOI Listing
February 2006

Molecular mimicry in multiple sclerosis.

Autoimmunity 2006 Feb;39(1):3-8

Unitat de Neuroimmunologia Clinica, Hospital Universitari Vall d'Hebron, Pg. Vall d'Hebron, 119-129, Barcelona, 08035, Spain.

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http://www.tandfonline.com/doi/full/10.1080/0891693050048492
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http://dx.doi.org/10.1080/08916930500484922DOI Listing
February 2006

Insulin alleles and autoimmune regulator (AIRE) gene expression both influence insulin expression in the thymus.

J Autoimmun 2005 Dec 24;25(4):312-8. Epub 2005 Oct 24.

Laboratory of Immunology for Research Applied to Diagnosis (LIRAD), Blood and Tissue Bank, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Hospital Universitari Germans Trias i Pujol, Crtra. del Canyet s/n, 08916 Badalona, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S089684110500104
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http://dx.doi.org/10.1016/j.jaut.2005.08.006DOI Listing
December 2005

Recognition of conserved amino acid motifs of common viruses and its role in autoimmunity.

PLoS Pathog 2005 Dec 16;1(4):e41. Epub 2005 Dec 16.

Cellular Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1371/journal.ppat.0010041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1315278PMC
December 2005

Immunology of multiple sclerosis.

Annu Rev Immunol 2005 ;23:683-747

Cellular Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1400, USA.

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http://dx.doi.org/10.1146/annurev.immunol.23.021704.115707DOI Listing
June 2005

Different patterns of nicotinic acetylcholine receptor subunit transcription in human thymus.

J Neuroimmunol 2004 Apr;149(1-2):147-59

Reference Health Services-Center for Transfusion and Tissue Bank, Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Hospital Universitari Germans Trias i Pujol, Spain.

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http://dx.doi.org/10.1016/j.jneuroim.2003.11.022DOI Listing
April 2004

Use of combinatorial peptide libraries for T-cell epitope mapping.

Methods 2003 Mar;29(3):236-47

Neuroimmunology Branch, NINDS, National Institutes of Health, 10 Center Drive, MSC 1400, Bethesda, MD 20892-1400, USA.

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March 2003

Multiple sclerosis candidate autoantigens except myelin oligodendrocyte glycoprotein are transcribed in human thymus.

Eur J Immunol 2002 Oct;32(10):2737-47

Laboratory of Immunobiology for Research and Diagnostic Applications (LIRAD) Transfusion Center and Tissue Bank, Hospital Universitari Germans Trias i Pujol, Carretera de Canyet s/n, E-08916 Badalona, Barcelona, Spain.

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http://dx.doi.org/10.1002/1521-4141(2002010)32:10<2737::AID-IMMU2737>3.0.CO;2-0DOI Listing
October 2002