Publications by authors named "Mircea Onaca"

2 Publications

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Retroperitoneal Laparoscopic Radical Prostatectomy.

Chirurgia (Bucur) 2018 Jul-Aug;113(4):542-550

Retroperitoneal Laparoscopic Radical Prostatectomy (RLRP) has been introduced in our department as the first line treatment for patients with localized prostatic cancer and life expectancy over 10 years. At the time, the surgical team had already extensive experience in minimally invasive urologic surgery. Our aim is to describe the laparoscopic technique we currently use and to analyze our oncologic and functional results. Patients and All the patients who underwent RLRP in our institution (PONDERAS ACADEMIC HOSPITAL) from January 2015 to March 2017 were included into a prospective study. The standard preoperative protocol included blood tests, prostate biopsy, pelvis MRI and bone scintigraphy, while the particular therapy was discussed and approved by the Institutional Multidisciplinary Tumor Board. In all the 45 cases, RLRP was indicated for localized prostate cancer. The average patient’s age was 68 years (range 45 â€" 74 years), mean preoperative prostate specific antigen (PSAi) level was 8 ng/mL (range 3â€"15 ng/mL) and prostatic volume between 26 and 52 cc. The laparoscopic approach was completed in all 45 cases â€" no conversions to open surgery. Bilateral nerve sparing was performed in 7 cases (16%) and unilateral in 23 cases (51%). The mean operative time was 165 minutes (range 120 - 240 min), while the average blood loss was 255 mL (range 20â€"800) and two patients received blood transfusions. The mean catheterization time was 10 days (range 7â€"14 days). Positive surgical margins were observed in 8 cases (17.7%). Overall, 86% and respectively, 93% of the patients were continent during the following 3 and 6 months. 51% of the patients had erectile disfunction 6 month after the intervention. Four complications were encountered: intraoperatively - rectal injury (1 case) and postoperatively - bleeding (2 cases) and stenosis at the vesicourethral anastomosis (1 case). No mortality or late morbidity encountered. The radical laparoscopic prostatectomy is a safe and efficient procedure for localized prostate cancer with minimal complications and short hospitalization time, but it requires an experienced team of laparoscopic surgeons. The functional and oncological outcomes of LRP are expected to be improved as the medical team experience is extended.
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June 2019

3D cone-beam CT guidance, a novel technique in renal biopsy--results in 41 patients with suspected renal masses.

Eur Radiol 2012 Nov 2;22(11):2547-52. Epub 2012 Jun 2.

Department of Radiology, St Antonius Hospital, PO Box 2500, 3430 EM, Nieuwegein, The Netherlands.

Objective: To determine whether 3D cone-beam computed tomography (CBCT) guidance allows safe and accurate biopsy of suspected small renal masses (SRM), especially in hard-to-reach anatomical locations.

Materials And Methods: CBCT guidance was used to perform 41 stereotactic biopsy procedures of lesions that were inaccessible for ultrasound guidance or CT guidance. In CBCT guidance, a 3D-volume data set is acquired by rotating a C-arm flat-panel detector angiosystem around the patient. In the data set, a needle trajectory is determined and, after co-registration, a fusion image is created from fluoroscopy and a slice from the data set, enabling the needle to be positioned in real time.

Results: Of the 41 lesions, 22 were malignant, 17 were benign, and 2 were nondiagnostic. The two nondiagnostic lesions proved to be renal cell carcinoma. There was no growth during follow-up imaging of the benign lesions (mean 29 months). This resulted in a sensitivity, specificity, PPV, NPV, and accuracy of 91.7, 100, 100, 89.5, and 95.1%, respectively. Mean dose-area product value was 44.0 Gy·cm(2) (range 16.5-126.5). There was one minor bleeding complication.

Conclusion: With CBCT guidance, safe and accurate biopsy of a suspected SRM is feasible, especially in hard-to-reach locations of the kidney.

Key Points : • Cone-beam computed tomography has potential advantages over conventional CT for interventional procedures. • CBCT guidance incorporates 3D CBCT data, fluoroscopy, and guidance software. • In hard-to-reach renal masses, CBCT guidance offers an alternative biopsy method. • CBCT guidance offers good outcome and safety and has potential clinical significance.
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November 2012