Publications by authors named "Mira Shoukry"

3 Publications

  • Page 1 of 1

The Emerging Role of Circulating Tumor DNA in the Management of Breast Cancer.

Cancers (Basel) 2021 Jul 29;13(15). Epub 2021 Jul 29.

Department of Surgery, Section of Surgical Oncology, Mayo Clinic, Jacksonville, FL 32224, USA.

With the incidence of breast cancer steadily rising, it is important to explore novel technologies that can allow for earlier detection of disease as well more a personalized and effective treatment approach. The concept of "liquid biopsies" and the data they provide have been increasingly studied in the recent decades. More specifically, circulating tumor DNA (ctDNA) has emerged as a potential biomarker for various cancers, including breast cancer. While methods such as mammography and tissue biopsies are the current standards for the detection and surveillance of breast cancer, ctDNA analysis has shown some promise. This review discusses the versatility of ctDNA by exploring its multiple emerging uses for the management of breast cancer. Its efficacy is also compared to current biomarkers and technologies.
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July 2021

Utilization of ECMO in vascular surgery: A presentation of two cases.

Int J Surg Case Rep 2021 Aug 29;85:106141. Epub 2021 Jun 29.

Department of Surgery, Division of Vascular Surgery, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

Introduction: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a form of temporary mechanical circulatory support commonly used during cardiothoracic interventions. Malperfusion during complex vascular procedures remains a significant risk that may potentially lead to multiple complications. Here, we report two cases highlighting the efficacy of VA-ECMO in both planned and emergent vascular interventions.

Presentation Of Case: In our first case, VA-ECMO was used to support an 82-year-old male during a high-risk thoracoabdominal aortic aneurysm repair. Our second case details an emergent pulmonary embolectomy in which VA-ECMO was used as a bridge to cardiopulmonary bypass. In both cases, the procedures were well-tolerated, and the patients were discharged 17 days postoperatively.

Discussion: VA-ECMO has been increasingly used as a form of post-operative circulatory support following cardiothoracic and vascular interventions. However, only few instances of perioperative VA-ECMO use have been reported in the field of vascular surgery.

Conclusion: The presented cases highlight that the perioperative use of VA-ECMO may be a viable modality for required perfusion during complex planned or emergent vascular procedures.
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August 2021

Inflammatory Pseudotumor Resembling a Malignant Pancreatic Disease Process.

Anticancer Res 2021 Apr;41(4):2079-2082

Department of General Surgery, Mayo Clinic, Jacksonville, FL, U.S.A.

Background/aim: Inflammatory pseudotumors are complex entities given that they carry varying characteristics with a multitude of behaviors that can resemble a malignancy clinically, radiographically, and histologically.

Patients And Methods: Our case report presents a 65-year-old-female with a history of fever, abdominal pain, and anemia with imaging suggestive of a malignant disease process involving an ill-defined soft tissue mass between the left adrenal gland and pancreatic tail.

Results: Following diagnostic laparoscopy with abdominal washings and subsequent open resection of the mass, final pathology revealed multiple specimens demonstrating dense fibrosis with admixed spindled cells and inflammatory cells, an overarching morphology, and an immunohistochemical staining profile consistent with pancreatic inflammatory pseudotumor.

Conclusion: Inflammatory pseudotumor is a challenging diagnosis and should be included in the differential diagnosis for a patient who presents with nonspecific symptoms and an ill-defined mass on imaging.
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April 2021